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Longevity-related molecular pathways are subject to midlife "switch" in humans.

Timmons JA, Volmar CH, Crossland H, Phillips BE, Sood S, Janczura KJ, Törmäkangas T, Kujala UM, Kraus WE, Atherton PJ, Wahlestedt C.

Aging Cell. 2019 Jun 6:e12970. doi: 10.1111/acel.12970. [Epub ahead of print]


Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer.

Mustafi S, Camarena V, Qureshi R, Yoon H, Volmar CH, Huff TC, Sant DW, Zheng L, Brothers SP, Wahlestedt C, Slingerland J, Wang G.

EBioMedicine. 2019 May;43:201-210. doi: 10.1016/j.ebiom.2019.04.006. Epub 2019 Apr 8.


HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons.

Bagheri A, Habibzadeh P, Razavipour SF, Volmar CH, Chee NT, Brothers SP, Wahlestedt C, Mowla SJ, Faghihi MA.

Int J Mol Sci. 2019 Mar 5;20(5). pii: E1109. doi: 10.3390/ijms20051109.


BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT.

Copsel SN, Lightbourn CO, Barreras H, Lohse I, Wolf D, Bader CS, Manov J, Kale BJ, Shah D, Brothers SP, Perez VL, Komanduri KV, Wahlestedt C, Levy RB.

Front Immunol. 2019 Jan 24;9:3104. doi: 10.3389/fimmu.2018.03104. eCollection 2018.


Precision medicine in the treatment stratification of AML patients: challenges and progress.

Lohse I, Statz-Geary K, Brothers SP, Wahlestedt C.

Oncotarget. 2018 Dec 28;9(102):37790-37797. doi: 10.18632/oncotarget.26492. eCollection 2018 Dec 28. Review.


Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue.

Janczura KJ, Volmar CH, Wahlestedt C.

J Vis Exp. 2018 Nov 30;(141). doi: 10.3791/58648.


Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG.

Nat Commun. 2018 Dec 14;9(1):5315. doi: 10.1038/s41467-018-07659-z.


Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.

Sartor GC, Malvezzi AM, Kumar A, Andrade NS, Wiedner HJ, Vilca SJ, Janczura KJ, Bagheri A, Al-Ali H, Powell SK, Brown PT, Volmar CH, Foster TC, Zeier Z, Wahlestedt C.

J Neurosci. 2019 Jan 23;39(4):612-626. doi: 10.1523/JNEUROSCI.1604-18.2018. Epub 2018 Nov 30.


Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.

Janczura KJ, Volmar CH, Sartor GC, Rao SJ, Ricciardi NR, Lambert G, Brothers SP, Wahlestedt C.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11148-E11157. doi: 10.1073/pnas.1805436115. Epub 2018 Nov 5.


Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma.

Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C.

PLoS One. 2018 Sep 13;13(9):e0203173. doi: 10.1371/journal.pone.0203173. eCollection 2018.


EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.

Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C.

Neurobiol Dis. 2018 Nov;119:149-158. doi: 10.1016/j.nbd.2018.08.005. Epub 2018 Aug 9.


Developments in lncRNA drug discovery: where are we heading?

Blokhin I, Khorkova O, Hsiao J, Wahlestedt C.

Expert Opin Drug Discov. 2018 Sep;13(9):837-849. doi: 10.1080/17460441.2018.1501024. Epub 2018 Aug 6. Review.


Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls.

Cao H, Wahlestedt C, Kapranov P.

Trends Genet. 2018 Sep;34(9):704-721. doi: 10.1016/j.tig.2018.06.002. Epub 2018 Jul 17. Review.


A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE.

Nucleic Acids Res. 2018 Sep 6;46(15):7772-7792. doi: 10.1093/nar/gky570.


Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.

Tan SK, Pastori C, Penas C, Komotar RJ, Ivan ME, Wahlestedt C, Ayad NG.

Mol Cancer. 2018 Mar 20;17(1):74. doi: 10.1186/s12943-018-0822-0.


Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Zhu W, Wang H, Wei J, Sartor GC, Bao MM, Pierce CT, Wahlestedt CR, Dykxhoorn DM, Dong C.

Hypertension. 2018 Apr;71(4):752-760. doi: 10.1161/HYPERTENSIONAHA.117.10213. Epub 2018 Feb 26.


Vitamin C Sensitizes Melanoma to BET Inhibitors.

Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G.

Cancer Res. 2018 Jan 15;78(2):572-583. doi: 10.1158/0008-5472.CAN-17-2040. Epub 2017 Nov 27.


Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.

Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, Rangwala S, Deutsch Y, Conneally E, Drusbosky L, Cogle CR, Wahlestedt C.

Leuk Res. 2018 Jan;64:34-41. doi: 10.1016/j.leukres.2017.11.008. Epub 2017 Nov 11.


Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density.

Seldeen KL, Halley PG, Volmar CH, Rodríguez MA, Hernandez M, Pang M, Carlsson SK, Suva LJ, Wahlestedt C, Troen BR, Brothers SP.

Neuropeptides. 2018 Feb;67:45-55. doi: 10.1016/j.npep.2017.11.005. Epub 2017 Nov 7.


Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.

Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC.

Blood. 2018 Jan 18;131(3):328-341. doi: 10.1182/blood-2017-06-789669. Epub 2017 Nov 7.


M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.

Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, Wahlestedt C.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9135-E9144. doi: 10.1073/pnas.1707544114. Epub 2017 Oct 9.


Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.

Sartor GC, Powell SK, Velmeshev D, Lin DY, Magistri M, Wiedner HJ, Malvezzi AM, Andrade NS, Faghihi MA, Wahlestedt C.

Mol Cell Neurosci. 2017 Dec;85:183-189. doi: 10.1016/j.mcn.2017.10.003. Epub 2017 Oct 18.


Oxytocin and social functioning.

Jones C, Barrera I, Brothers S, Ring R, Wahlestedt C.

Dialogues Clin Neurosci. 2017 Jun;19(2):193-201. Review.


A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Esanov R, Cabrera GT, Andrade NS, Gendron TF, Brown RH Jr, Benatar M, Wahlestedt C, Mueller C, Zeier Z.

Mol Neurodegener. 2017 Jun 12;12(1):46. doi: 10.1186/s13024-017-0185-9.


shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.

Khomtchouk BB, Hennessy JR, Wahlestedt C.

PLoS One. 2017 May 11;12(5):e0176334. doi: 10.1371/journal.pone.0176334. eCollection 2017.


How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C.

Brief Bioinform. 2017 Sep 1;18(5):905. doi: 10.1093/bib/bbx016. No abstract available.


Oligonucleotide therapies for disorders of the nervous system.

Khorkova O, Wahlestedt C.

Nat Biotechnol. 2017 Mar;35(3):249-263. doi: 10.1038/nbt.3784. Epub 2017 Feb 27.


The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.

Esanov R, Andrade NS, Bennison S, Wahlestedt C, Zeier Z.

Hum Mol Genet. 2016 Nov 15;25(22):4870-4880. doi: 10.1093/hmg/ddw311.


How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C.

Brief Bioinform. 2018 May 1;19(3):537-543. doi: 10.1093/bib/bbw130. Erratum in: Brief Bioinform. 2017 Sep 1;18(5):905.


Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation.

Gidlöf O, Johnstone AL, Bader K, Khomtchouk BB, O'Reilly JJ, Celik S, Van Booven DJ, Wahlestedt C, Metzler B, Erlinge D.

J Am Heart Assoc. 2016 Dec 22;5(12). pii: e004076. doi: 10.1161/JAHA.116.004076.


Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.

Wahlestedt C.

Neuropsychopharmacology. 2017 Jan;42(1):374. doi: 10.1038/npp.2016.203. No abstract available.


Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer.

Witt AE, Lee CW, Lee TI, Azzam DJ, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick EB, Gropper AB, Wahlestedt C, Richardson AL, Shiekhattar R, Young RA, Ince TA.

Oncogene. 2017 Mar 23;36(12):1707-1720. doi: 10.1038/onc.2016.337. Epub 2016 Oct 3.


MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.

Khomtchouk BB, Hennessy JR, Wahlestedt C.

BMC Bioinformatics. 2016 Sep 22;17(1):390.


Reprogramming of mPFC transcriptome and function in alcohol dependence.

Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt C, Sommer WH.

Genes Brain Behav. 2017 Jan;16(1):86-100. doi: 10.1111/gbb.12344. Epub 2016 Nov 24. Review.


Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring.

Silva JP, Lambert G, van Booven D, Wahlestedt C.

Genome Med. 2016 Sep 8;8(1):93. doi: 10.1186/s13073-016-0348-2.


Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2.

Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Nätt D, Wahlestedt C, Heilig M.

Mol Psychiatry. 2017 Dec;22(12):1746-1758. doi: 10.1038/mp.2016.131. Epub 2016 Aug 30.


The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.

Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A.

Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63. doi: 10.1007/s00213-016-4385-8. Epub 2016 Aug 11.


Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome.

Hsiao J, Yuan TY, Tsai MS, Lu CY, Lin YC, Lee ML, Lin SW, Chang FC, Liu Pimentel H, Olive C, Coito C, Shen G, Young M, Thorne T, Lawrence M, Magistri M, Faghihi MA, Khorkova O, Wahlestedt C.

EBioMedicine. 2016 Jul;9:257-277. doi: 10.1016/j.ebiom.2016.05.011. Epub 2016 May 13.


The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.

Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA.

Curr Alzheimer Res. 2016;13(9):985-95.


Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.

St Laurent G, Vyatkin Y, Antonets D, Ri M, Qi Y, Saik O, Shtokalo D, de Hoon MJ, Kawaji H, Itoh M, Lassmann T, Arner E, Forrest AR; FANTOM consortium, Nicolas E, McCaffrey TA, Carninci P, Hayashizaki Y, Wahlestedt C, Kapranov P.

Nucleic Acids Res. 2016 Apr 20;44(7):3233-52. doi: 10.1093/nar/gkw162. Epub 2016 Mar 21.


The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.

Peschansky VJ, Pastori C, Zeier Z, Wentzel K, Velmeshev D, Magistri M, Silva JP, Wahlestedt C.

Mol Cell Neurosci. 2016 Jul;74:49-57. doi: 10.1016/j.mcn.2016.03.008. Epub 2016 Mar 19.


Altering the course of schizophrenia: progress and perspectives.

Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D.

Nat Rev Drug Discov. 2016 Jul;15(7):485-515. doi: 10.1038/nrd.2016.28. Epub 2016 Mar 4. Review.


Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease.

Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind ER, Zabetian CP, Hu SC, Shi M, Wahlestedt C, Zhang J, Faghihi MA.

J Parkinsons Dis. 2016;6(1):109-17. doi: 10.3233/JPD-150737.


Orphan diseases: state of the drug discovery art.

Volmar CH, Wahlestedt C, Brothers SP.

Wien Med Wochenschr. 2017 Jun;167(9-10):197-204. doi: 10.1007/s10354-015-0423-0. Epub 2016 Jan 27.


C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z.

Exp Neurol. 2016 Mar;277:171-177. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31.


Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice.

Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP.

Brain Res. 2016 Feb 1;1632:34-41. doi: 10.1016/j.brainres.2015.11.044. Epub 2015 Dec 3.


Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.

Sartor GC, Powell SK, Brothers SP, Wahlestedt C.

J Neurosci. 2015 Nov 11;35(45):15062-72. doi: 10.1523/JNEUROSCI.0826-15.2015.


Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.

Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C.

Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263. eCollection 2015.


Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.

Pedram Fatemi R, Salah-Uddin S, Modarresi F, Khoury N, Wahlestedt C, Faghihi MA.

J Biomol Screen. 2015 Oct;20(9):1132-41. doi: 10.1177/1087057115594187. Epub 2015 Jul 14.


The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, St Laurent G, Ayad NG, Wahlestedt C.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8326-31. doi: 10.1073/pnas.1424220112. Epub 2015 Jun 25.

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