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Items: 1 to 50 of 163

1.

Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.

Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M.

Biochem J. 2012 Dec 15;448(3):409-16. doi: 10.1042/BJ20121158.

PMID:
23067267
2.

Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ.

J Biol Chem. 2012 Apr 6;287(15):12578-88. doi: 10.1074/jbc.M111.309559. Epub 2012 Feb 23.

3.

Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid.

Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. doi: 10.1073/pnas.1112334108. Epub 2011 Sep 9.

4.

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.

Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M.

J Med Chem. 2011 Jul 14;54(13):4923-7. doi: 10.1021/jm200304y. Epub 2011 Jun 8.

5.

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6. doi: 10.1073/pnas.0909731106. Epub 2009 Oct 22.

6.

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues.

Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17576-81. doi: 10.1073/pnas.0909055106. Epub 2009 Sep 24.

7.

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M.

Chem Biol. 2009 Aug 28;16(8):882-92. doi: 10.1016/j.chembiol.2009.07.007.

8.

Fatty acid metabolism: target for metabolic syndrome.

Wakil SJ, Abu-Elheiga LA.

J Lipid Res. 2009 Apr;50 Suppl:S138-43. doi: 10.1194/jlr.R800079-JLR200. Epub 2008 Dec 1. Review.

9.

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.

Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H256-65. doi: 10.1152/ajpheart.91489.2007. Epub 2008 May 16.

10.

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.

11.

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis.

Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8552-7. Epub 2006 May 22.

12.

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.

Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12011-6. Epub 2005 Aug 15.

13.

Structure and function of animal fatty acid synthase.

Chirala SS, Wakil SJ.

Lipids. 2004 Nov;39(11):1045-53. Review.

PMID:
15726818
14.

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice.

Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1384-9. Epub 2005 Jan 26.

15.

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.

Chakravarty B, Gu Z, Chirala SS, Wakil SJ, Quiocho FA.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15567-72. Epub 2004 Oct 26.

16.

David Ezra Green.

Beinert H, Stumpf PK, Wakil SJ.

Biogr Mem Natl Acad Sci. 2004;84:112-44. No abstract available.

PMID:
15484418
17.

Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis.

Brink J, Ludtke SJ, Kong Y, Wakil SJ, Ma J, Chiu W.

Structure. 2004 Feb;12(2):185-91.

18.

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

Abu-Elheiga L, Oh W, Kordari P, Wakil SJ.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10207-12. Epub 2003 Aug 14.

19.

Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region.

Mao J, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7515-20. Epub 2003 Jun 16.

20.

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero.

Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6358-63. Epub 2003 May 8.

21.

A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle.

Al-Feel W, DeMar JC, Wakil SJ.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3095-100. Epub 2003 Mar 7.

22.

Domain movements in human fatty acid synthase by quantized elastic deformational model.

Ming D, Kong Y, Wakil SJ, Brink J, Ma J.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7895-9.

23.

Quaternary structure of human fatty acid synthase by electron cryomicroscopy.

Brink J, Ludtke SJ, Yang CY, Gu ZW, Wakil SJ, Chiu W.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):138-43. Epub 2001 Dec 26.

24.

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.

Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ.

Science. 2001 Mar 30;291(5513):2613-6.

25.

Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer.

Chirala SS, Jayakumar A, Gu ZW, Wakil SJ.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3104-8.

26.

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.

Xiong S, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3948-53.

27.

The subcellular localization of acetyl-CoA carboxylase 2.

Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1444-9.

28.

Identification of thyroid hormone response elements in the human fatty acid synthase promoter.

Xiong S, Chirala SS, Hsu MH, Wakil SJ.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12260-5.

29.
30.

Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities.

Chirala SS, Huang WY, Jayakumar A, Sakai K, Wakil SJ.

Proc Natl Acad Sci U S A. 1997 May 27;94(11):5588-93.

31.

Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ.

J Biol Chem. 1997 Apr 18;272(16):10669-77.

32.

Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli.

Jayakumar A, Huang WY, Raetz B, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14509-14.

33.
34.

Human fatty acid synthase: properties and molecular cloning.

Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8695-9.

35.

Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.

Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):4011-5.

36.

Amino-terminal blocking group and sequence of the animal fatty acid synthase.

Huang WY, Chirala SS, Wakil SJ.

Arch Biochem Biophys. 1994 Oct;314(1):45-9.

PMID:
7944406
37.

Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene.

Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ.

Genomics. 1994 Sep 15;23(2):420-4.

PMID:
7835891
38.

Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.

Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ.

J Biol Chem. 1994 Mar 4;269(9):6859-65.

40.
41.

Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase.

Al-Feel W, Chirala SS, Wakil SJ.

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4534-8.

42.
43.
44.

Acute hormonal control of acetyl-CoA carboxylase. The roles of insulin, glucagon, and epinephrine.

Mabrouk GM, Helmy IM, Thampy KG, Wakil SJ.

J Biol Chem. 1990 Apr 15;265(11):6330-8.

45.
46.

Fatty acid synthase, a proficient multifunctional enzyme.

Wakil SJ.

Biochemistry. 1989 May 30;28(11):4523-30. Review. No abstract available.

PMID:
2669958
47.

Complete amino acid sequence of chicken liver acyl carrier protein derived from the fatty acid synthase.

Huang WY, Stoops JK, Wakil SJ.

Arch Biochem Biophys. 1989 Apr;270(1):92-8.

PMID:
2648999
48.

A novel cDNA extension procedure. Isolation of chicken fatty acid synthase cDNA clones.

Chirala SS, Kasturi R, Pazirandeh M, Stolow DT, Huang WY, Wakil SJ.

J Biol Chem. 1989 Mar 5;264(7):3750-7.

49.
50.

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