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Items: 20

1.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Bagal SK, Andrews M, Bechle BM, Bian J, Bilsland J, Blakemore DC, Braganza JF, Bungay PJ, Corbett MS, Cronin CN, Cui JJ, Dias R, Flanagan NJ, Greasley SE, Grimley R, James K, Johnson E, Kitching L, Kraus ML, McAlpine I, Nagata A, Ninkovic S, Omoto K, Scales S, Skerratt SE, Sun J, Tran-Dubé M, Waldron GJ, Wang F, Warmus JS.

J Med Chem. 2018 Aug 9;61(15):6779-6800. doi: 10.1021/acs.jmedchem.8b00633. Epub 2018 Jul 27.

PMID:
29944371
2.

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Bagal SK, Omoto K, Blakemore DC, Bungay PJ, Bilsland JG, Clarke PJ, Corbett MS, Cronin CN, Cui JJ, Dias R, Flanagan NJ, Greasley SE, Grimley R, Johnson E, Fengas D, Kitching L, Kraus ML, McAlpine I, Nagata A, Waldron GJ, Warmus JS.

J Med Chem. 2019 Jan 10;62(1):247-265. doi: 10.1021/acs.jmedchem.8b00280. Epub 2018 May 3.

PMID:
29672039
3.

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics.

Pryde DC, Swain NA, Stupple PA, West CW, Marron B, Markworth CJ, Printzenhoff D, Lin Z, Cox PJ, Suzuki R, McMurray S, Waldron GJ, Payne CE, Warmus JS, Chapman ML.

Medchemcomm. 2017 Apr 28;8(6):1255-1267. doi: 10.1039/c7md00131b. eCollection 2017 Jun 1.

4.

Patch clamping by numbers.

Wood C, Williams C, Waldron GJ.

Drug Discov Today. 2004 May 15;9(10):434-41. Review. No abstract available.

PMID:
15109948
5.

A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating.

Guo Y, Waldron GJ, Murrell-Lagnado R.

J Biol Chem. 2002 Dec 13;277(50):48289-94. Epub 2002 Oct 9.

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7.

Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase.

Waldron GJ, Ding H, Lovren F, Kubes P, Triggle CR.

Br J Pharmacol. 1999 Oct;128(3):653-8.

8.

Activation of vascular smooth muscle K+ channels by endothelium-derived relaxing factors.

Waldron GJ, Cole WC.

Clin Exp Pharmacol Physiol. 1999 Feb;26(2):180-4. Review.

PMID:
10065344
9.

Endothelium-derived hyperpolarizing factor(s): species and tissue heterogeneity.

Triggle CR, Dong H, Waldron GJ, Cole WC.

Clin Exp Pharmacol Physiol. 1999 Feb;26(2):176-9.

PMID:
10065343
10.

Delayed rectifier K+ current of dog bronchial myocytes: effect of pollen sensitization and PKC activation.

Waldron GJ, Sigurdsson SB, Aiello EA, Halayko AJ, Stephens NL, Cole WC.

Am J Physiol. 1998 Aug;275(2):L336-47. doi: 10.1152/ajplung.1998.275.2.L336.

PMID:
9700095
12.

Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries.

Plane F, Holland M, Waldron GJ, Garland CJ, Boyle JP.

Br J Pharmacol. 1997 Aug;121(8):1509-11.

13.

NO/PGI2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery.

Dong H, Waldron GJ, Galipeau D, Cole WC, Triggle CR.

Br J Pharmacol. 1997 Feb;120(4):695-701.

14.

Lack of endothelin ETB receptor-mediated smooth muscle hyperpolarization in rat mesenteric resistance arteries.

Waldron GJ, Roach AG, Garland CJ.

Eur J Pharmacol. 1996 Dec 27;318(1):89-92.

PMID:
9007517
15.

Endothelium-dependent hyperpolarization of vascular smooth muscle: role for a non-nitric oxide synthase product.

Waldron GJ, Dong H, Cole WC, Triggle CR.

Zhongguo Yao Li Xue Bao. 1996 Jan;17(1):3-7. Review.

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19.

Screening, ethics and the law.

Williams ES, Waldron GJ.

BMJ. 1992 Dec 5;305(6866):1433. No abstract available.

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