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Items: 10

1.

Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates.

Neumann CS, Olivas KC, Anderson ME, Cochran JH, Jin S, Li F, Loftus LV, Meyer DW, Neale J, Nix JC, Pittman PG, Simmons JK, Ulrich ML, Waight AB, Wong A, Zaval MC, Zeng W, Lyon RP, Senter PD.

Mol Cancer Ther. 2018 Sep 21. pii: molcanther.0643.2018. doi: 10.1158/1535-7163.MCT-18-0643. [Epub ahead of print]

PMID:
30242091
2.

Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR+ and Heterogeneous Tumor Models.

Burke PJ, Hamilton JZ, Pires TA, Lai HWH, Leiske CI, Emmerton KK, Waight AB, Senter PD, Lyon RP, Jeffrey SC.

Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.

PMID:
29866744
3.

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE.

PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890. eCollection 2016.

4.

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.

Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO.

J Mol Biol. 2016 Jul 31;428(15):2981-8. doi: 10.1016/j.jmb.2016.06.023. Epub 2016 Jul 6.

PMID:
27395016
5.

Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.

Burke PJ, Hamilton JZ, Pires TA, Setter JR, Hunter JH, Cochran JH, Waight AB, Gordon KA, Toki BE, Emmerton KK, Zeng W, Stone IJ, Senter PD, Lyon RP, Jeffrey SC.

Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.

6.

A previously undescribed tubulin binder.

Field JJ, Waight AB, Senter PD.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13684-5. doi: 10.1073/pnas.1414572111. Epub 2014 Sep 3. No abstract available.

7.

Ion selectivity and gating mechanisms of FNT channels.

Waight AB, Czyzewski BK, Wang DN.

Curr Opin Struct Biol. 2013 Aug;23(4):499-506. doi: 10.1016/j.sbi.2013.05.007. Epub 2013 Jun 14. Review.

8.

Structural basis for alternating access of a eukaryotic calcium/proton exchanger.

Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, Risenmay AJ, Sali A, Stroud RM.

Nature. 2013 Jul 4;499(7456):107-10. doi: 10.1038/nature12233. Epub 2013 May 19.

9.

Crystal structure of a eukaryotic phosphate transporter.

Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, Schlessinger A, Bonomi M, Harries W, Sali A, Johri AK, Stroud RM.

Nature. 2013 Apr 25;496(7446):533-6. doi: 10.1038/nature12042. Epub 2013 Mar 31.

10.

Structure and mechanism of a pentameric formate channel.

Waight AB, Love J, Wang DN.

Nat Struct Mol Biol. 2010 Jan;17(1):31-7. doi: 10.1038/nsmb.1740. Epub 2009 Dec 13.

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