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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.

Egusquiaguirre SP, Liu S, Tošić I, Jiang K, Walker SR, Nicolais M, Saw TY, Xiang M, Bartel K, Nelson EA, Frank DA.

Neoplasia. 2020 Jan;22(1):47-59. doi: 10.1016/j.neo.2019.10.002. Epub 2019 Nov 22.


Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X.

Nature. 2019 Sep;573(7772):139-143. doi: 10.1038/s41586-019-1511-x. Epub 2019 Aug 28.


Quality Decision Making in Health Technology Assessment: Issues Facing Companies and Agencies.

Bujar M, McAuslane N, Walker SR, Salek S.

Ther Innov Regul Sci. 2019 Mar 4:2168479019833660. doi: 10.1177/2168479019833660. [Epub ahead of print]


Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.

Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS.

Oncogenesis. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7.


The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.

Liu S, Marneth AE, Alexe G, Walker SR, Gandler HI, Ye DQ, Labella K, Mathur R, Toniolo PA, Tillgren M, Gokhale PC, Barbie D, Mullally A, Stegmaier K, Frank DA.

Blood Adv. 2018 Dec 11;2(23):3428-3442. doi: 10.1182/bloodadvances.2018016733.


Nellix Endobag rupture associated with a fatal outcome.

Walker SR, Sim E, Froelich JJ.

J Vasc Surg. 2019 Jun;69(6):1936-1939. doi: 10.1016/j.jvs.2018.09.041. Epub 2018 Nov 26.


IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.

Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK.

Cancer Res. 2018 Sep 1;78(17):4957-4970. doi: 10.1158/0008-5472.CAN-17-2268. Epub 2018 Jul 5.


Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS.

Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12.


The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.

Egusquiaguirre SP, Yeh JE, Walker SR, Liu S, Frank DA.

Neoplasia. 2018 May;20(5):489-498. doi: 10.1016/j.neo.2018.03.004. Epub 2018 Apr 2.


PET CT to Confirm an Infected Popliteal Stent Graft Used to Treat Popliteal Artery Aneurysm.

Walker SR.

Eur J Vasc Endovasc Surg. 2017 Nov;54(5):612. doi: 10.1016/j.ejvs.2017.08.007. Epub 2017 Sep 18. No abstract available.


A Comparison of Reimbursement Recommendations by European HTA Agencies: Is There Opportunity for Further Alignment?

Allen N, Liberti L, Walker SR, Salek S.

Front Pharmacol. 2017 Jun 30;8:384. doi: 10.3389/fphar.2017.00384. eCollection 2017.


Evaluating Quality of Decision-Making Processes in Medicines' Development, Regulatory Review, and Health Technology Assessment: A Systematic Review of the Literature.

Bujar M, McAuslane N, Walker SR, Salek S.

Front Pharmacol. 2017 Apr 10;8:189. doi: 10.3389/fphar.2017.00189. eCollection 2017. Review.


Invasive Nontuberculous Mycobacterial Infections among Cardiothoracic Surgical Patients Exposed to Heater-Cooler Devices1.

Lyman MM, Grigg C, Kinsey CB, Keckler MS, Moulton-Meissner H, Cooper E, Soe MM, Noble-Wang J, Longenberger A, Walker SR, Miller JR, Perz JF, Perkins KM.

Emerg Infect Dis. 2017 May;23(5):796-805. doi: 10.3201/eid2305.161899.


Health Technology Assessment (HTA) Case Studies: Factors Influencing Divergent HTA Reimbursement Recommendations in Australia, Canada, England, and Scotland.

Allen N, Walker SR, Liberti L, Salek S.

Value Health. 2017 Mar;20(3):320-328. doi: 10.1016/j.jval.2016.10.014. Epub 2016 Dec 22.


Dipeptidyl Peptidase-4 Inhibitors in Chronic Kidney Disease: A Systematic Review of Randomized Clinical Trials.

Walker SR, Komenda P, Khojah S, Al-Tuwaijri W, MacDonald K, Hiebert B, Tangri N, Nadurak SWD, Ferguson TW, Rigatto C, Tangri N.

Nephron. 2017;136(2):85-94. doi: 10.1159/000454683. Epub 2017 Feb 9. Review.


Evaluating alignment between Canadian Common Drug Review reimbursement recommendations and provincial drug plan listing decisions: an exploratory study.

Allen N, Walker SR, Liberti L, Sehgal C, Salek MS.

CMAJ Open. 2016 Nov 3;4(4):E674-E678. doi: 10.9778/cmajo.20160006. eCollection 2016 Oct-Dec.


NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ.

Cell Discov. 2016 Sep 20;2:16030. doi: 10.1038/celldisc.2016.30. eCollection 2016.


Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.

Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA.

Blood. 2016 Oct 6;128(14):1845-1853. doi: 10.1182/blood-2015-07-660506. Epub 2016 Aug 16.


Targeting BCL6 and STAT3 in triple negative breast cancer: the one-two punch?

Walker SR, Frank DA.

Oncoscience. 2015 Nov 21;2(11):912. eCollection 2015. No abstract available.


Frailty and physical function in chronic kidney disease: the CanFIT study.

Walker SR, Brar R, Eng F, Komenda P, Rigatto C, Prasad B, Bohm CJ, Storsley LJ, Tangri N.

Can J Kidney Health Dis. 2015 Sep 5;2:32. doi: 10.1186/s40697-015-0067-4. eCollection 2015.


An Economic Assessment Model of Rural and Remote Satellite Hemodialysis Units.

Ferguson TW, Zacharias J, Walker SR, Collister D, Rigatto C, Tangri N, Komenda P.

PLoS One. 2015 Aug 18;10(8):e0135587. doi: 10.1371/journal.pone.0135587. eCollection 2015.


Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.

Yeh JE, Kreimer S, Walker SR, Emori MM, Krystal H, Richardson A, Ivanov AR, Frank DA.

Genes Cancer. 2015 Mar;6(3-4):153-68.


Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.

Toniolo PA, Liu S, Yeh JE, Moraes-Vieira PM, Walker SR, Vafaizadeh V, Barbuto JA, Frank DA.

J Immunol. 2015 Apr 1;194(7):3180-90. doi: 10.4049/jimmunol.1401635. Epub 2015 Feb 27.


Cardiac involvement in myotonic dystrophy.

Khalighi K, Kodali A, Thapamagar SB, Walker SR.

J Community Hosp Intern Med Perspect. 2015 Feb 3;5(1):25319. doi: 10.3402/jchimp.v5.25319. eCollection 2015.


Subcutaneous cross pelvic bypass associated with occluded iliac veins.

Walker SR, Saunders A.

J Vasc Surg Venous Lymphat Disord. 2015 Jan;3(1):95. doi: 10.1016/j.jvsv.2014.04.003. Epub 2014 Dec 15. No abstract available.


Chronic kidney disease, frailty, and unsuccessful aging: a review.

Walker SR, Wagner M, Tangri N.

J Ren Nutr. 2014 Nov;24(6):364-70. doi: 10.1053/j.jrn.2014.09.001. Epub 2014 Oct 22. Review.


Evaluation of the Gulf Cooperation Council Centralized Procedure: The Way Forward.

Al-Rubaie MH, Walker SR, Salek SS.

Ther Innov Regul Sci. 2014 Nov;48(6):709-716. doi: 10.1177/2168479014529572.


Responding to traumatic birth: subgaleal hemorrhage, assessment, and management during transport.

Schierholz E, Walker SR.

Adv Neonatal Care. 2014 Oct;14 Suppl 5:S11-5. doi: 10.1097/ANC.0b013e3181fe9a49.


Comparison of location, depth, quality, and intensity of experimentally induced pain in 6 low back muscles.

Tucker KJ, Fels M, Walker SR, Hodges PW.

Clin J Pain. 2014 Sep;30(9):800-8. doi: 10.1097/AJP.0000000000000026.


Surviving an abdominal aortic aneurysm type II endoleak rupture without surgical intervention.

Smith JC, Walker SR.

Vascular. 2015 Apr;23(2):201-3. doi: 10.1177/1708538114540642. Epub 2014 Jun 17.


STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.

Walker SR, Xiang M, Frank DA.

Cancers (Basel). 2014 Apr 23;6(2):958-68. doi: 10.3390/cancers6020958.


The transcriptional modulator BCL6 as a molecular target for breast cancer therapy.

Walker SR, Liu S, Xiang M, Nicolais M, Hatzi K, Giannopoulou E, Elemento O, Cerchietti L, Melnick A, Frank DA.

Oncogene. 2015 Feb 26;34(9):1073-82. doi: 10.1038/onc.2014.61. Epub 2014 Mar 24.


Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.

Lee RE, Walker SR, Savery K, Frank DA, Gaudet S.

Mol Cell. 2014 Mar 20;53(6):867-79. doi: 10.1016/j.molcel.2014.01.026. Epub 2014 Feb 13.


STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes.

Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, Kroll Y, Boldin M, Taganov K, Groner B, Richardson AL, Frank DA.

Sci Signal. 2014 Jan 28;7(310):ra11. doi: 10.1126/scisignal.2004497.


Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction.

Walker SR, Czyz ML, Morris JC.

Org Lett. 2014 Feb 7;16(3):708-11. doi: 10.1021/ol403390m. Epub 2014 Jan 17.


Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.

Liu S, Walker SR, Nelson EA, Cerulli R, Xiang M, Toniolo PA, Qi J, Stone RM, Wadleigh M, Bradner JE, Frank DA.

Mol Cancer Ther. 2014 May;13(5):1194-205. doi: 10.1158/1535-7163.MCT-13-0341. Epub 2014 Jan 16.


Association of frailty and physical function in patients with non-dialysis CKD: a systematic review.

Walker SR, Gill K, Macdonald K, Komenda P, Rigatto C, Sood MM, Bohm CJ, Storsley LJ, Tangri N.

BMC Nephrol. 2013 Oct 22;14:228. doi: 10.1186/1471-2369-14-228. Review.


Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets.

Walker SR, Frank DA.

JAKSTAT. 2012 Oct 1;1(4):292-9. doi: 10.4161/jkst.22662. Review.


STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.

Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA.

Mol Cell Biol. 2013 Aug;33(15):2879-90. doi: 10.1128/MCB.01620-12. Epub 2013 May 28.


Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Zhang L, Holmes IP, Hochgräfe F, Walker SR, Ali NA, Humphrey ES, Wu J, de Silva M, Kersten WJ, Connor T, Falk H, Allan L, Street IP, Bentley JD, Pilling PA, Monahan BJ, Peat TS, Daly RJ.

J Proteome Res. 2013 Jul 5;12(7):3104-16. doi: 10.1021/pr3008495. Epub 2013 Jun 25.


Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.

Walker SR, Xiang M, Frank DA.

Mol Cell Endocrinol. 2014 Jan 25;382(1):616-621. doi: 10.1016/j.mce.2013.03.010. Epub 2013 Mar 24. Review.


Randomized, blinded study to assess the effect of povidone-iodine on the groin wound of patients undergoing primary varicose vein surgery.

Walker SR, Smith A.

ANZ J Surg. 2013 Nov;83(11):844-6. doi: 10.1111/ans.12077. Epub 2013 Jan 29.


Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

Chmielecki J, Crago AM, Rosenberg M, O'Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M.

Nat Genet. 2013 Feb;45(2):131-2. doi: 10.1038/ng.2522. Epub 2013 Jan 13.


The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations.

Nelson EA, Walker SR, Xiang M, Weisberg E, Bar-Natan M, Barrett R, Liu S, Kharbanda S, Christie AL, Nicolais M, Griffin JD, Stone RM, Kung AL, Frank DA.

Genes Cancer. 2012 Jul;3(7-8):503-11. doi: 10.1177/1947601912466555.


Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, Zhang J, Pho NH, Walker SR, Winckler W, Getz G, Frank D, Hahn WC, Eck MJ, Mani DR, Jaffe JD, Carr SA, Wong KK, Meyerson M.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14476-81. doi: 10.1073/pnas.1203201109. Epub 2012 Aug 20.


U Clips for arteriovenous anastomosis: a pilot, randomized study.

Walker SR.

ANZ J Surg. 2012 Sep;82(9):630-2. doi: 10.1111/j.1445-2197.2012.06153.x. Epub 2012 Aug 20.


Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells.

Bar-Natan M, Nelson EA, Walker SR, Kuang Y, Distel RJ, Frank DA.

Leukemia. 2012 Jun;26(6):1407-10. doi: 10.1038/leu.2011.338. Epub 2011 Dec 2. No abstract available.


STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents.

Walker SR, Chaudhury M, Frank DA.

Mol Cell Pharmacol. 2011 Jan 1;3(1):13-19.


Application of synchrotron microprobe methods to solid-phase speciation of metals and metalloids in house dust.

Walker SR, Jamieson HE, Rasmussen PE.

Environ Sci Technol. 2011 Oct 1;45(19):8233-40. doi: 10.1021/es2008227. Epub 2011 Sep 12.


The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K.

J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745.

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