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Items: 1 to 50 of 219

1.

LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training.

O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S.

Sci Signal. 2019 Jan 8;12(563). pii: eaaw2964. doi: 10.1126/scisignal.aaw2964. Review.

PMID:
30622195
2.

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans.

Witting M, Hastings J, Rodriguez N, Joshi CJ, Hattwell JPN, Ebert PR, van Weeghel M, Gao AW, Wakelam MJO, Houtkooper RH, Mains A, Le Novère N, Sadykoff S, Schroeder F, Lewis NE, Schirra HJ, Kaleta C, Casanueva O.

Front Mol Biosci. 2018 Nov 14;5:96. doi: 10.3389/fmolb.2018.00096. eCollection 2018.

3.

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.

Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL.

Mol Cancer Ther. 2019 Feb;18(2):376-388. doi: 10.1158/1535-7163.MCT-17-0857. Epub 2018 Nov 26.

PMID:
30478149
4.

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies.

Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, van Schelt S, Petrache AL, Wang H, Guardia Y, Bar-Nun S, Tyler E, Wakelam MJ, Gems D.

Curr Biol. 2018 Oct 22;28(20):3352. doi: 10.1016/j.cub.2018.10.003. No abstract available.

5.

CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways.

Sadej R, Lu X, Turczyk L, Novitskaya V, Lopez-Clavijo AF, Kordek R, Potemski P, Wakelam MJO, Romanska-Knight H, Berditchevski F.

J Cell Sci. 2018 Oct 29;131(21). pii: jcs220640. doi: 10.1242/jcs.220640.

PMID:
30257985
6.

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR.

J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163. Epub 2018 Aug 16.

7.

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies.

Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, van Schelt S, Petrache AL, Wang H, de la Guardia Y, Bar-Nun S, Tyler E, Wakelam MJ, Gems D.

Curr Biol. 2018 Aug 20;28(16):2544-2556.e5. doi: 10.1016/j.cub.2018.06.035. Epub 2018 Aug 9. Erratum in: Curr Biol. 2018 Oct 22;28(20):3352.

8.

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.

Nguyen A, Guedán A, Mousnier A, Swieboda D, Zhang Q, Horkai D, Le Novere N, Solari R, Wakelam MJO.

J Lipid Res. 2018 Sep;59(9):1671-1684. doi: 10.1194/jlr.M085910. Epub 2018 Jun 26.

PMID:
29946055
9.

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.

Riento K, Zhang Q, Clark J, Begum F, Stephens E, Wakelam MJ, Nichols BJ.

PLoS One. 2018 May 22;13(5):e0197401. doi: 10.1371/journal.pone.0197401. eCollection 2018.

10.

Extracellular vesicles: lipids as key components of their biogenesis and functions.

Record M, Silvente-Poirot S, Poirot M, Wakelam MJO.

J Lipid Res. 2018 Aug;59(8):1316-1324. doi: 10.1194/jlr.E086173. Epub 2018 May 15.

PMID:
29764923
11.

Phospholipid signaling in innate immune cells.

O'Donnell VB, Rossjohn J, Wakelam MJ.

J Clin Invest. 2018 Jul 2;128(7):2670-2679. doi: 10.1172/JCI97944. Epub 2018 Apr 23. Review.

12.

Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q, Wakelam MJO, Haemmerle G, Spener F, Köfeler HC, Thallinger GG.

Nat Methods. 2017 Dec;14(12):1171-1174. doi: 10.1038/nmeth.4470. Epub 2017 Oct 23.

13.

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L.

Genome Biol. 2017 Mar 28;18(1):56. doi: 10.1186/s13059-017-1187-1.

14.

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

Farquhar MJ, Humphreys IS, Rudge SA, Wilson GK, Bhattacharya B, Ciaccia M, Hu K, Zhang Q, Mailly L, Reynolds GM, Ashcroft M, Balfe P, Baumert TF, Roessler S, Wakelam MJO, McKeating JA.

J Hepatol. 2017 May;66(5):919-929. doi: 10.1016/j.jhep.2017.01.009. Epub 2017 Jan 23.

PMID:
28126468
15.

Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.

Kilbey A, Terry A, Wotton S, Borland G, Zhang Q, Mackay N, McDonald A, Bell M, Wakelam MJ, Cameron ER, Neil JC.

J Cell Biochem. 2017 Jun;118(6):1432-1441. doi: 10.1002/jcb.25802. Epub 2017 Jan 10.

16.

Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.

Thakur R, Panda A, Coessens E, Raj N, Yadav S, Balakrishnan S, Zhang Q, Georgiev P, Basak B, Pasricha R, Wakelam MJ, Ktistakis NT, Raghu P.

Elife. 2016 Nov 16;5. pii: e18515. doi: 10.7554/eLife.18515.

17.

Using lipidomics analysis to determine signalling and metabolic changes in cells.

Nguyen A, Rudge SA, Zhang Q, Wakelam MJ.

Curr Opin Biotechnol. 2017 Feb;43:96-103. doi: 10.1016/j.copbio.2016.10.003. Epub 2016 Nov 4. Review.

PMID:
27816901
18.

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.

Vermeren MM, Zhang Q, Smethurst E, Segonds-Pichon A, Schrewe H, Wakelam MJ.

PLoS One. 2016 Sep 22;11(9):e0162814. doi: 10.1371/journal.pone.0162814. eCollection 2016.

19.

Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells.

Jethwa SA, Leah EJ, Zhang Q, Bright NA, Oxley D, Bootman MD, Rudge SA, Wakelam MJ.

J Cell Sci. 2016 Oct 15;129(20):3948-3957. Epub 2016 Aug 24.

20.

C13orf31 (FAMIN) is a central regulator of immunometabolic function.

Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D'Amato M, Bradley A, Wakelam MJ, Dougan G, Kaser A.

Nat Immunol. 2016 Sep;17(9):1046-56. doi: 10.1038/ni.3532. Epub 2016 Aug 1.

21.

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E, Schulze A.

Cancer Metab. 2016 Apr 1;4:6. doi: 10.1186/s40170-016-0146-8. eCollection 2016.

22.

Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans.

Morales-Rios E, Watt IN, Zhang Q, Ding S, Fearnley IM, Montgomery MG, Wakelam MJ, Walker JE.

Open Biol. 2015 Sep;5(9):150119. doi: 10.1098/rsob.150119.

23.

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.

Sanchez-Alvarez M, Zhang Q, Finger F, Wakelam MJ, Bakal C.

Open Biol. 2015 Sep;5(9):150093. doi: 10.1098/rsob.150093.

24.

Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options.

Parker VE, Knox RG, Zhang Q, Wakelam MJ, Semple RK.

Lancet. 2015 Feb 26;385 Suppl 1:S77. doi: 10.1016/S0140-6736(15)60392-0.

PMID:
26312899
25.

Phosphatidylinositolphosphate phosphatase activities and cancer.

Rudge SA, Wakelam MJ.

J Lipid Res. 2016 Feb;57(2):176-92. doi: 10.1194/jlr.R059154. Epub 2015 Aug 24. Review.

26.

Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.

Randall AS, Liu CH, Chu B, Zhang Q, Dongre SA, Juusola M, Franze K, Wakelam MJ, Hardie RC.

J Neurosci. 2015 Feb 11;35(6):2731-46. doi: 10.1523/JNEUROSCI.1150-14.2015.

27.

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.

Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E.

Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002.

28.

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

Pan D, Amison RT, Riffo-Vasquez Y, Spina D, Cleary SJ, Wakelam MJ, Page CP, Pitchford SC, Welch HC.

Blood. 2015 Feb 12;125(7):1146-58. doi: 10.1182/blood-2014-07-591040. Epub 2014 Dec 23.

29.

The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.

Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ.

Mol Carcinog. 2016 Jan;55(1):15-26. doi: 10.1002/mc.22254. Epub 2014 Nov 18.

PMID:
25408419
30.

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH.

PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct.

31.

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A, Harris AL.

Cell Rep. 2014 Oct 9;9(1):349-365. doi: 10.1016/j.celrep.2014.08.056. Epub 2014 Sep 25.

32.

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.

Liefhebber JM, Hague CV, Zhang Q, Wakelam MJ, McLauchlan J.

J Biol Chem. 2014 Aug 1;289(31):21276-88. doi: 10.1074/jbc.M114.582999. Epub 2014 Jun 10.

33.

Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4.

Rohwedder A, Zhang Q, Rudge SA, Wakelam MJ.

J Cell Sci. 2014 Jul 15;127(Pt 14):3104-15. doi: 10.1242/jcs.145854. Epub 2014 May 29.

34.

The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies.

Wakelam MJ.

Biochim Biophys Acta. 2014 Aug;1841(8):1102-7. doi: 10.1016/j.bbalip.2014.04.005. Epub 2014 Apr 24. Review.

PMID:
24769341
35.

SnapShot: Lipid kinase and phosphatase reaction pathways.

Rudge SA, Wakelam MJ.

Cell. 2014 Jan 16;156(1-2):376-376.e1. doi: 10.1016/j.cell.2014.01.003. No abstract available.

36.

SnapShot: lipid kinases and phosphatases.

Rudge SA, Wakelam MJ.

Cell. 2013 Dec 19;155(7):1654-1654.e1. doi: 10.1016/j.cell.2013.12.005. No abstract available.

37.

Lipidomics in the analysis of malignancy.

Zhang Q, Wakelam MJ.

Adv Biol Regul. 2014 Jan;54:93-8. doi: 10.1016/j.jbior.2013.11.001. Epub 2013 Nov 18. Review.

PMID:
24332194
38.

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.

Lowe CE, Zhang Q, Dennis RJ, Aubry EM, O'Rahilly S, Wakelam MJ, Rochford JJ.

Obesity (Silver Spring). 2013 Sep;21(9):1823-9. doi: 10.1002/oby.20297. Epub 2013 May 23.

39.

LipidHome: a database of theoretical lipids optimized for high throughput mass spectrometry lipidomics.

Foster JM, Moreno P, Fabregat A, Hermjakob H, Steinbeck C, Apweiler R, Wakelam MJ, Vizcaíno JA.

PLoS One. 2013 May 7;8(5):e61951. doi: 10.1371/journal.pone.0061951. Print 2013.

40.

Shorthand notation for lipid structures derived from mass spectrometry.

Liebisch G, Vizcaíno JA, Köfeler H, Trötzmüller M, Griffiths WJ, Schmitz G, Spener F, Wakelam MJ.

J Lipid Res. 2013 Jun;54(6):1523-30. doi: 10.1194/jlr.M033506. Epub 2013 Apr 2.

41.

Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms.

Gaunt ER, Zhang Q, Cheung W, Wakelam MJ, Lever AM, Desselberger U.

J Gen Virol. 2013 Jul;94(Pt 7):1576-86. doi: 10.1099/vir.0.049635-0. Epub 2013 Mar 20.

42.

Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer.

Damery S, Nichols L, Holder R, Ward ST, Warmington S, Wilson S, Wakelam MJ, James J, Ismail T.

Br J Cancer. 2013 Mar 19;108(5):1149-56. doi: 10.1038/bjc.2013.49. Epub 2013 Feb 7.

43.

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology.

Domart MC, Hobday TM, Peddie CJ, Chung GH, Wang A, Yeh K, Jethwa N, Zhang Q, Wakelam MJ, Woscholski R, Byrne RD, Collinson LM, Poccia DL, Larijani B.

PLoS One. 2012;7(12):e51150. doi: 10.1371/journal.pone.0051150. Epub 2012 Dec 5.

44.

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

Pal A, Barber TM, Van de Bunt M, Rudge SA, Zhang Q, Lachlan KL, Cooper NS, Linden H, Levy JC, Wakelam MJ, Walker L, Karpe F, Gloyn AL.

N Engl J Med. 2012 Sep 13;367(11):1002-11. doi: 10.1056/NEJMoa1113966.

45.

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.

Lindhurst MJ, Parker VE, Payne F, Sapp JC, Rudge S, Harris J, Witkowski AM, Zhang Q, Groeneveld MP, Scott CE, Daly A, Huson SM, Tosi LL, Cunningham ML, Darling TN, Geer J, Gucev Z, Sutton VR, Tziotzios C, Dixon AK, Helliwell T, O'Rahilly S, Savage DB, Wakelam MJ, Barroso I, Biesecker LG, Semple RK.

Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.

46.

Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test.

Wilson S, Damery S, Stocken DD, Dowswell G, Holder R, Ward ST, Redman V, Wakelam MJ, James J, Hobbs FD, Ismail T.

Br J Cancer. 2012 Apr 10;106(8):1431-8. doi: 10.1038/bjc.2012.93. Epub 2012 Mar 20.

47.

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

Rainero E, Caswell PT, Muller PA, Grindlay J, McCaffrey MW, Zhang Q, Wakelam MJ, Vousden KH, Graziani A, Norman JC.

J Cell Biol. 2012 Jan 23;196(2):277-95. doi: 10.1083/jcb.201109112.

48.

Methods for analyzing phosphoinositides using mass spectrometry.

Wakelam MJ, Clark J.

Biochim Biophys Acta. 2011 Nov;1811(11):758-62. doi: 10.1016/j.bbalip.2011.09.004. Epub 2011 Sep 23. Review.

PMID:
21964281
49.

A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.

Holden NJ, Savage CO, Young SP, Wakelam MJ, Harper L, Williams JM.

Mol Med. 2011;17(11-12):1242-52. doi: 10.2119/molmed.2011.00028. Epub 2011 Aug 8.

50.

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils.

Norton LJ, Zhang Q, Saqib KM, Schrewe H, Macura K, Anderson KE, Lindsley CW, Brown HA, Rudge SA, Wakelam MJ.

J Cell Sci. 2011 Jun 15;124(Pt 12):1973-83. doi: 10.1242/jcs.082008. Epub 2011 May 24.

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