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Items: 1 to 50 of 54

1.

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.

Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C.

Elife. 2018 Nov 27;7. pii: e39720. doi: 10.7554/eLife.39720.

2.

The protein interaction networks of mucolipins and two-pore channels.

Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C.

Biochim Biophys Acta Mol Cell Res. 2018 Nov 2. pii: S0167-4889(18)30491-9. doi: 10.1016/j.bbamcr.2018.10.020. [Epub ahead of print] Review.

PMID:
30395881
3.

Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart.

Lin HA, Déan-Ben XL, Reiss M, Schöttle V, Wahl-Schott CA, Efimov IR, Razansky D.

Sci Rep. 2018 Sep 20;8(1):14132. doi: 10.1038/s41598-018-32317-1.

4.

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.

5.

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kammerbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8595-E8602. doi: 10.1073/pnas.1705739114. Epub 2017 Sep 18.

6.

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N.

Sci Rep. 2017 Aug 30;7(1):10038. doi: 10.1038/s41598-017-10607-4.

7.

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer MJM, Bruno A, Fenske S, Gruner C, Kramer F, Wachsmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A.

Pain. 2017 Oct;158(10):2012-2024. doi: 10.1097/j.pain.0000000000001005.

PMID:
28767511
8.

Small Molecules for Early Endosome-Specific Patch Clamping.

Chen CC, Butz ES, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C.

Cell Chem Biol. 2017 Jul 20;24(7):907-916.e4. doi: 10.1016/j.chembiol.2017.05.025.

9.

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.

Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C.

Nat Protoc. 2017 Aug;12(8):1639-1658. doi: 10.1038/nprot.2017.036. Epub 2017 Jul 20.

PMID:
28726848
10.

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

Böhm S, Riedmayr LM, Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E.

Sci Rep. 2017 May 24;7(1):2321. doi: 10.1038/s41598-017-02514-5.

11.

Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa.

Koch SF, Duong JK, Hsu CW, Tsai YT, Lin CS, Wahl-Schott CA, Tsang SH.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):5259-5264. doi: 10.1073/pnas.1615394114. Epub 2017 May 3. Erratum in: Proc Natl Acad Sci U S A. 2017 Jun 19;:.

12.

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Grimm C, Butz E, Chen CC, Wahl-Schott C, Biel M.

Cell Calcium. 2017 Nov;67:148-155. doi: 10.1016/j.ceca.2017.04.003. Epub 2017 Apr 23. Review.

PMID:
28457591
13.

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.

Bobak N, Feliciangeli S, Chen CC, Ben Soussia I, Bittner S, Pagnotta S, Ruck T, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F.

Sci Rep. 2017 Apr 5;7(1):649. doi: 10.1038/s41598-017-00640-8.

14.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2017 Jan 15;26(2):466. doi: 10.1093/hmg/ddw424. No abstract available.

PMID:
28365780
15.

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

Grimm C, Chen CC, Wahl-Schott C, Biel M.

Front Pharmacol. 2017 Feb 7;8:45. doi: 10.3389/fphar.2017.00045. eCollection 2017. Review.

16.

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM.

Cancer Res. 2017 Mar 15;77(6):1427-1438. doi: 10.1158/0008-5472.CAN-16-0852. Epub 2017 Jan 20.

17.

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays.

Butz ES, Ben-Johny M, Shen M, Yang PS, Sang L, Biel M, Yue DT, Wahl-Schott C.

Nat Protoc. 2016 Dec;11(12):2470-2498. doi: 10.1038/nprot.2016.128. Epub 2016 Nov 10.

PMID:
27831569
18.

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments.

Becirovic E, Böhm S, Nguyen ON, Riedmayr LM, Hammelmann V, Schön C, Butz ES, Wahl-Schott C, Biel M, Michalakis S.

Front Neurosci. 2016 Jul 28;10:356. doi: 10.3389/fnins.2016.00356. eCollection 2016.

19.

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology.

Barthmes M, Liao J, Jiang Y, Brüggemann A, Wahl-Schott C.

J Gen Physiol. 2016 Jun;147(6):485-96. doi: 10.1085/jgp.201611587.

20.

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

Nguyen ON, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandstätter JH, Wahl-Schott C, Biel M, Becirovic E.

Hum Mol Genet. 2016 Jun 15;25(12):2367-2377. Epub 2016 Mar 30.

PMID:
27033727
21.

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.

Fenske S, Pröbstle R, Auer F, Hassan S, Marks V, Pauza DH, Biel M, Wahl-Schott C.

Nat Protoc. 2016 Jan;11(1):61-86. doi: 10.1038/nprot.2015.139. Epub 2015 Dec 10.

PMID:
26658468
22.

In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

Tanimoto N, Michalakis S, Weber BH, Wahl-Schott CA, Hammes HP, Seeliger MW.

Adv Exp Med Biol. 2016;854:619-25. doi: 10.1007/978-3-319-17121-0_82.

PMID:
26427467
23.

Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation.

Alberdi A, Gomis-Perez C, Bernardo-Seisdedos G, Alaimo A, Malo C, Aldaregia J, Lopez-Robles C, Areso P, Butz E, Wahl-Schott C, Villarroel A.

J Cell Sci. 2015 Nov 1;128(21):4014-23. doi: 10.1242/jcs.176420. Epub 2015 Sep 10.

24.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A.

EMBO J. 2015 Jul 2;34(13):1743-58. doi: 10.15252/embj.201490009. Epub 2015 Apr 14.

25.

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA.

Science. 2015 Feb 27;347(6225):995-8. doi: 10.1126/science.1258758.

26.

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.

PMID:
25144390
27.

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C.

Nat Commun. 2014 Aug 14;5:4681. doi: 10.1038/ncomms5681.

PMID:
25119295
28.

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury.

Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R.

PLoS One. 2014 Jul 29;9(7):e103402. doi: 10.1371/journal.pone.0103402. eCollection 2014.

29.

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.

Becirovic E, Nguyen ON, Paparizos C, Butz ES, Stern-Schneider G, Wolfrum U, Hauck SM, Ueffing M, Wahl-Schott C, Michalakis S, Biel M.

Hum Mol Genet. 2014 Nov 15;23(22):5989-97. doi: 10.1093/hmg/ddu323. Epub 2014 Jun 24.

PMID:
24963162
30.

TRPML3.

Grimm C, Barthmes M, Wahl-Schott C.

Handb Exp Pharmacol. 2014;222:659-74. doi: 10.1007/978-3-642-54215-2_26. Review.

PMID:
24756725
31.

Studying mechanosensitive ion channels with an automated patch clamp.

Barthmes M, Jose MD, Birkner JP, Brüggemann A, Wahl-Schott C, Koçer A.

Eur Biophys J. 2014 Mar;43(2-3):97-104. doi: 10.1007/s00249-014-0944-2. Epub 2014 Feb 14.

PMID:
24526306
32.

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I.

Mol Biol Cell. 2014 Mar;25(6):948-64. doi: 10.1091/mbc.E13-09-0523. Epub 2014 Jan 22.

33.

HCN channels: new roles in sinoatrial node function.

Wahl-Schott C, Fenske S, Biel M.

Curr Opin Pharmacol. 2014 Apr;15:83-90. doi: 10.1016/j.coph.2013.12.005. Epub 2014 Jan 20. Review.

PMID:
24441197
34.

Sick sinus syndrome in HCN1-deficient mice.

Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA.

Circulation. 2013 Dec 17;128(24):2585-94. doi: 10.1161/CIRCULATIONAHA.113.003712. Epub 2013 Nov 11.

PMID:
24218458
35.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garcia Garrido M, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2014 Mar 15;23(6):1538-50. doi: 10.1093/hmg/ddt541. Epub 2013 Oct 26. Erratum in: Hum Mol Genet. 2017 Jan 15;26(2):466.

36.

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

Cao-Ehlker X, Zong X, Hammelmann V, Gruner C, Fenske S, Michalakis S, Wahl-Schott C, Biel M.

J Biol Chem. 2013 Mar 15;288(11):7580-9. doi: 10.1074/jbc.M112.434803. Epub 2013 Feb 4.

37.

Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).

Shaltiel L, Paparizos C, Fenske S, Hassan S, Gruner C, Rötzer K, Biel M, Wahl-Schott CA.

J Biol Chem. 2012 Oct 19;287(43):36312-21. doi: 10.1074/jbc.M112.392811. Epub 2012 Aug 30.

38.

Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model.

Direnberger S, Mues M, Micale V, Wotjak CT, Dietzel S, Schubert M, Scharr A, Hassan S, Wahl-Schott C, Biel M, Krishnamoorthy G, Griesbeck O.

Nat Commun. 2012;3:1031. doi: 10.1038/ncomms2035.

PMID:
22929788
39.

The role of HCN channels in ventricular repolarization.

Fenske S, Krause S, Biel M, Wahl-Schott C.

Trends Cardiovasc Med. 2011 Nov;21(8):216-20. doi: 10.1016/j.tcm.2012.05.013. Review.

PMID:
22902068
40.

Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.

Zong X, Krause S, Chen CC, Krüger J, Gruner C, Cao-Ehlker X, Fenske S, Wahl-Schott C, Biel M.

J Biol Chem. 2012 Aug 3;287(32):26506-12. doi: 10.1074/jbc.M112.357129. Epub 2012 Jun 19.

41.

Role of TRPML and two-pore channels in endolysosomal cation homeostasis.

Grimm C, Hassan S, Wahl-Schott C, Biel M.

J Pharmacol Exp Ther. 2012 Aug;342(2):236-44. doi: 10.1124/jpet.112.192880. Epub 2012 Apr 19.

42.

HCN3 contributes to the ventricular action potential waveform in the murine heart.

Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Hofmann F, Wahl-Schott C, Biel M.

Circ Res. 2011 Oct 14;109(9):1015-23. doi: 10.1161/CIRCRESAHA.111.246173. Epub 2011 Sep 8.

PMID:
21903939
43.

Planar patch clamp approach to characterize ionic currents from intact lysosomes.

Schieder M, Rötzer K, Brüggemann A, Biel M, Wahl-Schott C.

Sci Signal. 2010 Dec 7;3(151):pl3. doi: 10.1126/scisignal.3151pl3.

PMID:
21139138
44.

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

Schieder M, Rötzer K, Brüggemann A, Biel M, Wahl-Schott CA.

J Biol Chem. 2010 Jul 9;285(28):21219-22. doi: 10.1074/jbc.C110.143123. Epub 2010 May 21.

45.

Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels.

Griessmeier K, Cuny H, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.

J Biol Chem. 2009 Oct 23;284(43):29809-16. doi: 10.1074/jbc.M109.048082. Epub 2009 Aug 28.

46.

Hyperpolarization-activated cation channels: from genes to function.

Biel M, Wahl-Schott C, Michalakis S, Zong X.

Physiol Rev. 2009 Jul;89(3):847-85. doi: 10.1152/physrev.00029.2008. Review.

47.

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.

Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.

Pflugers Arch. 2009 Sep;458(5):891-9. doi: 10.1007/s00424-009-0690-y. Epub 2009 Jun 26.

48.

HCN channels: structure, cellular regulation and physiological function.

Wahl-Schott C, Biel M.

Cell Mol Life Sci. 2009 Feb;66(3):470-94. doi: 10.1007/s00018-008-8525-0. Review.

PMID:
18953682
49.

Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain.

Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15657-62. Epub 2006 Oct 6.

50.

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.

Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z, Biel M.

J Biol Chem. 2005 Oct 7;280(40):34224-32. Epub 2005 Aug 3.

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