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Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.

Fasinu PS, Nanayakkara NPD, Wang YH, Chaurasiya ND, Herath HMB, McChesney JD, Avula B, Khan I, Tekwani BL, Walker LA.

Malar J. 2019 Jan 30;18(1):30. doi: 10.1186/s12936-019-2658-5.


Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition.

Duvenage L, Walker LA, Bojarczuk A, Johnston SA, MacCallum DM, Munro CA, Gourlay CW.

MBio. 2019 Jan 29;10(1). pii: e02535-18. doi: 10.1128/mBio.02535-18.


Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function.

Saxena V, Fitch J, Ketz J, White P, Wetzel A, Chanley MA, Spencer JD, Becknell B, Pierce KR, Arregui SW, Nelson RD, Schwartz GJ, Velazquez V, Walker LA, Chen X, Yan P, Hains DS, Schwaderer AL.

Sci Rep. 2019 Jan 24;9(1):545. doi: 10.1038/s41598-018-36921-z.


LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.

Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. doi: 10.1073/pnas.1808618116. Epub 2018 Dec 24.


Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats.

Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB.

Oxid Med Cell Longev. 2018 Sep 23;2018:7363485. doi: 10.1155/2018/7363485. eCollection 2018.


Trait Mindfulness and Wellness in Multiple Sclerosis.

Mioduszewski O, MacLean H, Poulin PA, Smith AM, Walker LAS.

Can J Neurol Sci. 2018 Sep;45(5):580-582. doi: 10.1017/cjn.2018.51.


Longitudinal Stability of Cognition in Early-Phase Relapsing-Remitting Multiple Sclerosis: Does Cognitive Reserve Play a Role?

Barbu RM, Berard JA, Gresham LM, Walker LAS.

Int J MS Care. 2018 Jul-Aug;20(4):173-179. doi: 10.7224/1537-2073.2016-073.


Generating genomic platforms to study Candida albicans pathogenesis.

Legrand M, Bachellier-Bassi S, Lee KK, Chaudhari Y, Tournu H, Arbogast L, Boyer H, Chauvel M, Cabral V, Maufrais C, Nesseir A, Maslanka I, Permal E, Rossignol T, Walker LA, Zeidler U, Znaidi S, Schoeters F, Majgier C, Julien RA, Ma L, Tichit M, Bouchier C, Van Dijck P, Munro CA, d'Enfert C.

Nucleic Acids Res. 2018 Sep 19;46(16):8664. doi: 10.1093/nar/gky747. No abstract available.


Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

Avula B, Tekwani BL, Chaurasiya ND, Fasinu P, Dhammika Nanayakkara NP, Bhandara Herath HMT, Wang YH, Bae JY, Khan SI, Elsohly MA, McChesney JD, Zimmerman PA, Khan IA, Walker LA.

Malar J. 2018 Aug 13;17(1):294. doi: 10.1186/s12936-018-2433-z.


Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction.

Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA.

PLoS One. 2018 Jul 11;13(7):e0199705. doi: 10.1371/journal.pone.0199705. eCollection 2018.


Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats.

Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB.

Physiol Rep. 2018 Jul;6(13):e13754. doi: 10.14814/phy2.13754.


Generating genomic platforms to study Candida albicans pathogenesis.

Legrand M, Bachellier-Bassi S, Lee KK, Chaudhari Y, Tournu H, Arbogast L, Boyer H, Chauvel M, Cabral V, Maufrais C, Nesseir A, Maslanka I, Permal E, Rossignol T, Walker LA, Zeidler U, Znaidi S, Schoeters F, Majgier C, Julien RA, Ma L, Tichit M, Bouchier C, Van Dijck P, Munro CA, d'Enfert C.

Nucleic Acids Res. 2018 Aug 21;46(14):6935-6949. doi: 10.1093/nar/gky594.


Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter.

Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM.

Pharmacol Res. 2019 Feb;140:56-66. doi: 10.1016/j.phrs.2018.06.008. Epub 2018 Jun 9.


A Longitudinal Evaluation of Cognitive Fatigue on a Task of Sustained Attention in Early Relapsing-Remitting Multiple Sclerosis.

Berard JA, Smith AM, Walker LAS.

Int J MS Care. 2018 Mar-Apr;20(2):55-61. doi: 10.7224/1537-2073.2016-106.


Lay responder naloxone access and Good Samaritan law compliance: postcard survey results from 20 Indiana counties.

Watson DP, Ray B, Robison L, Huynh P, Sightes E, Walker S, Brucker K, Duwve J.

Harm Reduct J. 2018 Apr 6;15(1):18. doi: 10.1186/s12954-018-0226-x.


Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.

Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Saurí J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR.

Chem Sci. 2017 Nov 6;9(2):307-314. doi: 10.1039/c7sc01996c. eCollection 2018 Jan 14.


Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers.

Lopes-Bezerra LM, Walker LA, Niño-Vega G, Mora-Montes HM, Neves GWP, Villalobos-Duno H, Barreto L, Garcia K, Franco B, Martínez-Álvarez JA, Munro CA, Gow NAR.

PLoS Negl Trop Dis. 2018 Mar 9;12(3):e0006169. doi: 10.1371/journal.pntd.0006169. eCollection 2018 Mar.


Predictive Models of Cognitive Fatigue in Multiple Sclerosis.

Berard JA, Smith AM, Walker LAS.

Arch Clin Neuropsychol. 2019 Feb 1;34(1):31-38. doi: 10.1093/arclin/acy014.


Emerging therapeutic potential of graviola and its constituents in cancers.

Qazi AK, Siddiqui JA, Jahan R, Chaudhary S, Walker LA, Sayed Z, Jones DT, Batra SK, Macha MA.

Carcinogenesis. 2018 Apr 5;39(4):522-533. doi: 10.1093/carcin/bgy024. Review.


Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs-Implication for Herb-Drug Interaction.

Fasinu PS, Manda VK, Dale OR, Egiebor NO, Walker LA, Khan SI.

Molecules. 2017 Nov 23;22(12). pii: E2049. doi: 10.3390/molecules22122049.


Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B.

Chaurasiya ND, León F, Ding Y, Gómez-Betancur I, Benjumea D, Walker LA, Cutler SJ, Tekwani BL.

Evid Based Complement Alternat Med. 2017;2017:4018724. doi: 10.1155/2017/4018724. Epub 2017 Aug 24.


PXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids.

Manda VK, Avula B, Dale OR, Ali Z, Khan IA, Walker LA, Khan SI.

Phytother Res. 2017 Dec;31(12):1935-1945. doi: 10.1002/ptr.5942. Epub 2017 Oct 26.


Deconstructing the symbol digit modalities test in multiple sclerosis: The role of memory.

Patel VP, Walker LAS, Feinstein A.

Mult Scler Relat Disord. 2017 Oct;17:184-189. doi: 10.1016/j.msard.2017.08.006. Epub 2017 Aug 16.


Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF.

Nat Commun. 2017 Oct 3;8(1):767. doi: 10.1038/s41467-017-00992-9.


Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner.

Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA.

World J Cardiol. 2017 Aug 26;9(8):673-684. doi: 10.4330/wjc.v9.i8.673.


Exercise and Pharmacology as Medicine for Cardiovascular Diseases: From Bench to Bedside and Back.

Bruns DR, Walker LA.

Exerc Sport Sci Rev. 2018 Jan;46(1):2-3. doi: 10.1249/JES.0000000000000133. No abstract available.


Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition.

Tyagi S, Beqollari D, Lee CS, Walker LA, Bannister RA.

J Vis Exp. 2017 Aug 31;(126). doi: 10.3791/56024.


Canadian Normative Data for Minimal Assessment of Cognitive Function in Multiple Sclerosis.

Walker LAS, Marino D, Berard JA, Feinstein A, Morrow SA, Cousineau D.

Can J Neurol Sci. 2017 Sep;44(5):547-555. doi: 10.1017/cjn.2017.199. Epub 2017 Jul 7.


Distractibility in multiple sclerosis: The role of depression.

Patel VP, Zambrana A, Walker LA, Herrmann N, Swartz RH, Feinstein A.

Mult Scler J Exp Transl Clin. 2016 Jun 7;2:2055217316653150. doi: 10.1177/2055217316653150. eCollection 2016 Jan-Dec.


Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.

Jain J, Jain SK, Walker LA, Tekwani BL.

BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40. doi: 10.1186/s40360-017-0147-4.


Widespread Use of Prescription Nonsteroidal Anti-Inflammatory Drugs Among U.S. Army Active Duty Soldiers.

Walker LA, Zambraski EJ, Williams RF.

Mil Med. 2017 Mar;182(3):e1709-e1712. doi: 10.7205/MILMED-D-16-00183.


Revisiting cognitive reserve and cognition in multiple sclerosis: A closer look at depression.

Patel VP, Walker LA, Feinstein A.

Mult Scler. 2018 Feb;24(2):186-195. doi: 10.1177/1352458517692887. Epub 2017 Feb 13.


Cannabis cultivation: Methodological issues for obtaining medical-grade product.

Chandra S, Lata H, ElSohly MA, Walker LA, Potter D.

Epilepsy Behav. 2017 May;70(Pt B):302-312. doi: 10.1016/j.yebeh.2016.11.029. Epub 2017 Feb 13. Review.


Both Phenolic and Non-phenolic Green Tea Fractions Inhibit Migration of Cancer Cells.

Seo EJ, Wu CF, Ali Z, Wang YH, Khan SI, Walker LA, Khan IA, Efferth T.

Front Pharmacol. 2016 Nov 3;7:398. doi: 10.3389/fphar.2016.00398. eCollection 2016.


Processing speed and distractibility in multiple sclerosis: the role of sleep.

Patel VP, Walker LA, Feinstein A.

Mult Scler Relat Disord. 2017 Jan;11:40-42. doi: 10.1016/j.msard.2016.11.012. Epub 2016 Dec 1.


Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model.

Walker LA, Sullivan DJ Jr.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02499-16. doi: 10.1128/AAC.02499-16. Print 2017 Apr.


Proteoform-Specific Protein Binding of Small Molecules in Complex Matrices.

Gil G, Mao P, Avula B, Ali Z, Chittiboyina AG, Khan IA, Walker LA, Wang D.

ACS Chem Biol. 2017 Feb 17;12(2):389-397. doi: 10.1021/acschembio.6b01018. Epub 2016 Dec 21.


Lactate signalling regulates fungal β-glucan masking and immune evasion.

Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, Erwig LP, Munro CA, Gow NA, Brown GD, MacCallum DM, Brown AJ.

Nat Microbiol. 2016 Dec 12;2:16238. doi: 10.1038/nmicrobiol.2016.238.


Repetition-lag memory training is feasible in patients with chronic stroke, including those with memory problems.

Stamenova V, Jennings JM, Cook SP, Gao F, Walker LA, Smith AM, Davidson PS.

Brain Inj. 2017;31(1):57-67. doi: 10.1080/02699052.2016.1222081. Epub 2016 Nov 23.


Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.

Walker LA, Bourque P, Smith AM, Warman Chardon J.

Neuropsychology. 2017 Mar;31(3):292-303. doi: 10.1037/neu0000322. Epub 2016 Nov 21.


Mechanism for neurotropic action of vorinostat, a pan histone deacetylase inhibitor.

Shukla S, Shariat-Madar Z, Walker LA, Tekwani BL.

Mol Cell Neurosci. 2016 Dec;77:11-20. doi: 10.1016/j.mcn.2016.09.003. Epub 2016 Sep 24.


Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.

Chaurasiya ND, Gogineni V, Elokely KM, León F, Núñez MJ, Klein ML, Walker LA, Cutler SJ, Tekwani BL.

J Nat Prod. 2016 Oct 28;79(10):2538-2544. Epub 2016 Oct 18.


Sexually selected sentinels? Evidence of a role for intrasexual competition in sentinel behavior.

Walker LA, York JE, Young AJ.

Behav Ecol. 2016 Sep-Oct;27(5):1461-1470. Epub 2016 Apr 24.


Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine.

Fasinu PS, Tekwani BL, Avula B, Chaurasiya ND, Nanayakkara NP, Wang YH, Khan IA, Walker LA.

Malar J. 2016 Sep 13;15:466. doi: 10.1186/s12936-016-1509-x.


Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.

Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5906-13. doi: 10.1128/AAC.00600-16. Print 2016 Oct.


Gene expression profiling and pathway analysis data in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.

Aumsuwan P, Khan SI, Khan IA, Walker LA, Dasmahapatra AK.

Data Brief. 2016 May 25;8:272-9. doi: 10.1016/j.dib.2016.05.040. eCollection 2016 Sep.


New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert.

Ndunda B, Langat MK, Mulholland DA, Eastman H, Jacob MR, Khan SI, Walker LA, Muhammad I, Kerubo LO, Midiwo JO.

Planta Med. 2016 Jul;82(11-12):1079-86. doi: 10.1055/s-0042-108857. Epub 2016 Jun 10.


Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents.

Fasinu PS, Phillips S, ElSohly MA, Walker LA.

Pharmacotherapy. 2016 Jul;36(7):781-96. doi: 10.1002/phar.1780. Review.


Repetition-lag memory training is feasible in patients with chronic stroke, including those with memory problems.

Stamenova V, Jennings JM, Cook SP, Gao F, Walker LA, Smith AM, Davidson PS.

Brain Inj. 2016 May 31:1-11. [Epub ahead of print]


Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA, Wheeler RT, Brown AJ, Wong KH, Cowen LE.

Nat Commun. 2016 May 26;7:11704. doi: 10.1038/ncomms11704.

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