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Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

Oh HYP, Ellero-Simatos S, Manickam R, Tan NS, Guillou H, Wahli W.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E812. doi: 10.3390/ijms20040812.


Hepatic PPARα is critical in the metabolic adaptation to sepsis.

Paumelle R, Haas JT, Hennuyer N, Baugé E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B.

J Hepatol. 2019 Jan 21. pii: S0168-8278(19)30027-3. doi: 10.1016/j.jhep.2018.12.037. [Epub ahead of print]


The Role of PPARβ/δ in Melanoma Metastasis.

Lim JCW, Kwan YP, Tan MS, Teo MHY, Chiba S, Wahli W, Wang X.

Int J Mol Sci. 2018 Sep 20;19(10). pii: E2860. doi: 10.3390/ijms19102860.


Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism.

Manickam R, Oh HYP, Tan CK, Paramalingam E, Wahli W.

Int J Mol Sci. 2018 Aug 16;19(8). pii: E2418. doi: 10.3390/ijms19082418.


Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.

Duszka K, Wahli W.

Int J Mol Sci. 2018 Jul 28;19(8). pii: E2210. doi: 10.3390/ijms19082210. Review.


Complementary intestinal mucosa and microbiota responses to caloric restriction.

Duszka K, Ellero-Simatos S, Ow GS, Defernez M, Paramalingam E, Tett A, Ying S, König J, Narbad A, Kuznetsov VA, Guillou H, Wahli W.

Sci Rep. 2018 Jul 27;8(1):11338. doi: 10.1038/s41598-018-29815-7.


Insights into the Role of PPARβ/δ in NAFLD.

Chen J, Montagner A, Tan NS, Wahli W.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1893. doi: 10.3390/ijms19071893. Review.


The OEA effect on food intake is independent from the presence of PPARα in the intestine and the nodose ganglion, while the impact of OEA on energy expenditure requires the presence of PPARα in mice.

Caillon A, Duszka K, Wahli W, Rohner-Jeanrenaud F, Altirriba J.

Metabolism. 2018 Oct;87:13-17. doi: 10.1016/j.metabol.2018.06.005. Epub 2018 Jun 21.


Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression.

Sng MK, Chan JSK, Teo Z, Phua T, Tan EHP, Wee JWK, Koh NJN, Tan CK, Chen JP, Pal M, Tong BMK, Tnay YL, Ng XR, Zhu P, Chiba S, Wang X, Wahli W, Tan NS.

Cell Discov. 2018 Apr 3;4:15. doi: 10.1038/s41421-018-0014-5. eCollection 2018.


ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.

Tan EHP, Sng MK, How ISB, Chan JSK, Chen J, Tan CK, Wahli W, Tan NS.

Oncogene. 2018 Apr;37(15):2067-2078. doi: 10.1038/s41388-017-0109-8. Epub 2018 Jan 25.


Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.

Lasar D, Rosenwald M, Kiehlmann E, Balaz M, Tall B, Opitz L, Lidell ME, Zamboni N, Krznar P, Sun W, Varga L, Stefanicka P, Ukropec J, Nuutila P, Virtanen K, Amri EZ, Enerbäck S, Wahli W, Wolfrum C.

Cell Rep. 2018 Jan 16;22(3):760-773. doi: 10.1016/j.celrep.2017.12.067.


Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway.

Kirkby NS, Sampaio W, Etelvino G, Alves DT, Anders KL, Temponi R, Shala F, Nair AS, Ahmetaj-Shala B, Jiao J, Herschman HR, Wang X, Wahli W, Santos RA, Mitchell JA.

Hypertension. 2018 Feb;71(2):297-305. doi: 10.1161/HYPERTENSIONAHA.117.09906. Epub 2018 Jan 2. Erratum in: Hypertension. 2018 Mar;71(3):e10.


Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.

Zarei M, Barroso E, Palomer X, Dai J, Rada P, Quesada-López T, Escolà-Gil JC, Cedó L, Zali MR, Molaei M, Dabiri R, Vázquez S, Pujol E, Valverde ÁM, Villarroya F, Liu Y, Wahli W, Vázquez-Carrera M.

Mol Metab. 2018 Feb;8:117-131. doi: 10.1016/j.molmet.2017.12.008. Epub 2017 Dec 19.


PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium.

Duszka K, Oresic M, Le May C, König J, Wahli W.

Int J Mol Sci. 2017 Nov 28;18(12). pii: E2559. doi: 10.3390/ijms18122559.


Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models.

Jain MR, Giri SR, Bhoi B, Trivedi C, Rath A, Rathod R, Ranvir R, Kadam S, Patel H, Swain P, Roy SS, Das N, Karmakar E, Wahli W, Patel PR.

Liver Int. 2018 Jun;38(6):1084-1094. doi: 10.1111/liv.13634. Epub 2017 Dec 14.


A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.

Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C.

Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065.


Insights into the role of hepatocyte PPARα activity in response to fasting.

Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, Smati S, Marrot A, Lasserre F, Naylies C, Batut A, Viars F, Bertrand-Michel J, Postic C, Loiseau N, Wahli W, Guillou H, Montagner A.

Mol Cell Endocrinol. 2018 Aug 15;471:75-88. doi: 10.1016/j.mce.2017.07.035. Epub 2017 Jul 31.


Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome.

Tan CK, Zhuang Y, Wahli W.

Expert Opin Ther Targets. 2017 Mar;21(3):333-348. doi: 10.1080/14728222.2017.1280467. Epub 2017 Jan 25. Review.


Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology.

Manickam R, Wahli W.

Biochimie. 2017 May;136:42-48. doi: 10.1016/j.biochi.2016.11.010. Epub 2016 Dec 2. Review.


Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.

Duszka K, Picard A, Ellero-Simatos S, Chen J, Defernez M, Paramalingam E, Pigram A, Vanoaica L, Canlet C, Parini P, Narbad A, Guillou H, Thorens B, Wahli W.

Sci Rep. 2016 Nov 17;6:36937. doi: 10.1038/srep36937.


Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ.

Tan NS, Vázquez-Carrera M, Montagner A, Sng MK, Guillou H, Wahli W.

Prog Lipid Res. 2016 Oct;64:98-122. doi: 10.1016/j.plipres.2016.09.001. Epub 2016 Sep 22. Review. No abstract available.


Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids.

Polizzi A, Fouché E, Ducheix S, Lasserre F, Marmugi AP, Mselli-Lakhal L, Loiseau N, Wahli W, Guillou H, Montagner A.

Int J Mol Sci. 2016 Sep 24;17(10). pii: E1624. doi: 10.3390/ijms17101624.


High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine.

Tomas J, Mulet C, Saffarian A, Cavin JB, Ducroc R, Regnault B, Kun Tan C, Duszka K, Burcelin R, Wahli W, Sansonetti PJ, Pédron T.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5934-E5943. Epub 2016 Sep 16.


Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.

Zarei M, Barroso E, Leiva R, Barniol-Xicota M, Pujol E, Escolano C, Vázquez S, Palomer X, Pardo V, González-Rodríguez Á, Valverde ÁM, Quesada-López T, Villarroya F, Wahli W, Vázquez-Carrera M.

Diabetes. 2016 Oct;65(10):3185-99. doi: 10.2337/db16-0155. Epub 2016 Aug 2.


Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism.

Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W.

Elife. 2016 Jul 1;5. pii: e11853. doi: 10.7554/eLife.11853.


"Every day I dream ..." An interview with the Rwandan Health Minister.

Suter PM, Wahli W.

Swiss Med Wkly. 2016 May 6;146:w14316. doi: 10.4414/smw.2016.14316. eCollection 2016. No abstract available.


Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Apr 20;6:23951. doi: 10.1038/srep23951. No abstract available.


Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Feb 16;6:20127. doi: 10.1038/srep20127. Erratum in: Sci Rep. 2016;6:23951. Maha, Al-Asmakh [corrected to Al-Asmakh, Maha].


Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H.

Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1.


A trilogy of glucocorticoid receptor actions.

Tan CK, Wahli W.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1115-7. doi: 10.1073/pnas.1524215113. Epub 2016 Jan 20. No abstract available.


PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice.

Garbacz WG, Huang JT, Higgins LG, Wahli W, Palmer CN.

PPAR Res. 2015;2015:927057. doi: 10.1155/2015/927057. Epub 2015 Oct 29.


Nuclear receptor peroxisome proliferator activated receptor (PPAR) β/δ in skin wound healing and cancer.

Montagner A, Wahli W, Tan NS.

Eur J Dermatol. 2015 Apr;25 Suppl 1:4-11. Review.


Inactivation of PPARβ/δ adversely affects satellite cells and reduces postnatal myogenesis.

Chandrashekar P, Manickam R, Ge X, Bonala S, McFarlane C, Sharma M, Wahli W, Kambadur R.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E122-31. doi: 10.1152/ajpendo.00586.2014. Epub 2015 Apr 28.


PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation.

Barroso E, Rodríguez-Rodríguez R, Chacón MR, Maymó-Masip E, Ferrer L, Salvadó L, Salmerón E, Wabistch M, Palomer X, Vendrell J, Wahli W, Vázquez-Carrera M.

Biochim Biophys Acta. 2015 May;1852(5):1049-58. doi: 10.1016/j.bbadis.2015.02.010. Epub 2015 Feb 26.


Authorship in scientific publications: analysis and recommendations.

Scientific Integrity Committee of Swiss Academies of Arts And Sciences, Hess CW, Brückner C, Kaiser T, Mauron A, Wahli W, Wenzel UJ, Salathé M.

Swiss Med Wkly. 2015 Feb 21;145:w14108. doi: 10.4414/smw.2015.14108. eCollection 2015.


PPAR-β/δ activation promotes phospholipid transfer protein expression.

Chehaibi K, Cedó L, Metso J, Palomer X, Santos D, Quesada H, Naceur Slimane M, Wahli W, Julve J, Vázquez-Carrera M, Jauhiainen M, Blanco-Vaca F, Escolà-Gil JC.

Biochem Pharmacol. 2015 Mar 15;94(2):101-8. doi: 10.1016/j.bcp.2015.01.016. Epub 2015 Feb 7.


The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet.

Pérez-Schindler J, Svensson K, Vargas-Fernández E, Santos G, Wahli W, Handschin C.

Diabetologia. 2014 Nov;57(11):2405-12. doi: 10.1007/s00125-014-3352-3. Epub 2014 Aug 13.


PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.

Salvadó L, Barroso E, Gómez-Foix AM, Palomer X, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetologia. 2014 Oct;57(10):2126-35. doi: 10.1007/s00125-014-3331-8. Epub 2014 Jul 26.


PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.

Palomer X, Capdevila-Busquets E, Botteri G, Salvadó L, Barroso E, Davidson MM, Michalik L, Wahli W, Vázquez-Carrera M.

Int J Cardiol. 2014 Jun 1;174(1):110-8. doi: 10.1016/j.ijcard.2014.03.176. Epub 2014 Apr 8.


The emerging role of Nrf2 in dermatotoxicology.

Tan NS, Wahli W.

EMBO Mol Med. 2014 Apr;6(4):431-3. doi: 10.1002/emmm.201303797. Epub 2014 Feb 12.


Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway.

Kundu P, Ling TW, Korecka A, Li Y, D'Arienzo R, Bunte RM, Berger T, Arulampalam V, Chambon P, Mak TW, Wahli W, Pettersson S.

PLoS Pathog. 2014 Jan;10(1):e1003887. doi: 10.1371/journal.ppat.1003887. Epub 2014 Jan 23.


Myostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle.

Sriram S, Subramanian S, Juvvuna PK, Ge X, Lokireddy S, McFarlane CD, Wahli W, Kambadur R, Sharma M.

Mol Endocrinol. 2014 Mar;28(3):317-30. doi: 10.1210/me.2013-1179. Epub 2014 Jan 17. Erratum in: Mol Endocrinol. 2016 Feb;30(2):272-3.


PPARβ interprets a chromatin signature of pluripotency to promote embryonic differentiation at gastrulation.

Rotman N, Guex N, Gouranton E, Wahli W.

PLoS One. 2013 Dec 18;8(12):e83300. doi: 10.1371/journal.pone.0083300. eCollection 2013.


Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer.

Montagner A, Delgado MB, Tallichet-Blanc C, Chan JS, Sng MK, Mottaz H, Degueurce G, Lippi Y, Moret C, Baruchet M, Antsiferova M, Werner S, Hohl D, Saati TA, Farmer PJ, Tan NS, Michalik L, Wahli W.

EMBO Mol Med. 2014 Jan;6(1):80-98.


The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids.

Ding J, Loizides-Mangold U, Rando G, Zoete V, Michielin O, Reddy JK, Wahli W, Riezman H, Thorens B.

Cell Rep. 2013 Oct 17;5(1):248-58. doi: 10.1016/j.celrep.2013.08.032. Epub 2013 Sep 26.


Role of the circadian clock gene Per2 in adaptation to cold temperature.

Chappuis S, Ripperger JA, Schnell A, Rando G, Jud C, Wahli W, Albrecht U.

Mol Metab. 2013 May 10;2(3):184-93. doi: 10.1016/j.molmet.2013.05.002. eCollection 2013.


Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.

Barroso E, del Valle J, Porquet D, Vieira Santos AM, Salvadó L, Rodríguez-Rodríguez R, Gutiérrez P, Anglada-Huguet M, Alberch J, Camins A, Palomer X, Pallàs M, Michalik L, Wahli W, Vázquez-Carrera M.

Biochim Biophys Acta. 2013 Aug;1832(8):1241-8. doi: 10.1016/j.bbadis.2013.03.006. Epub 2013 Mar 16.


Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease.

Montagner A, Wahli W.

Biomol Concepts. 2013 Feb;4(1):53-64. doi: 10.1515/bmc-2012-0035. Review.


Studying Wound Repair in the Mouse.

Tan NS, Wahli W.

Curr Protoc Mouse Biol. 2013 Oct 18;3(3):171-85. doi: 10.1002/9780470942390.mo130135.


PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W.

J Clin Invest. 2012 Nov;122(11):4105-17. doi: 10.1172/JCI42127. Epub 2012 Oct 24.

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