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Items: 1 to 50 of 955

1.

Identification of Quinolinols as Activators of TEAD-dependent Transcription.

Pobbati AV, Mejuch T, Chakraborty S, Karatas H, Bharath SR, Guéret SM, Goy PA, Hahne G, Pahl A, Sievers S, Guccione E, Song H, Waldmann H, Hong W.

ACS Chem Biol. 2019 Nov 19. doi: 10.1021/acschembio.9b00786. [Epub ahead of print]

PMID:
31742995
2.

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.

Cromm PM, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN.

Chembiochem. 2019 Nov 3. doi: 10.1002/cbic.201900615. [Epub ahead of print]

PMID:
31680402
3.

Small-Molecule Inhibition of Glucose Transporters GLUT-1-4.

Reckzeh ES, Waldmann H.

Chembiochem. 2019 Sep 25. doi: 10.1002/cbic.201900544. [Epub ahead of print] Review.

PMID:
31553512
4.

Toward the role of cholesterol and cholesterol transfer protein in autophagosome biogenesis.

Wu YW, Waldmann H.

Autophagy. 2019 Dec;15(12):2167-2168. doi: 10.1080/15548627.2019.1666595. Epub 2019 Sep 18.

PMID:
31512558
5.

Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3.

Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales MA, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H.

Angew Chem Int Ed Engl. 2019 Nov 18;58(47):17016-17025. doi: 10.1002/anie.201909518. Epub 2019 Oct 7. Review.

PMID:
31469221
6.

A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

Howie D, Ten Bokum A, Cobbold SP, Yu Z, Kessler BM, Waldmann H.

Front Immunol. 2019 Aug 13;10:1860. doi: 10.3389/fimmu.2019.01860. eCollection 2019.

7.

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H.

Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. doi: 10.1002/anie.201907632. Epub 2019 Oct 4. Review.

PMID:
31454140
8.

Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.

Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M.

ACS Chem Biol. 2019 Sep 20;14(9):1860-1865. doi: 10.1021/acschembio.9b00444. Epub 2019 Aug 26.

PMID:
31436407
9.

Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products.

Christoforow A, Wilke J, Binici A, Pahl A, Ostermann C, Sievers S, Waldmann H.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14715-14723. doi: 10.1002/anie.201907853. Epub 2019 Aug 28. Review.

PMID:
31339620
10.

Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.

Reckzeh ES, Karageorgis G, Schwalfenberg M, Ceballos J, Nowacki J, Stroet MCM, Binici A, Knauer L, Brand S, Choidas A, Strohmann C, Ziegler S, Waldmann H.

Cell Chem Biol. 2019 Sep 19;26(9):1214-1228.e25. doi: 10.1016/j.chembiol.2019.06.005. Epub 2019 Jul 11.

PMID:
31303578
11.

The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery.

Friese A, Ursu A, Hochheimer A, Schöler HR, Waldmann H, Bruder JM.

Cell Chem Biol. 2019 Aug 15;26(8):1050-1066. doi: 10.1016/j.chembiol.2019.05.007. Epub 2019 Jun 20. Review.

PMID:
31231030
12.

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.

Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW, Waldmann H.

Nat Chem Biol. 2019 Jul;15(7):710-720. doi: 10.1038/s41589-019-0307-5. Epub 2019 Jun 20.

PMID:
31222192
13.

Chemical Genetics Reveals a Role of dCTP Pyrophosphatase 1 in Wnt Signaling.

Friese A, Kapoor S, Schneidewind T, Vidadala SR, Sardana J, Brause A, Förster T, Bischoff M, Wagner J, Janning P, Ziegler S, Waldmann H.

Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13009-13013. doi: 10.1002/anie.201905977. Epub 2019 Jul 8.

PMID:
31173446
14.

Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells.

Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens PIH, Waldmann H.

Cell Chem Biol. 2019 Jun 20;26(6):842-851.e7. doi: 10.1016/j.chembiol.2019.02.019. Epub 2019 Apr 4.

PMID:
30956149
15.

Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin.

Kaiser N, Corkery D, Wu Y, Laraia L, Waldmann H.

Bioorg Med Chem. 2019 Jun 15;27(12):2444-2448. doi: 10.1016/j.bmc.2019.02.028. Epub 2019 Feb 16.

PMID:
30795990
16.

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.

Schneidewind T, Kapoor S, Garivet G, Karageorgis G, Narayan R, Vendrell-Navarro G, Antonchick AP, Ziegler S, Waldmann H.

Cell Chem Biol. 2019 Apr 18;26(4):512-523.e5. doi: 10.1016/j.chembiol.2018.11.014. Epub 2019 Jan 24.

PMID:
30686759
17.

Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.

Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schröder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K.

Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066. doi: 10.1002/anie.201810312. Epub 2018 Dec 20.

PMID:
30569600
18.

Human Monoclonal Antibodies: The Benefits of Humanization.

Waldmann H.

Methods Mol Biol. 2019;1904:1-10. doi: 10.1007/978-1-4939-8958-4_1. Review.

PMID:
30539464
19.

Target Engagement of Small Molecules: Thermal Profiling Approaches on Different Levels.

Reckzeh ES, Brockmeyer A, Metz M, Waldmann H, Janning P.

Methods Mol Biol. 2019;1888:73-98. doi: 10.1007/978-1-4939-8891-4_4.

PMID:
30519941
20.

Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.

Li H, Gontla R, Flegel J, Merten C, Ziegler S, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):307-311. doi: 10.1002/anie.201811041. Epub 2018 Dec 4.

PMID:
30511449
21.

Herman Waldmann, FRS, FRCP, FMEDSci: Emeritus Professor of Pathology, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.

Waldmann H.

Transplantation. 2018 Nov;102(11):1785-1786. doi: 10.1097/TP.0000000000002408. No abstract available.

PMID:
30346374
22.

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H.

Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. doi: 10.1016/j.chembiol.2018.05.016. Epub 2018 Jun 28.

23.

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells.

Leung CS, Yang KY, Li X, Chan VW, Ku M, Waldmann H, Hori S, Tsang JCH, Lo YMD, Lui KO.

Genome Med. 2018 Sep 20;10(1):71. doi: 10.1186/s13073-018-0581-y.

24.

C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.

Shan G, Flegel J, Li H, Merten C, Ziegler S, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14250-14254. doi: 10.1002/anie.201809680. Epub 2018 Oct 11.

PMID:
30203905
25.

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3.

Karageorgis G, Reckzeh ES, Ceballos J, Schwalfenberg M, Sievers S, Ostermann C, Pahl A, Ziegler S, Waldmann H.

Nat Chem. 2018 Nov;10(11):1103-1111. doi: 10.1038/s41557-018-0132-6. Epub 2018 Sep 10.

26.

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions.

Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H.

Chembiochem. 2019 Jan 18;20(2):134-139. doi: 10.1002/cbic.201800406. Epub 2018 Oct 17.

PMID:
30129686
27.

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes.

Leung OM, Li J, Li X, Chan VW, Yang KY, Ku M, Ji L, Sun H, Waldmann H, Tian XY, Huang Y, Lau J, Zhou B, Lui KO.

Cell Rep. 2018 Aug 7;24(6):1610-1626. doi: 10.1016/j.celrep.2018.07.019.

28.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.

29.

Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.

Stockenhuber K, Hegazy AN, West NR, Ilott NE, Stockenhuber A, Bullers SJ, Thornton EE, Arnold IC, Tucci A, Waldmann H, Ogg GS, Powrie F.

J Exp Med. 2018 Aug 6;215(8):1987-1998. doi: 10.1084/jem.20172094. Epub 2018 Jul 6.

30.

CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Cobbold SP, Adams E, Howie D, Waldmann H.

Front Immunol. 2018 Jun 18;9:1381. doi: 10.3389/fimmu.2018.01381. eCollection 2018.

31.

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.

Benson RA, Garcon F, Recino A, Ferdinand JR, Clatworthy MR, Waldmann H, Brewer JM, Okkenhaug K, Cooke A, Garside P, Wållberg M.

Front Immunol. 2018 May 18;9:1006. doi: 10.3389/fimmu.2018.01006. eCollection 2018.

32.

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.

Chem Sci. 2018 Feb 26;9(11):3014-3022. doi: 10.1039/c7sc05040b. eCollection 2018 Mar 21.

33.

UNC119A Decreases the Membrane Binding of Myristoylated c-Src.

Erwin N, Dwivedi M, Mejuch T, Waldmann H, Winter R.

Chembiochem. 2018 Apr 27. doi: 10.1002/cbic.201800158. [Epub ahead of print]

PMID:
29700916
34.

Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity.

Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.

J Org Chem. 2018 Jul 6;83(13):7033-7041. doi: 10.1021/acs.joc.7b03202. Epub 2018 Feb 20.

PMID:
29460633
35.

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis.

Jia ZJ, Shan G, Daniliuc CG, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14493-14497. doi: 10.1002/anie.201712882. Epub 2018 Mar 1.

PMID:
29419912
36.

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, Reinhardt L, Abo-Rady M, Glatza M, King SJ, Nussbaumer P, Ziegler S, Klebl B, Schroer TA, Schöler HR, Waldmann H, Sterneckert J.

Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6. doi: 10.1016/j.chembiol.2017.12.014. Epub 2018 Jan 27.

37.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

38.

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival.

Howie D, Ten Bokum A, Necula AS, Cobbold SP, Waldmann H.

Front Immunol. 2018 Jan 12;8:1949. doi: 10.3389/fimmu.2017.01949. eCollection 2017. Review.

39.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D.

Cell Chem Biol. 2018 Mar 15;25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. Epub 2018 Jan 4.

40.

Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Rubaiy HN, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech DJ.

Br J Pharmacol. 2018 Mar;175(5):830-839. doi: 10.1111/bph.14128. Epub 2018 Jan 25.

41.

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells.

Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ.

Sci Rep. 2017 Dec 5;7(1):16988. doi: 10.1038/s41598-017-17303-3.

42.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.

Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.

Bioorg Med Chem. 2018 May 1;26(8):1453-1461. doi: 10.1016/j.bmc.2017.11.009. Epub 2017 Nov 4.

PMID:
29170028
43.

Ligand-Directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems.

Lee YC, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5212-5226. doi: 10.1002/anie.201710247. Epub 2018 Mar 6. Review.

PMID:
29105306
44.

Exploring Natural Product Fragments for Drug and Probe Discovery.

Pahl A, Waldmann H, Kumar K.

Chimia (Aarau). 2017 Oct 25;71(10):653-660. doi: 10.2533/chimia.2017.653.

PMID:
29070410
45.

Identification of novel PDEδ interacting proteins.

Küchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.

Bioorg Med Chem. 2018 May 1;26(8):1426-1434. doi: 10.1016/j.bmc.2017.08.033. Epub 2017 Aug 31.

PMID:
28935183
46.

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HR, Sterneckert J, Ziegler S, Schneider G, Waldmann H.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025. doi: 10.1002/anie.201707394. Epub 2017 Sep 18.

PMID:
28833911
47.

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.

Xu H, Laraia L, Schneider L, Louven K, Strohmann C, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11232-11236. doi: 10.1002/anie.201706005. Epub 2017 Jul 28.

PMID:
28696533
48.

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.

Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S, Waldmann H.

Chembiochem. 2017 Sep 19;18(18):1797-1806. doi: 10.1002/cbic.201700260. Epub 2017 Jul 31.

PMID:
28678390
49.

Lateral Organization of Host Heterogeneous Raft-like Membranes Altered by the Myristoyl Modification of Tyrosine Kinase c-Src.

Dwivedi M, Mejuch T, Waldmann H, Winter R.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10511-10515. doi: 10.1002/anie.201706233. Epub 2017 Jul 24.

PMID:
28657213
50.

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification.

Laraia L, Waldmann H.

Drug Discov Today Technol. 2017 Mar;23:75-82. doi: 10.1016/j.ddtec.2017.03.003. Epub 2017 Apr 14. Review.

PMID:
28647090

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