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Items: 1 to 50 of 92

1.

Proteomic Analysis of the Secretome of Cellulomonas fimi ATCC 484 and Cellulomonas flavigena ATCC 482.

Wakarchuk WW, Brochu D, Foote S, Robotham A, Saxena H, Erak T, Kelly J.

PLoS One. 2016 Mar 7;11(3):e0151186. doi: 10.1371/journal.pone.0151186. eCollection 2016.

2.

Preparation of legionaminic acid analogs of sialo-glycoconjugates by means of mammalian sialyltransferases.

Watson DC, Wakarchuk WW, Gervais C, Durocher Y, Robotham A, Fernandes SM, Schnaar RL, Young NM, Gilbert M.

Glycoconj J. 2015 Dec;32(9):729-34. doi: 10.1007/s10719-015-9624-4. Epub 2015 Oct 9.

PMID:
26452603
3.

Sialyltransferases with enhanced legionaminic acid transferase activity for the preparation of analogs of sialoglycoconjugates.

Watson DC, Wakarchuk WW, Leclerc S, Schur MJ, Schoenhofen IC, Young NM, Gilbert M.

Glycobiology. 2015 Jul;25(7):767-73. doi: 10.1093/glycob/cwv017. Epub 2015 Apr 3.

PMID:
25840968
4.

A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis.

Yu CC, Huang LD, Kwan DH, Wakarchuk WW, Withers SG, Lin CC.

Chem Commun (Camb). 2013 Oct 3;49(86):10166-8. doi: 10.1039/c3cc45147j.

PMID:
24051967
5.

Biochemical characterization of a polysialyltransferase from Mannheimia haemolytica A2 and comparison to other bacterial polysialyltransferases.

Lindhout T, Bainbridge CR, Costain WJ, Gilbert M, Wakarchuk WW.

PLoS One. 2013 Jul 26;8(7):e69888. doi: 10.1371/journal.pone.0069888. Print 2013.

6.

Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins.

Young NM, Foote SJ, Wakarchuk WW.

Mol Immunol. 2013 Dec;56(4):563-73. doi: 10.1016/j.molimm.2013.05.237. Epub 2013 Aug 1. Review.

7.

Domain organization of the polymerizing mannosyltransferases involved in synthesis of the Escherichia coli O8 and O9a lipopolysaccharide O-antigens.

Greenfield LK, Richards MR, Vinogradov E, Wakarchuk WW, Lowary TL, Whitfield C.

J Biol Chem. 2012 Nov 2;287(45):38135-49. doi: 10.1074/jbc.M112.412577. Epub 2012 Sep 18.

8.

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.

Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea RL, Peters T, Buck CB, Stehle T.

PLoS Pathog. 2012;8(7):e1002738. doi: 10.1371/journal.ppat.1002738. Epub 2012 Jul 26.

9.

Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases.

Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C.

J Biol Chem. 2012 Oct 12;287(42):35078-91. doi: 10.1074/jbc.M112.401000. Epub 2012 Aug 8.

10.

Thiogalactopyranosides are resistant to hydrolysis by α-galactosidases.

Adlercreutz D, Yoshimura Y, Mannerstedt K, Wakarchuk WW, Bennett EP, Dovichi NJ, Hindsgaul O, Palcic MM.

Chembiochem. 2012 Jul 23;13(11):1673-9. doi: 10.1002/cbic.201200155. Epub 2012 Jun 27.

11.

Characterization of α2,3- and α2,6-sialyltransferases from Helicobacter acinonychis.

Schur MJ, Lameignere E, Strynadka NC, Wakarchuk WW.

Glycobiology. 2012 Jul;22(7):997-1006. doi: 10.1093/glycob/cws071. Epub 2012 Apr 14.

12.

Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis.

Lin LY, Rakic B, Chiu CP, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC.

J Biol Chem. 2011 Oct 28;286(43):37237-48. doi: 10.1074/jbc.M111.249920. Epub 2011 Aug 31.

13.

Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.

Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC.

J Biol Chem. 2011 Oct 14;286(41):35922-32. doi: 10.1074/jbc.M111.261172. Epub 2011 Aug 5.

14.

Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes.

Lindhout T, Iqbal U, Willis LM, Reid AN, Li J, Liu X, Moreno M, Wakarchuk WW.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7397-402. doi: 10.1073/pnas.1019266108. Epub 2011 Apr 18.

15.

Enzymatic synthesis and properties of glycoconjugates with legionaminic acid as a replacement for neuraminic acid.

Watson DC, Leclerc S, Wakarchuk WW, Young NM.

Glycobiology. 2011 Jan;21(1):99-108. doi: 10.1093/glycob/cwq135. Epub 2010 Oct 25.

PMID:
20978010
16.

Fluorescence activated cell sorting as a general ultra-high-throughput screening method for directed evolution of glycosyltransferases.

Yang G, Rich JR, Gilbert M, Wakarchuk WW, Feng Y, Withers SG.

J Am Chem Soc. 2010 Aug 4;132(30):10570-7. doi: 10.1021/ja104167y.

PMID:
20662530
17.

NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base.

Chan PH, Lairson LL, Lee HJ, Wakarchuk WW, Strynadka NC, Withers SG, McIntosh LP.

Biochemistry. 2009 Dec 1;48(47):11220-30. doi: 10.1021/bi901606n.

PMID:
19824695
18.

Structural insight into mammalian sialyltransferases.

Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC.

Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. doi: 10.1038/nsmb.1685. Epub 2009 Oct 11.

PMID:
19820709
19.

Mechanistic investigation of the endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae R6.

Willis LM, Zhang R, Reid A, Withers SG, Wakarchuk WW.

Biochemistry. 2009 Nov 3;48(43):10334-41. doi: 10.1021/bi9013825.

20.

Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis.

Lee HJ, Rakić B, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC.

J Biol Chem. 2009 Sep 4;284(36):24501-11. doi: 10.1074/jbc.M109.006049. Epub 2009 Jun 12.

21.

A new sialidase mechanism: bacteriophage K1F endo-sialidase is an inverting glycosidase.

Morley TJ, Willis LM, Whitfield C, Wakarchuk WW, Withers SG.

J Biol Chem. 2009 Jun 26;284(26):17404-10. doi: 10.1074/jbc.M109.003970. Epub 2009 May 1.

22.

Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter jejuni and Pasteurella multocida.

Houliston RS, Bernatchez S, Karwaski MF, Mandrell RE, Jarrell HC, Wakarchuk WW, Gilbert M.

Glycobiology. 2009 Feb;19(2):153-9. doi: 10.1093/glycob/cwn117. Epub 2008 Oct 25.

PMID:
18955372
23.

The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design.

Caines ME, Zhu H, Vuckovic M, Willis LM, Withers SG, Wakarchuk WW, Strynadka NC.

J Biol Chem. 2008 Nov 14;283(46):31279-83. doi: 10.1074/jbc.C800150200. Epub 2008 Sep 10.

24.

Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.

Sauerzapfe B, Krenek K, Schmiedel J, Wakarchuk WW, Pelantová H, Kren V, Elling L.

Glycoconj J. 2009 Feb;26(2):141-59. doi: 10.1007/s10719-008-9172-2. Epub 2008 Aug 29.

PMID:
18758940
25.

A beta-1,4-galactosyltransferase from Helicobacter pylori is an efficient and versatile biocatalyst displaying a novel activity for thioglycoside synthesis.

Namdjou DJ, Chen HM, Vinogradov E, Brochu D, Withers SG, Wakarchuk WW.

Chembiochem. 2008 Jul 2;9(10):1632-40. doi: 10.1002/cbic.200700775.

PMID:
18491328
26.
27.

Variants of the beta 1,3-galactosyltransferase CgtB from the bacterium Campylobacter jejuni have distinct acceptor specificities.

Bernatchez S, Gilbert M, Blanchard MC, Karwaski MF, Li J, Defrees S, Wakarchuk WW.

Glycobiology. 2007 Dec;17(12):1333-43. Epub 2007 Aug 30.

PMID:
17766267
28.

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.

Tateno H, Li H, Schur MJ, Bovin N, Crocker PR, Wakarchuk WW, Paulson JC.

Mol Cell Biol. 2007 Aug;27(16):5699-710. Epub 2007 Jun 11.

29.

Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.

Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC.

Biochemistry. 2007 Jun 19;46(24):7196-204. Epub 2007 May 23.

PMID:
17518445
30.

Alternative donor substrates for inverting and retaining glycosyltransferases.

Lairson LL, Wakarchuk WW, Withers SG.

Chem Commun (Camb). 2007 Jan 28;(4):365-7. Epub 2006 Nov 7.

PMID:
17220972
31.

Mechanism of stabilization of Bacillus circulans xylanase upon the introduction of disulfide bonds.

Davoodi J, Wakarchuk WW, Carey PR, Surewicz WK.

Biophys Chem. 2007 Feb;125(2-3):453-61. Epub 2006 Oct 25.

PMID:
17141401
32.

Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid.

Fox KL, Cox AD, Gilbert M, Wakarchuk WW, Li J, Makepeace K, Richards JC, Moxon ER, Hood DW.

J Biol Chem. 2006 Dec 29;281(52):40024-32. Epub 2006 Oct 27.

33.

Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.

Lairson LL, Watts AG, Wakarchuk WW, Withers SG.

Nat Chem Biol. 2006 Dec;2(12):724-8. Epub 2006 Oct 22.

PMID:
17057723
34.

High-throughput screening methodology for the directed evolution of glycosyltransferases.

Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG.

Nat Methods. 2006 Aug;3(8):609-14.

PMID:
16862135
35.

Identification of a sialate O-acetyltransferase from Campylobacter jejuni: demonstration of direct transfer to the C-9 position of terminalalpha-2, 8-linked sialic acid.

Houliston RS, Endtz HP, Yuki N, Li J, Jarrell HC, Koga M, van Belkum A, Karwaski MF, Wakarchuk WW, Gilbert M.

J Biol Chem. 2006 Apr 28;281(17):11480-6. Epub 2006 Feb 14.

36.

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori.

Schoenhofen IC, Lunin VV, Julien JP, Li Y, Ajamian E, Matte A, Cygler M, Brisson JR, Aubry A, Logan SM, Bhatia S, Wakarchuk WW, Young NM.

J Biol Chem. 2006 Mar 31;281(13):8907-16. Epub 2006 Jan 18.

37.

Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.

Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM.

J Biol Chem. 2006 Jan 13;281(2):723-32. Epub 2005 Nov 11.

38.
39.

Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase.

Chou WK, Dick S, Wakarchuk WW, Tanner ME.

J Biol Chem. 2005 Oct 28;280(43):35922-8. Epub 2005 Aug 24.

40.

Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori.

Logan SM, Altman E, Mykytczuk O, Brisson JR, Chandan V, Schur MJ, St Michael F, Masson A, Leclerc S, Hiratsuka K, Smirnova N, Li J, Wu Y, Wakarchuk WW.

Glycobiology. 2005 Jul;15(7):721-33. Epub 2005 Apr 6. Erratum in: Glycobiology. 2005 Nov;15(11):25G. Schur, Melissa J [added].

PMID:
15814825
41.

Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses.

Karlyshev AV, Champion OL, Churcher C, Brisson JR, Jarrell HC, Gilbert M, Brochu D, St Michael F, Li J, Wakarchuk WW, Goodhead I, Sanders M, Stevens K, White B, Parkhill J, Wren BW, Szymanski CM.

Mol Microbiol. 2005 Jan;55(1):90-103.

42.

Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase.

Murkin AS, Chou WK, Wakarchuk WW, Tanner ME.

Biochemistry. 2004 Nov 9;43(44):14290-8.

PMID:
15518580
43.

Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol.

Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC.

J Biol Chem. 2005 Feb 4;280(5):3555-63. Epub 2004 Oct 29.

44.

A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni.

Bernatchez S, Szymanski CM, Ishiyama N, Li J, Jarrell HC, Lau PC, Berghuis AM, Young NM, Wakarchuk WW.

J Biol Chem. 2005 Feb 11;280(6):4792-802. Epub 2004 Oct 27.

45.

Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.

Lairson LL, Chiu CP, Ly HD, He S, Wakarchuk WW, Strynadka NC, Withers SG.

J Biol Chem. 2004 Jul 2;279(27):28339-44. Epub 2004 Apr 9.

46.
47.

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.

Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC.

Nat Struct Mol Biol. 2004 Feb;11(2):163-70. Epub 2004 Jan 18.

PMID:
14730352
48.

Preparative-scale chemoenzymatic synthesis of large carbohydrate assemblies using alpha (1-->4)-galactosyltransferase/UDP-4'-Gal-epimerase fusion protein.

Kitov PI, Paszkiewicz E, Wakarchuk WW, Bundle DR.

Methods Enzymol. 2003;362:86-105. No abstract available.

PMID:
12968359
49.

Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli.

Antoine T, Priem B, Heyraud A, Greffe L, Gilbert M, Wakarchuk WW, Lam JS, Samain E.

Chembiochem. 2003 May 9;4(5):406-12.

PMID:
12740812
50.

Simplifying oligosaccharide synthesis: efficient synthesis of lactosamine and siaylated lactosamine oligosaccharide donors.

Yan F, Mehta S, Eichler E, Wakarchuk WW, Gilbert M, Schur MJ, Whitfield DM.

J Org Chem. 2003 Mar 21;68(6):2426-31.

PMID:
12636412

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