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Retrospective multicentre matched cohort study comparing safety and efficacy outcomes of intermittent-infusion versus continuous-infusion vancomycin.

Ma NH, Walker SAN, Elligsen M, Kiss A, Palmay L, Ho G, Powis J, Bansal V, Leis JA.

J Antimicrob Chemother. 2020 Apr 1;75(4):1038-1046. doi: 10.1093/jac/dkz531.


Dynamics of human monocytes and airway macrophages during healthy aging and after transplant.

Byrne AJ, Powell JE, O'Sullivan BJ, Ogger PP, Hoffland A, Cook J, Bonner KL, Hewitt RJ, Wolf S, Ghai P, Walker SA, Lukowski SW, Molyneaux PL, Saglani S, Chambers DC, Maher TM, Lloyd CM.

J Exp Med. 2020 Mar 2;217(3). pii: e20191236. doi: 10.1084/jem.20191236.


Development and validation of a screening tool for early identification of bloodstream infection in older patients - a retrospective case-control study.

Walker SAN, Bannerman H, Ma N, Peragine C, Elligsen M, Palmay L, Williams E, Liu B.

BMC Geriatr. 2020 Jan 3;20(1):6. doi: 10.1186/s12877-019-1402-x.


Impact of a comprehensive antimicrobial stewardship program on institutional burden of antimicrobial resistance: a 14-year controlled interrupted time series study.

Peragine C, Walker SAN, Simor A, Walker SE, Kiss A, Leis JA.

Clin Infect Dis. 2019 Dec 9. pii: ciz1183. doi: 10.1093/cid/ciz1183. [Epub ahead of print]


An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ.

Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13.


Autophagosome Biogenesis Machinery.

Walker SA, Ktistakis NT.

J Mol Biol. 2019 Nov 6. pii: S0022-2836(19)30623-0. doi: 10.1016/j.jmb.2019.10.027. [Epub ahead of print] Review.


Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation.

Patel DF, Peiró T, Bruno N, Vuononvirta J, Akthar S, Puttur F, Pyle CJ, Suveizdytė K, Walker SA, Singanayagam A, Carlin LM, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Immunol. 2019 Nov 8;4(41). pii: eaax7006. doi: 10.1126/sciimmunol.aax7006.


Voriconazole prophylaxis in leukemic patients: A retrospective single-center study.

Bui V, Walker SA, Elligsen M, Vyas A, Kiss A, Palmay L.

J Oncol Pharm Pract. 2019 Sep 29:1078155219876683. doi: 10.1177/1078155219876683. [Epub ahead of print]


Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation - a retrospective study.

Bergenwall M, Walker SAN, Elligsen M, Iaboni DC, Findlater C, Seto W, Ng E.

BMC Pediatr. 2019 Sep 6;19(1):318. doi: 10.1186/s12887-019-1676-3.


A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma.

Branchett WJ, Stölting H, Oliver RA, Walker SA, Puttur F, Gregory LG, Gabryšová L, Wilson MS, O'Garra A, Lloyd CM.

J Allergy Clin Immunol. 2020 Feb;145(2):666-678.e9. doi: 10.1016/j.jaci.2019.08.006. Epub 2019 Aug 22.


Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Zachari M, Gudmundsson SR, Li Z, Manifava M, Shah R, Smith M, Stronge J, Karanasios E, Piunti C, Kishi-Itakura C, Vihinen H, Jokitalo E, Guan JL, Buss F, Smith AM, Walker SA, Eskelinen EL, Ktistakis NT.

Dev Cell. 2019 Sep 9;50(5):627-643.e5. doi: 10.1016/j.devcel.2019.06.016. Epub 2019 Jul 25.


Development, evaluation and validation of a screening tool for late onset bacteremia in neonates - a pilot study.

Walker SAN, Cormier M, Elligsen M, Choudhury J, Rolnitsky A, Findlater C, Iaboni D.

BMC Pediatr. 2019 Jul 24;19(1):253. doi: 10.1186/s12887-019-1633-1.


Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.

Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM.

Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638.


Fluoroquinolone Antibiotic Prophylaxis to Prevent Post-Traumatic Bacterial Infectious Endophthalmitis: Using Monte Carlo Simulation to Evaluate the Probability of Success.

Peragine C, Walker SAN, Walker S, Palmay L.

J Ocul Pharmacol Ther. 2019 Jul/Aug;35(6):366-371. doi: 10.1089/jop.2019.0013. Epub 2019 May 8.


The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis.

Allden SJ, Ogger PP, Ghai P, McErlean P, Hewitt R, Toshner R, Walker SA, Saunders P, Kingston S, Molyneaux PL, Maher TM, Lloyd CM, Byrne AJ.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):209-219. doi: 10.1164/rccm.201809-1775OC.


Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.

Uwadiae FI, Pyle CJ, Walker SA, Lloyd CM, Harker JA.

Allergy. 2019 Apr;74(4):650-662. doi: 10.1111/all.13602. Epub 2018 Nov 12.


Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization.

Scott AJ, Walker SA, Krank JJ, Wilkinson AS, Johnson KM, Lewis EM, Wilkinson JC.

J Biol Chem. 2018 Sep 21;293(38):14707-14722. doi: 10.1074/jbc.RA118.004022. Epub 2018 Aug 9.


The impact of vancomycin trough concentrations on outcomes in non-deep seated infections: a retrospective cohort study.

Wan M, Walker SAN, Martin E, Elligsen M, Palmay L, Leis JA.

BMC Pharmacol Toxicol. 2018 Jul 31;19(1):47. doi: 10.1186/s40360-018-0236-z.


Lung Defense through IL-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function.

Reynolds CJ, Quigley K, Cheng X, Suresh A, Tahir S, Ahmed-Jushuf F, Nawab K, Choy K, Walker SA, Mathie SA, Sim M, Stowell J, Manji J, Pollard T, Altmann DM, Boyton RJ.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):557-571. doi: 10.1165/rcmb.2018-0007OC.


Prophylactic Antimicrobial Therapy for Acute Aspiration Pneumonitis.

Dragan V, Wei Y, Elligsen M, Kiss A, Walker SAN, Leis JA.

Clin Infect Dis. 2018 Aug 1;67(4):513-518. doi: 10.1093/cid/ciy120.


Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.

Zhang Y, Poobalasingam T, Yates LL, Walker SA, Taylor MS, Chessum L, Harrison J, Tsaprouni L, Adcock IM, Lloyd CM, Cookson WO, Moffatt MF, Dean CH.

Dis Model Mech. 2018 Jan 29;11(1). pii: dmm031369. doi: 10.1242/dmm.031369.


Steady-State Pharmacokinetics of Oral Ciprofloxacin in Continuous Cycling Peritoneal Dialysis Patients: Brief Report.

Lee C, Walker SAN, Palmay L, Walker SE, Tobe S, Simor A.

Perit Dial Int. 2018 Jan-Feb;38(1):73-76. doi: 10.3747/pdi.2017.00052.


Period-dependent Associations between Hypotension during and for Four Days after Noncardiac Surgery and a Composite of Myocardial Infarction and Death: A Substudy of the POISE-2 Trial.

Sessler DI, Meyhoff CS, Zimmerman NM, Mao G, Leslie K, Vásquez SM, Balaji P, Alvarez-Garcia J, Cavalcanti AB, Parlow JL, Rahate PV, Seeberger MD, Gossetti B, Walker SA, Premchand RK, Dahl RM, Duceppe E, Rodseth R, Botto F, Devereaux PJ.

Anesthesiology. 2018 Feb;128(2):317-327. doi: 10.1097/ALN.0000000000001985.


A meta-analysis and systematic review of reactivity to judgements of learning.

Double KS, Birney DP, Walker SA.

Memory. 2018 Jul;26(6):741-750. doi: 10.1080/09658211.2017.1404111. Epub 2017 Nov 21.


A prospective study evaluating tobramycin pharmacokinetics and optimal once daily dosing in burn patients.

Lee C, Walker SAN, Walker SE, Seto W, Simor A, Jeschke M.

Burns. 2017 Dec;43(8):1766-1774. doi: 10.1016/j.burns.2017.05.009. Epub 2017 Jun 21.


Point-of-Care β-Lactam Allergy Skin Testing by Antimicrobial Stewardship Programs: A Pragmatic Multicenter Prospective Evaluation.

Leis JA, Palmay L, Ho G, Raybardhan S, Gill S, Kan T, Campbell J, Kiss A, McCready JB, Das P, Minnema B, Powis JE, Walker SAN, Ferguson H, Wong B, Weber E.

Clin Infect Dis. 2017 Oct 1;65(7):1059-1065. doi: 10.1093/cid/cix512.


Correlative Live Cell and Super Resolution Imaging of Autophagosome Formation.

Walker SA, Karanasios E, Ktistakis NT.

Methods Enzymol. 2017;587:1-20. doi: 10.1016/bs.mie.2016.09.050. Epub 2016 Nov 17.


Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH.

Dis Model Mech. 2017 Apr 1;10(4):409-423. doi: 10.1242/dmm.028175. Epub 2017 Feb 24.


Elimination of Screening Urine Cultures Prior to Elective Joint Arthroplasty.

Lamb MJ, Baillie L, Pajak D, Flynn J, Bansal V, Simor A, Vearncombe M, Walker SA, Clark S, Gollish J, Leis JA.

Clin Infect Dis. 2017 Mar 15;64(6):806-809. doi: 10.1093/cid/ciw848.


Assembly of early machinery for autophagy induction: novel insights from high resolution microscopy.

Ktistakis NT, Walker SA, Karanasios E.

Oncotarget. 2016 Dec 27;7(52):85678-85679. doi: 10.18632/oncotarget.13144. No abstract available.


A critical role for IRF5 in regulating allergic airway inflammation.

Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA.

Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19.


Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

Löser S, Gregory LG, Zhang Y, Schaefer K, Walker SA, Buckley J, Denney L, Dean CH, Cookson WOC, Moffatt MF, Lloyd CM.

J Allergy Clin Immunol. 2017 May;139(5):1496-1507.e3. doi: 10.1016/j.jaci.2016.07.033. Epub 2016 Sep 10.


Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles.

Karanasios E, Walker SA, Okkenhaug H, Manifava M, Hummel E, Zimmermann H, Ahmed Q, Domart MC, Collinson L, Ktistakis NT.

Nat Commun. 2016 Aug 11;7:12420. doi: 10.1038/ncomms12420.


The Clinical Utility of Next Generation Sequencing Results in a Community-Based Hereditary Cancer Risk Program.

Bunnell AE, Garby CA, Pearson EJ, Walker SA, Panos LE, Blum JL.

J Genet Couns. 2017 Feb;26(1):105-112. doi: 10.1007/s10897-016-9985-2. Epub 2016 Jun 9.


Antibiotic Use and Need for Antimicrobial Stewardship in Long-Term Care.

Wu LD, Walker SA, Elligsen M, Palmay L, Simor A, Daneman N.

Can J Hosp Pharm. 2015 Nov-Dec;68(6):445-9. Erratum in: Can J Hosp Pharm. 2017 May-Jun;70(3):224.


Impact of infection with extended-spectrum β-lactamase-producing Escherichia coli or Klebsiella species on outcome and hospitalization costs.

Maslikowska JA, Walker SA, Elligsen M, Mittmann N, Palmay L, Daneman N, Simor A.

J Hosp Infect. 2016 Jan;92(1):33-41. doi: 10.1016/j.jhin.2015.10.001. Epub 2015 Oct 22.


Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

Denney L, Byrne AJ, Shea TJ, Buckley JS, Pease JE, Herledan GM, Walker SA, Gregory LG, Lloyd CM.

Immunity. 2015 Nov 17;43(5):945-58. doi: 10.1016/j.immuni.2015.10.012.


Neurocognitive Function at the First-Line Failure and on the Second-Line Antiretroviral Therapy in Africa: Analyses From the EARNEST Trial.

Kambugu A, Thompson J, Hakim J, Tumukunde D, van Oosterhout JJ, Mwebaze R, Hoppe A, Abach J, Kwobah C, Arenas-Pinto A, Walker SA, Paton NI; EARNEST Trial Team.

J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):506-13. doi: 10.1097/QAI.0000000000000898.


Impact of hospital length of stay on the distribution of Gram negative bacteria and likelihood of isolating a resistant organism in a Canadian burn center.

Wanis M, Walker SAN, Daneman N, Elligsen M, Palmay L, Simor A, Cartotto R.

Burns. 2016 Feb;42(1):104-111. doi: 10.1016/j.burns.2015.07.010. Epub 2015 Nov 5.


Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig.

Lafrenaye AD, Todani M, Walker SA, Povlishock JT.

J Neuroinflammation. 2015 Oct 6;12:186. doi: 10.1186/s12974-015-0405-6.


Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

Badavi FF, Walker SA, Santos Koos LM.

Life Sci Space Res (Amst). 2015 Apr;5:21-30. doi: 10.1016/j.lssr.2015.04.001. Epub 2015 Apr 9.


Point prevalence survey of antimicrobial utilization in a Canadian tertiary-care teaching hospital.

Lee C, Walker SA, Daneman N, Elligsen M, Palmay L, Coburn B, Simor A.

J Epidemiol Glob Health. 2015 Jun;5(2):143-50. doi: 10.1016/j.jegh.2014.06.003. Epub 2014 Aug 8.


Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.


Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.

Johnson JR, Folestad E, Rowley JE, Noll EM, Walker SA, Lloyd CM, Rankin SM, Pietras K, Eriksson U, Fuxe J.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L658-71. doi: 10.1152/ajplung.00286.2014. Epub 2015 Jan 30.


Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge.

Mathie SA, Dixon KL, Walker SA, Tyrrell V, Mondhe M, O'Donnell VB, Gregory LG, Lloyd CM.

Allergy. 2015 Jan;70(1):80-9. doi: 10.1111/all.12536. Epub 2014 Nov 28.


Impact of second-line antiretroviral regimens on lipid profiles in an African setting: the DART trial sub-study.

Gomo ZA, Hakim JG, Walker SA, Tinago W, Mandozana G, Kityo C, Munderi P, Katabira E, Reid A, Gibb DM, Gilks CF; DART Team.

AIDS Res Ther. 2014 Oct 2;11(1):32. doi: 10.1186/1742-6405-11-32. eCollection 2014.


Lessons from audit and feedback of hospitalized patients with bacteriuria.

Leis JA, Palmay L, Elligsen M, Walker SA, Lee C, Daneman N.

Am J Infect Control. 2014 Oct;42(10):1136-7. doi: 10.1016/j.ajic.2014.06.020.


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