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APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT.

Cell Rep. 2019 Apr 30;27(5):1345-1355.e6. doi: 10.1016/j.celrep.2019.03.087.


Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.

Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G.

J Biol Chem. 2019 Mar 22;294(12):4477-4487. doi: 10.1074/jbc.RA118.006379. Epub 2019 Jan 28.


Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.

van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB.

Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24.


Preneoplastic Lesion in a Pancreas Allograft: Dilemma for the Pancreas Transplant Surgeon.

Serrano OK, Wagner SL, Sun S, Kandaswamy R.

Transplant Proc. 2018 Dec;50(10):3694-3697. doi: 10.1016/j.transproceed.2018.06.047. Epub 2018 Jun 30.


Sleep Duration and Obesity in Children and Adolescents.

Sluggett L, Wagner SL, Harris RL.

Can J Diabetes. 2019 Mar;43(2):146-152. doi: 10.1016/j.jcjd.2018.06.006. Epub 2018 Jul 4. Review.


Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.

Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9665-E9674. doi: 10.1073/pnas.1708568114. Epub 2017 Oct 23.


Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C.

EBioMedicine. 2017 Oct;24:93-101. doi: 10.1016/j.ebiom.2017.08.028. Epub 2017 Sep 4.


Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.

Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE.

J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. doi: 10.1124/jpet.117.240861. Epub 2017 Apr 17.


Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.

Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3928-37. doi: 10.1016/j.bmcl.2016.07.011. Epub 2016 Jul 6.


Associations between Sleep Duration and Indicators of Cardiometabolic Disease in Canadian Children and Adolescents: Analyses of the 2007-2009 Canadian Health Measures Survey.

Sluggett L, Wagner SL, Hardy C, Harris RL.

Child Obes. 2016 Oct;12(5):325-33. doi: 10.1089/chi.2015.0214. Epub 2016 May 19.


Physical Activity and Exercise Interventions in the Workplace Impacting Work Outcomes: A Stakeholder-Centered Best Evidence Synthesis of Systematic Reviews.

White MI, Dionne CE, Wärje O, Koehoorn M, Wagner SL, Schultz IZ, Koehn C, Williams-Whitt K, Harder HG, Pasca R, Hsu V, McGuire L, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2016 Apr;7(2):61-74. doi: 10.15171/ijoem.2016.739. Review.


Mental Health Interventions in the Workplace and Work Outcomes: A Best-Evidence Synthesis of Systematic Reviews.

Wagner SL, Koehn C, White MI, Harder HG, Schultz IZ, Williams-Whitt K, Warje O, Dionne CE, Koehoorn M, Pasca R, Hsu V, McGuire L, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2016 Jan;7(1):1-14. doi: 10.15171/ijoem.2016.607. Review.


Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.

Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S.

Nat Neurosci. 2016 Jan;19(1):55-64. doi: 10.1038/nn.4188. Epub 2015 Dec 7.


Social Support and Supervisory Quality Interventions in the Workplace: A Stakeholder-Centered Best-Evidence Synthesis of Systematic Reviews on Work Outcomes.

Wagner SL, White MI, Schultz IZ, Williams-Whitt K, Koehn C, Dionne CE, Koehoorn M, Harder HG, Pasca R, Wärje O, Hsu V, McGuire L, Lama I, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2015 Oct;6(4):189-204. doi: 10.15171/ijoem.2015.608. Review.


Non-modifiable worker and workplace risk factors contributing to workplace absence: A stakeholder-centred synthesis of systematic reviews.

White MI, Wagner SL, Schultz IZ, Murray E, Bradley SM, Hsu V, McGuire L, Schulz W.

Work. 2015;52(2):353-73. doi: 10.3233/WOR-152134. Review.


[Formula: see text]Higher cortisol is associated with poorer executive functioning in preschool children: The role of parenting stress, parent coping and quality of daycare.

Wagner SL, Cepeda I, Krieger D, Maggi S, D'Angiulli A, Weinberg J, Grunau RE.

Child Neuropsychol. 2016;22(7):853-69. doi: 10.1080/09297049.2015.1080232. Epub 2015 Sep 3.


Characteristics of the traumatic stressors experienced by rural first responders.

Regambal MJ, Alden LE, Wagner SL, Harder HG, Koch WJ, Fung K, Parsons C.

J Anxiety Disord. 2015 Aug;34:86-93. doi: 10.1016/j.janxdis.2015.06.006. Epub 2015 Jul 2.


γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation.

D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM.

FASEB J. 2015 Aug;29(8):3335-41. doi: 10.1096/fj.15-271015. Epub 2015 Apr 22.


Job demand and control interventions: a stakeholder-centered best-evidence synthesis of systematic reviews on workplace disability.

Williams-Whitt K, White MI, Wagner SL, Schultz IZ, Koehn C, Dionne CE, Koehoorn M, Harder H, Pasca R, Warje O, Hsu V, McGuire L, Schulz W, Kube D, Hook A, Wright MD.

Int J Occup Environ Med. 2015 Apr;6(2):61-78. doi: 10.15171/ijoem.2015.553. Review.


A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.

Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C.

PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015.


A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.

Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS.

J Biol Chem. 2014 Dec 12;289(50):34851-61. doi: 10.1074/jbc.M114.609636. Epub 2014 Oct 28.


A three-dimensional human neural cell culture model of Alzheimer's disease.

Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY.

Nature. 2014 Nov 13;515(7526):274-8. doi: 10.1038/nature13800. Epub 2014 Oct 12.


Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.

Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH.

JAMA Neurol. 2014 Dec;71(12):1481-9. doi: 10.1001/jamaneurol.2014.2482.


Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE.

Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22.


Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion.

Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G.

J Biol Chem. 2013 Sep 13;288(37):26955-66. doi: 10.1074/jbc.M113.473355. Epub 2013 Jul 31.


Potential use of γ-secretase modulators in the treatment of Alzheimer disease.

Wagner SL, Tanzi RE, Mobley WC, Galasko D.

Arch Neurol. 2012 Oct;69(10):1255-8. Review.


Effects of a Web-based intervention for adults with chronic conditions on patient activation: online randomized controlled trial.

Solomon M, Wagner SL, Goes J.

J Med Internet Res. 2012 Feb 21;14(1):e32. doi: 10.2196/jmir.1924.


Auxin-induced leaf blade expansion in Arabidopsis requires both wounding and detachment.

Keller CP, Grundstad ML, Evanoff MA, Keith JD, Lentz DS, Wagner SL, Culler AH, Cohen JD.

Plant Signal Behav. 2011 Dec;6(12):1997-2007.


Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.


Occupational stress in the multicultural workplace.

Pasca R, Wagner SL.

J Immigr Minor Health. 2011 Aug;13(4):697-705. doi: 10.1007/s10903-011-9457-6. Review.


And four equals one: presenilin takes the gamma-secretase role by itself.

Lessard CB, Wagner SL, Koo EH.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21236-7. doi: 10.1073/pnas.1016284108. Epub 2010 Dec 6. No abstract available.


Work disability prevention in rural healthcare workers.

Franche RL, Murray EJ, Ostry A, Ratner PA, Wagner SL, Harder HG.

Rural Remote Health. 2010 Oct-Dec;10(4):1502. Epub 2010 Oct 16. Review.


Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G.

J Biol Chem. 2010 Dec 3;285(49):38042-52. doi: 10.1074/jbc.M110.132613. Epub 2010 Oct 4.


Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL.

Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018.


Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC.

Sci Transl Med. 2009 Nov 18;1(7):7ra17. doi: 10.1126/scitranslmed.3000258.


A biopsychosocial perspective on the management of work-related musculoskeletal disorders.

Noonan J, Wagner SL.

AAOHN J. 2010 Mar;58(3):105-14; quiz 115-6. doi: 10.3928/08910162-20100224-01. Review.


NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.

Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K.

J Clin Invest. 2009 Dec;119(12):3692-702. doi: 10.1172/JCI39716. Epub 2009 Nov 9.


Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE.

Hum Mol Genet. 2009 Oct 15;18(20):3987-96. doi: 10.1093/hmg/ddp323. Epub 2009 Jul 15.


Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE.

Am J Hum Genet. 2008 Nov;83(5):623-32. doi: 10.1016/j.ajhg.2008.10.008. Epub 2008 Oct 30.


Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?

Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE.

J Med Genet. 2007 Jan;44(1):e63.


Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.

Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE.

J Biol Chem. 2006 Oct 27;281(43):32240-53. Epub 2006 Aug 31.


Physician-stakeholder collaboration in Disability Management: a Canadian perspective on guidelines and expectations.

Reynolds CA, Wagner SL, Harder HG.

Disabil Rehabil. 2006 Aug 15;28(15):955-63.


Emergency response service personnel and the critical incident stress debriefing debate.

Wagner SL.

Int J Emerg Ment Health. 2005 Winter;7(1):33-41. Review.


STIM1, an essential and conserved component of store-operated Ca2+ channel function.

Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA.

J Cell Biol. 2005 May 9;169(3):435-45. Epub 2005 May 2.


Family-based association between Alzheimer's disease and variants in UBQLN1.

Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE.

N Engl J Med. 2005 Mar 3;352(9):884-94.


Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL.

Biochem Pharmacol. 2005 Feb 15;69(4):689-98. Epub 2005 Jan 7.


ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.

Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB.

J Biol Chem. 2004 Dec 24;279(52):54216-20. Epub 2004 Oct 19.


Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

Tanzi RE, Moir RD, Wagner SL.

Neuron. 2004 Sep 2;43(5):605-8. Review.


Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR.

Hum Mol Genet. 2004 Jan 15;13(2):159-70. Epub 2003 Nov 25.


Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.

Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D.

Hum Mol Genet. 2003 Nov 1;12(21):2765-76. Epub 2003 Sep 9.


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