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Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry.

Byford E, Carr M, Piñon L, Ahearne MJ, Wagner SD.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58431.


Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma.

Mamand S, Allchin RL, Ahearne MJ, Wagner SD.

Sci Rep. 2018 Sep 21;8(1):14216. doi: 10.1038/s41598-018-32634-5.


PD1hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma.

Wickenden K, Nawaz N, Mamand S, Kotecha D, Wilson AL, Wagner SD, Ahearne MJ.

Diagn Pathol. 2018 Sep 15;13(1):74. doi: 10.1186/s13000-018-0750-8.


CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM.

Lezina L, Spriggs RV, Beck D, Jones C, Dudek KM, Bzura A, Jones GDD, Packham G, Willis AE, Wagner SD.

Blood Adv. 2018 Aug 14;2(15):1869-1881. doi: 10.1182/bloodadvances.2017015560.


An increased fraction of circulating miR-363 and miR-16 is particle bound in patients with chronic lymphocytic leukaemia as compared to normal subjects.

Alharthi A, Beck D, Howard DR, Hillmen P, Oates M, Pettitt A, Wagner SD.

BMC Res Notes. 2018 May 8;11(1):280. doi: 10.1186/s13104-018-3391-9.


Clonal evolution in the transition from cutaneous disease to acute leukemia suggested by liquid biopsy in blastic plasmacytoid dendritic cell neoplasm.

Ladikou E, Ottolini B, Nawaz N, Allchin RL, Payne D, Ali H, Marafioti T, Shaw J, Ahearne MJ, Wagner SD.

Haematologica. 2018 May;103(5):e196-e199. doi: 10.3324/haematol.2017.171876. Epub 2018 Feb 1. No abstract available.


Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient.

Joffe M, Wagner SD, Tang JW.

BMC Infect Dis. 2018 Jan 27;18(1):58. doi: 10.1186/s12879-018-2962-7.


Circulating Tfh1 (cTfh1) cell numbers and PD1 expression are elevated in low-grade B-cell non-Hodgkin's lymphoma and cTfh gene expression is perturbed in marginal zone lymphoma.

Byford ET, Carr M, Ladikou E, Ahearne MJ, Wagner SD.

PLoS One. 2018 Jan 2;13(1):e0190468. doi: 10.1371/journal.pone.0190468. eCollection 2018.


Backbone resonance assignment of the BCL6-BTB/POZ domain.

Lin LY, Evans SE, Fairall L, Schwabe JWR, Wagner SD, Muskett FW.

Biomol NMR Assign. 2018 Apr;12(1):47-50. doi: 10.1007/s12104-017-9778-z. Epub 2017 Sep 19.


POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with the human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.

Pero R, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M.

J Biol Chem. 2017 Mar 31;292(13):5609. doi: 10.1074/jbc.A117.346270. No abstract available.


Developmental effects of fipronil on Japanese Medaka (Oryzias latipes) embryos.

Wagner SD, Kurobe T, Hammock BG, Lam CH, Wu G, Vasylieva N, Gee SJ, Hammock BD, Teh SJ.

Chemosphere. 2017 Jan;166:511-520. doi: 10.1016/j.chemosphere.2016.09.069. Epub 2016 Oct 3.


Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy.

Wagner SD, Struck AJ, Gupta R, Farnsworth DR, Mahady AE, Eichinger K, Thornton CA, Wang ET, Berglund JA.

PLoS Genet. 2016 Sep 28;12(9):e1006316. doi: 10.1371/journal.pgen.1006316. eCollection 2016 Sep.


IL-4, IgM, and resistance to BTKi and PI3Kδi in CLL.

Wagner SD.

Blood. 2016 Jun 16;127(24):2944-6. doi: 10.1182/blood-2016-04-708180. No abstract available.


Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.

Beck D, Zobel J, Barber R, Evans S, Lezina L, Allchin RL, Blades M, Elliott R, Lord CJ, Ashworth A, Porter AC, Wagner SD.

J Biol Chem. 2016 Aug 5;291(32):16686-98. doi: 10.1074/jbc.M116.736868. Epub 2016 Jun 6.


A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.

Sbarrato T, Horvilleur E, Pöyry T, Hill K, Chaplin LC, Spriggs RV, Stoneley M, Wilson L, Jayne S, Vulliamy T, Beck D, Dokal I, Dyer MJ, Yeomans AM, Packham G, Bushell M, Wagner SD, Willis AE.

Cell Death Dis. 2016 Jun 2;7(6):e2249. doi: 10.1038/cddis.2016.148.


Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells.

Smallwood DT, Apollonio B, Willimott S, Lezina L, Alharthi A, Ambrose AR, De Rossi G, Ramsay AG, Wagner SD.

Blood. 2016 Jul 28;128(4):542-52. doi: 10.1182/blood-2015-11-682377. Epub 2016 Apr 26.


Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.

Siboni RB, Nakamori M, Wagner SD, Struck AJ, Coonrod LA, Harriott SA, Cass DM, Tanner MK, Berglund JA.

Cell Rep. 2015 Dec 22;13(11):2386-2394. doi: 10.1016/j.celrep.2015.11.028. Epub 2015 Dec 10.


Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.

Blood. 2016 Jan 28;127(4):449-57. doi: 10.1182/blood-2015-07-660969. Epub 2015 Oct 21.


A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome.

Sanders L, Jayne S, Kennedy B, Miall F, Aukema SM, Siebert R, Wagner SD, Dyer MJ.

Case Rep Hematol. 2014;2014:120714. doi: 10.1155/2014/120714. Epub 2014 Oct 1.


Bone marrow assessment in asymptomatic IgM monoclonal gammopathies - reply to Varettoni et al.

Owen RG, Pratt G, Auer RL, Flatley R, Kyriakou C, Lunn MP, Matthey F, McCarthy H, McNicholl FP, Rassam SM, Wagner SD, Streetly M, D'Sa S; British Committee for Standards in Haematology.

Br J Haematol. 2015 Jan;168(2):302-3. doi: 10.1111/bjh.13095. Epub 2014 Aug 27. No abstract available.


Targeting primary mediastinal B-cell lymphoma.

Wagner SD.

Oncotarget. 2014 Aug 30;5(16):6552-3. No abstract available.


Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma.

Ahearne MJ, Bhuller K, Hew R, Ibrahim H, Naresh K, Wagner SD.

Virchows Arch. 2014 Sep;465(3):351-8. doi: 10.1007/s00428-014-1615-5. Epub 2014 Jul 11.


Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment.

Ahearne MJ, Allchin RL, Fox CP, Wagner SD.

Br J Haematol. 2014 Aug;166(3):326-35. doi: 10.1111/bjh.12941. Epub 2014 May 12. Review.


The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD.

PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection 2014.


Alternative pre-mRNA splicing.

Wagner SD, Berglund JA.

Methods Mol Biol. 2014;1126:45-54. doi: 10.1007/978-1-62703-980-2_4.


Guidelines on the diagnosis and management of Waldenström macroglobulinaemia.

Owen RG, Pratt G, Auer RL, Flatley R, Kyriakou C, Lunn MP, Matthey F, McCarthy H, McNicholl FP, Rassam SM, Wagner SD, Streetly M, D'Sa S; British Committee for Standards in Haematology.

Br J Haematol. 2014 May;165(3):316-33. doi: 10.1111/bjh.12760. Epub 2014 Feb 15. No abstract available.


Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus.

Batlle-López A, Cortiguera MG, Rosa-Garrido M, Blanco R, del Cerro E, Torrano V, Wagner SD, Delgado MD.

Oncogene. 2015 Jan 8;34(2):246-56. doi: 10.1038/onc.2013.535. Epub 2013 Dec 23.


Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia.

Ahearne MJ, Willimott S, Piñon L, Kennedy DB, Miall F, Dyer MJ, Wagner SD.

Br J Haematol. 2013 Aug;162(3):360-70. doi: 10.1111/bjh.12401. Epub 2013 May 27.


Cap-translation inhibitor, 4EGI-1, restores sensitivity to ABT-737 apoptosis through cap-dependent and -independent mechanisms in chronic lymphocytic leukemia.

Willimott S, Beck D, Ahearne MJ, Adams VC, Wagner SD.

Clin Cancer Res. 2013 Jun 15;19(12):3212-23. doi: 10.1158/1078-0432.CCR-12-2185. Epub 2013 Apr 30.


RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA.

Wagner SD, Yakovchuk P, Gilman B, Ponicsan SL, Drullinger LF, Kugel JF, Goodrich JA.

EMBO J. 2013 Mar 20;32(6):781-90. doi: 10.1038/emboj.2013.18. Epub 2013 Feb 8.


POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.

Pero R, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M.

J Biol Chem. 2012 May 25;287(22):18308-17. doi: 10.1074/jbc.M112.346270. Epub 2012 Apr 9. Retraction in: J Biol Chem. 2017 Mar 31;292(13):5609.


miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells.

Willimott S, Wagner SD.

J Biol Chem. 2012 Jan 20;287(4):2608-17. doi: 10.1074/jbc.M111.285718. Epub 2011 Dec 2.


Stromal cells and CD40 ligand (CD154) alter the miRNome and induce miRNA clusters including, miR-125b/miR-99a/let-7c and miR-17-92 in chronic lymphocytic leukaemia.

Willimott S, Wagner SD.

Leukemia. 2012 May;26(5):1113-6. doi: 10.1038/leu.2011.299. Epub 2011 Oct 25. No abstract available.


Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant.

Stadler LK, Hoffmann T, Tomlinson DC, Song Q, Lee T, Busby M, Nyathi Y, Gendra E, Tiede C, Flanagan K, Cockell SJ, Wipat A, Harwood C, Wagner SD, Knowles MA, Davis JJ, Keegan N, Ferrigno PK.

Protein Eng Des Sel. 2011 Sep;24(9):751-63. doi: 10.1093/protein/gzr019. Epub 2011 May 25.


TP53 codon 72 polymorphism in patients with chronic lymphocytic leukaemia: identification of a subgroup with mutated IGHV genes and poor clinical outcome.

Majid A, Richards T, Dusanjh P, Kennedy DB, Miall F, Gesk S, Siebert R, Wagner SD, Dyer MJ.

Br J Haematol. 2011 May;153(4):533-5. doi: 10.1111/j.1365-2141.2010.08484.x. Epub 2011 Feb 17. No abstract available.


Apoptosis induces Bcl-XS and cleaved Bcl-XL in chronic lymphocytic leukaemia.

Willimott S, Merriam T, Wagner SD.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):480-5. doi: 10.1016/j.bbrc.2011.01.057. Epub 2011 Jan 20.


Post-transcriptional and post-translational regulation of Bcl2.

Willimott S, Wagner SD.

Biochem Soc Trans. 2010 Dec;38(6):1571-5. doi: 10.1042/BST0381571. Review.


The role of BCL6 in lymphomas and routes to therapy.

Wagner SD, Ahearne M, Ko Ferrigno P.

Br J Haematol. 2011 Jan;152(1):3-12. doi: 10.1111/j.1365-2141.2010.08420.x. Epub 2010 Nov 18. Review.


Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant.

Hoffmann T, Stadler LK, Busby M, Song Q, Buxton AT, Wagner SD, Davis JJ, Ko Ferrigno P.

Protein Eng Des Sel. 2010 May;23(5):403-13. doi: 10.1093/protein/gzq012. Epub 2010 Feb 23.


ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.

Papadopoulou V, Postigo A, Sánchez-Tilló E, Porter AC, Wagner SD.

Biochem J. 2010 Apr 14;427(3):541-50. doi: 10.1042/BJ20091578.


TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain.

Wagner SD, Kugel JF, Goodrich JA.

Mol Cell Biol. 2010 Jan;30(1):91-7. doi: 10.1128/MCB.01115-09.


Specific patterns of chromosomal gains and losses associate with t(3;14), t(8;14), and t(14;18) in diffuse large B-cell lymphoma.

Sheth A, de Melo VA, Szydlo R, Macdonald DH, Reid AG, Wagner SD.

Cancer Genet Cytogenet. 2009 Oct;194(1):48-52. doi: 10.1016/j.cancergencyto.2009.05.011.


CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression.

Batlle A, Papadopoulou V, Gomes AR, Willimott S, Melo JV, Naresh K, Lam EW, Wagner SD.

Mol Immunol. 2009 May;46(8-9):1727-35. doi: 10.1016/j.molimm.2009.02.003. Epub 2009 Mar 6.


Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.

Ambrose HE, Willimott S, Beswick RW, Dantzer F, de Murcia JM, Yelamos J, Wagner SD.

Immunology. 2009 Jun;127(2):178-86. doi: 10.1111/j.1365-2567.2008.02921.x. Epub 2008 Sep 4.


Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock.

Mariner PD, Walters RD, Espinoza CA, Drullinger LF, Wagner SD, Kugel JF, Goodrich JA.

Mol Cell. 2008 Feb 29;29(4):499-509. doi: 10.1016/j.molcel.2007.12.013.


Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.

Willimott S, Baou M, Huf S, Deaglio S, Wagner SD.

Haematologica. 2007 Oct;92(10):1359-66.


V lambda genes in chronic lymphocytic leukaemia: highly skewed V gene segment usage with similar CDR3 sequences.

Abusedra A, Joshi R, Bybee A, Apperley JF, Wagner SD.

Leukemia. 2008 May;22(5):1073-5. Epub 2007 Nov 1. No abstract available.


CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia.

Willimott S, Baou M, Naresh K, Wagner SD.

Br J Haematol. 2007 Sep;138(6):721-32.


Separate cell culture conditions to promote proliferation or quiescent cell survival in chronic lymphocytic leukemia.

Willimott S, Baou M, Huf S, Wagner SD.

Leuk Lymphoma. 2007 Aug;48(8):1647-50. No abstract available.


Bcl-6 and c-Myc are rarely co-expressed in adult diffuse large B-cell lymphoma.

Wagner SD, Amen F, Trivedi PS, Horncastle D, Elderfield K, Naresh KN.

Leuk Lymphoma. 2007 Aug;48(8):1510-3.


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