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Items: 43


New-Onset Diabetes Mellitus After Chronic Pancreatitis Diagnosis: A Systematic Review and Meta-analysis.

Zhu X, Liu D, Wei Q, Lin H, Zhi M, Chen Y, Qi L, Waldron RT, Lugea A, Pandol SJ, Li L.

Pancreas. 2019 Aug;48(7):868-875. doi: 10.1097/MPA.0000000000001359.


Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis.

Zhi M, Zhu X, Lugea A, Waldron RT, Pandol SJ, Li L.

Front Physiol. 2019 May 31;10:637. doi: 10.3389/fphys.2019.00637. eCollection 2019.


The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis.

Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ.

J Physiol. 2019 Jun;597(12):3085-3105. doi: 10.1113/JP277856. Epub 2019 May 22.


Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.

Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I.

Pancreas. 2019 Apr;48(4):459-470. doi: 10.1097/MPA.0000000000001298.


Proteomic Identification of Novel Plasma Biomarkers and Pathobiologic Pathways in Alcoholic Acute Pancreatitis.

Waldron RT, Lugea A, Gulla A, Pandol SJ.

Front Physiol. 2018 Aug 30;9:1215. doi: 10.3389/fphys.2018.01215. eCollection 2018.


Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model.

Waldron RT, Su HY, Piplani H, Capri J, Cohn W, Whitelegge JP, Faull KF, Sakkiah S, Abrol R, Yang W, Zhou B, Freeman MR, Pandol SJ, Lugea A.

Cell Mol Gastroenterol Hepatol. 2018 Jan 6;5(4):479-497. doi: 10.1016/j.jcmgh.2018.01.001. eCollection 2018.


The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis.

Hu C, Wen L, Deng L, Zhang C, Lugea A, Su HY, Waldron RT, Pandol SJ, Xia Q.

Gastroenterol Res Pract. 2017;2017:9505460. doi: 10.1155/2017/9505460. Epub 2017 Oct 8. Review.


Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.

Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ.

Am J Pathol. 2017 Dec;187(12):2726-2743. doi: 10.1016/j.ajpath.2017.08.017. Epub 2017 Sep 19.


Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.

Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G.

PLoS One. 2017 Sep 8;12(9):e0184455. doi: 10.1371/journal.pone.0184455. eCollection 2017.


The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells.

Lugea A, Gerloff A, Su HY, Xu Z, Go A, Hu C, French SW, Wilson JS, Apte MV, Waldron RT, Pandol SJ.

Gastroenterology. 2017 Dec;153(6):1674-1686. doi: 10.1053/j.gastro.2017.08.036. Epub 2017 Aug 25.


Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells.

Yang J, Waldron RT, Su HY, Moro A, Chang HH, Eibl G, Ferreri K, Kandeel FR, Lugea A, Li L, Pandol SJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G675-G687. doi: 10.1152/ajpgi.00251.2016. Epub 2016 Sep 8.


The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells.

Su HY, Waldron RT, Gong R, Ramanujan VK, Pandol SJ, Lugea A.

PLoS One. 2016 Feb 5;11(2):e0148999. doi: 10.1371/journal.pone.0148999. eCollection 2016.


Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response.

Lugea A, Waldron RT, Pandol SJ.

Pancreatology. 2015 Jul;15(4 Suppl):S1-5. doi: 10.1016/j.pan.2015.01.011. Epub 2015 Feb 7. Review.


Diabetes, pancreatic cancer, and metformin therapy.

Gong J, Robbins LA, Lugea A, Waldron RT, Jeon CY, Pandol SJ.

Front Physiol. 2014 Nov 7;5:426. doi: 10.3389/fphys.2014.00426. eCollection 2014. Review.


Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis.

Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova O, Waldron RT, Pandol SJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G550-63. doi: 10.1152/ajpgi.00432.2013. Epub 2014 Jul 17.


Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis.

Shalbueva N, Mareninova OA, Gerloff A, Yuan J, Waldron RT, Pandol SJ, Gukovskaya AS.

Gastroenterology. 2013 Feb;144(2):437-446.e6. doi: 10.1053/j.gastro.2012.10.037. Epub 2012 Oct 24.


Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.

Waldron RT, Innamorati G, Torres-Marquez ME, Sinnett-Smith J, Rozengurt E.

Cell Signal. 2012 Apr;24(4):914-21. doi: 10.1016/j.cellsig.2011.12.014. Epub 2011 Dec 29.


Genes, tolerance and systemic autoimmunity.

Singh RP, Waldron RT, Hahn BH.

Autoimmun Rev. 2012 Jul;11(9):664-9. doi: 10.1016/j.autrev.2011.11.017. Epub 2011 Nov 30. Review.


Drinking and driving pancreatitis: links between endoplasmic reticulum stress and autophagy.

Lugea A, Waldron RT, French SW, Pandol SJ.

Autophagy. 2011 Jul;7(7):783-5. Epub 2011 Jul 1.


CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.

Torres-Marquez E, Sinnett-Smith J, Guha S, Kui R, Waldron RT, Rey O, Rozengurt E.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):63-8. doi: 10.1016/j.bbrc.2009.11.002. Epub 2009 Nov 5.


Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

Sinnett-Smith J, Jacamo R, Kui R, Wang YM, Young SH, Rey O, Waldron RT, Rozengurt E.

J Biol Chem. 2009 May 15;284(20):13434-45. doi: 10.1074/jbc.M806554200. Epub 2009 Mar 16.


Protein kinase D isozymes activation and localization during mitosis.

Papazyan R, Doche M, Waldron RT, Rozengurt E, Moyer MP, Rey O.

Exp Cell Res. 2008 Oct 1;314(16):3057-68. doi: 10.1016/j.yexcr.2008.07.014. Epub 2008 Jul 26.


Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation.

Jacamo R, Sinnett-Smith J, Rey O, Waldron RT, Rozengurt E.

J Biol Chem. 2008 May 9;283(19):12877-87. doi: 10.1074/jbc.M800442200. Epub 2008 Mar 12.


Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D.

Waldron RT, Whitelegge JP, Faull KF, Rozengurt E.

Biochem Biophys Res Commun. 2007 May 4;356(2):361-7. Epub 2007 Mar 5.


The nuclear import of protein kinase D3 requires its catalytic activity.

Rey O, Papazyan R, Waldron RT, Young SH, Lippincott-Schwartz J, Jacamo R, Rozengurt E.

J Biol Chem. 2006 Feb 24;281(8):5149-57. Epub 2005 Dec 27.


Protein kinase D signaling.

Rozengurt E, Rey O, Waldron RT.

J Biol Chem. 2005 Apr 8;280(14):13205-8. Epub 2005 Feb 8. Review. No abstract available.


Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D.

Waldron RT, Rey O, Zhukova E, Rozengurt E.

J Biol Chem. 2004 Jun 25;279(26):27482-93. Epub 2004 Apr 14.


The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, Colicelli J.

Mol Cell Biol. 2002 Feb;22(3):916-26.


Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.

Waldron RT, Rey O, Iglesias T, Tugal T, Cantrell D, Rozengurt E.

J Biol Chem. 2001 Aug 31;276(35):32606-15. Epub 2001 Jun 15.


Phosphorylation-dependent protein kinase D activation.

Waldron RT, Iglesias T, Rozengurt E.

Electrophoresis. 1999 Feb;20(2):382-90. Review.


Identification of in vivo phosphorylation sites required for protein kinase D activation.

Iglesias T, Waldron RT, Rozengurt E.

J Biol Chem. 1998 Oct 16;273(42):27662-7.


Store-operated Ca2+ entry and coupling to Ca2+ pool depletion in thapsigargin-resistant cells.

Waldron RT, Short AD, Gill DL.

J Biol Chem. 1997 Mar 7;272(10):6440-7.


Calcium pools, calcium entry, and cell growth.

Gill DL, Waldron RT, Rys-Sikora KE, Ufret-Vincenty CA, Graber MN, Favre CJ, Alfonso A.

Biosci Rep. 1996 Apr;16(2):139-57. Review.


Thapsigargin-resistant intracellular calcium pumps. Role in calcium pool function and growth of thapsigargin-resistant cells.

Waldron RT, Short AD, Gill DL.

J Biol Chem. 1995 May 19;270(20):11955-61. Erratum in: J Biol Chem 1995 Aug 4;270(31):18710.


Endoplasmic reticulum calcium pump expression and control of cell growth.

Waldron RT, Short AD, Meadows JJ, Ghosh TK, Gill DL.

J Biol Chem. 1994 Apr 22;269(16):11927-33.


Intracellular Ca2+ pool content is linked to control of cell growth.

Short AD, Bian J, Ghosh TK, Waldron RT, Rybak SL, Gill DL.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4986-90.


Function and organization of the inositol 1,4,5-trisphosphate-sensitive calcium pool.

Gill DL, Ghosh TK, Bian J, Short AD, Waldron RT, Rybak SL.

Adv Second Messenger Phosphoprotein Res. 1992;26:265-308. Review. No abstract available.


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