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The Role of Microglia and Astrocytes in Huntington's Disease.

Palpagama TH, Waldvogel HJ, Faull RLM, Kwakowsky A.

Front Mol Neurosci. 2019 Oct 25;12:258. doi: 10.3389/fnmol.2019.00258. eCollection 2019.


GABAA Receptors Are Well Preserved in the Hippocampus of Aged Mice.

Palpagama TH, Sagniez M, Kim S, Waldvogel HJ, Faull RL, Kwakowsky A.

eNeuro. 2019 Aug 14;6(4). pii: ENEURO.0496-18.2019. doi: 10.1523/ENEURO.0496-18.2019. Print 2019 Jul/Aug.


Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease.

Patassini S, Begley P, Xu J, Church SJ, Kureishy N, Reid SJ, Waldvogel HJ, Faull RLM, Snell RG, Unwin RD, Cooper GJS.

Metabolites. 2019 Jun 11;9(6). pii: E113. doi: 10.3390/metabo9060113.


Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?

Govindpani K, McNamara LG, Smith NR, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A.

J Clin Med. 2019 May 10;8(5). pii: E651. doi: 10.3390/jcm8050651. Review.


Variable colocalisation of GABAA receptor subunits and glycine receptors on neurons in the human hypoglossal nucleus.

Waldvogel HJ, Biggins FM, Singh A, Arasaratnam CJ, Faull RLM.

J Chem Neuroanat. 2019 Apr;97:99-111. doi: 10.1016/j.jchemneu.2019.02.005. Epub 2019 Feb 27.


Regional protein expression in human Alzheimer's brain correlates with disease severity.

Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, Faull RLM, Dowsey AW, Cooper GJS, Unwin RD.

Commun Biol. 2019 Feb 4;2:43. doi: 10.1038/s42003-018-0254-9. eCollection 2019.


Chemical neuroanatomy of the substantia nigra in the ovine brain.

Murray SJ, Black BL, Reid SJ, Rudiger SR, Simon Bawden C, Snell RG, Waldvogel HJ, Faull RLM.

J Chem Neuroanat. 2019 Apr;97:43-56. doi: 10.1016/j.jchemneu.2019.01.007. Epub 2019 Jan 18.


Sex- and age-related changes in GABA signaling components in the human cortex.

Pandya M, Palpagama TH, Turner C, Waldvogel HJ, Faull RL, Kwakowsky A.

Biol Sex Differ. 2019 Jan 14;10(1):5. doi: 10.1186/s13293-018-0214-6.


Cerebellar degeneration correlates with motor symptoms in Huntington disease.

Singh-Bains MK, Mehrabi NF, Sehji T, Austria MDR, Tan AYS, Tippett LJ, Dragunow M, Waldvogel HJ, Faull RLM.

Ann Neurol. 2019 Mar;85(3):396-405. doi: 10.1002/ana.25413. Epub 2019 Feb 4.


Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway.

Kwakowsky A, Calvo-Flores Guzmán B, Govindpani K, Waldvogel HJ, Faull RL.

Neural Regen Res. 2018 Aug;13(8):1362-1363. doi: 10.4103/1673-5374.235240. No abstract available.


Stereological Methods to Quantify Cell Loss in the Huntington's Disease Human Brain.

Mehrabi NF, Singh-Bains MK, Waldvogel HJ, Faull RLM.

Methods Mol Biol. 2018;1780:1-16. doi: 10.1007/978-1-4939-7825-0_1.


Emergence of breath testing as a new non-invasive diagnostic modality for neurodegenerative diseases.

Subramaniam NS, Bawden CS, Waldvogel H, Faull RML, Howarth GS, Snell RG.

Brain Res. 2018 Jul 15;1691:75-86. doi: 10.1016/j.brainres.2018.04.017. Epub 2018 Apr 22. Review.


Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone.

Dieriks BV, Dean JM, Aronica E, Waldvogel HJ, Faull RLM, Curtis MA.

Dev Neurosci. 2018;40(2):145-161. doi: 10.1159/000487633. Epub 2018 Apr 20.


The GABAergic system as a therapeutic target for Alzheimer's disease.

Calvo-Flores Guzmán B, Vinnakota C, Govindpani K, Waldvogel HJ, Faull RLM, Kwakowsky A.

J Neurochem. 2018 Sep;146(6):649-669. doi: 10.1111/jnc.14345. Epub 2018 Aug 1. Review.


GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.

Kwakowsky A, Calvo-Flores Guzmán B, Pandya M, Turner C, Waldvogel HJ, Faull RL.

J Neurochem. 2018 Jun;145(5):374-392. doi: 10.1111/jnc.14325.


Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11.


GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus.

Wu XH, Song JJ, Faull RLM, Waldvogel HJ.

J Comp Neurol. 2018 Apr 1;526(5):803-823. doi: 10.1002/cne.24368. Epub 2017 Dec 22.


Imposed running exercise does not alter cell proliferation in the neurogenic niches of young lambs.

Swanson MEV, Murray HC, Oliver MH, Waldvogel HJ, Firth EC, Curtis MA.

J Anim Sci. 2017 Oct;95(10):4381-4390. doi: 10.2527/jas2017.1710.


Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Govindpani K, Calvo-Flores Guzmán B, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A.

Int J Mol Sci. 2017 Aug 21;18(8). pii: E1813. doi: 10.3390/ijms18081813. Review.


Alzheimer's disease markers in the aged sheep (Ovis aries).

Reid SJ, Mckean NE, Henty K, Portelius E, Blennow K, Rudiger SR, Bawden CS, Handley RR, Verma PJ, Faull RLM, Waldvogel HJ, Zetterberg H, Snell RG.

Neurobiol Aging. 2017 Oct;58:112-119. doi: 10.1016/j.neurobiolaging.2017.06.020. Epub 2017 Jun 24.


The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.

Tippett LJ, Waldvogel HJ, Snell RG, Vonsattel JP, Young AB, Faull RLM.

Adv Neurobiol. 2017;15:129-161. doi: 10.1007/978-3-319-57193-5_5. Review.


Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, Faull RLM, Unwin RD, Cooper GJS.

Metallomics. 2017 Aug 16;9(8):1106-1119. doi: 10.1039/c7mt00074j.


Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates.

Schut MH, Patassini S, Kim EH, Bullock J, Waldvogel HJ, Faull RLM, Pepers BA, den Dunnen JT, van Ommen GB, van Roon-Mom WMC.

PLoS One. 2017 Jun 1;12(6):e0178556. doi: 10.1371/journal.pone.0178556. eCollection 2017.


The immunohistochemical distribution of the GABAA receptor α1, α2, α3, β2/3 and γ2 subunits in the human thalamus.

Waldvogel HJ, Munkle M, van Roon-Mom W, Mohler H, Faull RLM.

J Chem Neuroanat. 2017 Jul;82:39-55. doi: 10.1016/j.jchemneu.2017.04.006. Epub 2017 Apr 23.


Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.

Fuhrer TE, Palpagama TH, Waldvogel HJ, Synek BJL, Turner C, Faull RL, Kwakowsky A.

Neuroscience. 2017 May 20;351:108-118. doi: 10.1016/j.neuroscience.2017.03.041. Epub 2017 Apr 4.


Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease.

Kwakowsky A, Milne MR, Waldvogel HJ, Faull RL.

Int J Mol Sci. 2016 Dec 17;17(12). pii: E2122. doi: 10.3390/ijms17122122. Review.


Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease.

D'Souza GX, Waldvogel HJ.

J Huntingtons Dis. 2016 Dec 15;5(4):333-342. Review.


Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex.

Mehrabi NF, Waldvogel HJ, Tippett LJ, Hogg VM, Synek BJ, Faull RL.

Neurobiol Dis. 2016 Dec;96:67-74. doi: 10.1016/j.nbd.2016.08.015. Epub 2016 Aug 25.


The role of the human globus pallidus in Huntington's disease.

Singh-Bains MK, Waldvogel HJ, Faull RL.

Brain Pathol. 2016 Nov;26(6):741-751. doi: 10.1111/bpa.12429. Review.


C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue.

Scotter EL, Smyth L, Bailey JAWT, Wong CH, de Majo M, Vance CA, Synek BJ, Turner C, Pereira J, Charleston A, Waldvogel HJ, Curtis MA, Dragunow M, Shaw CE, Smith BN, Faull RLM.

Neurobiol Aging. 2017 Jan;49:214.e1-214.e5. doi: 10.1016/j.neurobiolaging.2016.06.019. Epub 2016 Jul 5.


Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.

Horvath S, Langfelder P, Kwak S, Aaronson J, Rosinski J, Vogt TF, Eszes M, Faull RL, Curtis MA, Waldvogel HJ, Choi OW, Tung S, Vinters HV, Coppola G, Yang XW.

Aging (Albany NY). 2016 Jul;8(7):1485-512. doi: 10.18632/aging.101005.


Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.

Lin L, Park JW, Ramachandran S, Zhang Y, Tseng YT, Shen S, Waldvogel HJ, Curtis MA, Faull RL, Troncoso JC, Pletnikova O, Ross CA, Davidson BL, Xing Y.

Hum Mol Genet. 2016 Aug 15;25(16):3454-3466. doi: 10.1093/hmg/ddw187. Epub 2016 Jul 4.


Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.


Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.


Globus pallidus degeneration and clinicopathological features of Huntington disease.

Singh-Bains MK, Tippett LJ, Hogg VM, Synek BJ, Roxburgh RH, Waldvogel HJ, Faull RL.

Ann Neurol. 2016 Aug;80(2):185-201. doi: 10.1002/ana.24694. Epub 2016 Jun 24.


Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.

Xu J, Begley P, Church SJ, Patassini S, Hollywood KA, Jüllig M, Curtis MA, Waldvogel HJ, Faull RL, Unwin RD, Cooper GJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1084-92. doi: 10.1016/j.bbadis.2016.03.001. Epub 2016 Mar 5.


Mapping the calcitonin receptor in human brain stem.

Bower RL, Eftekhari S, Waldvogel HJ, Faull RL, Tajti J, Edvinsson L, Hay DL, Walker CS.

Am J Physiol Regul Integr Comp Physiol. 2016 May 1;310(9):R788-93. doi: 10.1152/ajpregu.00539.2015. Epub 2016 Feb 24.


Metabolic disruption identified in the Huntington's disease transgenic sheep model.

Handley RR, Reid SJ, Patassini S, Rudiger SR, Obolonkin V, McLaughlan CJ, Jacobsen JC, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RL, Snell RG.

Sci Rep. 2016 Feb 11;6:20681. doi: 10.1038/srep20681.


Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Patassini S, Begley P, Reid SJ, Xu J, Church SJ, Curtis M, Dragunow M, Waldvogel HJ, Unwin RD, Snell RG, Faull RL, Cooper GJ.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):161-6. doi: 10.1016/j.bbrc.2015.10.140. Epub 2015 Oct 30.


String Vessel Formation is Increased in the Brain of Parkinson Disease.

Yang P, Pavlovic D, Waldvogel H, Dragunow M, Synek B, Turner C, Faull R, Guan J.

J Parkinsons Dis. 2015;5(4):821-36. doi: 10.3233/JPD-140454.


A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.

Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL.

Ann Clin Transl Neurol. 2015 Jun;2(6):595-608. doi: 10.1002/acn3.197. Epub 2015 Apr 1.


Disrupted vasculature and blood-brain barrier in Huntington disease.

Waldvogel HJ, Dragunow M, Faull RL.

Ann Neurol. 2015 Aug;78(2):158-9. doi: 10.1002/ana.24445. Epub 2015 Jul 1. No abstract available.


The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease.

Kim J, Waldvogel HJ, Faull RL, Curtis MA, Nicholson LF.

J Neurochem. 2015 Sep;134(5):927-42. doi: 10.1111/jnc.13178. Epub 2015 Jul 1.


The diversity of GABA(A) receptor subunit distribution in the normal and Huntington's disease human brain.

Waldvogel HJ, Faull RL.

Adv Pharmacol. 2015;73:223-64. doi: 10.1016/bs.apha.2014.11.010. Epub 2015 Jan 17. Review.


Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW.

Sci Transl Med. 2014 Dec 24;6(268):268ra178. doi: 10.1126/scitranslmed.3010523.


The Neuropathology of Huntington's Disease.

Waldvogel HJ, Kim EH, Tippett LJ, Vonsattel JP, Faull RL.

Curr Top Behav Neurosci. 2015;22:33-80. doi: 10.1007/7854_2014_354. Review.


Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity.

Lowe MT, Faull RL, Christie DL, Waldvogel HJ.

J Comp Neurol. 2015 Apr 1;523(5):699-725. doi: 10.1002/cne.23667. Epub 2014 Sep 12.


Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease.

Nana AL, Kim EH, Thu DC, Oorschot DE, Tippett LJ, Hogg VM, Synek BJ, Roxburgh R, Waldvogel HJ, Faull RL.

J Huntingtons Dis. 2014;3(1):45-64. doi: 10.3233/JHD-140092.


Cortical interneuron loss and symptom heterogeneity in Huntington disease.

Kim EH, Thu DC, Tippett LJ, Oorschot DE, Hogg VM, Roxburgh R, Synek BJ, Waldvogel HJ, Faull RL.

Ann Neurol. 2014 May;75(5):717-27. doi: 10.1002/ana.24162. Epub 2014 May 13.


Altered arginine metabolism in Alzheimer's disease brains.

Liu P, Fleete MS, Jing Y, Collie ND, Curtis MA, Waldvogel HJ, Faull RL, Abraham WC, Zhang H.

Neurobiol Aging. 2014 Sep;35(9):1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013. Epub 2014 Mar 20.


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