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Items: 34

1.

Potent and Selective Peptide-based Inhibition of the G Protein Gαq.

Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J.

J Biol Chem. 2016 Dec 2;291(49):25608-25616. Epub 2016 Oct 14.

2.

Membrane-induced allosteric control of phospholipase C-β isozymes.

Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J.

J Biol Chem. 2014 Oct 24;289(43):29545-57. doi: 10.1074/jbc.M114.586784. Epub 2014 Sep 5.

3.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

4.

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.

Harden TK, Waldo GL, Hicks SN, Sondek J.

Chem Rev. 2011 Oct 12;111(10):6120-9. doi: 10.1021/cr200209p. No abstract available.

5.

Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.

Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK.

Science. 2010 Nov 12;330(6006):974-80. doi: 10.1126/science.1193438. Epub 2010 Oct 21.

6.

Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins.

Bodor ET, Waldo GL, Blaesius R, Harden TK.

Purinergic Signal. 2004 Dec;1(1):43-9. doi: 10.1007/s11302-004-4748-1.

7.

Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor.

Waldo GL, Harden TK.

Mol Pharmacol. 2004 Feb;65(2):426-36. Erratum in: Mol Pharmacol. 2004 Mar;65(3):811.

PMID:
14742685
8.

Purification and functional reconstitution of the human P2Y12 receptor.

Bodor ET, Waldo GL, Hooks SB, Corbitt J, Boyer JL, Harden TK.

Mol Pharmacol. 2003 Nov;64(5):1210-6.

PMID:
14573771
9.

RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity.

Hooks SB, Waldo GL, Corbitt J, Bodor ET, Krumins AM, Harden TK.

J Biol Chem. 2003 Mar 21;278(12):10087-93. Epub 2003 Jan 16.

10.

Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.

Waldo GL, Corbitt J, Boyer JL, Ravi G, Kim HS, Ji XD, Lacy J, Jacobson KA, Harden TK.

Mol Pharmacol. 2002 Nov;62(5):1249-57.

11.

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.

Singer AU, Waldo GL, Harden TK, Sondek J.

Nat Struct Biol. 2002 Jan;9(1):32-6.

PMID:
11753430
12.

Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.

Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK.

J Biol Chem. 2001 Feb 23;276(8):5438-44. Epub 2000 Nov 3.

13.

Molecular cloning and expression of an avian G protein-coupled P2Y receptor.

Boyer JL, Waldo GL, Harden TK.

Mol Pharmacol. 1997 Dec;52(6):928-34.

PMID:
9415702
14.
15.

Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.

Boyer JL, Graber SG, Waldo GL, Harden TK, Garrison JC.

J Biol Chem. 1994 Jan 28;269(4):2814-9.

16.

Purification of phospholipase C-activating G protein, G11, from turkey erythrocytes.

Waldo GL, Boyer JL, Harden TK.

Methods Enzymol. 1994;237:182-91. No abstract available.

PMID:
7934996
17.

Purification of G-protein-regulated phospholipase C from turkey erythrocytes.

Waldo GL, Morris AJ, Harden TK.

Methods Enzymol. 1994;238:195-207. No abstract available.

PMID:
7799785
18.

Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes.

Maurice DH, Waldo GL, Morris AJ, Nicholas RA, Harden TK.

Biochem J. 1993 Mar 15;290 ( Pt 3):765-70.

19.

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

Boyer JL, Waldo GL, Harden TK.

J Biol Chem. 1992 Dec 15;267(35):25451-6.

21.

Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein.

Waldo GL, Boyer JL, Morris AJ, Harden TK.

J Biol Chem. 1991 Aug 5;266(22):14217-25.

22.

Avian G-protein-regulated phospholipase C.

Harden TK, Morris AJ, Waldo GL, Downes CP, Boyer JL.

Biochem Soc Trans. 1991 Apr;19(2):342-6. Review. No abstract available.

PMID:
1909665
24.
25.

Regulation of phospholipase C.

Morris AJ, Waldo GL, Boyer JL, Hepler JR, Downes CP, Harden TK.

Soc Gen Physiol Ser. 1990;45:61-75. Review. No abstract available.

PMID:
2116041
26.

Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits.

Boyer JL, Waldo GL, Evans T, Northup JK, Downes CP, Harden TK.

J Biol Chem. 1989 Aug 15;264(23):13917-22.

27.

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go.

Waldo GL, Evans T, Fraser ED, Northup JK, Martin MW, Harden TK.

Biochem J. 1987 Sep 1;246(2):431-9.

28.

Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.

Toews ML, Waldo GL, Harden TK, Perkins JP.

J Cyclic Nucleotide Protein Phosphor Res. 1986;11(1):47-62.

PMID:
3009571
29.

Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.

Harden TK, Petch LA, Traynelis SF, Waldo GL.

J Biol Chem. 1985 Oct 25;260(24):13060-6.

32.
33.

Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.

Frederich RC Jr, Waldo GL, Harden TK, Perkins JP.

J Cyclic Nucleotide Protein Phosphor Res. 1983;9(2):103-18.

PMID:
6315795
34.

Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.

Harden TK, Cotton CU, Waldo GL, Lutton JK, Perkins JP.

Science. 1980 Oct;210(4468):441-3.

PMID:
6254143

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