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Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.

Caval V, Jiao W, Berry N, Khalfi P, Pitré E, Thiers V, Vartanian JP, Wain-Hobson S, Suspène R.

BMC Genomics. 2019 Nov 14;20(1):858. doi: 10.1186/s12864-019-6216-x.


A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors.

Teixeira L, Medioni J, Garibal J, Adotevi O, Doucet L, Durey MD, Ghrieb Z, Kiladjian JJ, Brizard M, Laheurte C, Wehbe M, Pliquet E, Escande M, Defrance R, Culine S, Oudard S, Wain-Hobson S, Doppler V, Huet T, Langlade-Demoyen P.

Clin Cancer Res. 2020 Feb 1;26(3):588-597. doi: 10.1158/1078-0432.CCR-19-1614. Epub 2019 Sep 26.


A DNA telomerase vaccine for canine cancer immunotherapy.

Thalmensi J, Pliquet E, Liard C, Chamel G, Kreuz C, Bestetti T, Escande M, Kostrzak A, Pailhes-Jimenez AS, Bourges E, Julithe M, Bourre L, Keravel O, Clayette P, Huet T, Wain-Hobson S, Langlade-Demoyen P.

Oncotarget. 2019 May 21;10(36):3361-3372. doi: 10.18632/oncotarget.26927. eCollection 2019 May 21.


Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.

Hallez C, Li X, Suspène R, Thiers V, Bouzidi MS, M Dorobantu C, Lucansky V, Wain-Hobson S, Gaudin R, Vartanian JP.

Nat Microbiol. 2019 Jul;4(7):1196-1207. doi: 10.1038/s41564-019-0405-x. Epub 2019 Apr 1.


Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level.

Mussil B, Suspène R, Caval V, Durandy A, Wain-Hobson S, Vartanian JP.

Sci Rep. 2019 Feb 28;9(1):3109. doi: 10.1038/s41598-019-39245-8.


Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis.

Li X, Caval V, Wain-Hobson S, Vartanian JP.

Sci Rep. 2019 Jan 24;9(1):728. doi: 10.1038/s41598-018-37305-z.


Strong antigen-specific T-cell immunity induced by a recombinant human TERT measles virus vaccine and amplified by a DNA/viral vector prime boost in IFNAR/CD46 mice.

Pliquet E, Ruffie C, Escande M, Thalmensi J, Najburg V, Combredet C, Bestetti T, Julithe M, Liard C, Huet T, Wain-Hobson S, Tangy F, Langlade-Demoyen P.

Cancer Immunol Immunother. 2019 Apr;68(4):533-544. doi: 10.1007/s00262-018-2272-3. Epub 2019 Jan 17.


The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.

Laude HC, Caval V, Bouzidi MS, Li X, Jamet F, Henry M, Suspène R, Wain-Hobson S, Vartanian JP.

Oncotarget. 2018 Jun 12;9(45):27809-27822. doi: 10.18632/oncotarget.25593. eCollection 2018 Jun 12.


Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage.

Suspène R, Mussil B, Laude H, Caval V, Berry N, Bouzidi MS, Thiers V, Wain-Hobson S, Vartanian JP.

Nucleic Acids Res. 2017 Apr 7;45(6):3231-3241. doi: 10.1093/nar/gkx001.


PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA.

Suspène R, Thiers V, Vartanian JP, Wain-Hobson S.

Retrovirology. 2016 Dec 20;13(1):84. doi: 10.1186/s12977-016-0318-1.


APOBEC3A intratumoral DNA electroporation in mice.

Kostrzak A, Caval V, Escande M, Pliquet E, Thalmensi J, Bestetti T, Julithe M, Fiette L, Huet T, Wain-Hobson S, Langlade-Demoyen P.

Gene Ther. 2017 Feb;24(2):74-83. doi: 10.1038/gt.2016.77. Epub 2016 Nov 18.


APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.

Bouzidi MS, Caval V, Suspène R, Hallez C, Pineau P, Wain-Hobson S, Vartanian JP.

J Mol Biol. 2016 Aug 28;428(17):3514-28. doi: 10.1016/j.jmb.2016.05.022. Epub 2016 Jun 8.


Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response.

Thalmensi J, Pliquet E, Liard C, Escande M, Bestetti T, Julithe M, Kostrzak A, Pailhes-Jimenez AS, Bourges E, Loustau M, Caumartin J, Lachgar A, Huet T, Wain-Hobson S, Langlade-Demoyen P.

Oncoimmunology. 2015 Nov 5;5(3):e1083670. eCollection 2016 Mar.


Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme.

Caval V, Bouzidi MS, Suspène R, Laude H, Dumargne MC, Bashamboo A, Krey T, Vartanian JP, Wain-Hobson S.

Nucleic Acids Res. 2015 Oct 30;43(19):9340-9. doi: 10.1093/nar/gkv935. Epub 2015 Sep 17.


An avian H7N1 gain-of-function experiment of great concern.

Wain-Hobson S.

mBio. 2014 Oct 14;5(5):e01882-14. doi: 10.1128/mBio.01882-14.


A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.

Caval V, Suspène R, Shapira M, Vartanian JP, Wain-Hobson S.

Nat Commun. 2014 Oct 9;5:5129. doi: 10.1038/ncomms6129.


APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle.

Kostrzak A, Henry M, Demoyen PL, Wain-Hobson S, Vartanian JP.

Gene Ther. 2015 Jan;22(1):96-103. doi: 10.1038/gt.2014.88. Epub 2014 Oct 9.


The Irrationality of GOF Avian Influenza Virus Research.

Wain-Hobson S.

Front Public Health. 2014 Jul 16;2:77. doi: 10.3389/fpubh.2014.00077. eCollection 2014. Review.


Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics.

Suspène R, Caval V, Henry M, Bouzidi MS, Wain-Hobson S, Vartanian JP.

Br J Cancer. 2014 May 13;110(10):2615-22. doi: 10.1038/bjc.2014.176. Epub 2014 Apr 1.


Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments.

Wain-Hobson S.

EMBO Mol Med. 2013 Nov;5(11):1637-41. doi: 10.1002/emmm.201303475. Epub 2013 Oct 24. No abstract available.


Orthologous mammalian APOBEC3A cytidine deaminases hypermutate nuclear DNA.

Caval V, Suspène R, Vartanian JP, Wain-Hobson S.

Mol Biol Evol. 2014 Feb;31(2):330-40. doi: 10.1093/molbev/mst195. Epub 2013 Oct 25.


Gain-of-function research: unknown risks.

Rey F, Schwartz O, Wain-Hobson S.

Science. 2013 Oct 18;342(6156):311. doi: 10.1126/science.342.6156.311-a. No abstract available.


Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.

Ezzikouri S, Kitab B, Rebbani K, Marchio A, Wain-Hobson S, Dejean A, Vartanian JP, Pineau P, Benjelloun S.

J Viral Hepat. 2013 Oct;20(10):678-86. doi: 10.1111/jvh.12042. Epub 2012 Dec 28.


Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.

Mussil B, Suspène R, Aynaud MM, Gauvrit A, Vartanian JP, Wain-Hobson S.

PLoS One. 2013 Aug 20;8(8):e73641. doi: 10.1371/journal.pone.0073641. eCollection 2013.


Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase.

Suspène R, Aynaud MM, Vartanian JP, Wain-Hobson S.

PLoS One. 2013 Jun 20;8(6):e63461. doi: 10.1371/journal.pone.0063461. Print 2013.


H5N1 viral-engineering dangers will not go away.

Wain-Hobson S.

Nature. 2013 Mar 28;495(7442):411. doi: 10.1038/495411a. No abstract available.


Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor.

Dosset M, Godet Y, Vauchy C, Beziaud L, Lone YC, Sedlik C, Liard C, Levionnois E, Clerc B, Sandoval F, Daguindau E, Wain-Hobson S, Tartour E, Langlade-Demoyen P, Borg C, Adotévi O.

Clin Cancer Res. 2012 Nov 15;18(22):6284-95. doi: 10.1158/1078-0432.CCR-12-0896. Epub 2012 Oct 2.


Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1.

Ko NL, Birlouez E, Wain-Hobson S, Mahieux R, Vartanian JP.

J Gen Virol. 2012 Dec;93(Pt 12):2646-51. doi: 10.1099/vir.0.045146-0. Epub 2012 Sep 19.


Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

Aynaud MM, Suspène R, Vidalain PO, Mussil B, Guétard D, Tangy F, Wain-Hobson S, Vartanian JP.

J Biol Chem. 2012 Nov 9;287(46):39182-92. doi: 10.1074/jbc.M112.372722. Epub 2012 Sep 13.


Structural variability of the herpes simplex virus 1 genome in vitro and in vivo.

Mahiet C, Ergani A, Huot N, Alende N, Azough A, Salvaire F, Bensimon A, Conseiller E, Wain-Hobson S, Labetoulle M, Barradeau S.

J Virol. 2012 Aug;86(16):8592-601. doi: 10.1128/JVI.00223-12. Epub 2012 Jun 6.


Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions.

Henry M, Terzian C, Peeters M, Wain-Hobson S, Vartanian JP.

PLoS One. 2012;7(1):e30036. doi: 10.1371/journal.pone.0030036. Epub 2012 Jan 17.


Research investment: Vaccine research loses out.

Hale P, Wain-Hobson S, Weiss RA.

Nature. 2011 Oct 12;478(7368):188. doi: 10.1038/478188b. No abstract available.


Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.

Perales C, Henry M, Domingo E, Wain-Hobson S, Vartanian JP.

J Virol. 2011 Dec;85(23):12227-40. doi: 10.1128/JVI.00716-11. Epub 2011 Sep 14.


Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.

Suspène R, Aynaud MM, Koch S, Pasdeloup D, Labetoulle M, Gaertner B, Vartanian JP, Meyerhans A, Wain-Hobson S.

J Virol. 2011 Aug;85(15):7594-602. doi: 10.1128/JVI.00290-11. Epub 2011 Jun 1.


Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1.

Martínez JP, Bocharov G, Ignatovich A, Reiter J, Dittmar MT, Wain-Hobson S, Meyerhans A.

PLoS One. 2011 Mar 31;6(3):e18375. doi: 10.1371/journal.pone.0018375.


Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.

Suspène R, Aynaud MM, Guétard D, Henry M, Eckhoff G, Marchio A, Pineau P, Dejean A, Vartanian JP, Wain-Hobson S.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4858-63. doi: 10.1073/pnas.1009687108. Epub 2011 Mar 2.


Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines.

Suspène R, Petit V, Puyraimond-Zemmour D, Aynaud MM, Henry M, Guétard D, Rusniok C, Wain-Hobson S, Vartanian JP.

J Virol. 2011 Mar;85(5):2458-62. doi: 10.1128/JVI.02138-10. Epub 2010 Dec 15.


Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice.

Rusakiewicz S, Dosset M, Mollier K, Souque P, Charneau P, Wain-Hobson S, Langlade-Demoyen P, Adotévi O.

Vaccine. 2010 Aug 31;28(38):6374-81. doi: 10.1016/j.vaccine.2010.06.071. Epub 2010 Jul 21.


APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo.

Renard M, Henry M, Guétard D, Vartanian JP, Wain-Hobson S.

J Mol Biol. 2010 Jul 16;400(3):323-34. doi: 10.1016/j.jmb.2010.05.029. Epub 2010 May 28.


Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis.

Vartanian JP, Henry M, Marchio A, Suspène R, Aynaud MM, Guétard D, Cervantes-Gonzalez M, Battiston C, Mazzaferro V, Pineau P, Dejean A, Wain-Hobson S.

PLoS Pathog. 2010 May 27;6(5):e1000928. doi: 10.1371/journal.ppat.1000928.


APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.

Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M.

J Virol. 2010 Jul;84(14):7278-87. doi: 10.1128/JVI.02239-09. Epub 2010 May 12.


Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo.

Adotévi O, Mollier K, Neuveut C, Dosset M, Ravel P, Fridman WH, Tartour E, Charneau P, Wain-Hobson S, Langlade-Demoyen P.

Blood. 2010 Apr 15;115(15):3025-32. doi: 10.1182/blood-2009-11-253641. Epub 2010 Feb 3.


Human APOBEC1 cytidine deaminase edits HBV DNA.

Gonzalez MC, Suspène R, Henry M, Guétard D, Wain-Hobson S, Vartanian JP.

Retrovirology. 2009 Oct 21;6:96. doi: 10.1186/1742-4690-6-96.


Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells.

Kostrzak A, Cervantes Gonzalez M, Guetard D, Nagaraju DB, Wain-Hobson S, Tepfer D, Pniewski T, Sala M.

Vaccine. 2009 Jul 30;27(35):4798-807. doi: 10.1016/j.vaccine.2009.05.092. Epub 2009 Jun 17.


A step ahead on the HIV collaboratory.

Murphy RL, Autran B, Katlama C, Brucker G, Debre P, Calvez V, Clotet B, Clumeck N, Costagliola D, Deeks SG, Dorrell L, Gatell J, Haase A, Klein M, Lazzarin A, McMichael AJ, Papagno L, Schacker TW, Wain-Hobson S, Walker BD, Youle M.

Science. 2009 Jun 5;324(5932):1264-5. doi: 10.1126/science.324_1264b. No abstract available.


The 30th anniversary of quasispecies. Meeting on 'Quasispecies: past, present and future'.

Domingo E, Wain-Hobson S.

EMBO Rep. 2009 May;10(5):444-8. doi: 10.1038/embor.2009.61. Epub 2009 Apr 3. No abstract available.


Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G.

Henry M, Guétard D, Suspène R, Rusniok C, Wain-Hobson S, Vartanian JP.

PLoS One. 2009;4(1):e4277. doi: 10.1371/journal.pone.0004277. Epub 2009 Jan 26.


Powerful mutators lurking in the genome.

Petit V, Vartanian JP, Wain-Hobson S.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):705-15. doi: 10.1098/rstb.2008.0272. Review.


Guidelines for naming nonprimate APOBEC3 genes and proteins.

LaRue RS, Andrésdóttir V, Blanchard Y, Conticello SG, Derse D, Emerman M, Greene WC, Jónsson SR, Landau NR, Löchelt M, Malik HS, Malim MH, Münk C, O'Brien SJ, Pathak VK, Strebel K, Wain-Hobson S, Yu XF, Yuhki N, Harris RS.

J Virol. 2009 Jan;83(2):494-7. doi: 10.1128/JVI.01976-08. Epub 2008 Nov 5. No abstract available.


Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.

Petit V, Guétard D, Renard M, Keriel A, Sitbon M, Wain-Hobson S, Vartanian JP.

J Mol Biol. 2009 Jan 9;385(1):65-78. doi: 10.1016/j.jmb.2008.10.043. Epub 2008 Nov 1.


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