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Items: 1 to 50 of 266

1.

ANTERIOR INSULAR CORTEX IS CRITICAL FOR THE PROPENSITY TO RELAPSE FOLLOWING PUNISHMENT-IMPOSED ABSTINENCE OF ALCOHOL SEEKING.

Campbell EJ, Flanagan JPM, Walker LC, Hill MKRI, Marchant NJ, Lawrence AJ.

J Neurosci. 2018 Dec 3. pii: 1596-18. doi: 10.1523/JNEUROSCI.1596-18.2018. [Epub ahead of print]

PMID:
30509960
2.

Which patients are satisfied with their overall outcome but dissatisfied with their return to recreational activities after total knee arthroplasty?

Clement ND, Walker LC, Merrie K, Bardgett M, Weir D, Holland J, Deehan DJ.

Knee. 2018 Nov 14. pii: S0968-0160(18)30343-0. doi: 10.1016/j.knee.2018.09.013. [Epub ahead of print]

PMID:
30447900
3.

The effect of acute or repeated stress on the corticotropin releasing factor system in the CRH-IRES-Cre mouse: A validation study.

Walker LC, Cornish LC, Lawrence AJ, Campbell EJ.

Neuropharmacology. 2018 Sep 26. pii: S0028-3908(18)30703-2. doi: 10.1016/j.neuropharm.2018.09.037. [Epub ahead of print]

PMID:
30266597
4.

Patient age of less than 55 years is not an independent predictor of functional improvement or satisfaction after total knee arthroplasty.

Clement ND, Walker LC, Bardgett M, Weir D, Holland J, Gerrand C, Deehan DJ.

Arch Orthop Trauma Surg. 2018 Dec;138(12):1755-1763. doi: 10.1007/s00402-018-3041-7. Epub 2018 Sep 26.

PMID:
30259126
5.

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases.

Jucker M, Walker LC.

Nat Neurosci. 2018 Oct;21(10):1341-1349. doi: 10.1038/s41593-018-0238-6. Epub 2018 Sep 26. Review.

PMID:
30258241
6.

A standard model of Alzheimer's disease?

Walker LC, Lynn DG, Chernoff YO.

Prion. 2018;12(5-6):261-265. doi: 10.1080/19336896.2018.1525256. Epub 2018 Oct 9.

PMID:
30220236
7.

Correction: Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.

Walker LC, Marquart L, Pearson JF, Wiggins GAR, O'Mara TA, Parsons MT; BCFR, Barrowdale D, McGuffog L, Dennis J, Benitez J, Slavin TP, Radice P, Frost D; EMBRACE, Godwin AK, Meindl A, Schmutzler RK; GEMO Study Collaborators, Isaacs C, Peshkin BN, Caldes T, Hogervorst FBL; HEBON, Lazaro C, Jakubowska A, Montagna M; KConFab Investigators, Chen X, Offit K, Hulick PJ, Andrulis IL, Lindblom A, Nussbaum RL, Nathanson KL, Chenevix-Trench G, Antoniou AC, Couch FJ, Spurdle AB.

Eur J Hum Genet. 2018 Aug 22. doi: 10.1038/s41431-018-0216-1. [Epub ahead of print]

PMID:
30135485
8.

Investigational drug therapies in phase I and phase II clinical trials for alcohol use disorders.

Walker LC, Lawrence AJ.

Expert Opin Investig Drugs. 2018 Jul 27:1-14. doi: 10.1080/13543784.2018.1502269. [Epub ahead of print]

PMID:
30019949
9.

Predicting the Outcome of Total Knee Arthroplasty Using the WOMAC Score: A Review of the Literature.

Walker LC, Clement ND, Deehan DJ.

J Knee Surg. 2018 Jul 10. doi: 10.1055/s-0038-1666866. [Epub ahead of print]

PMID:
29991079
10.

Prion-like mechanisms in Alzheimer disease.

Walker LC.

Handb Clin Neurol. 2018;153:303-319. doi: 10.1016/B978-0-444-63945-5.00016-7. Review.

PMID:
29887142
11.

Sabotage by the brain's supporting cells helps fuel neurodegeneration.

Walker LC.

Nature. 2018 May;557(7706):499-500. doi: 10.1038/d41586-018-04988-3. No abstract available.

PMID:
29777188
12.

Investigation of Experimental Factors That Underlie BRCA1/2 mRNA Isoform Expression Variation: Recommendations for Utilizing Targeted RNA Sequencing to Evaluate Potential Spliceogenic Variants.

Lattimore VL, Pearson JF, Currie MJ, Spurdle AB; kConFab Investigators, Robinson BA, Walker LC.

Front Oncol. 2018 May 3;8:140. doi: 10.3389/fonc.2018.00140. eCollection 2018.

13.

Correction to: The WOMAC score can be reliably used to classify patient satisfaction after total knee arthroplasty.

Walker LC, Clement ND, Bardgett M, Weir D, Holland J, Gerrand C, Deehan DJ.

Knee Surg Sports Traumatol Arthrosc. 2018 Apr 11. doi: 10.1007/s00167-018-4937-z. [Epub ahead of print]

PMID:
29644386
14.

Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease.

Kamara DM, Gangishetti U, Gearing M, Willis-Parker M, Zhao L, Hu WT, Walker LC.

J Alzheimers Dis. 2018;62(4):1815-1826. doi: 10.3233/JAD-170954.

15.

The WOMAC score can be reliably used to classify patient satisfaction after total knee arthroplasty.

Walker LC, Clement ND, Bardgett M, Weir D, Holland J, Gerrand C, Deehan DJ.

Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3333-3341. doi: 10.1007/s00167-018-4879-5. Epub 2018 Feb 26. Erratum in: Knee Surg Sports Traumatol Arthrosc. 2018 Apr 11;:.

PMID:
29484445
16.

Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events.

de Jong LC, Cree S, Lattimore V, Wiggins GAR, Spurdle AB; kConFab Investigators, Miller A, Kennedy MA, Walker LC.

Breast Cancer Res. 2017 Nov 28;19(1):127. doi: 10.1186/s13058-017-0919-1.

17.

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.

Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarström P, Staufenbiel M, Walker LC, Jucker M.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13018-13023. doi: 10.1073/pnas.1713215114. Epub 2017 Nov 20.

18.

Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain.

Diner I, Dooyema J, Gearing M, Walker LC, Seyfried NT.

Bioconjug Chem. 2017 Oct 18;28(10):2627-2637. doi: 10.1021/acs.bioconjchem.7b00500. Epub 2017 Sep 22.

19.

Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats.

Walker LC, Kastman HE, Krstew EV, Gundlach AL, Lawrence AJ.

Br J Pharmacol. 2017 Oct;174(19):3359-3369. doi: 10.1111/bph.13955. Epub 2017 Aug 23.

20.

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.

Ye L, Rasmussen J, Kaeser SA, Marzesco AM, Obermüller U, Mahler J, Schelle J, Odenthal J, Krüger C, Fritschi SK, Walker LC, Staufenbiel M, Baumann F, Jucker M.

EMBO Rep. 2017 Sep;18(9):1536-1544. doi: 10.15252/embr.201744067. Epub 2017 Jul 12.

21.

Aβ seeds and prions: How close the fit?

Rasmussen J, Jucker M, Walker LC.

Prion. 2017 Jul 4;11(4):215-225. doi: 10.1080/19336896.2017.1334029. Epub 2017 Jun 28.

22.

The Exceptional Vulnerability of Humans to Alzheimer's Disease.

Walker LC, Jucker M.

Trends Mol Med. 2017 Jun;23(6):534-545. doi: 10.1016/j.molmed.2017.04.001. Epub 2017 May 5. Review.

23.

Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry.

Walker LC, Pearson JF, Wiggins GA, Giles GG, Hopper JL, Southey MC.

Breast Cancer Res. 2017 Mar 16;19(1):30. doi: 10.1186/s13058-017-0825-6.

24.

Amyloid-Related Imaging Abnormalities in an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy.

Heuer E, Jacobs J, Du R, Wang S, Keifer OP, Cintron AF, Dooyema J, Meng Y, Zhang X, Walker LC.

J Alzheimers Dis. 2017;57(2):519-530. doi: 10.3233/JAD-160981.

25.

Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.

Walker LC, Marquart L, Pearson JF, Wiggins GA, O'Mara TA, Parsons MT; BCFR, Barrowdale D, McGuffog L, Dennis J, Benitez J, Slavin TP, Radice P, Frost D; EMBRACE, Godwin AK, Meindl A, Schmutzler RK; GEMO Study Collaborators, Isaacs C, Peshkin BN, Caldes T, Hogervorst FB; HEBON, Lazaro C, Jakubowska A, Montagna M; KConFab Investigators, Chen X, Offit K, Hulick PJ, Andrulis IL, Lindblom A, Nussbaum RL, Nathanson KL, Chenevix-Trench G, Antoniou AC, Couch FJ, Spurdle AB.

Eur J Hum Genet. 2017 Apr;25(4):432-438. doi: 10.1038/ejhg.2016.203. Epub 2017 Feb 1. Erratum in: Eur J Hum Genet. 2018 Aug 22;:.

26.

The Role of Orexins/Hypocretins in Alcohol Use and Abuse.

Walker LC, Lawrence AJ.

Curr Top Behav Neurosci. 2017;33:221-246. doi: 10.1007/7854_2016_55. Review.

PMID:
27909991
27.

Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases.

Walker LC.

Annu Rev Genet. 2016 Nov 23;50:329-346. Review.

PMID:
27893962
28.

CRF and the nucleus incertus: a node for integration of stress signals.

Walker LC, Lawrence AJ.

Nat Rev Neurosci. 2017 Feb;18(2):158. doi: 10.1038/nrn.2016.158. Epub 2016 Nov 24. No abstract available.

PMID:
27881855
29.

Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.

de la Hoya M, Soukarieh O, López-Perolio I, Vega A, Walker LC, van Ierland Y, Baralle D, Santamariña M, Lattimore V, Wijnen J, Whiley P, Blanco A, Raponi M, Hauke J, Wappenschmidt B, Becker A, Hansen TV, Behar R, Investigators K, Niederacher D, Arnold N, Dworniczak B, Steinemann D, Faust U, Rubinstein W, Hulick PJ, Houdayer C, Caputo SM, Castera L, Pesaran T, Chao E, Brewer C, Southey MC, van Asperen CJ, Singer CF, Sullivan J, Poplawski N, Mai P, Peto J, Johnson N, Burwinkel B, Surowy H, Bojesen SE, Flyger H, Lindblom A, Margolin S, Chang-Claude J, Rudolph A, Radice P, Galastri L, Olson JE, Hallberg E, Giles GG, Milne RL, Andrulis IL, Glendon G, Hall P, Czene K, Blows F, Shah M, Wang Q, Dennis J, Michailidou K, McGuffog L, Bolla MK, Antoniou AC, Easton DF, Couch FJ, Tavtigian S, Vreeswijk MP, Parsons M, Meeks HD, Martins A, Goldgar DE, Spurdle AB.

Hum Mol Genet. 2016 Jun 1;25(11):2256-2268. Epub 2016 Mar 23.

30.

Microbial resistance related to antibiotic-loaded bone cement: a historical review.

Walker LC, Baker P, Holleyman R, Deehan D.

Knee Surg Sports Traumatol Arthrosc. 2017 Dec;25(12):3808-3817. doi: 10.1007/s00167-016-4309-5. Epub 2016 Sep 12. Review.

PMID:
27620468
31.

Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol seeking in rats.

Walker LC, Kastman HE, Koeleman JA, Smith CM, Perry CJ, Krstew EV, Gundlach AL, Lawrence AJ.

Addict Biol. 2017 Nov;22(6):1641-1654. doi: 10.1111/adb.12426. Epub 2016 Jul 20.

PMID:
27440230
32.

The Malignant Protein Puzzle.

Walker LC, Jucker M.

Cerebrum. 2016 Mar 1;2016. pii: cer-04-16. eCollection 2016 Mar-Apr.

33.

Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease.

Rosen RF, Tomidokoro Y, Farberg AS, Dooyema J, Ciliax B, Preuss TM, Neubert TA, Ghiso JA, LeVine H 3rd, Walker LC.

Neurobiol Aging. 2016 Aug;44:185-196. doi: 10.1016/j.neurobiolaging.2016.04.019. Epub 2016 May 2.

34.

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease.

Walker LC, Schelle J, Jucker M.

Cold Spring Harb Perspect Med. 2016 Jul 1;6(7). pii: a024398. doi: 10.1101/cshperspect.a024398. Review.

35.

What amyloid ligands can tell us about molecular polymorphism and disease.

LeVine H 3rd, Walker LC.

Neurobiol Aging. 2016 Jun;42:205-12. doi: 10.1016/j.neurobiolaging.2016.03.019. Epub 2016 Mar 24. Review.

36.

Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples.

Fackenthal JD, Yoshimatsu T, Zhang B, de Garibay GR, Colombo M, De Vecchi G, Ayoub SC, Lal K, Olopade OI, Vega A, Santamariña M, Blanco A, Wappenschmidt B, Becker A, Houdayer C, Walker LC, López-Perolio I, Thomassen M, Parsons M, Whiley P, Blok MJ, Brandão RD, Tserpelis D, Baralle D, Montalban G, Gutiérrez-Enríquez S, Díez O, Lazaro C; kConFaB Investigators, Spurdle AB, Radice P, de la Hoya M.

J Med Genet. 2016 Aug;53(8):548-58. doi: 10.1136/jmedgenet-2015-103570. Epub 2016 Apr 8.

PMID:
27060066
37.

Translating colorectal cancer genetics into clinically useful biomarkers.

Morley-Bunker A, Walker LC, Currie MJ, Pearson J, Eglinton T.

Colorectal Dis. 2016 Aug;18(8):749-62. doi: 10.1111/codi.13334. Review.

PMID:
26990814
38.

Provision of total hip replacement for displaced intracapsular hip fracture and the outcomes: audit of local practice based on NICE guidelines.

Walker LC, Lee LH, Webb M, Walmsley J, O'Brien S, Krishnan KM, Nanu AM.

Hip Int. 2016 Mar-Apr;26(2):153-7. doi: 10.5301/hipint.5000326. Epub 2016 Feb 5.

PMID:
26868116
39.

Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing.

Lattimore V, Currie M, Lintott C, Sullivan J, Robinson BA, Walker LC.

N Z Med J. 2015 Aug 7;128(1419):56-61.

PMID:
26365847
40.

Neurodegeneration: Amyloid-β pathology induced in humans.

Jucker M, Walker LC.

Nature. 2015 Sep 10;525(7568):193-4. doi: 10.1038/525193a. No abstract available.

PMID:
26354478
41.

Persistence of Aβ seeds in APP null mouse brain.

Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA, Eisele YS, Walker LC, Baumann F, Staufenbiel M, Jucker M.

Nat Neurosci. 2015 Nov;18(11):1559-61. doi: 10.1038/nn.4117. Epub 2015 Sep 9.

PMID:
26352792
42.

Transport of cargo from periphery to brain by circulating monocytes.

Cintron AF, Dalal NV, Dooyema J, Betarbet R, Walker LC.

Brain Res. 2015 Oct 5;1622:328-38. doi: 10.1016/j.brainres.2015.06.047. Epub 2015 Jul 10.

43.

Extracellular Glycoside Hydrolase Activities in the Human Oral Cavity.

Inui T, Walker LC, Dodds MW, Hanley AB.

Appl Environ Microbiol. 2015 Aug 15;81(16):5471-6. doi: 10.1128/AEM.01180-15. Epub 2015 Jun 5.

44.

Neurodegenerative diseases: expanding the prion concept.

Walker LC, Jucker M.

Annu Rev Neurosci. 2015 Jul 8;38:87-103. doi: 10.1146/annurev-neuro-071714-033828. Epub 2015 Mar 30. Review.

45.

Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients.

Gerring Z, Pearson JF, Morrin HR, Robinson BA, Harris GC, Walker LC.

Histopathology. 2015 Oct;67(4):538-47. doi: 10.1111/his.12678. Epub 2015 Mar 31.

PMID:
25728258
46.

Cytomegalovirus and Epstein-Barr virus in breast cancer.

Richardson AK, Currie MJ, Robinson BA, Morrin H, Phung Y, Pearson JF, Anderson TP, Potter JD, Walker LC.

PLoS One. 2015 Feb 27;10(2):e0118989. doi: 10.1371/journal.pone.0118989. eCollection 2015. Review.

47.

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome.

Ye L, Hamaguchi T, Fritschi SK, Eisele YS, Obermüller U, Jucker M, Walker LC.

Brain Pathol. 2015 Nov;25(6):743-52. doi: 10.1111/bpa.12252. Epub 2015 Mar 24.

48.

The Role of Constitutional Copy Number Variants in Breast Cancer.

Walker LC, Wiggins GA, Pearson JF.

Microarrays (Basel). 2015 Sep 8;4(3):407-23. doi: 10.3390/microarrays4030407. Review.

49.

Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition.

Moir-Meyer GL, Pearson JF, Lose F; Australian National Endometrial Cancer Study Group, Scott RJ, McEvoy M, Attia J, Holliday EG; Hunter Community Study; Studies of Epidemiology and Risk Factors in Cancer Heredity, Pharoah PD, Dunning AM, Thompson DJ, Easton DF, Spurdle AB, Walker LC.

Hum Genet. 2015 Mar;134(3):269-78. doi: 10.1007/s00439-014-1507-4. Epub 2014 Nov 9.

PMID:
25381466
50.

Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Peterlongo P, Chang-Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J, Soucy P, Eeles RA, Easton DF, Hamann U, Wilkening S, Chen B, Rookus MA, Schmidt MK, van der Baan FH, Spurdle AB, Walker LC, Lose F, Maia AT, Montagna M, Matricardi L, Lubinski J, Jakubowska A, Gómez Garcia EB, Olopade OI, Nussbaum RL, Nathanson KL, Domchek SM, Rebbeck TR, Arun BK, Karlan BY, Orsulic S, Lester J, Chung WK, Miron A, Southey MC, Goldgar DE, Buys SS, Janavicius R, Dorfling CM, van Rensburg EJ, Ding YC, Neuhausen SL, Hansen TV, Gerdes AM, Ejlertsen B, Jønson L, Osorio A, Martínez-Bouzas C, Benitez J, Conway EE, Blazer KR, Weitzel JN, Manoukian S, Peissel B, Zaffaroni D, Scuvera G, Barile M, Ficarazzi F, Mariette F, Fortuzzi S, Viel A, Giannini G, Papi L, Martayan A, Tibiletti MG, Radice P, Vratimos A, Fostira F, Garber JE, Donaldson A, Brewer C, Foo C, Evans DG, Frost D, Eccles D, Brady A, Cook J, Tischkowitz M, Adlard J, Barwell J, Walker L, Izatt L, Side LE, Kennedy MJ, Rogers MT, Porteous ME, Morrison PJ, Platte R, Davidson R, Hodgson SV, Ellis S, Cole T; EMBRACE, Godwin AK, Claes K, Van Maerken T, Meindl A, Gehrig A, Sutter C, Engel C, Niederacher D, Steinemann D, Plendl H, Kast K, Rhiem K, Ditsch N, Arnold N, Varon-Mateeva R, Wappenschmidt B, Wang-Gohrke S, Bressac-de Paillerets B, Buecher B, Delnatte C, Houdayer C, Stoppa-Lyonnet D, Damiola F, Coupier I, Barjhoux L, Venat-Bouvet L, Golmard L, Boutry-Kryza N, Sinilnikova OM, Caron O, Pujol P, Mazoyer S, Belotti M; GEMO Study Collaborators, Piedmonte M, Friedlander ML, Rodriguez GC, Copeland LJ, de la Hoya M, Segura PP, Nevanlinna H, Aittomäki K, van Os TA, Meijers-Heijboer HE, van der Hout AH, Vreeswijk MP, Hoogerbrugge N, Ausems MG, van Doorn HC, Collée JM; HEBON, Olah E, Diez O, Blanco I, Lazaro C, Brunet J, Feliubadalo L, Cybulski C, Gronwald J, Durda K, Jaworska-Bieniek K, Sukiennicki G, Arason A, Chiquette J, Teixeira MR, Olswold C, Couch FJ, Lindor NM, Wang X, Szabo CI, Offit K, Corines M, Jacobs L, Robson ME, Zhang L, Joseph V, Berger A, Singer CF, Rappaport C, Kaulich DG, Pfeiler G, Tea MK, Phelan CM, Greene MH, Mai PL, Rennert G, Mulligan AM, Glendon G, Tchatchou S, Andrulis IL, Toland AE, Bojesen A, Pedersen IS, Thomassen M, Jensen UB, Laitman Y, Rantala J, von Wachenfeldt A, Ehrencrona H, Askmalm MS, Borg Å, Kuchenbaecker KB, McGuffog L, Barrowdale D, Healey S, Lee A, Pharoah PD, Chenevix-Trench G; KConFab Investigators, Antoniou AC, Friedman E.

Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):308-16. doi: 10.1158/1055-9965.EPI-14-0532. Epub 2014 Oct 21.

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