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Items: 45


Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.

Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA.

Nat Struct Mol Biol. 2018 Jul;25(7):616-622. doi: 10.1038/s41594-018-0085-x. Epub 2018 Jul 2.


Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein.

de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, Yang PL.

Cell Chem Biol. 2018 Aug 16;25(8):1006-1016.e8. doi: 10.1016/j.chembiol.2018.05.011. Epub 2018 Jun 21.


Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes.

Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR.

Methods Mol Biol. 2018;1764:153-171. doi: 10.1007/978-1-4939-7759-8_10.


Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.

Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD.

Mol Cell. 2018 Mar 1;69(5):729-743.e7. doi: 10.1016/j.molcel.2018.02.005.


Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

Moroco JA, Alvarado JJ, Staudt RP, Shi H, Wales TE, Smithgall TE, Engen JR.

J Mol Biol. 2018 Feb 2;430(3):310-321. doi: 10.1016/j.jmb.2017.12.008. Epub 2017 Dec 16.


Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH.

Structure. 2017 Oct 3;25(10):1481-1494.e4. doi: 10.1016/j.str.2017.07.014. Epub 2017 Aug 31.


Allosteric sensitization of proapoptotic BAX.

Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD.

Nat Chem Biol. 2017 Sep;13(9):961-967. doi: 10.1038/nchembio.2433. Epub 2017 Jul 10.


Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry.

Wales TE, Fadgen KE, Eggertson MJ, Engen JR.

J Chromatogr A. 2017 Nov 10;1523:275-282. doi: 10.1016/j.chroma.2017.05.067. Epub 2017 Jun 3.


Allosteric inhibition of antiapoptotic MCL-1.

Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD.

Nat Struct Mol Biol. 2016 Jun;23(6):600-7. doi: 10.1038/nsmb.3223. Epub 2016 May 9.


Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR.

J Am Soc Mass Spectrom. 2016 Jun;27(6):1048-61. doi: 10.1007/s13361-016-1365-5. Epub 2016 Mar 31.


Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH.

PLoS Comput Biol. 2016 Mar 24;12(3):e1004826. doi: 10.1371/journal.pcbi.1004826. eCollection 2016 Mar.


Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.

Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK.

J Am Soc Mass Spectrom. 2016 Apr;27(4):662-8. doi: 10.1007/s13361-015-1330-8. Epub 2016 Jan 26.


Dynamics of the Tec-family tyrosine kinase SH3 domains.

Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE.

Protein Sci. 2016 Apr;25(4):852-64. doi: 10.1002/pro.2887. Epub 2016 Mar 18.


Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O.

J Mol Biol. 2016 Jan 29;428(2 Pt B):449-62. doi: 10.1016/j.jmb.2015.10.029. Epub 2015 Nov 10.


Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.

Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR.

Biochemistry. 2015 Oct 20;54(41):6382-91. doi: 10.1021/acs.biochem.5b00875. Epub 2015 Oct 6.


Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7030-5. doi: 10.1021/acs.analchem.5b01725. Epub 2015 Jul 2.


Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Engen JR, Wales TE.

Annu Rev Anal Chem (Palo Alto Calif). 2015;8:127-48. doi: 10.1146/annurev-anchem-062011-143113. Epub 2015 May 29. Review.


Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-886. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.


A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2.


Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.


Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.

Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA.

Anal Chem. 2013 Dec 3;85(23):11185-8. doi: 10.1021/ac403173p. Epub 2013 Nov 14.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.


Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.

Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A.

Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8.


Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.


Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O.

J Biol Chem. 2013 Jul 5;288(27):19845-60. doi: 10.1074/jbc.M113.460170. Epub 2013 May 17.


Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE.

Int Rev Phys Chem. 2013 Jan 1;32(1):96-127.


Considerations in the analysis of hydrogen exchange mass spectrometry data.

Wales TE, Eggertson MJ, Engen JR.

Methods Mol Biol. 2013;1007:263-88. doi: 10.1007/978-1-62703-392-3_11.


Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.

Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A.

Protein Sci. 2013 Jun;22(6):774-87. doi: 10.1002/pro.2257. Epub 2013 Apr 29.


Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE.

J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9.


Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A.

ACS Chem Neurosci. 2012 May 16;3(5):393-9. doi: 10.1021/cn3000263. Epub 2012 Mar 20.


HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE.

BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1.


Conformational locking upon cooperative assembly of notch transcription complexes.

Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.

Structure. 2012 Feb 8;20(2):340-9. doi: 10.1016/j.str.2011.12.011.


Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.

Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC.

Structure. 2011 Apr 13;19(4):546-54. doi: 10.1016/j.str.2011.01.016.


Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ.

J Mol Biol. 2010 Apr 23;398(1):40-53. doi: 10.1016/j.jmb.2010.02.040. Epub 2010 Mar 4.


High-speed and high-resolution UPLC separation at zero degrees Celsius.

Wales TE, Fadgen KE, Gerhardt GC, Engen JR.

Anal Chem. 2008 Sep 1;80(17):6815-20. doi: 10.1021/ac8008862. Epub 2008 Aug 2.


Structure and dynamic regulation of Src-family kinases.

Engen JR, Wales TE, Hochrein JM, Meyn MA 3rd, Banu Ozkan S, Bahar I, Smithgall TE.

Cell Mol Life Sci. 2008 Oct;65(19):3058-73. doi: 10.1007/s00018-008-8122-2. Review.


Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE.

J Mol Biol. 2007 Nov 16;374(1):121-9. Epub 2007 Sep 11.


Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis.

Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck LF.

J Am Soc Mass Spectrom. 2006 Nov;17(11):1498-1509. doi: 10.1016/j.jasms.2006.05.014. Epub 2006 Jul 27.


Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.

Hochrein JM, Wales TE, Lerner EC, Schiavone AP, Smithgall TE, Engen JR.

Biochemistry. 2006 Jun 27;45(25):7733-9.


Partial unfolding of diverse SH3 domains on a wide timescale.

Wales TE, Engen JR.

J Mol Biol. 2006 Apr 14;357(5):1592-604. Epub 2006 Feb 6.


Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold.

Wang M, Wales TE, Fitzgerald MC.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2600-4. Epub 2006 Feb 10.


Hydrogen exchange mass spectrometry for the analysis of protein dynamics.

Wales TE, Engen JR.

Mass Spectrom Rev. 2006 Jan-Feb;25(1):158-70. Review.


Facile chemical synthesis and equilibrium unfolding properties of CopG.

Wales TE, Richardson JS, Fitzgerald MC.

Protein Sci. 2004 Jul;13(7):1918-26. Epub 2004 May 28.


The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant.

Wales TE, Fitzgerald MC.

J Am Chem Soc. 2001 Aug 8;123(31):7709-10. No abstract available.


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