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Items: 9


Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage.

Ito M, Tanaka T, Ishii T, Wakashima T, Fukui K, Nangaku M.

Kidney Int. 2019 Nov 9. pii: S0085-2538(19)31113-5. doi: 10.1016/j.kint.2019.10.020. [Epub ahead of print]


Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.

Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, Ueda M, Fukui K, Shimizu A, Inagi R, Yamauchi T, Kadowaki T, Nangaku M.

J Am Soc Nephrol. 2020 Jan 29. pii: ASN.2019060582. doi: 10.1681/ASN.2019060582. [Epub ahead of print]


Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease.

Uchida L, Tanaka T, Saito H, Sugahara M, Wakashima T, Fukui K, Nangaku M.

Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F388-F401. doi: 10.1152/ajprenal.00419.2019. Epub 2019 Dec 16.


JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors.

Wakashima T, Tanaka T, Fukui K, Komoda Y, Shinozaki Y, Kobayashi H, Matsuo A, Nangaku M.

Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F14-F24. doi: 10.1152/ajprenal.00323.2019. Epub 2019 Oct 21.


Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet.

Saito H, Tanaka T, Sugahara M, Tanaka S, Fukui K, Wakashima T, Nangaku M.

Lab Invest. 2019 Jul;99(8):1217-1232. doi: 10.1038/s41374-019-0239-4. Epub 2019 Apr 5.


Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury.

Saito H, Tanaka T, Tanaka S, Higashijima Y, Yamaguchi J, Sugahara M, Ito M, Uchida L, Hasegawa S, Wakashima T, Fukui K, Nangaku M.

Physiol Rep. 2018 May;6(10):e13707. doi: 10.14814/phy2.13707.


Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation.

Wakashima T, Abe K, Kihara A.

J Biol Chem. 2014 Sep 5;289(36):24736-48. doi: 10.1074/jbc.M114.571869. Epub 2014 Jul 21.


Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid.

Sassa T, Wakashima T, Ohno Y, Kihara A.

J Lipid Res. 2014 Mar;55(3):524-30. doi: 10.1194/jlr.M044586. Epub 2014 Jan 31.


Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation.

Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y.

PLoS One. 2013 Jun 27;8(6):e67317. doi: 10.1371/journal.pone.0067317. Print 2013.

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