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APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis.

Blomain ES, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA.

Cancer Biol Ther. 2020 Feb 9:1-11. doi: 10.1080/15384047.2020.1721262. [Epub ahead of print]


Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.

Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA.

Brain Struct Funct. 2019 Nov;224(8):2983-2999. doi: 10.1007/s00429-019-01949-y. Epub 2019 Sep 4.


Biomarker targeting of colorectal cancer stem cells.

Caparosa EM, Stem J, Snook AE, Waldman SA.

Biomark Med. 2019 Aug;13(11):891-894. doi: 10.2217/bmm-2019-0227. Epub 2019 Aug 6. No abstract available.


Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation.

Waldman SA, Tenenbaum R, Foehl HC, Winkle P, Griffin P.

Clin Transl Gastroenterol. 2019 Jul;10(7):e00016. doi: 10.14309/ctg.0000000000000016.


Therapeutic targeting of gastrointestinal cancer stem cells.

Stem J, Flickinger JC Jr, Merlino D, Caparosa EM, Snook AE, Waldman SA.

Regen Med. 2019 May;14(4):331-343. doi: 10.2217/rme-2018-0146. Epub 2019 Apr 26.


Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.

Snook AE, Baybutt TR, Xiang B, Abraham TS, Flickinger JC Jr, Hyslop T, Zhan T, Kraft WK, Sato T, Waldman SA.

J Immunother Cancer. 2019 Apr 23;7(1):104. doi: 10.1186/s40425-019-0576-2.


Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA.

Hum Pathol. 2019 May;87:103-114. doi: 10.1016/j.humpath.2018.11.032. Epub 2019 Feb 2.


TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.

Abraham TS, Flickinger JC Jr, Waldman SA, Snook AE.

J Immunol. 2019 Feb 15;202(4):1301-1310. doi: 10.4049/jimmunol.1801206. Epub 2019 Jan 14.


Health Care Evolves From Reactive to Proactive.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2019 Jan;105(1):10-13. doi: 10.1002/cpt.1295. No abstract available.


Pain and Addiction in Specialty and Primary Care: The Bookends of a Crisis.

Schottenfeld JR, Waldman SA, Gluck AR, Tobin DG.

J Law Med Ethics. 2018 Jun;46(2):220-237. doi: 10.1177/1073110518782923.


Treatment Innovation in Orthopedic Surgery: A Case Study from Hospital for Special Surgery.

Waldman SA, Schottenfeld JR, Gluck AR.

J Law Med Ethics. 2018 Jun;46(2):238-240. doi: 10.1177/1073110518782924.


The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia.

Rappaport JA, Waldman SA.

Front Oncol. 2018 Aug 6;8:299. doi: 10.3389/fonc.2018.00299. eCollection 2018. Review.


Prenatal Regeneration in Clinical Practice.

Waldman SA.

Mayo Clin Proc. 2018 Jun;93(6):673-675. doi: 10.1016/j.mayocp.2018.04.004. Epub 2018 May 23. No abstract available.


Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.

Magee MS, Abraham TS, Baybutt TR, Flickinger JC Jr, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE.

Cancer Immunol Res. 2018 May;6(5):509-516. doi: 10.1158/2326-6066.CIR-16-0362. Epub 2018 Apr 3.


Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders.

Waldman SA, Camilleri M.

Gut. 2018 Aug;67(8):1543-1552. doi: 10.1136/gutjnl-2018-316029. Epub 2018 Mar 21. Review.


Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice.

Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E676-E693. doi: 10.1152/ajpendo.00224.2017. Epub 2018 Mar 6.


First-in-Human Use of a Retention-Enhanced Catheter for Endomyocardial Cell Delivery.

Sherman W, Bartunek J, Dolatabadi D, Sanz-Ruiz R, Beleslin B, Wojakowski W, Heyndrickx G, Kimpalou JZ, Waldman SA, Laarman GJ, Seron A, Behfar A, Latere JP, Terzic A, Wijns W; CHART Program.

JACC Cardiovasc Interv. 2018 Feb 26;11(4):412-414. doi: 10.1016/j.jcin.2017.10.036. No abstract available.


Process Improvement for Maximized Therapeutic Innovation Outcome.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2018 Jan;103(1):8-12. doi: 10.1002/cpt.929.


GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress.

Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA.

Oncotarget. 2017 Oct 26;8(61):102923-102933. doi: 10.18632/oncotarget.22084. eCollection 2017 Nov 28.


An Evidence-Based Approach to the Prescription Opioid Epidemic in Orthopedic Surgery.

Soffin EM, Waldman SA, Stack RJ, Liguori GA.

Anesth Analg. 2017 Nov;125(5):1704-1713. doi: 10.1213/ANE.0000000000002433. Review.


GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.

Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA.

Cancer Res. 2017 Sep 15;77(18):5095-5106. doi: 10.1158/0008-5472.CAN-17-0859.


Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.

Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey JA, Basu-Mallick A, Jiang BH, Hou L, Shu J, Sun Y, Xing J, Li B, Yang H.

Ann Oncol. 2017 Sep 1;28(9):2135-2141. doi: 10.1093/annonc/mdx278.


ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice.

Li P, Lin JE, Snook AE, Waldman SA.

Toxins (Basel). 2017 Sep 12;9(9). pii: E279. doi: 10.3390/toxins9090279.


Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2017 Sep;102(3):373-377. doi: 10.1002/cpt.763.


Modeling qRT-PCR dynamics with application to cancer biomarker quantification.

Chervoneva I, Freydin B, Hyslop T, Waldman SA.

Stat Methods Med Res. 2018 Sep;27(9):2581-2595. doi: 10.1177/0962280216683204. Epub 2017 May 14.


Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention.

Weinberg DS, Lin JE, Foster NR, Della'Zanna G, Umar A, Seisler D, Kraft WK, Kastenberg DM, Katz LC, Limburg PJ, Waldman SA.

Cancer Prev Res (Phila). 2017 Jun;10(6):345-354. doi: 10.1158/1940-6207.CAPR-16-0286. Epub 2017 Apr 10.


Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells.

Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE.

J Immunol. 2017 May 1;198(9):3507-3514. doi: 10.4049/jimmunol.1502672. Epub 2017 Mar 24.


Clinical Pharmacology & Therapeutics: Past, Present, and Future.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2017 Mar;101(3):300-303. doi: 10.1002/cpt.592.


Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.

Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA.

Expert Rev Clin Pharmacol. 2017 May;10(5):549-557. doi: 10.1080/17512433.2017.1292124. Epub 2017 Apr 10. Review.


Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial.

Bartunek J, Terzic A, Davison BA, Filippatos GS, Radovanovic S, Beleslin B, Merkely B, Musialek P, Wojakowski W, Andreka P, Horvath IG, Katz A, Dolatabadi D, El Nakadi B, Arandjelovic A, Edes I, Seferovic PM, Obradovic S, Vanderheyden M, Jagic N, Petrov I, Atar S, Halabi M, Gelev VL, Shochat MK, Kasprzak JD, Sanz-Ruiz R, Heyndrickx GR, Nyolczas N, Legrand V, Guédès A, Heyse A, Moccetti T, Fernandez-Aviles F, Jimenez-Quevedo P, Bayes-Genis A, Hernandez-Garcia JM, Ribichini F, Gruchala M, Waldman SA, Teerlink JR, Gersh BJ, Povsic TJ, Henry TD, Metra M, Hajjar RJ, Tendera M, Behfar A, Alexandre B, Seron A, Stough WG, Sherman W, Cotter G, Wijns W; CHART Program.

Eur Heart J. 2017 Mar 1;38(9):648-660. doi: 10.1093/eurheartj/ehw543.


Managing Innovation to Maximize Value Along the Discovery-Translation-Application Continuum.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2017 Jan;101(1):8-12. doi: 10.1002/cpt.551. Epub 2016 Nov 21.


GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.

Magee MS, Kraft CL, Abraham TS, Baybutt TR, Marszalowicz GP, Li P, Waldman SA, Snook AE.

Oncoimmunology. 2016 Sep 2;5(10):e1227897. eCollection 2016.


Editorial (Thematic Issue: Ferid Murad, at 80: A Legacy of Science, Medicine, and Mentorship).

Atta-Ur-Rahman, Waldman SA.

Curr Med Chem. 2016;23(24):2556-2558. No abstract available.


Guanylyl cyclase C signaling axis and colon cancer prevention.

Pattison AM, Merlino DJ, Blomain ES, Waldman SA.

World J Gastroenterol. 2016 Sep 28;22(36):8070-7. doi: 10.3748/wjg.v22.i36.8070. Review.


Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus.

Cantarin MP, Keith SW, Lin Z, Doria C, Frank AM, Maley WR, Ramirez C, Lallas CD, Shah A, Waldman SA, Falkner B.

Cardiorenal Med. 2016 Aug;6(4):289-300. doi: 10.1159/000446294. Epub 2016 May 18.


Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA.

Infect Immun. 2016 Sep 19;84(10):3083-91. doi: 10.1128/IAI.00639-16. Print 2016 Oct.


Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.

Blomain ES, Merlino DJ, Pattison AM, Snook AE, Waldman SA.

Mol Pharmacol. 2016 Sep;90(3):199-204. doi: 10.1124/mol.115.103192. Epub 2016 Jun 1. Review.


Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity.

Kim GW, Lin JE, Snook AE, Aing AS, Merlino DJ, Li P, Waldman SA.

Nutr Diabetes. 2016 May 23;6:e211. doi: 10.1038/nutd.2016.18.


GUCY2C ligand replacement to prevent colorectal cancer.

Blomain ES, Pattison AM, Waldman SA.

Cancer Biol Ther. 2016 Jul 2;17(7):713-8. doi: 10.1080/15384047.2016.1178429. Epub 2016 Apr 22. Review.


The incidence and risk factors for post-operative ileus after spinal fusion surgery: a multivariate analysis.

Kiely PD, Mount LE, Du JY, Nguyen JT, Weitzman G, Memstoudis S, Waldman SA, Lebl DR.

Int Orthop. 2016 Jun;40(6):1067-74. doi: 10.1007/s00264-016-3148-9. Epub 2016 Mar 10.


Does obesity promote the development of colorectal cancer?

Blomain ES, Waldman SA.

Expert Rev Anticancer Ther. 2016 May;16(5):465-7. doi: 10.1586/14737140.2016.1162102. Epub 2016 Mar 24. No abstract available.


Big Data Transforms Discovery-Utilization Therapeutics Continuum.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2016 Mar;99(3):250-4. doi: 10.1002/cpt.322.


Bioinnovation Enterprise: An engine driving breakthrough therapies.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2016 Jan;99(1):8-13. doi: 10.1002/cpt.272.


Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA.

Cancer Res. 2016 Jan 15;76(2):339-46. doi: 10.1158/0008-5472.CAN-15-1467-T.


CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia.

Krishnan V, Xu X, Kelly D, Snook A, Waldman SA, Mason RW, Jia X, Rajasekaran AK.

Mol Pharm. 2015 Jun 1;12(6):2101-11. doi: 10.1021/acs.molpharmaceut.5b00071. Epub 2015 May 4.


Clinical Pharmacology & Therapeutics: the next five years.

Waldman SA, Terzic A.

Clin Pharmacol Ther. 2015 Jan;97(1):2-6. doi: 10.1002/cpt.22. Epub 2014 Dec 5.


Companion diagnostics at the intersection of personalized medicine and healthcare delivery.

Waldman SA, Terzic A.

Biomark Med. 2015;9(1):1-3. doi: 10.2217/bmm.14.99. No abstract available.


Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation.

Rodriguez E, Sakowski L, Hobson GM, Armani MH, Kreiger PA, Zhu Y, Waldman SA, Shaffer TH.

Pulm Pharmacol Ther. 2015 Feb;30:22-31. doi: 10.1016/j.pupt.2014.10.004. Epub 2014 Nov 4.

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