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Items: 37

1.

Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-coil Domain Truncations.

Brown ZZ, Mapelli C, Farasat I, Shoultz AV, Orvieto F, Santoprete A, Bianchi E, Johnson SA, McCracken AB, Chen K, Zhu X, Demma MJ, Lacey BM, Canada KA, Garbaccio RM, O'Neil J, Walji A.

J Org Chem. 2019 Oct 29. doi: 10.1021/acs.joc.9b02467. [Epub ahead of print]

PMID:
31660743
2.

Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene.

Demma MJ, Mapelli C, Sun A, Bodea S, Ruprecht B, Javaid S, Wiswell D, Muise E, Chen S, Zelina J, Orvieto F, Santoprete A, Altezza S, Tucci F, Escandon E, Hall B, Ray K, Walji A, O'Neil J.

Mol Cell Biol. 2019 Oct 28;39(22). pii: e00248-19. doi: 10.1128/MCB.00248-19. Print 2019 Nov 15.

3.

Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.

Koole M, Lohith TG, Valentine JL, Bennacef I, Declercq R, Reynders T, Riffel K, Celen S, Serdons K, Bormans G, Ferry-Martin S, Laroque P, Walji A, Hostetler ED, Briscoe RJ, de Hoon J, Sur C, Van Laere K, Struyk A.

Mol Imaging Biol. 2019 May 20. doi: 10.1007/s11307-019-01367-w. [Epub ahead of print]

PMID:
31111397
4.

Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles.

Lohith TG, Bennacef I, Vandenberghe R, Vandenbulcke M, Salinas CA, Declercq R, Reynders T, Telan-Choing NF, Riffel K, Celen S, Serdons K, Bormans G, Tsai K, Walji A, Hostetler ED, Evelhoch JL, Van Laere K, Forman M, Stoch A, Sur C, Struyk A.

J Nucl Med. 2019 Jan;60(1):107-114. doi: 10.2967/jnumed.118.208215. Epub 2018 Jun 7.

PMID:
29880509
5.

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.

Sanders JM, Beshore DC, Culberson JC, Fells JI, Imbriglio JE, Gunaydin H, Haidle AM, Labroli M, Mattioni BE, Sciammetta N, Shipe WD, Sheridan RP, Suen LM, Verras A, Walji A, Joshi EM, Bueters T.

J Med Chem. 2017 Aug 24;60(16):6771-6780. doi: 10.1021/acs.jmedchem.6b01577. Epub 2017 May 5. Review.

PMID:
28418656
6.

Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.

Schreier JD, Embrey MW, Raheem IT, Barbe G, Campeau LC, Dubost D, McCabe Dunn J, Grobler J, Hartingh TJ, Hazuda DJ, Klein D, Miller MD, Moore KP, Nguyen N, Pajkovic N, Powell DA, Rada V, Sanders JM, Sisko J, Steele TG, Wai J, Walji A, Xu M, Coleman PJ.

Bioorg Med Chem Lett. 2017 May 1;27(9):2038-2046. doi: 10.1016/j.bmcl.2017.02.039. Epub 2017 Feb 20.

PMID:
28285916
7.

cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles.

Collier TL, Yokell DL, Livni E, Rice PA, Celen S, Serdons K, Neelamegam R, Bormans G, Harris D, Walji A, Hostetler ED, Bennacef I, Vasdev N.

J Labelled Comp Radiopharm. 2017 May 15;60(5):263-269. doi: 10.1002/jlcr.3496. Epub 2017 Mar 23.

PMID:
28185305
8.

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.

Hostetler ED, Walji AM, Zeng Z, Miller P, Bennacef I, Salinas C, Connolly B, Gantert L, Haley H, Holahan M, Purcell M, Riffel K, Lohith TG, Coleman P, Soriano A, Ogawa A, Xu S, Zhang X, Joshi E, Della Rocca J, Hesk D, Schenk DJ, Evelhoch JL.

J Nucl Med. 2016 Oct;57(10):1599-1606. Epub 2016 May 26.

9.

Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

Walji AM, Hostetler ED, Selnick H, Zeng Z, Miller P, Bennacef I, Salinas C, Connolly B, Gantert L, Holahan M, O'Malley S, Purcell M, Riffel K, Li J, Balsells J, OBrien JA, Melquist S, Soriano A, Zhang X, Ogawa A, Xu S, Joshi E, Della Rocca J, Hess FJ, Schachter J, Hesk D, Schenk D, Struyk A, Babaoglu K, Lohith TG, Wang Y, Yang K, Fu J, Evelhoch JL, Coleman PJ.

J Med Chem. 2016 May 26;59(10):4778-89. doi: 10.1021/acs.jmedchem.6b00166. Epub 2016 May 5.

PMID:
27088900
10.

Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ.

J Med Chem. 2016 Jan 14;59(1):486. doi: 10.1021/acs.jmedchem.5b01957. Epub 2015 Dec 28. No abstract available.

PMID:
26709958
11.

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ.

J Med Chem. 2015 Oct 22;58(20):8154-65. doi: 10.1021/acs.jmedchem.5b01037. Epub 2015 Oct 8. Erratum in: J Med Chem. 2016 Jan 14;59(1):486. Childers, Karla [added]; Christensen, Melodie [added]; Kuethe, Jeffrey T. [added]; McCabe Dunn, Jamie [added]; Nolting, Andrew [added]; Peng, Zuihui [corrected].

PMID:
26397965
12.

Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.

Walji AM, Sanchez RI, Clas SD, Nofsinger R, de Lera Ruiz M, Li J, Bennet A, John C, Bennett DJ, Sanders JM, Di Marco CN, Kim SH, Balsells J, Ceglia SS, Dang Q, Manser K, Nissley B, Wai JS, Hafey M, Wang J, Chessen G, Templeton A, Higgins J, Smith R, Wu Y, Grobler J, Coleman PJ.

ChemMedChem. 2015 Feb;10(2):245-52. doi: 10.1002/cmdc.201402393. Epub 2014 Dec 2.

PMID:
25469982
13.

Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.

Nofsinger R, Clas SD, Sanchez RI, Walji A, Manser K, Nissley B, Balsells J, Nair A, Dang Q, Bennett DJ, Hafey M, Wang J, Higgins J, Templeton A, Coleman P, Grobler J, Smith R, Wu Y.

Pharmaceuticals (Basel). 2014 Feb 24;7(2):207-19. doi: 10.3390/ph7020207.

14.

Airway sonography in live models and cadavers.

Tsui B, Ip V, Walji A.

J Ultrasound Med. 2013 Jun;32(6):1049-58. doi: 10.7863/ultra.32.6.1049.

PMID:
23716527
15.

Imaging of vascular complications and their consequences following transplantation in the abdomen.

Low G, Crockett AM, Leung K, Walji AH, Patel VH, Shapiro AM, Lomas DJ, Coulden RA.

Radiographics. 2013 May;33(3):633-52. doi: 10.1148/rg.333125728.

PMID:
23674767
16.

Comparison of blind and electrically guided tracheal needle insertion in human cadavers.

Tsui BC, Neufeld A, Walji AH.

Anaesthesia. 2013 Jul;68(7):689-93. doi: 10.1111/anae.12283. Epub 2013 May 15.

17.

The Architecture of a Software System for Supporting Community-based Primary Health Care with Mobile Technology: The Mobile Technology for Community Health (MoTeCH) Initiative in Ghana.

Macleod B, Phillips J, Stone AE, Walji A, Awoonor-Williams JK.

Online J Public Health Inform. 2012;4(1). pii: ojphi.v4i1.3910. doi: 10.5210/ojphi.v4i1.3910. Epub 2012 May 17.

18.

Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.

Rajapakse HA, Walji AM, Moore KP, Zhu H, Mitra AW, Gregro AR, Tinney E, Burlein C, Touch S, Paton BL, Carroll SS, DiStefano DJ, Lai MT, Grobler JA, Sanchez RI, Williams TM, Vacca JP, Nantermet PG.

ChemMedChem. 2011 Feb 7;6(2):253-7. doi: 10.1002/cmdc.201000395. Epub 2010 Dec 29. No abstract available.

PMID:
21275047
19.

Direct and enantioselective {alpha}-allylation of ketones via singly occupied molecular orbital (SOMO) catalysis.

Mastracchio A, Warkentin AA, Walji AM, MacMillan DW.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20648-51. doi: 10.1073/pnas.1002845107. Epub 2010 Oct 4.

20.

Cycle-specific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis.

Simmons B, Walji AM, MacMillan DW.

Angew Chem Int Ed Engl. 2009;48(24):4349-53. doi: 10.1002/anie.200900220.

21.

Diploic venous anatomy studied in-vivo by MRI.

Jivraj K, Bhargava R, Aronyk K, Quateen A, Walji A.

Clin Anat. 2009 Apr;22(3):296-301. doi: 10.1002/ca.20767.

PMID:
19173254
22.

Ultrasound imaging in cadavers: training in imaging for regional blockade at the trunk.

Tsui B, Dillane D, Pillay J, Walji A.

Can J Anaesth. 2008 Feb;55(2):105-11. doi: 10.1007/BF03016322.

PMID:
18245070
23.

Imaging evaluation of potential donors in living-donor liver transplantation.

Low G, Wiebe E, Walji AH, Bigam DL.

Clin Radiol. 2008 Feb;63(2):136-45. doi: 10.1016/j.crad.2007.08.008. Epub 2007 Dec 26. Review. Erratum in: Clin Radiol. 2008 Jun;63(6):738.

PMID:
18194688
24.

Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters.

Ouellet SG, Walji AM, MacMillan DW.

Acc Chem Res. 2007 Dec;40(12):1327-39. Review.

PMID:
18085748
25.

Access to cerebrospinal fluid absorption sites by infusion into vascular channels of the skull diplö.

Johnston KD, Walji AH, Fox RJ, Pugh JA, Aronyk KE.

J Neurosurg. 2007 Oct;107(4):841-3.

PMID:
17937232
26.

Cadaveric ultrasound imaging for training in ultrasound-guided peripheral nerve blocks: lower extremity.

Tsui BC, Dillane D, Pillay J, Ramji AK, Walji AH.

Can J Anaesth. 2007 Jun;54(6):475-80. No abstract available.

PMID:
17541078
27.

Cadaveric ultrasound imaging for training in ultrasound-guided peripheral nerve blocks: upper extremity.

Tsui BC, Dillane D, Walji AH.

Can J Anaesth. 2007 May;54(5):392-6. No abstract available.

PMID:
17470892
28.

Enantioselective organo-cascade catalysis.

Huang Y, Walji AM, Larsen CH, MacMillan DW.

J Am Chem Soc. 2005 Nov 2;127(43):15051-3.

PMID:
16248643
29.

Universal strategy for the immobilization of chiral dirhodium catalysts.

Davies HM, Walji AM.

Org Lett. 2005 Jul 7;7(14):2941-4.

PMID:
15987175
30.

Direct synthesis of (+)-erogorgiaene through a kinetic enantiodifferentiating step.

Davies HM, Walji AM.

Angew Chem Int Ed Engl. 2005 Mar 4;44(11):1733-5. No abstract available.

PMID:
15712310
31.

Simple strategy for the immobilization of dirhodium tetraprolinate catalysts using a pyridine-linked solid support.

Davies HM, Walji AM, Nagashima T.

J Am Chem Soc. 2004 Apr 7;126(13):4271-80.

PMID:
15053617
33.

Anatomic details of intradural channels in the parasagittal dura: a possible pathway for flow of cerebrospinal fluid.

Fox RJ, Walji AH, Mielke B, Petruk KC, Aronyk KE.

Neurosurgery. 1996 Jul;39(1):84-90; discussion 90-1.

PMID:
8805143
35.
37.

Structural and functional organization of the suprapatella in two cercopithecines.

Walji AH, Fasana FV.

J Morphol. 1983 Apr;176(1):113-9.

PMID:
6854652

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