Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 90

1.

Investigation into the potential for post-mortem formation of carboxyhemoglobin in bodies retrieved from fires.

Sully CJ, Walker GS, Langlois NEI.

Forensic Sci Med Pathol. 2018 Jul 4. doi: 10.1007/s12024-018-9998-2. [Epub ahead of print]

PMID:
29971695
2.

Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program.

Brodney MA, Sharma R, Lazzaro JT, Walker GS, Scott Obach R.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2068-2073. doi: 10.1016/j.bmcl.2018.04.054. Epub 2018 Apr 23.

PMID:
29716781
3.

Review of autopsy reports of deaths relating to fire in South Australia 2000-2015.

Sully CJ, Walker GS, Langlois NEI.

Forensic Sci Med Pathol. 2018 Jun;14(2):180-187. doi: 10.1007/s12024-018-9981-y. Epub 2018 Apr 28.

PMID:
29705973
4.

Non-Uniform Sampling for All: More NMR Spectral Quality, Less Measurement Time.

Delaglio F, Walker GS, Farley KA, Sharma R, Hoch JC, Arbogast LW, Brinson RG, Marino JP.

Am Pharm Rev. 2017 May/Jun;20(4). pii: 339681. Epub 2017 Jun 30. No abstract available.

5.

Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.

Obach RS, Walker GS, Sharma R, Jenkinson S, Tran TP, Stepan AF.

J Med Chem. 2018 Apr 26;61(8):3626-3640. doi: 10.1021/acs.jmedchem.8b00116. Epub 2018 Apr 9.

PMID:
29601185
6.

Structured education using Dose Adjustment for Normal Eating (DAFNE) reduces long-term HbA1c and HbA1c variability.

Walker GS, Chen JY, Hopkinson H, Sainsbury CAR, Jones GC.

Diabet Med. 2018 Jun;35(6):745-749. doi: 10.1111/dme.13621. Epub 2018 Mar 30.

PMID:
29573459
7.

Biosynthesis and Identification of Metabolites of Maraviroc and Their Use in Experiments to Delineate the Relative Contributions of Cytochrome P4503A4 versus 3A5.

Tseng E, Fate GD, Walker GS, Goosen TC, Obach RS.

Drug Metab Dispos. 2018 May;46(5):493-502. doi: 10.1124/dmd.117.079855. Epub 2018 Feb 23.

PMID:
29475834
8.

Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

Stepan AF, Tran TP, Helal CJ, Brown MS, Chang C, O'Connor RE, De Vivo M, Doran SD, Fisher EL, Jenkinson S, Karanian D, Kormos BL, Sharma R, Walker GS, Wright AS, Yang EX, Brodney MA, Wager TT, Verhoest PR, Obach RS.

ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. doi: 10.1021/acsmedchemlett.7b00343. eCollection 2018 Feb 8.

9.

HbA1c variability is associated with increased mortality and earlier hospital admission in people with Type 1 diabetes.

Walker GS, Cunningham SG, Sainsbury CAR, Jones GC.

Diabet Med. 2017 Nov;34(11):1541-1545. doi: 10.1111/dme.13455. Epub 2017 Sep 11.

PMID:
28833535
10.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD.

Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10.

11.

Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory - Victoria, Australia, 2015.

Wright J, Kenneally ME, Edwards JW, Walker GS.

MMWR Morb Mortal Wkly Rep. 2017 Jan 6;65(52):1470-1473. doi: 10.15585/mmwr.mm6552a3.

12.
13.

Boston Society's 11th Annual Applied Pharmaceutical Analysis conference.

Lee V, Liu A, Groeber E, Moghaddam M, Schiller J, Tweed JA, Walker GS.

Bioanalysis. 2016 Feb;8(4):259-64. doi: 10.4155/bio.15.250. Epub 2016 Feb 8.

14.

In Vitro Kinetic Characterization of Axitinib Metabolism.

Zientek MA, Goosen TC, Tseng E, Lin J, Bauman JN, Walker GS, Kang P, Jiang Y, Freiwald S, Neul D, Smith BJ.

Drug Metab Dispos. 2016 Jan;44(1):102-14. doi: 10.1124/dmd.115.065615. Epub 2015 Oct 28.

15.

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, Chen JM, Hayward MM, Noe MC, Obach RS, Philippe L, Shanmugasundaram V, Shapiro MJ, Starr J, Stroh J, Che Y.

J Med Chem. 2014 Dec 11;57(23):10072-9. doi: 10.1021/jm501412a. Epub 2014 Nov 26.

PMID:
25375838
16.

American BRCA Outcomes and Utilization of Testing (ABOUT) study: a pragmatic research model that incorporates personalized medicine/patient-centered outcomes in a real world setting.

Armstrong J, Toscano M, Kotchko N, Friedman S, Schwartz MD, Virgo KS, Lynch K, Andrews JE, Aguado Loi CX, Bauer JE, Casares C, Teten RT, Kondoff MR, Molina AD, Abdollahian M, Brand L, Walker GS, Sutphen R.

J Genet Couns. 2015 Feb;24(1):18-28. doi: 10.1007/s10897-014-9750-3. Epub 2014 Sep 12.

PMID:
25209347
17.

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.

Walker GS, Bauman JN, Ryder TF, Smith EB, Spracklin DK, Obach RS.

Drug Metab Dispos. 2014 Oct;42(10):1627-39. doi: 10.1124/dmd.114.059204. Epub 2014 Jul 22.

18.

Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects.

Johnson TR, Tan W, Goulet L, Smith EB, Yamazaki S, Walker GS, O'Gorman MT, Bedarida G, Zou HY, Christensen JG, Nguyen LN, Shen Z, Dalvie D, Bello A, Smith BJ.

Xenobiotica. 2015 Jan;45(1):45-59. doi: 10.3109/00498254.2014.941964. Epub 2014 Jul 18.

PMID:
25034009
19.

Single-entity hydrocodone extended-release capsules in opioid-tolerant subjects with moderate-to-severe chronic low back pain: a randomized double-blind, placebo-controlled study.

Rauck RL, Nalamachu S, Wild JE, Walker GS, Robinson CY, Davis CS, Farr SJ.

Pain Med. 2014 Jun;15(6):975-85. doi: 10.1111/pme.12377. Epub 2014 Feb 12.

PMID:
24517082
20.

The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.

Dowty ME, Lin J, Ryder TF, Wang W, Walker GS, Vaz A, Chan GL, Krishnaswami S, Prakash C.

Drug Metab Dispos. 2014 Apr;42(4):759-73. doi: 10.1124/dmd.113.054940. Epub 2014 Jan 24.

21.

Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity.

Li X, Jeso V, Heyward S, Walker GS, Sharma R, Micalizio GC, Cameron MD.

Drug Metab Dispos. 2014 Mar;42(3):334-42. doi: 10.1124/dmd.113.054726. Epub 2013 Dec 11.

22.

Cytocompatibility assessment of chemical surface treatments for phosphate glass to improve adhesion between glass and polyester.

S Hasan M, Ahmed I, Parsons AJ, Walker GS, Scotchford CA.

J Biomed Mater Res A. 2013 Nov;101(11):3301-10. doi: 10.1002/jbm.a.34534. Epub 2013 Aug 26.

PMID:
23983190
23.

The influence of coupling agents on mechanical property retention and long-term cytocompatibility of phosphate glass fibre reinforced PLA composites.

Hasan MS, Ahmed I, Parsons AJ, Walker GS, Scotchford CA.

J Mech Behav Biomed Mater. 2013 Dec;28:1-14. doi: 10.1016/j.jmbbm.2013.07.014. Epub 2013 Jul 23.

PMID:
23959231
24.

Reducing the dehydrogenation temperature of lithium hydride through alloying with germanium.

Abbas MA, Grant DM, Brunelli M, Hansen TC, Walker GS.

Phys Chem Chem Phys. 2013 Aug 7;15(29):12139-46. doi: 10.1039/c3cp51330k. Epub 2013 May 15.

PMID:
23674125
25.

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.

Kalgutkar AS, Ryder TF, Walker GS, Orr ST, Cabral S, Goosen TC, Lapham K, Eng H.

Drug Metab Dispos. 2013 Jul;41(7):1375-88. doi: 10.1124/dmd.113.051839. Epub 2013 Apr 22.

26.

Metabolism of a serotonin-4 receptor partial agonist 4-{4-[4-tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (TBPT): identification of an unusual pharmacologically active cyclized oxazolidine metabolite in human.

Sawant-Basak A, Coffman KJ, Walker GS, Ryder TF, Tseng E, Miller E, Lee C, Vanase-Frawley MA, Wong JW, Brodney MA, Rapp T, Obach RS.

J Pharm Sci. 2013 Sep;102(9):3277-93. doi: 10.1002/jps.23542. Epub 2013 Apr 15.

PMID:
23589342
27.

Bacterial degradation of risperidone and paliperidone in decomposing blood.

Butzbach DM, Stockham PC, Kobus HJ, Sims DN, Byard RW, Lokan RJ, Walker GS.

J Forensic Sci. 2013 Jan;58(1):90-100. doi: 10.1111/j.1556-4029.2012.02280.x. Epub 2012 Sep 20.

PMID:
22994980
28.

Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.

Ryder T, Walker GS, Goosen TC, Ruggeri RB, Conn EL, Rocke BN, Lapham K, Steppan CM, Hepworth D, Kalgutkar AS.

Chem Res Toxicol. 2012 Oct 15;25(10):2138-52. doi: 10.1021/tx300243v. Epub 2012 Sep 27.

PMID:
22989032
29.

Stability of serotonin-selective antidepressants in sterile and decomposing liver tissue.

Butzbach DM, Stockham PC, Kobus HJ, Sims DN, Byard RW, Lokan RJ, Walker GS.

J Forensic Sci. 2013 Jan;58 Suppl 1:S117-25. doi: 10.1111/j.1556-4029.2012.02266.x. Epub 2012 Aug 29.

PMID:
22931374
30.

Investigating the use of coupling agents to improve the interfacial properties between a resorbable phosphate glass and polylactic acid matrix.

Hasan MS, Ahmed I, Parsons AJ, Rudd CD, Walker GS, Scotchford CA.

J Biomater Appl. 2013 Sep;28(3):354-66. doi: 10.1177/0885328212453634. Epub 2012 Jul 10.

PMID:
22781920
31.

Material characterisation and cytocompatibility assessment of quinternary phosphate glasses.

Hasan MS, Ahmed I, Parsons AJ, Walker GS, Scotchford CA.

J Mater Sci Mater Med. 2012 Oct;23(10):2531-41. doi: 10.1007/s10856-012-4708-1. Epub 2012 Jul 4.

PMID:
22760401
32.

Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.

Walsky RL, Obach RS, Hyland R, Kang P, Zhou S, West M, Geoghegan KF, Helal CJ, Walker GS, Goosen TC, Zientek MA.

Drug Metab Dispos. 2012 Sep;40(9):1686-97. doi: 10.1124/dmd.112.045302. Epub 2012 May 29.

33.

Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.

Lee CA, Jones JP 3rd, Katayama J, Kaspera R, Jiang Y, Freiwald S, Smith E, Walker GS, Totah RA.

Drug Metab Dispos. 2012 May;40(5):943-51. doi: 10.1124/dmd.111.043505. Epub 2012 Feb 10.

34.

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.

Sharma R, Eng H, Walker GS, Barreiro G, Stepan AF, McClure KF, Wolford A, Bonin PD, Cornelius P, Kalgutkar AS.

Chem Res Toxicol. 2011 Dec 19;24(12):2207-16. doi: 10.1021/tx200329k. Epub 2011 Oct 4.

PMID:
21939274
35.

Rapid screening for the detection and differentiation of γ-hydroxybutyrate using ion chromatography.

Hughes RR, Walker GS.

J Forensic Sci. 2011 Sep;56(5):1256-60. doi: 10.1111/j.1556-4029.2011.01845.x. Epub 2011 Jul 25.

PMID:
21790598
36.

In vitro degradation, flexural, compressive and shear properties of fully bioresorbable composite rods.

Felfel RM, Ahmed I, Parsons AJ, Walker GS, Rudd CD.

J Mech Behav Biomed Mater. 2011 Oct;4(7):1462-72. doi: 10.1016/j.jmbbm.2011.05.016. Epub 2011 May 13.

PMID:
21783156
37.

The effect of H2 partial pressure on the reaction progression and reversibility of lithium-containing multicomponent destabilized hydrogen storage systems.

Price TE, Grant DM, Weston D, Hansen T, Arnbjerg LM, Ravnsbæk DB, Jensen TR, Walker GS.

J Am Chem Soc. 2011 Aug 31;133(34):13534-8. doi: 10.1021/ja204381n. Epub 2011 Aug 4.

PMID:
21755995
38.

Destabilisation of magnesium hydride by germanium as a new potential multicomponent hydrogen storage system.

Walker GS, Abbas M, Grant DM, Udeh C.

Chem Commun (Camb). 2011 Jul 28;47(28):8001-3. doi: 10.1039/c0cc03425h. Epub 2011 Jun 15.

PMID:
21674102
39.

Composites for bone repair: phosphate glass fibre reinforced PLA with varying fibre architecture.

Ahmed I, Jones IA, Parsons AJ, Bernard J, Farmer J, Scotchford CA, Walker GS, Rudd CD.

J Mater Sci Mater Med. 2011 Aug;22(8):1825-34. doi: 10.1007/s10856-011-4361-0. Epub 2011 Jun 14.

PMID:
21671001
40.

Re-oxygenation of post-mortem lividity by passive diffusion through the skin at low temperature.

Watchman H, Walker GS, Randeberg LL, Langlois NE.

Forensic Sci Med Pathol. 2011 Dec;7(4):333-5. doi: 10.1007/s12024-011-9244-7. Epub 2011 May 18.

PMID:
21590457
41.

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

Dow RL, Li JC, Pence MP, Gibbs EM, LaPerle JL, Litchfield J, Piotrowski DW, Munchhof MJ, Manion TB, Zavadoski WJ, Walker GS, McPherson RK, Tapley S, Sugarman E, Guzman-Perez A, DaSilva-Jardine P.

ACS Med Chem Lett. 2011 Mar 18;2(5):407-12. doi: 10.1021/ml200051p. eCollection 2011 May 12.

42.

The analysis of dyes in ball point pen inks on single paper fibres using laser desorption ionisation time of flight mass spectrometry (LDI-TOFMS).

Matthews B, Walker GS, Kobus H, Pigou P, Bird C, Smith G.

Forensic Sci Int. 2011 Jun 15;209(1-3):e26-30. doi: 10.1016/j.forsciint.2011.03.033. Epub 2011 Apr 23.

PMID:
21515007
43.

Metabolism of a dopamine receptor partial agonist in rats, including an unusual N-dearylation reaction.

Zhao SX, Wang WW, Walker GS, Zhang L, Obach RS.

Drug Metab Pharmacokinet. 2011 Jun;26(3):266-79. doi: 10.2133/dmpk.DMPK-10-RG-109. Epub 2011 Mar 4.

44.

The effect of complex halides and binary halides on hydrogen release for the 2LiBH4:1MgH2 system.

Yang Z, Grant DM, Wang P, Walker GS.

Faraday Discuss. 2011;151:133-41; discussion 199-212.

PMID:
22455066
45.

Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.

Talakad JC, Shah MB, Walker GS, Xiang C, Halpert JR, Dalvie D.

Drug Metab Dispos. 2011 Mar;39(3):539-50. doi: 10.1124/dmd.110.037101. Epub 2010 Dec 14.

46.

Investigation of crystallinity, molecular weight change, and mechanical properties of PLA/PBG bioresorbable composites as bone fracture fixation plates.

Felfel RM, Ahmed I, Parsons AJ, Haque P, Walker GS, Rudd CD.

J Biomater Appl. 2012 Mar;26(7):765-89. doi: 10.1177/0885328210384532. Epub 2010 Dec 1.

PMID:
21123285
47.

Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.

Walker GS, Ryder TF, Sharma R, Smith EB, Freund A.

Drug Metab Dispos. 2011 Mar;39(3):433-40. doi: 10.1124/dmd.110.036343. Epub 2010 Nov 22.

48.

Structures and H2 adsorption properties of porous scandium metal-organic frameworks.

Ibarra IA, Lin X, Yang S, Blake AJ, Walker GS, Barnett SA, Allan DR, Champness NR, Hubberstey P, Schröder M.

Chemistry. 2010 Dec 10;16(46):13671-9. doi: 10.1002/chem.201000926.

PMID:
20960440
49.

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites.

Bessire AJ, Vaz AD, Walker GS, Wang WW, Sharma R.

Rapid Commun Mass Spectrom. 2010 Jul 30;24(14):2151-61. doi: 10.1002/rcm.4595.

PMID:
20552706
50.

Metal-organic polyhedral frameworks: high h(2) adsorption capacities and neutron powder diffraction studies.

Yan Y, Telepeni I, Yang S, Lin X, Kockelmann W, Dailly A, Blake AJ, Lewis W, Walker GS, Allan DR, Barnett SA, Champness NR, Schröder M.

J Am Chem Soc. 2010 Mar 31;132(12):4092-4. doi: 10.1021/ja1001407.

PMID:
20199070

Supplemental Content

Loading ...
Support Center