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Items: 1 to 50 of 929

1.

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes.

Leung OM, Li J, Li X, Chan VW, Yang KY, Ku M, Ji L, Sun H, Waldmann H, Tian XY, Huang Y, Lau J, Zhou B, Lui KO.

Cell Rep. 2018 Aug 7;24(6):1610-1626. doi: 10.1016/j.celrep.2018.07.019.

2.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.

3.

Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.

Stockenhuber K, Hegazy AN, West NR, Ilott NE, Stockenhuber A, Bullers SJ, Thornton EE, Arnold IC, Tucci A, Waldmann H, Ogg GS, Powrie F.

J Exp Med. 2018 Aug 6;215(8):1987-1998. doi: 10.1084/jem.20172094. Epub 2018 Jul 6.

PMID:
29980582
4.

CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Cobbold SP, Adams E, Howie D, Waldmann H.

Front Immunol. 2018 Jun 18;9:1381. doi: 10.3389/fimmu.2018.01381. eCollection 2018.

5.

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.

Benson RA, Garcon F, Recino A, Ferdinand JR, Clatworthy MR, Waldmann H, Brewer JM, Okkenhaug K, Cooke A, Garside P, Wållberg M.

Front Immunol. 2018 May 18;9:1006. doi: 10.3389/fimmu.2018.01006. eCollection 2018.

6.

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.

Chem Sci. 2018 Feb 26;9(11):3014-3022. doi: 10.1039/c7sc05040b. eCollection 2018 Mar 21.

7.

UNC119A Decreases the Membrane Binding of Myristoylated c-Src.

Erwin N, Dwivedi M, Mejuch T, Waldmann H, Winter R.

Chembiochem. 2018 Apr 27. doi: 10.1002/cbic.201800158. [Epub ahead of print]

PMID:
29700916
8.

Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity.

Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.

J Org Chem. 2018 Jul 6;83(13):7033-7041. doi: 10.1021/acs.joc.7b03202. Epub 2018 Feb 20.

PMID:
29460633
9.

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis.

Jia ZJ, Shan G, Daniliuc CG, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2018 Feb 8. doi: 10.1002/anie.201712882. [Epub ahead of print]

PMID:
29419912
10.

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, Reinhardt L, Abo-Rady M, Glatza M, King SJ, Nussbaumer P, Ziegler S, Klebl B, Schroer TA, Schöler HR, Waldmann H, Sterneckert J.

Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6. doi: 10.1016/j.chembiol.2017.12.014. Epub 2018 Jan 27.

PMID:
29396292
11.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

12.

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival.

Howie D, Ten Bokum A, Necula AS, Cobbold SP, Waldmann H.

Front Immunol. 2018 Jan 12;8:1949. doi: 10.3389/fimmu.2017.01949. eCollection 2017. Review.

13.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D.

Cell Chem Biol. 2018 Mar 15;25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. Epub 2018 Jan 4.

PMID:
29307839
14.

Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Rubaiy HN, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech DJ.

Br J Pharmacol. 2018 Mar;175(5):830-839. doi: 10.1111/bph.14128. Epub 2018 Jan 25.

PMID:
29247460
15.

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells.

Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ.

Sci Rep. 2017 Dec 5;7(1):16988. doi: 10.1038/s41598-017-17303-3.

16.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.

Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.

Bioorg Med Chem. 2018 May 1;26(8):1453-1461. doi: 10.1016/j.bmc.2017.11.009. Epub 2017 Nov 4.

PMID:
29170028
17.

Ligand-Directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems.

Lee YC, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5212-5226. doi: 10.1002/anie.201710247. Epub 2018 Mar 6. Review.

PMID:
29105306
18.

Exploring Natural Product Fragments for Drug and Probe Discovery.

Pahl A, Waldmann H, Kumar K.

Chimia (Aarau). 2017 Oct 25;71(10):653-660. doi: 10.2533/chimia.2017.653.

PMID:
29070410
19.

Identification of novel PDEδ interacting proteins.

Küchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.

Bioorg Med Chem. 2018 May 1;26(8):1426-1434. doi: 10.1016/j.bmc.2017.08.033. Epub 2017 Aug 31.

PMID:
28935183
20.

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HR, Sterneckert J, Ziegler S, Schneider G, Waldmann H.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025. doi: 10.1002/anie.201707394. Epub 2017 Sep 18.

PMID:
28833911
21.

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.

Xu H, Laraia L, Schneider L, Louven K, Strohmann C, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11232-11236. doi: 10.1002/anie.201706005. Epub 2017 Jul 28.

PMID:
28696533
22.

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.

Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S, Waldmann H.

Chembiochem. 2017 Sep 19;18(18):1797-1806. doi: 10.1002/cbic.201700260. Epub 2017 Jul 31.

PMID:
28678390
23.

Lateral Organization of Host Heterogeneous Raft-like Membranes Altered by the Myristoyl Modification of Tyrosine Kinase c-Src.

Dwivedi M, Mejuch T, Waldmann H, Winter R.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10511-10515. doi: 10.1002/anie.201706233. Epub 2017 Jul 24.

PMID:
28657213
24.

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification.

Laraia L, Waldmann H.

Drug Discov Today Technol. 2017 Mar;23:75-82. doi: 10.1016/j.ddtec.2017.03.003. Epub 2017 Apr 14. Review.

PMID:
28647090
25.

Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

Plowright AT, Ottmann C, Arkin M, Auberson YP, Timmerman H, Waldmann H.

Cell Chem Biol. 2017 Sep 21;24(9):1058-1065. doi: 10.1016/j.chembiol.2017.05.019. Epub 2017 Jun 8. Review.

PMID:
28602761
26.

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J.

Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157. doi: 10.1002/anie.201703738. Epub 2017 Jun 12.

PMID:
28544137
27.

Small-molecule phenotypic screening with stem cells.

Ursu A, Schöler HR, Waldmann H.

Nat Chem Biol. 2017 May 17;13(6):560-563. doi: 10.1038/nchembio.2383. No abstract available.

PMID:
28514421
28.

Small-Molecule Inhibition of the UNC119-Cargo Interaction.

Mejuch T, Garivet G, Hofer W, Kaiser N, Fansa EK, Ehrt C, Koch O, Baumann M, Ziegler S, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. doi: 10.1002/anie.201701905. Epub 2017 May 4.

PMID:
28471079
29.

Covalent Protein Labeling at Glutamic Acids.

Martín-Gago P, Fansa EK, Winzker M, Murarka S, Janning P, Schultz-Fademrecht C, Baumann M, Wittinghofer A, Waldmann H.

Cell Chem Biol. 2017 May 18;24(5):589-597.e5. doi: 10.1016/j.chembiol.2017.03.015. Epub 2017 Apr 20.

30.

Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity.

Förster T, López-Tosco S, Ziegler S, Antonchick AP, Waldmann H.

Chembiochem. 2017 Jun 19;18(12):1098-1108. doi: 10.1002/cbic.201700015. Epub 2017 May 19.

PMID:
28421720
31.

A Bacterial Artificial Chromosome Reporter System for Expression of the Human FOXP3 Gene in Mouse Regulatory T-Cells.

Tsuda M, Tone Y, Ogawa C, Nagaoka Y, Katsumata M, Necula A, Howie D, Masuda E, Waldmann H, Tone M.

Front Immunol. 2017 Mar 13;8:279. doi: 10.3389/fimmu.2017.00279. eCollection 2017.

32.

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.

Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ.

J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21.

33.

The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells.

Besançon A, Baas M, Goncalves T, Valette F, Waldmann H, Chatenoud L, You S.

Front Immunol. 2017 Mar 6;8:218. doi: 10.3389/fimmu.2017.00218. eCollection 2017.

34.

Structure of the RZZ complex and molecular basis of its interaction with Spindly.

Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S, Musacchio A.

J Cell Biol. 2017 Apr 3;216(4):961-981. doi: 10.1083/jcb.201611060. Epub 2017 Mar 20.

35.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T, Bao P, Kastner B, Urlaub H, Waldmann H, Lührmann R.

Elife. 2017 Mar 16;6. pii: e23533. doi: 10.7554/eLife.23533.

36.

Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation.

Martinez NE, Zimmermann TJ, Goosmann C, Alexander T, Hedberg C, Ziegler S, Zychlinsky A, Waldmann H.

Chembiochem. 2017 May 18;18(10):888-893. doi: 10.1002/cbic.201600650. Epub 2017 Mar 31.

PMID:
28240414
37.

Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity.

Wallberg M, Recino A, Phillips J, Howie D, Vienne M, Paluch C, Azuma M, Wong FS, Waldmann H, Cooke A.

Immunology. 2017 Jun;151(2):248-260. doi: 10.1111/imm.12729. Epub 2017 Mar 16. Erratum in: Immunology. 2017 Aug;151(4):481.

38.

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.

Lee YC, Patil S, Golz C, Strohmann C, Ziegler S, Kumar K, Waldmann H.

Nat Commun. 2017 Feb 14;8:14043. doi: 10.1038/ncomms14043.

39.

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

Howie D, Cobbold SP, Adams E, Ten Bokum A, Necula AS, Zhang W, Huang H, Roberts DJ, Thomas B, Hester SS, Vaux DJ, Betz AG, Waldmann H.

JCI Insight. 2017 Feb 9;2(3):e89160. doi: 10.1172/jci.insight.89160.

40.

New Modalities for Challenging Targets in Drug Discovery.

Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H, Grossmann TN, Plowright AT.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10294-10323. doi: 10.1002/anie.201611914. Epub 2017 Jul 24. Review.

PMID:
28186380
41.

Transplantation tolerance: the big picture. Where do we stand, where should we go?

Waldmann H.

Clin Exp Immunol. 2017 Aug;189(2):135-137. doi: 10.1111/cei.12933. Epub 2017 Mar 2.

42.

General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands.

Jia ZJ, Merten C, Gontla R, Daniliuc CG, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2429-2434. doi: 10.1002/anie.201611981. Epub 2017 Jan 26.

PMID:
28124831
43.

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20.

PMID:
28106325
44.

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.

Laraia L, Ohsawa K, Konstantinidis G, Robke L, Wu YW, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2145-2150. doi: 10.1002/anie.201611670. Epub 2017 Jan 18.

PMID:
28097798
45.

Structure-based development of PDEδ inhibitors.

Martín-Gago P, Fansa EK, Wittinghofer A, Waldmann H.

Biol Chem. 2017 May 1;398(5-6):535-545. doi: 10.1515/hsz-2016-0272. Review.

PMID:
27935847
46.

Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors.

Schröder P, Bauer JO, Strohmann C, Kumar K, Waldmann H.

J Org Chem. 2016 Nov 4;81(21):10242-10255. Epub 2016 Jul 15.

PMID:
27352173
47.

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.

Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H.

Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3.

PMID:
27809361
48.

Induction of Immunological Tolerance as a Therapeutic Procedure.

Waldmann H, Howie D, Cobbold S.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0019-2015. Review.

PMID:
27726804
49.

CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment.

Hotta R, Ohira M, Matsuura T, Muraoka I, Tryphonopoulos P, Fan J, Tekin A, Selvaggi G, Levi D, Ruiz P, Ricordi C, Vianna R, Ohdan H, Waldmann H, Tzakis AG, Nishida S.

PLoS One. 2016 Aug 25;11(8):e0161618. doi: 10.1371/journal.pone.0161618. eCollection 2016.

50.

Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.

Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A.

J Biol Chem. 2016 Sep 23;291(39):20766-78. doi: 10.1074/jbc.M116.741827. Epub 2016 Aug 1.

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