Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 128

1.

Genomic Analysis of 48 Paenibacillus larvae Bacteriophages.

Stamereilers C, Fajardo CP, Walker JK, Mendez KN, Castro-Nallar E, Grose JH, Hope S, Tsourkas PK.

Viruses. 2018 Jul 19;10(7). pii: E377. doi: 10.3390/v10070377.

2.

Complete Genome Sequences of Paenibacillus larvae Phages BN12, Dragolir, Kiel007, Leyra, Likha, Pagassa, PBL1c, and Tadhana.

Walker JK, Merrill BD, Berg JA, Dhalai A, Dingman DW, Fajardo CP, Graves K, Hill HL, Hilton JA, Imahara C, Knabe BK, Mangohig J, Monk J, Mun H, Payne AM, Salisbury A, Stamereilers C, Velez K, Ward AT, Breakwell DP, Grose JH, Hope S, Tsourkas PK.

Genome Announc. 2018 Jun 14;6(24). pii: e01602-17. doi: 10.1128/genomeA.01602-17.

3.

Commentary: Central-acting therapeutics alleviate respiratory weakness caused by heart failure-induced ventilatory overdrive.

Pastva AM, Walker JKL.

Front Physiol. 2018 May 23;9:554. doi: 10.3389/fphys.2018.00554. eCollection 2018. No abstract available.

4.

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa.

Cooper SJ, Krishnamoorthy G, Wolloscheck D, Walker JK, Rybenkov VV, Parks JM, Zgurskaya HI.

ACS Infect Dis. 2018 Aug 10;4(8):1223-1234. doi: 10.1021/acsinfecdis.8b00036. Epub 2018 May 25.

PMID:
29756762
5.

β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.

Lin R, Choi YH, Zidar DA, Walker JKL.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):745-755. doi: 10.1165/rcmb.2017-0240OC.

PMID:
29361236
6.

β-Arrestin2 mediates progression of murine primary myelofibrosis.

Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ.

JCI Insight. 2017 Dec 21;2(24). pii: 98094. doi: 10.1172/jci.insight.98094. [Epub ahead of print]

7.

Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.

Walker JKL, Theriot BS, Ghio M, Trempus CS, Wong JE, McQuade VL, Liang J, Jiang D, Noble PW, Garantziotis S, Kraft M, Ingram JL.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):702-710. doi: 10.1165/rcmb.2017-0095OC.

PMID:
28787175
8.

A Survey of Public Opinion on Cat (Felis catus) Predation and the Future Direction of Cat Management in New Zealand.

Walker JK, Bruce SJ, Dale AR.

Animals (Basel). 2017 Jul 3;7(7). pii: E49. doi: 10.3390/ani7070049.

9.

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.

Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry J, Rybenkov VV, Smith JC, Walker JK.

J Med Chem. 2017 Jul 27;60(14):6205-6219. doi: 10.1021/acs.jmedchem.7b00453. Epub 2017 Jul 11.

10.

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.

Woehl JL, Ramyar KX, Katz BB, Walker JK, Geisbrecht BV.

Protein Sci. 2017 Aug;26(8):1595-1608. doi: 10.1002/pro.3195. Epub 2017 May 31.

11.

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

Garcia BL, Skaff DA, Chatterjee A, Hanning A, Walker JK, Wyckoff GJ, Geisbrecht BV.

J Immunol. 2017 May 1;198(9):3705-3718. doi: 10.4049/jimmunol.1601932. Epub 2017 Mar 15.

12.

Owners' Perceptions of Their Animal's Behavioural Response to the Loss of an Animal Companion.

Walker JK, Waran NK, Phillips CJ.

Animals (Basel). 2016 Nov 3;6(11). pii: E68.

13.

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.

Abdali N, Parks JM, Haynes KM, Chaney JL, Green AT, Wolloscheck D, Walker JK, Rybenkov VV, Baudry J, Smith JC, Zgurskaya HI.

ACS Infect Dis. 2017 Jan 13;3(1):89-98. doi: 10.1021/acsinfecdis.6b00167. Epub 2016 Nov 2.

14.

Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.

Forkuo GS, Kim H, Thanawala VJ, Al-Sawalha N, Valdez D, Joshi R, Parra S, Pera T, Gonnella PA, Knoll BJ, Walker JK, Penn RB, Bond RA.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):234-42. doi: 10.1165/rcmb.2015-0373OC.

15.

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism.

Wang Y, Billon C, Walker JK, Burris TP.

ACS Chem Neurosci. 2016 Feb 17;7(2):143-8. doi: 10.1021/acschemneuro.5b00159. Epub 2015 Dec 3.

16.

The effect of conspecific removal on behavioral and physiological responses of dairy cattle.

Walker JK, Arney DR, Waran NK, Handel IG, Phillips CJ.

J Dairy Sci. 2015 Dec;98(12):8610-22. doi: 10.3168/jds.2014-8937. Epub 2015 Oct 9.

PMID:
26454304
17.

Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.

Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB.

FASEB J. 2015 Oct;29(10):4227-35. doi: 10.1096/fj.15-273094. Epub 2015 Jun 23.

18.

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.

Hegde A, Strachan RT, Walker JK.

PLoS One. 2015 Feb 6;10(2):e0116458. doi: 10.1371/journal.pone.0116458. eCollection 2015.

19.

Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model.

Chen M, Hegde A, Choi YH, Theriot BS, Premont RT, Chen W, Walker JK.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):346-54. doi: 10.1165/rcmb.2014-0231OC.

20.

Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.

Walker JK, DeFea KA.

Curr Opin Pharmacol. 2014 Jun;16:142-7. doi: 10.1016/j.coph.2014.03.007. Epub 2014 Jun 5. Review.

21.

Editorial overview: Respiratory: GPCR signaling and the lung.

Walker JK, Fisher JT.

Curr Opin Pharmacol. 2014 Jun;16:iv-vi. doi: 10.1016/j.coph.2014.05.006. Epub 2014 Jun 2. No abstract available.

22.

Testing the link between community structure and function for ectomycorrhizal fungi involved in a global tripartite symbiosis.

Walker JK, Cohen H, Higgins LM, Kennedy PG.

New Phytol. 2014 Apr;202(1):287-96. doi: 10.1111/nph.12638. Epub 2013 Dec 10.

23.

GPCRs and arrestins in airways: implications for asthma.

Penn RB, Bond RA, Walker JK.

Handb Exp Pharmacol. 2014;219:387-403. doi: 10.1007/978-3-642-41199-1_20.

24.

Reply: Adverse effects of long-acting beta-agonists on airway hyperresponsiveness.

Forkuo GS, Thanawala VJ, Al-Sawalha N, Bond RA, Walker JK.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):502. doi: 10.1165/rcmb.2013-0161LE. No abstract available.

26.

Assessment of murine lung mechanics outcome measures: alignment with those made in asthmatics.

Walker JK, Kraft M, Fisher JT.

Front Physiol. 2013 Feb 12;3:491. doi: 10.3389/fphys.2012.00491. eCollection 2012.

27.

β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model.

Thanawala VJ, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, Knoll BJ, Walker JK, Bond RA.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):220-9. doi: 10.1165/rcmb.2012-0364OC. Epub 2012 Nov 29.

28.

β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway.

Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16660-5. doi: 10.1073/pnas.1208881109. Epub 2012 Sep 25.

29.

Living donor kidney paired donation transplantation: experience as a founding member center of the National Kidney Registry.

Leeser DB, Aull MJ, Afaneh C, Dadhania D, Charlton M, Walker JK, Hartono C, Serur D, Del Pizzo JJ, Kapur S.

Clin Transplant. 2012 May-Jun;26(3):E213-22. Epub 2012 Mar 12.

PMID:
22872872
30.

Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate.

Xing L, Devadas B, Devraj RV, Selness SR, Shieh H, Walker JK, Mao M, Messing D, Samas B, Yang JZ, Anderson GD, Webb EG, Monahan JB.

ChemMedChem. 2012 Feb 6;7(2):273-80. doi: 10.1002/cmdc.201100439. Epub 2011 Dec 15.

PMID:
22174080
31.

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

Lin R, Degan S, Theriot BS, Fischer BM, Strachan RT, Liang J, Pierce RA, Sunday ME, Noble PW, Kraft M, Brody AR, Walker JK.

Br J Pharmacol. 2012 Apr;165(7):2365-77. doi: 10.1111/j.1476-5381.2011.01725.x.

32.

Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.

Hughes RO, Maddux T, Joseph Rogier D, Lu S, Walker JK, Jon Jacobsen E, Rumsey JM, Zheng Y, Macinnes A, Bond BR, Han S.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6348-52. doi: 10.1016/j.bmcl.2011.08.106. Epub 2011 Aug 31.

PMID:
21955943
33.

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.

Selness SR, Devraj RV, Devadas B, Walker JK, Boehm TL, Durley RC, Shieh H, Xing L, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R, Messing D, Yang J, Mao MK, Yalamanchili G, Vonder Embse R, Hirsch J, Saabye M, Bonar S, Webb E, Anderson G, Monahan JB.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71. doi: 10.1016/j.bmcl.2011.04.121. Epub 2011 May 11.

PMID:
21641211
34.

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.

Selness SR, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R, Devraj RV, Messing D, Schindler JF, Hirsch J, Saabye M, Bonar S, Webb E, Anderson G, Monahan JB.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4059-65. doi: 10.1016/j.bmcl.2011.04.120. Epub 2011 May 13.

PMID:
21640588
35.

New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.

Walker JK, Penn RB, Hanania NA, Dickey BF, Bond RA.

Br J Pharmacol. 2011 May;163(1):18-28. doi: 10.1111/j.1476-5381.2010.01178.x. Review.

36.

A survey of owners' perceptions of fear of fireworks in a sample of dogs and cats in New Zealand.

Dale AR, Walker JK, Farnworth MJ, Morrissey SV, Waran NK.

N Z Vet J. 2010 Dec;58(6):286-91. doi: 10.1080/00480169.2010.69403.

PMID:
21151214
37.

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

Morris DL, O'Neil SP, Devraj RV, Portanova JP, Gilles RW, Gross CJ, Curtiss SW, Komocsar WJ, Garner DS, Happa FA, Kraus LJ, Nikula KJ, Monahan JB, Selness SR, Galluppi GR, Shevlin KM, Kramer JA, Walker JK, Messing DM, Anderson DR, Mourey RJ, Whiteley LO, Daniels JS, Yang JZ, Rowlands PC, Alden CL, Davis JW 2nd, Sagartz JE.

Toxicol Pathol. 2010 Jun;38(4):606-18. doi: 10.1177/0192623310367807. Epub 2010 May 6.

PMID:
20448081
38.

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.

Tollefson MB, Acker BA, Jacobsen EJ, Hughes RO, Walker JK, Fox DN, Palmer MJ, Freeman SK, Yu Y, Bond BR.

Bioorg Med Chem Lett. 2010 May 15;20(10):3120-4.

PMID:
20443228
39.

1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.

Tollefson MB, Acker BA, Jacobsen EJ, Hughes RO, Walker JK, Fox DN, Palmer MJ, Freeman SK, Yu Y, Bond BR.

Bioorg Med Chem Lett. 2010 May 15;20(10):3125-8. doi: 10.1016/j.bmcl.2010.03.106. Epub 2010 Apr 3.

PMID:
20400309
40.

beta-Adrenoceptor inverse agonists in asthma.

Dickey BF, Walker JK, Hanania NA, Bond RA.

Curr Opin Pharmacol. 2010 Jun;10(3):254-9. doi: 10.1016/j.coph.2010.03.002. Review.

41.

Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.

Jerome KD, Hepperle ME, Walker JK, Xing L, Devraj RV, Benson AG, Baldus JE, Selness SR.

Bioorg Med Chem Lett. 2010 May 15;20(10):3146-9. doi: 10.1016/j.bmcl.2010.03.088. Epub 2010 Mar 31.

PMID:
20395140
42.

Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.

Pastva AM, Walker JK, Maddox LA, Mukherjee S, Giamberardino C, Hsia B, Potts E, Zhu H, Degan S, Sunday ME, Lawson BL, Korfhagen TR, Schwartz DA, Eu JP, Foster WM, McMahon TJ, Que L, Wright JR.

Am J Respir Cell Mol Biol. 2011 Feb;44(2):175-84. doi: 10.1165/rcmb.2009-0284OC. Epub 2010 Mar 26. Retraction in: Am J Respir Cell Mol Biol. 2016 Nov;55(5):758.

43.

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.

Walker JK, Selness SR, Devraj RV, Hepperle ME, Naing W, Shieh H, Kurambail R, Yang S, Flynn DL, Benson AG, Messing DM, Dice T, Kim T, Lindmark RJ, Monahan JB, Portanova J.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8. doi: 10.1016/j.bmcl.2010.02.047. Epub 2010 Feb 14.

PMID:
20227876
44.

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

Hughes RO, Rogier DJ, Jacobsen EJ, Walker JK, Macinnes A, Bond BR, Zhang LL, Yu Y, Zheng Y, Rumsey JM, Walgren JL, Curtiss SW, Fobian YM, Heasley SE, Cubbage JW, Moon JB, Brown DL, Acker BA, Maddux TM, Tollefson MB, Mischke BV, Owen DR, Freskos JN, Molyneaux JM, Benson AG, Blevis-Bal RM.

J Med Chem. 2010 Mar 25;53(6):2656-60. doi: 10.1021/jm901781q.

PMID:
20196613
45.

Asbestos and the lung. Diffuse pleural thickening has new definition for claims.

Hoyle JL, Walker JK.

BMJ. 2009 Sep 29;339:b3953. doi: 10.1136/bmj.b3953. No abstract available.

PMID:
19808812
46.

Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease.

Hollingsworth JW, Theriot BS, Li Z, Lawson BL, Sunday M, Schwartz DA, Walker JK.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):269-75. doi: 10.1165/rcmb.2009-0198OC. Epub 2009 Oct 5.

47.

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.

Selness SR, Devraj RV, Monahan JB, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5851-6. doi: 10.1016/j.bmcl.2009.08.082. Epub 2009 Aug 27.

PMID:
19751974
48.

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

Hughes RO, Walker JK, Rogier DJ, Heasley SE, Blevis-Bal RM, Benson AG, Jacobsen EJ, Cubbage JW, Fobian YM, Owen DR, Freskos JN, Molyneaux JM, Brown DL, Acker BA, Maddux TM, Tollefson MB, Moon JB, Mischke BV, Rumsey JM, Zheng Y, MacInnes A, Bond BR, Yu Y.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5209-13. doi: 10.1016/j.bmcl.2009.07.019. Epub 2009 Jul 10.

PMID:
19631533
49.

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.

Owen DR, Walker JK, Jon Jacobsen E, Freskos JN, Hughes RO, Brown DL, Bell AS, Brown DG, Phillips C, Mischke BV, Molyneaux JM, Fobian YM, Heasley SE, Moon JB, Stallings WC, Joseph Rogier D, Fox DN, Palmer MJ, Ringer T, Rodriquez-Lens M, Cubbage JW, Blevis-Bal RM, Benson AG, Acker BA, Maddux TM, Tollefson MB, Bond BR, Macinnes A, Yu Y.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4088-91. doi: 10.1016/j.bmcl.2009.06.012. Epub 2009 Jun 6.

PMID:
19540112
50.

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.

Hughes RO, Walker JK, Cubbage JW, Fobian YM, Rogier DJ, Heasley SE, Blevis-Bal RM, Benson AG, Owen DR, Jacobsen EJ, Freskos JN, Molyneaux JM, Brown DL, Stallings WC, Acker BA, Maddux TM, Tollefson MB, Williams JM, Moon JB, Mischke BV, Rumsey JM, Zheng Y, Macinnes A, Bond BR, Yu Y.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4092-6. doi: 10.1016/j.bmcl.2009.06.004. Epub 2009 Jun 6.

PMID:
19539468

Supplemental Content

Loading ...
Support Center