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Items: 1 to 50 of 62

1.

Circulating adipokines and metabolic setting in differentiated thyroid cancer.

Mele C, Samà MT, Bisoffi AA, Caputo M, Bullara V, Mai S, Walker GE, Prodam F, Marzullo P, Aimaretti G, Pagano L.

Endocr Connect. 2019 Jun 1. pii: EC-19-0262. doi: 10.1530/EC-19-0262. [Epub ahead of print]

2.

Identification of Haptoglobin as a Readout of rhGH Therapy in GH Deficiency.

De Feudis M, Walker GE, Genoni G, Manfredi M, Agosti E, Giordano M, Caputo M, Di Trapani L, Marengo E, Aimaretti G, Filigheddu N, Bellone S, Bona G, Prodam F.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5263-5273. doi: 10.1210/jc.2019-00562.

PMID:
31215990
3.

Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D.

Walker GE, Follenzi A, Bruscaggin V, Manfredi M, Bellone S, Marengo E, Maiuri L, Prodam F, Bona G.

J Steroid Biochem Mol Biol. 2018 Sep;182:37-49. doi: 10.1016/j.jsbmb.2018.04.009. Epub 2018 Apr 21.

4.

Acute Vitamin D₃ Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin.

Mai S, Walker GE, Vietti R, Cattaldo S, Mele C, Priano L, Mauro A, Bona G, Aimaretti G, Scacchi M, Marzullo P.

Nutrients. 2017 May 5;9(5). pii: E459. doi: 10.3390/nu9050459.

5.

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).

Bradbury RH, Callis R, Carr GR, Chen H, Clark E, Feron L, Glossop S, Graham MA, Hattersley M, Jones C, Lamont SG, Ouvry G, Patel A, Patel J, Rabow AA, Roberts CA, Stokes S, Stratton N, Walker GE, Ward L, Whalley D, Whittaker D, Wrigley G, Waring MJ.

J Med Chem. 2016 Sep 8;59(17):7801-17. doi: 10.1021/acs.jmedchem.6b00070. Epub 2016 Aug 24.

PMID:
27528113
6.

Intracoronary Des-Acyl Ghrelin Acutely Increases Cardiac Perfusion Through a Nitric Oxide-Related Mechanism in Female Anesthetized Pigs.

Grossini E, Raina G, Farruggio S, Camillo L, Molinari C, Mary D, Walker GE, Bona G, Vacca G, Moia S, Prodam F, Surico D.

Endocrinology. 2016 Jun;157(6):2403-15. doi: 10.1210/en.2015-1922. Epub 2016 Apr 21.

PMID:
27100620
7.

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.

Weir HM, Bradbury RH, Lawson M, Rabow AA, Buttar D, Callis RJ, Curwen JO, de Almeida C, Ballard P, Hulse M, Donald CS, Feron LJ, Karoutchi G, MacFaul P, Moss T, Norman RA, Pearson SE, Tonge M, Davies G, Walker GE, Wilson Z, Rowlinson R, Powell S, Sadler C, Richmond G, Ladd B, Pazolli E, Mazzola AM, D'Cruz C, De Savi C.

Cancer Res. 2016 Jun 1;76(11):3307-18. doi: 10.1158/0008-5472.CAN-15-2357. Epub 2016 Mar 28.

8.

Influence of Ultraviolet Radiation on the Association between 25-Hydroxy Vitamin D Levels and Cardiovascular Risk Factors in Obesity.

Prodam F, Zanetta S, Ricotti R, Marolda A, Giglione E, Monzani A, Walker GE, Rampone S, Castagno M, Bellone S, Petri A, Aimaretti G, Bona G.

J Pediatr. 2016 Apr;171:83-9.e1. doi: 10.1016/j.jpeds.2015.12.032. Epub 2016 Jan 12.

PMID:
26794470
9.

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.

De Savi C, Bradbury RH, Rabow AA, Norman RA, de Almeida C, Andrews DM, Ballard P, Buttar D, Callis RJ, Currie GS, Curwen JO, Davies CD, Donald CS, Feron LJ, Gingell H, Glossop SC, Hayter BR, Hussain S, Karoutchi G, Lamont SG, MacFaul P, Moss TA, Pearson SE, Tonge M, Walker GE, Weir HM, Wilson Z.

J Med Chem. 2015 Oct 22;58(20):8128-40. doi: 10.1021/acs.jmedchem.5b00984. Epub 2015 Oct 7.

PMID:
26407012
10.

Adiponectin oligomers are similarly distributed in adequate-for-gestational-age obese children irrespective of feeding in their first year.

Prodam F, Roccio M, Trovato L, Ricotti R, Moia S, Giglione E, Petri A, Walker GE, Bellone S, Bona G.

Pediatr Res. 2015 Jun;77(6):808-13. doi: 10.1038/pr.2015.52. Epub 2015 Mar 11.

PMID:
25760548
11.

The pathophysiology of abdominal adipose tissue depots in health and disease.

Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F.

Horm Mol Biol Clin Investig. 2014 Jul;19(1):57-74. doi: 10.1515/hmbci-2014-0023. Review.

12.

Inherent insulin sensitivity is a major determinant of multimeric adiponectin responsiveness to short-term weight loss in extreme obesity.

Mai S, Walker GE, Brunani A, Guzzaloni G, Grossi G, Oldani A, Aimaretti G, Scacchi M, Marzullo P.

Sci Rep. 2014 Jul 24;4:5803. doi: 10.1038/srep05803.

13.

Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig.

Grossini E, Prodam F, Walker GE, Sigaudo L, Farruggio S, Bellofatto K, Marotta P, Molinari C, Mary D, Bona G, Vacca G.

J Endocrinol. 2014 Jul;222(1):137-49. doi: 10.1530/JOE-14-0170. Epub 2014 May 23.

PMID:
24860147
14.

Novel mutations in the GH gene (GH1) uncover putative splicing regulatory elements.

Babu D, Mellone S, Fusco I, Petri A, Walker GE, Bellone S, Prodam F, Momigliano-Richiardi P, Bona G, Giordano M.

Endocrinology. 2014 May;155(5):1786-92. doi: 10.1210/en.2013-2146. Epub 2014 Mar 17.

PMID:
24635352
15.

Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions.

Walker GE, Ricotti R, Roccio M, Moia S, Bellone S, Prodam F, Bona G.

PLoS One. 2014 Jan 3;9(1):e83685. doi: 10.1371/journal.pone.0083685. eCollection 2014.

16.

Obesity modifies expression profiles of metabolic markers in superficial and deep subcutaneous abdominal adipose tissue depots.

Walker GE, Marzullo P, Prodam F, Bona G, Di Blasio AM.

Endocrine. 2014 May;46(1):99-106. doi: 10.1007/s12020-013-0040-x. Epub 2013 Sep 13.

PMID:
24030694
17.

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo.

Loddick SA, Ross SJ, Thomason AG, Robinson DM, Walker GE, Dunkley TP, Brave SR, Broadbent N, Stratton NC, Trueman D, Mouchet E, Shaheen FS, Jacobs VN, Cumberbatch M, Wilson J, Jones RD, Bradbury RH, Rabow A, Gaughan L, Womack C, Barry ST, Robson CN, Critchlow SE, Wedge SR, Brooks AN.

Mol Cancer Ther. 2013 Sep;12(9):1715-27. doi: 10.1158/1535-7163.MCT-12-1174. Epub 2013 Jul 16.

18.

Lymphocytes and immunoglobulin patterns across the threshold of severe obesity.

Marzullo P, Minocci A, Giarda P, Marconi C, Tagliaferri A, Walker GE, Scacchi M, Aimaretti G, Liuzzi A.

Endocrine. 2014 Apr;45(3):392-400. doi: 10.1007/s12020-013-0006-z. Epub 2013 Jun 26.

PMID:
23801194
19.

The W520X mutation in the TSHR gene brings on subclinical hypothyroidism through an haploinsufficiency mechanism.

Moia S, Godi M, Walker GE, Roccio M, Agretti P, Tonacchera M, Berardi R, Bellone S, Prodam F, Giordano M, Bona G.

J Endocrinol Invest. 2013 Oct;36(9):716-21. doi: 10.3275/8930. Epub 2013 Apr 8.

PMID:
23563316
20.

Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.

Bradbury RH, Acton DG, Broadbent NL, Brooks AN, Carr GR, Hatter G, Hayter BR, Hill KJ, Howe NJ, Jones RD, Jude D, Lamont SG, Loddick SA, McFarland HL, Parveen Z, Rabow AA, Sharma-Singh G, Stratton NC, Thomason AG, Trueman D, Walker GE, Wells SL, Wilson J, Wood JM.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. doi: 10.1016/j.bmcl.2013.02.056. Epub 2013 Feb 21.

PMID:
23466225
21.

High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study.

Prodam F, Ricotti R, Agarla V, Parlamento S, Genoni G, Balossini C, Walker GE, Aimaretti G, Bona G, Bellone S.

BMC Med. 2013 Feb 20;11:44. doi: 10.1186/1741-7015-11-44.

22.

Intravenous fluid use in the acutely unwell adult medical inpatient: improving practice through a clinical audit process.

Walker GE, Stewart-Parker E, Chinthapalli S, Ostermann M, Dargan PI, Wood DM.

J R Coll Physicians Edinb. 2012;42(3):211-5. doi: 10.4997/JRCPE.2012.304.

PMID:
22953313
23.

Involvement of genes related to inflammation and cell cycle in idiopathic short stature.

Trovato L, Prodam F, Genoni G, De Rienzo F, Walker GE, Moia S, Riccomagno S, Bellone S, Bona G.

Pituitary. 2013 Mar;16(1):83-90. doi: 10.1007/s11102-012-0378-8.

PMID:
22382915
24.

A novel familial variation of the thyroid hormone receptor beta gene (I276N) associated with resistance to thyroid hormone.

Monzani A, Moia S, Prodam F, Walker GE, Bellone S, Petri A, Bona G.

Thyroid. 2012 Apr;22(4):440-1. doi: 10.1089/thy.2011.0443. Epub 2012 Feb 23. No abstract available.

PMID:
22360271
25.

Isolated GHD: investigation and implication of JAK/STAT related genes before and after rhGH treatment.

Trovato L, Riccomagno S, Prodam F, Genoni G, Walker GE, Moia S, Bellone S, Bona G.

Pituitary. 2012 Dec;15(4):482-9. doi: 10.1007/s11102-011-0354-8.

PMID:
22038029
26.

Acylated/unacylated ghrelin ratio in cord blood: correlation with anthropometric and metabolic parameters and pediatric lifespan comparison.

Bellone S, Prodam F, Savastio S, Avanzo D, Pagani A, Trovato L, Walker GE, Genoni G, Bona G.

Eur J Endocrinol. 2012 Jan;166(1):115-20. doi: 10.1530/EJE-11-0346. Epub 2011 Oct 17.

PMID:
22004908
27.

Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.

Bradbury RH, Hales NJ, Rabow AA, Walker GE, Acton DG, Andrews DM, Ballard P, Brooks NA, Colclough N, Girdwood A, Hancox UJ, Jones O, Jude D, Loddick SA, Mortlock AA.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5442-5. doi: 10.1016/j.bmcl.2011.06.122. Epub 2011 Jul 2.

PMID:
21782422
28.

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.

Ducray R, Simpson I, Jung FH, Nissink JW, Kenny PW, Fitzek M, Walker GE, Ward LT, Hudson K.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4698-701. doi: 10.1016/j.bmcl.2011.06.093. Epub 2011 Jun 29.

PMID:
21775140
29.

Seasonality and attendance at a pulmonary rehabilitation programme.

Walker GE, Lee C, Elkin SL.

Thorax. 2011 Jul;66(7):634-5. doi: 10.1136/thx.2010.153668. Epub 2010 Nov 23. No abstract available.

PMID:
21098803
30.

Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects.

Walker GE, Marzullo P, Verti B, Guzzaloni G, Maestrini S, Zurleni F, Liuzzi A, Di Blasio AM.

Obesity (Silver Spring). 2008 Sep;16(9):1983-91. doi: 10.1038/oby.2008.326.

31.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.

Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM.

Mol Cancer Ther. 2008 Sep;7(9):2955-66. doi: 10.1158/1535-7163.MCT-08-0492.

32.

Acylated ghrelin decreases during acute exercise in the lean and obese state.

Marzullo P, Salvadori A, Brunani A, Verti B, Walker GE, Fanari P, Tovaglieri I, De Medici C, Savia G, Liuzzi A.

Clin Endocrinol (Oxf). 2008 Dec;69(6):970-1. doi: 10.1111/j.1365-2265.2008.03275.x. Epub 2008 Apr 14. No abstract available.

PMID:
18419786
33.

Sporadic mutations in melanocortin receptor 3 in morbid obese individuals.

Mencarelli M, Walker GE, Maestrini S, Alberti L, Verti B, Brunani A, Petroni ML, Tagliaferri M, Liuzzi A, Di Blasio AM.

Eur J Hum Genet. 2008 May;16(5):581-6. doi: 10.1038/sj.ejhg.5202005. Epub 2008 Jan 30.

34.

Deep subcutaneous adipose tissue: a distinct abdominal adipose depot.

Walker GE, Verti B, Marzullo P, Savia G, Mencarelli M, Zurleni F, Liuzzi A, Di Blasio AM.

Obesity (Silver Spring). 2007 Aug;15(8):1933-43.

35.

Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients.

Maestrini S, Mencarelli M, Verti B, Walker GE, Savia G, Marzullo P, Tagliaferri M, Liuzzi A, Di Blasio AM.

J Endocrinol Invest. 2006 Oct;29(9):776-80.

PMID:
17114907
36.

Predictors of postabsorptive ghrelin secretion after intake of different macronutrients.

Marzullo P, Caumo A, Savia G, Verti B, Walker GE, Maestrini S, Tagliaferri A, Di Blasio AM, Liuzzi A.

J Clin Endocrinol Metab. 2006 Oct;91(10):4124-30. Epub 2006 Aug 1.

PMID:
16882748
37.
38.

Isotopic scrambling in Di-13C-labeled 2-butyl cation: evidence for a protonated cyclopropane intermediate.

Walker GE, Kronja O, Saunders M.

J Org Chem. 2004 May 14;69(10):3598-601.

PMID:
15132583
39.
40.

The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure.

Marzullo P, Verti B, Savia G, Walker GE, Guzzaloni G, Tagliaferri M, Di Blasio A, Liuzzi A.

J Clin Endocrinol Metab. 2004 Feb;89(2):936-9.

PMID:
14764817
42.

A conserved region in the first intron of the insulin receptor gene binds nuclear proteins during adipocyte differentiation.

McKeon C, Accili D, Chen H, Pham T, Walker GE.

Biochem Biophys Res Commun. 1997 Nov 26;240(3):701-6.

PMID:
9398630
43.
44.
45.

A catalase from Streptomyces coelicolor A3(2).

Walker GE, Dunbar B, Hunter IS, Nimmo HG, Coggins JR.

Microbiology. 1995 Jun;141 ( Pt 6):1377-83.

PMID:
7670639
46.

Isolating physical effects in the exclusive (N,N' pi ) reaction.

Mehrem R, Londergan JT, Walker GE.

Phys Rev C Nucl Phys. 1995 Apr;51(4):2031-2043. No abstract available.

PMID:
9970272
47.

Proximal enhancer of the human insulin receptor gene binds the transcription factor Sp1.

Chen H, Walker GE, Taylor SI, McKeon C.

Diabetes. 1994 Jul;43(7):884-9.

PMID:
8013752
48.

The amino acid sequence of the small monomeric phosphoglycerate mutase from the fission yeast Schizosaccharomyces pombe.

Nairn J, Price NC, Fothergill-Gilmore LA, Walker GE, Fothergill JE, Dunbar B.

Biochem J. 1994 Feb 1;297 ( Pt 3):603-8.

49.

Distorted-wave calculation of the (p,p' pi +) reaction.

Mehrem R, Londergan JT, Walker GE.

Phys Rev C Nucl Phys. 1993 Sep;48(3):1192-1220. No abstract available.

PMID:
9968952
50.

Finite velocity meson exchange in nuclei.

Crecca MA, Walker GE.

Phys Rev C Nucl Phys. 1991 Apr;43(4):1709-1724. No abstract available.

PMID:
9967222

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