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Items: 1 to 50 of 260

1.

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE.

Nucleic Acids Res. 2018 Jul 9. doi: 10.1093/nar/gky570. [Epub ahead of print]

PMID:
29986096
2.

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.

Tan SK, Pastori C, Penas C, Komotar RJ, Ivan ME, Wahlestedt C, Ayad NG.

Mol Cancer. 2018 Mar 20;17(1):74. doi: 10.1186/s12943-018-0822-0.

3.

Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Zhu W, Wang H, Wei J, Sartor GC, Bao MM, Pierce CT, Wahlestedt CR, Dykxhoorn DM, Dong C.

Hypertension. 2018 Apr;71(4):752-760. doi: 10.1161/HYPERTENSIONAHA.117.10213. Epub 2018 Feb 26.

PMID:
29483230
4.

Vitamin C Sensitizes Melanoma to BET Inhibitors.

Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G.

Cancer Res. 2018 Jan 15;78(2):572-583. doi: 10.1158/0008-5472.CAN-17-2040. Epub 2017 Nov 27.

PMID:
29180474
5.

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.

Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, Rangwala S, Deutsch Y, Conneally E, Drusbosky L, Cogle CR, Wahlestedt C.

Leuk Res. 2018 Jan;64:34-41. doi: 10.1016/j.leukres.2017.11.008. Epub 2017 Nov 11.

6.

Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density.

Seldeen KL, Halley PG, Volmar CH, Rodríguez MA, Hernandez M, Pang M, Carlsson SK, Suva LJ, Wahlestedt C, Troen BR, Brothers SP.

Neuropeptides. 2018 Feb;67:45-55. doi: 10.1016/j.npep.2017.11.005. Epub 2017 Nov 7.

PMID:
29129406
7.

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.

Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC.

Blood. 2018 Jan 18;131(3):328-341. doi: 10.1182/blood-2017-06-789669. Epub 2017 Nov 7.

PMID:
29113963
8.

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.

Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, Wahlestedt C.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9135-E9144. doi: 10.1073/pnas.1707544114. Epub 2017 Oct 9.

9.

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.

Sartor GC, Powell SK, Velmeshev D, Lin DY, Magistri M, Wiedner HJ, Malvezzi AM, Andrade NS, Faghihi MA, Wahlestedt C.

Mol Cell Neurosci. 2017 Dec;85:183-189. doi: 10.1016/j.mcn.2017.10.003. Epub 2017 Oct 18.

PMID:
29055697
10.

Oxytocin and social functioning.

Jones C, Barrera I, Brothers S, Ring R, Wahlestedt C.

Dialogues Clin Neurosci. 2017 Jun;19(2):193-201. Review.

11.

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Esanov R, Cabrera GT, Andrade NS, Gendron TF, Brown RH Jr, Benatar M, Wahlestedt C, Mueller C, Zeier Z.

Mol Neurodegener. 2017 Jun 12;12(1):46. doi: 10.1186/s13024-017-0185-9.

12.

shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.

Khomtchouk BB, Hennessy JR, Wahlestedt C.

PLoS One. 2017 May 11;12(5):e0176334. doi: 10.1371/journal.pone.0176334. eCollection 2017.

13.

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C.

Brief Bioinform. 2017 Sep 1;18(5):905. doi: 10.1093/bib/bbx016. No abstract available.

14.

Oligonucleotide therapies for disorders of the nervous system.

Khorkova O, Wahlestedt C.

Nat Biotechnol. 2017 Mar;35(3):249-263. doi: 10.1038/nbt.3784. Epub 2017 Feb 27.

PMID:
28244991
15.

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.

Esanov R, Andrade NS, Bennison S, Wahlestedt C, Zeier Z.

Hum Mol Genet. 2016 Nov 15;25(22):4870-4880. doi: 10.1093/hmg/ddw311.

PMID:
28173181
16.

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C.

Brief Bioinform. 2018 May 1;19(3):537-543. doi: 10.1093/bib/bbw130. Erratum in: Brief Bioinform. 2017 Sep 1;18(5):905.

17.

Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation.

Gidlöf O, Johnstone AL, Bader K, Khomtchouk BB, O'Reilly JJ, Celik S, Van Booven DJ, Wahlestedt C, Metzler B, Erlinge D.

J Am Heart Assoc. 2016 Dec 22;5(12). pii: e004076. doi: 10.1161/JAHA.116.004076.

18.

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.

Wahlestedt C.

Neuropsychopharmacology. 2017 Jan;42(1):374. doi: 10.1038/npp.2016.203. No abstract available.

19.

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer.

Witt AE, Lee CW, Lee TI, Azzam DJ, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick EB, Gropper AB, Wahlestedt C, Richardson AL, Shiekhattar R, Young RA, Ince TA.

Oncogene. 2017 Mar 23;36(12):1707-1720. doi: 10.1038/onc.2016.337. Epub 2016 Oct 3.

20.

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.

Khomtchouk BB, Hennessy JR, Wahlestedt C.

BMC Bioinformatics. 2016 Sep 22;17(1):390.

21.

Reprogramming of mPFC transcriptome and function in alcohol dependence.

Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt C, Sommer WH.

Genes Brain Behav. 2017 Jan;16(1):86-100. doi: 10.1111/gbb.12344. Epub 2016 Nov 24. Review.

22.

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring.

Silva JP, Lambert G, van Booven D, Wahlestedt C.

Genome Med. 2016 Sep 8;8(1):93. doi: 10.1186/s13073-016-0348-2.

23.

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2.

Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Nätt D, Wahlestedt C, Heilig M.

Mol Psychiatry. 2017 Dec;22(12):1746-1758. doi: 10.1038/mp.2016.131. Epub 2016 Aug 30.

24.

The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.

Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A.

Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63. doi: 10.1007/s00213-016-4385-8. Epub 2016 Aug 11.

25.

Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome.

Hsiao J, Yuan TY, Tsai MS, Lu CY, Lin YC, Lee ML, Lin SW, Chang FC, Liu Pimentel H, Olive C, Coito C, Shen G, Young M, Thorne T, Lawrence M, Magistri M, Faghihi MA, Khorkova O, Wahlestedt C.

EBioMedicine. 2016 Jul;9:257-277. doi: 10.1016/j.ebiom.2016.05.011. Epub 2016 May 13.

26.

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.

Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA.

Curr Alzheimer Res. 2016;13(9):985-95.

27.

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.

St Laurent G, Vyatkin Y, Antonets D, Ri M, Qi Y, Saik O, Shtokalo D, de Hoon MJ, Kawaji H, Itoh M, Lassmann T, Arner E, Forrest AR; FANTOM consortium, Nicolas E, McCaffrey TA, Carninci P, Hayashizaki Y, Wahlestedt C, Kapranov P.

Nucleic Acids Res. 2016 Apr 20;44(7):3233-52. doi: 10.1093/nar/gkw162. Epub 2016 Mar 21.

28.

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.

Peschansky VJ, Pastori C, Zeier Z, Wentzel K, Velmeshev D, Magistri M, Silva JP, Wahlestedt C.

Mol Cell Neurosci. 2016 Jul;74:49-57. doi: 10.1016/j.mcn.2016.03.008. Epub 2016 Mar 19.

29.

Altering the course of schizophrenia: progress and perspectives.

Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D.

Nat Rev Drug Discov. 2016 Jul;15(7):485-515. doi: 10.1038/nrd.2016.28. Epub 2016 Mar 4. Review.

PMID:
26939910
30.

Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease.

Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind ER, Zabetian CP, Hu SC, Shi M, Wahlestedt C, Zhang J, Faghihi MA.

J Parkinsons Dis. 2016;6(1):109-17. doi: 10.3233/JPD-150737.

31.

Orphan diseases: state of the drug discovery art.

Volmar CH, Wahlestedt C, Brothers SP.

Wien Med Wochenschr. 2017 Jun;167(9-10):197-204. doi: 10.1007/s10354-015-0423-0. Epub 2016 Jan 27.

32.

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z.

Exp Neurol. 2016 Mar;277:171-177. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31.

33.

Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice.

Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP.

Brain Res. 2016 Feb 1;1632:34-41. doi: 10.1016/j.brainres.2015.11.044. Epub 2015 Dec 3.

34.

Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.

Sartor GC, Powell SK, Brothers SP, Wahlestedt C.

J Neurosci. 2015 Nov 11;35(45):15062-72. doi: 10.1523/JNEUROSCI.0826-15.2015.

35.

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.

Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C.

Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263. eCollection 2015.

36.

Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.

Pedram Fatemi R, Salah-Uddin S, Modarresi F, Khoury N, Wahlestedt C, Faghihi MA.

J Biomol Screen. 2015 Oct;20(9):1132-41. doi: 10.1177/1087057115594187. Epub 2015 Jul 14.

37.

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, St Laurent G, Ayad NG, Wahlestedt C.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8326-31. doi: 10.1073/pnas.1424220112. Epub 2015 Jun 25.

38.

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, Wahlestedt C.

Exp Neurol. 2015 Sep;271:241-50. doi: 10.1016/j.expneurol.2015.06.017. Epub 2015 Jun 20.

39.

Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through miR-22-Mediated ICAM-1 Inhibition.

Gidlöf O, Sathanoori R, Magistri M, Faghihi MA, Wahlestedt C, Olde B, Erlinge D.

J Vasc Res. 2015;52(2):71-80. doi: 10.1159/000431367. Epub 2015 Jun 13.

PMID:
26088024
40.

Basic biology and therapeutic implications of lncRNA.

Khorkova O, Hsiao J, Wahlestedt C.

Adv Drug Deliv Rev. 2015 Jun 29;87:15-24. doi: 10.1016/j.addr.2015.05.012. Epub 2015 May 27. Review.

41.

Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.

Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, Lotz M, Wahlestedt C.

Cell Rep. 2015 May 12;11(6):967-976. doi: 10.1016/j.celrep.2015.04.011. Epub 2015 Apr 30.

42.

The Landscape of long noncoding RNA classification.

St Laurent G, Wahlestedt C, Kapranov P.

Trends Genet. 2015 May;31(5):239-51. doi: 10.1016/j.tig.2015.03.007. Epub 2015 Apr 10. Review.

43.

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

Khomtchouk BB, Van Booven DJ, Wahlestedt C.

Source Code Biol Med. 2014 Dec 24;9(1):30. doi: 10.1186/s13029-014-0030-2. eCollection 2014.

44.

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem. 2014 Dec 19;289(51):35494-502. doi: 10.1074/jbc.M114.595348. Epub 2014 Oct 29.

45.

Emerging treatment strategies for glioblastoma multiforme.

Carlsson SK, Brothers SP, Wahlestedt C.

EMBO Mol Med. 2014 Nov;6(11):1359-70. doi: 10.15252/emmm.201302627. Review.

46.

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.

Plotkin A, Volmar CH, Wahlestedt C, Ayad N, El-Ashry D.

Breast Cancer Res Treat. 2014 Sep;147(2):249-63. doi: 10.1007/s10549-014-3093-5. Epub 2014 Aug 17.

PMID:
25129342
47.

I-BET151 selectively regulates IL-6 production.

Barrett E, Brothers S, Wahlestedt C, Beurel E.

Biochim Biophys Acta. 2014 Sep;1842(9):1549-55. doi: 10.1016/j.bbadis.2014.05.013. Epub 2014 May 22.

48.

HuD regulates coding and noncoding RNA to induce APP→Aβ processing.

Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M.

Cell Rep. 2014 Jun 12;7(5):1401-1409. doi: 10.1016/j.celrep.2014.04.050. Epub 2014 May 22.

49.

Natural antisense transcripts.

Khorkova O, Myers AJ, Hsiao J, Wahlestedt C.

Hum Mol Genet. 2014 Sep 15;23(R1):R54-63. doi: 10.1093/hmg/ddu207. Epub 2014 May 16. Review.

50.

Non-coding RNAs as direct and indirect modulators of epigenetic regulation.

Peschansky VJ, Wahlestedt C.

Epigenetics. 2014 Jan;9(1):3-12. doi: 10.4161/epi.27473. Review.

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