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Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.

Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M.

Immunity. 2019 Sep 17;51(3):508-521.e6. doi: 10.1016/j.immuni.2019.05.021. Epub 2019 Aug 27.


Different Synchrony in Rhythmic Movement Caused by Morphological Difference between Five- and Six-armed Brittle Stars.

Wakita D, Hayase Y, Aonuma H.

Sci Rep. 2019 Jun 5;9(1):8298. doi: 10.1038/s41598-019-44808-w.


Cisplatin Augments Antitumor T-Cell Responses Leading to a Potent Therapeutic Effect in Combination With PD-L1 Blockade.

Wakita D, Iwai T, Harada S, Suzuki M, Yamamoto K, Sugimoto M.

Anticancer Res. 2019 Apr;39(4):1749-1760. doi: 10.21873/anticanres.13281.


Sea stars of the genus Henricia Gray, 1840 (Echinodermata, Asteroidea) from Vostok Bay, Sea of Japan.

Chichvarkhin A, Chichvarkhina O, Wakita D.

PeerJ. 2019 Mar 21;7:e6585. doi: 10.7717/peerj.6585. eCollection 2019.


T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.

Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M.

Immunity. 2018 Nov 20;49(5):873-885.e7. doi: 10.1016/j.immuni.2018.08.022. Epub 2018 Oct 23.


Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies.

Iwai T, Sugimoto M, Wakita D, Yorozu K, Kurasawa M, Yamamoto K.

Oncotarget. 2018 Jul 31;9(59):31411-31421. doi: 10.18632/oncotarget.25830. eCollection 2018 Jul 31.


Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.

Domiciano TP, Wakita D, Jones HD, Crother TR, Verri WA Jr, Arditi M, Shimada K.

Sci Rep. 2017 Feb 2;7:41539. doi: 10.1038/srep41539.


CD8+ T Cells Contribute to the Development of Coronary Arteritis in the Lactobacillus casei Cell Wall Extract-Induced Murine Model of Kawasaki Disease.

Noval Rivas M, Lee Y, Wakita D, Chiba N, Dagvadorj J, Shimada K, Chen S, Fishbein MC, Lehman TJ, Crother TR, Arditi M.

Arthritis Rheumatol. 2017 Feb;69(2):410-421. doi: 10.1002/art.39939.


Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.

Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):886-97. doi: 10.1161/ATVBAHA.115.307072. Epub 2016 Mar 3.


IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.

Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2605-16. doi: 10.1161/ATVBAHA.115.306475. Epub 2015 Oct 29.


Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy.

Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T.

Immunol Lett. 2015 Jan;163(1):102-12. doi: 10.1016/j.imlet.2014.11.016. Epub 2014 Dec 3.


The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice.

Narita Y, Kitamura H, Wakita D, Sumida K, Masuko K, Terada S, Nakano K, Nishimura T.

J Immunol. 2013 Jan 15;190(2):812-20. doi: 10.4049/jimmunol.1103797. Epub 2012 Dec 17.


Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner.

Koizumi S, Masuko K, Wakita D, Tanaka S, Mitamura R, Kato Y, Tabata H, Nakahara M, Kitamura H, Nishimura T.

Cell Immunol. 2012 Mar-Apr;276(1-2):153-61. doi: 10.1016/j.cellimm.2012.05.002. Epub 2012 May 17.


The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.

Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T.

Eur J Immunol. 2012 Sep;42(9):2329-42. doi: 10.1002/eji.201142240. Epub 2012 Jul 4.


Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses.

Sumida K, Wakita D, Narita Y, Masuko K, Terada S, Watanabe K, Satoh T, Kitamura H, Nishimura T.

Eur J Immunol. 2012 Aug;42(8):2060-72. doi: 10.1002/eji.201142335.


Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells.

Yoshida T, Katsuya K, Oka T, Koizumi S, Wakita D, Kitamura H, Nishimura T.

Biomed Res. 2012 Apr;33(2):67-74.


Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.

Kitamura H, Kobayashi M, Wakita D, Nishimura T.

J Immunol. 2012 May 1;188(9):4200-8. doi: 10.4049/jimmunol.1102521. Epub 2012 Apr 2.


First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer-hybrid epitope long peptide of MAGE-A4 cancer antigen.

Takahashi N, Ohkuri T, Homma S, Ohtake J, Wakita D, Togashi Y, Kitamura H, Todo S, Nishimura T.

Cancer Sci. 2012 Jan;103(1):150-3. doi: 10.1111/j.1349-7006.2011.02106.x.


IFN-γ elevates airway hyper-responsiveness via up-regulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model.

Kobayashi M, Ashino S, Shiohama Y, Wakita D, Kitamura H, Nishimura T.

Eur J Immunol. 2012 Feb;42(2):393-402. doi: 10.1002/eji.201141845. Epub 2011 Dec 27.


IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.

Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.

Int Immunol. 2011 Dec;23(12):751-9. doi: 10.1093/intimm/dxr086. Epub 2011 Oct 29.


Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen.

Noguchi D, Wakita D, Ohkuri T, Tajima M, Chamoto K, Kitamura H, Nishimura T.

Immunol Lett. 2011 May;136(2):146-55. doi: 10.1016/j.imlet.2011.01.004. Epub 2011 Jan 20.


Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture conditions.

Takahashi D, Azuma H, Sakai H, Sou K, Wakita D, Abe H, Fujihara M, Horinouchi H, Nishimura T, Kobayashi K, Ikeda H.

J Pharmacol Exp Ther. 2011 Apr;337(1):42-9. doi: 10.1124/jpet.110.172510. Epub 2011 Jan 6.


Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.

Tanaka S, Koizumi S, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T.

Int Immunopharmacol. 2011 Feb;11(2):226-32. doi: 10.1016/j.intimp.2010.11.026. Epub 2010 Dec 7.


The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γ by DC or NK1.1(+) cells in a TLR4- and TLR2-dependent manner.

Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T.

Cell Immunol. 2011;266(2):135-42. doi: 10.1016/j.cellimm.2010.09.009. Epub 2010 Oct 1.


1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells.

Ikeda U, Wakita D, Ohkuri T, Chamoto K, Kitamura H, Iwakura Y, Nishimura T.

Immunol Lett. 2010 Nov 30;134(1):7-16. doi: 10.1016/j.imlet.2010.07.002. Epub 2010 Jul 23.


A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness.

Ashino S, Wakita D, Shiohama Y, Iwakura Y, Chamoto K, Ohkuri T, Kitamura H, Nishimura T.

Int Immunol. 2010 Jun;22(6):503-13. doi: 10.1093/intimm/dxq034. Epub 2010 May 25.


Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis.

Wakita D, Sumida K, Iwakura Y, Nishikawa H, Ohkuri T, Chamoto K, Kitamura H, Nishimura T.

Eur J Immunol. 2010 Jul;40(7):1927-37. doi: 10.1002/eji.200940157.


Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: its potentiation by combination with Th1 cell therapy.

Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.

Cancer Res. 2010 Apr 1;70(7):2697-706. doi: 10.1158/0008-5472.CAN-09-2982. Epub 2010 Mar 9.


3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.

Chamoto K, Wakita D, Ohkuri T, Uchinami Y, Matsushima K, Kitamura H, Nishimura T.

Cancer Sci. 2010 Apr;101(4):855-61. doi: 10.1111/j.1349-7006.2009.01469.x. Epub 2009 Dec 11.


IFN-gamma-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model.

Wakita D, Chamoto K, Ohkuri T, Narita Y, Ashino S, Sumida K, Nishikawa H, Shiku H, Togashi Y, Kitamura H, Nishimura T.

Carcinogenesis. 2009 Aug;30(8):1408-15. doi: 10.1093/carcin/bgp144. Epub 2009 Jun 9.


Identification of novel helper epitopes of MAGE-A4 tumour antigen: useful tool for the propagation of Th1 cells.

Ohkuri T, Wakita D, Chamoto K, Togashi Y, Kitamura H, Nishimura T.

Br J Cancer. 2009 Apr 7;100(7):1135-43. doi: 10.1038/sj.bjc.6604966. Epub 2009 Mar 10.


Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells.

Chamoto K, Takeshima T, Wakita D, Ohkuri T, Ashino S, Omatsu T, Shirato H, Kitamura H, Togashi Y, Nishimura T.

Cancer Sci. 2009 May;100(5):934-9. doi: 10.1111/j.1349-7006.2009.01114.x. Epub 2009 Feb 24.


Essential role of Toll-like receptors for dendritic cell and NK1.1(+) cell-dependent activation of type 1 immunity by Lactobacillus pentosus strain S-PT84.

Koizumi S, Wakita D, Sato T, Mitamura R, Izumo T, Shibata H, Kiso Y, Chamoto K, Togashi Y, Kitamura H, Nishimura T.

Immunol Lett. 2008 Oct 30;120(1-2):14-9. doi: 10.1016/j.imlet.2008.06.003. Epub 2008 Jul 11. Erratum in: Immunol Lett.2008 Dec 22;121(2):173-4.


Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets.

Zhang Y, Ohkuri T, Wakita D, Narita Y, Chamoto K, Kitamura H, Nishimura T.

J Leukoc Biol. 2008 Sep;84(3):730-5. doi: 10.1189/jlb.0907599. Epub 2008 Jun 3.


IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.

Tajima M, Wakita D, Noguchi D, Chamoto K, Yue Z, Fugo K, Ishigame H, Iwakura Y, Kitamura H, Nishimura T.

J Exp Med. 2008 May 12;205(5):1019-27. doi: 10.1084/jem.20071133. Epub 2008 Apr 21.


CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung.

Ashino S, Wakita D, Zhang Y, Chamoto K, Kitamura H, Nishimura T.

Int Immunol. 2008 Feb;20(2):259-66. Epub 2007 Dec 21.


Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner.

Noguchi D, Wakita D, Tajima M, Ashino S, Iwakura Y, Zhang Y, Chamoto K, Kitamura H, Nishimura T.

Int Immunol. 2007 Dec;19(12):1431-40. Epub 2007 Nov 1.


Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma.

Yokouchi H, Chamoto K, Wakita D, Yamazaki K, Shirato H, Takeshima T, Dosaka-Akita H, Nishimura M, Yue Z, Kitamura H, Nishimura T.

Clin Exp Metastasis. 2007;24(7):533-40. Epub 2007 Jul 25.


Isolation and characterization of a lipid-degrading bacterium and its application to lipid-containing wastewater treatment.

Matsumiya Y, Wakita D, Kimura A, Sanpa S, Kubo M.

J Biosci Bioeng. 2007 Apr;103(4):325-30.


Natural killer T cells from interleukin-4-deficient mice are defective in early interferon-gamma production in response to alpha-galactosylceramide.

Togashi Y, Chamoto K, Wakita D, Tsutsumi N, Iwakura Y, Matsubara N, Kitamura H, Nishimura T.

Cancer Sci. 2007 May;98(5):721-5. Epub 2007 Mar 14.


AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-gamma-dependent type 1 immunity.

Kosaka A, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T.

Int Immunol. 2007 Mar;19(3):249-56. Epub 2007 Jan 17.


Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs.

Zhang Y, Wakita D, Chamoto K, Narita Y, Matsubara N, Kitamura H, Nishimura T.

Int Immunol. 2007 Feb;19(2):151-61. Epub 2006 Dec 22.


Interleukin-12-responding asialoGM1+CD8+ central memory-type T cells as precursor cells for interferon-gamma-producing killer T cells.

Kosaka A, Lee U, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T.

Cancer Sci. 2006 Nov;97(11):1236-41. Epub 2006 Sep 5. Erratum in: Cancer Sci. 2007 Mar;98(3):464.


Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.

Yoshida N, Abe H, Ohkuri T, Wakita D, Sato M, Noguchi D, Miyamoto M, Morikawa T, Kondo S, Ikeda H, Nishimura T.

Int J Oncol. 2006 May;28(5):1089-98.


An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy.

Chamoto K, Wakita D, Narita Y, Zhang Y, Noguchi D, Ohnishi H, Iguchi T, Sakai T, Ikeda H, Nishimura T.

Cancer Res. 2006 Feb 1;66(3):1809-17.


Tetramer-blocking assay for defining antigen-specific cytotoxic T lymphocytes using peptide-MHC tetramer.

Yokouchi H, Chamoto K, Wakita D, Noguchi D, Yamazaki K, Dosaka-Akita H, Nishimura M, Ikeda H, Nishimura T.

Cancer Sci. 2006 Feb;97(2):148-54.


An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen.

Wakita D, Chamoto K, Zhang Y, Narita Y, Noguchi D, Ohnishi H, Iguchi T, Sakai T, Ikeda H, Nishimura T.

Int Immunol. 2006 Mar;18(3):425-34. Epub 2006 Jan 13.


[Regulation of antitumor immunity by controlling immune balance].

Wakita D, Nishimura T.

Nihon Rinsho. 2005 Apr;63 Suppl 4:555-61. Review. Japanese. No abstract available.


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