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Items: 1 to 50 of 99

1.

Novel ultrasonic in-die measurements during powder compression at production relevant speed.

Hagelstein V, Frindt B, Hucke M, Pieper J, Carstens J, Lammens RF, Wagner KG.

Int J Pharm. 2019 Nov 25;571:118761. doi: 10.1016/j.ijpharm.2019.118761. Epub 2019 Oct 14.

PMID:
31622743
2.

Correction: Sophia, B.; et al. Presenting Precision Glycomacromolecules on Gold Nanoparticles for Increased Lectin Binding. Polymers 2017, 9, 716.

Boden S, Wagner KG, Karg M, Hartmann L.

Polymers (Basel). 2019 Aug 30;11(9). pii: E1426. doi: 10.3390/polym11091426.

3.

Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution.

Steffens KE, Wagner KG.

Int J Pharm. 2019 Oct 30;570:118649. doi: 10.1016/j.ijpharm.2019.118649. Epub 2019 Aug 28.

PMID:
31472217
4.

A MedChem toolbox for cereblon-directed PROTACs.

Steinebach C, Sosič I, Lindner S, Bricelj A, Kohl F, Ng YLD, Monschke M, Wagner KG, Krönke J, Gütschow M.

Medchemcomm. 2019 May 28;10(6):1037-1041. doi: 10.1039/c9md00185a. eCollection 2019 Jun 1.

PMID:
31304001
5.

Holistic QbD approach for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling.

Evans RC, Bochmann ES, Kyeremateng SO, Gryczke A, Wagner KG.

Eur J Pharm Biopharm. 2019 Aug;141:149-160. doi: 10.1016/j.ejpb.2019.05.021. Epub 2019 May 24.

PMID:
31132400
6.

Micro-scale solubility assessments and prediction models for active pharmaceutical ingredients in polymeric matrices.

Bochmann ES, Neumann D, Gryczke A, Wagner KG.

Eur J Pharm Biopharm. 2019 Aug;141:111-120. doi: 10.1016/j.ejpb.2019.05.012. Epub 2019 May 14.

PMID:
31100430
7.

Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.

Monschke M, Wagner KG.

Int J Pharm. 2019 Jun 10;564:162-170. doi: 10.1016/j.ijpharm.2019.04.034. Epub 2019 Apr 13.

PMID:
30991134
8.

Modeling, design and manufacture of innovative floating gastroretentive drug delivery systems based on hot-melt extruded tubes.

Simons FJ, Wagner KG.

Eur J Pharm Biopharm. 2019 Apr;137:196-208. doi: 10.1016/j.ejpb.2019.02.022. Epub 2019 Feb 28.

PMID:
30826475
9.

PROTAC-mediated crosstalk between E3 ligases.

Steinebach C, Kehm H, Lindner S, Vu LP, Köpff S, López Mármol Á, Weiler C, Wagner KG, Reichenzeller M, Krönke J, Gütschow M.

Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824. doi: 10.1039/c8cc09541h.

PMID:
30672516
10.

Mechanistic study on hydrodynamics in the mini-scale biphasic dissolution model and its influence on in vitro dissolution and partitioning.

Locher K, Borghardt JM, Wachtel H, Schaefer KJ, Wagner KG.

Eur J Pharm Sci. 2018 Nov 1;124:328-338. doi: 10.1016/j.ejps.2018.09.005. Epub 2018 Sep 6.

PMID:
30195650
11.

Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation.

Bochmann ES, Gryczke A, Wagner KG.

Pharmaceutics. 2018 Aug 18;10(3). pii: E132. doi: 10.3390/pharmaceutics10030132.

12.

Team Approach: Timing of Operative Intervention in Multiply-Injured Patients.

Vallier HA, Como JJ, Wagner KG, Moore TA.

JBJS Rev. 2018 Aug;6(8):e2. doi: 10.2106/JBJS.RVW.17.00171. Review. No abstract available.

PMID:
30085943
13.

Tricalcium citrate - a new brittle tableting excipient for direct compression and dry granulation with enormous hardness yield.

Hagelstein V, Gerhart M, Wagner KG.

Drug Dev Ind Pharm. 2018 Oct;44(10):1631-1641. doi: 10.1080/03639045.2018.1483389. Epub 2018 Jul 4.

PMID:
29916271
14.

Development and Performance of a Highly Sensitive Model Formulation Based on Torasemide to Enhance Hot-Melt Extrusion Process Understanding and Process Development.

Evans RC, Kyeremateng SO, Asmus L, Degenhardt M, Rosenberg J, Wagner KG.

AAPS PharmSciTech. 2018 May;19(4):1592-1605. doi: 10.1208/s12249-018-0970-y. Epub 2018 Feb 27.

PMID:
29488197
15.

From benchtop to pilot scale-experimental study and computational assessment of a hot-melt extrusion scale-up of a solid dispersion of dipyridamole and copovidone.

Zecevic DE, Evans RC, Paulsen K, Wagner KG.

Int J Pharm. 2018 Feb 15;537(1-2):132-139. doi: 10.1016/j.ijpharm.2017.12.033. Epub 2017 Dec 15.

PMID:
29253586
16.

Presenting Precision Glycomacromolecules on Gold Nanoparticles for Increased Lectin Binding.

Boden S, Wagner KG, Karg M, Hartmann L.

Polymers (Basel). 2017 Dec 14;9(12). pii: E716. doi: 10.3390/polym9120716. Erratum in: Polymers (Basel). 2019 Aug 30;11(9):.

17.

Numerical simulation of hot-melt extrusion processes for amorphous solid dispersions using model-based melt viscosity.

Bochmann ES, Steffens KE, Gryczke A, Wagner KG.

Eur J Pharm Biopharm. 2018 Mar;124:34-42. doi: 10.1016/j.ejpb.2017.12.001. Epub 2017 Dec 6.

PMID:
29221654
18.

Synthesis and Optical Properties of Phenanthroline-Derived Schiff Base-Like Dinuclear RuII -NiII Complexes.

Kurz H, Lochenie C, Wagner KG, Schneider S, Karg M, Weber B.

Chemistry. 2018 Apr 6;24(20):5100-5111. doi: 10.1002/chem.201704632. Epub 2018 Jan 5.

PMID:
29143988
19.

Predicting melt rheology for hot-melt extrusion by means of a simple Tg-measurement.

Bochmann ES, Üstüner EE, Gryczke A, Wagner KG.

Eur J Pharm Biopharm. 2017 Oct;119:47-55. doi: 10.1016/j.ejpb.2017.05.010. Epub 2017 May 19.

PMID:
28532677
20.

Prediction of solid fraction from powder mixtures based on single component compression analysis.

Schmidtke R, Schröder D, Menth J, Staab A, Braun M, Wagner KG.

Int J Pharm. 2017 May 15;523(1):366-375. doi: 10.1016/j.ijpharm.2017.03.054. Epub 2017 Mar 25.

PMID:
28347849
21.

Fully Reversible Quantitative Phase Transfer of Gold Nanoparticles Using Bifunctional PNIPAM Ligands.

Honold T, Skrybeck D, Wagner KG, Karg M.

Langmuir. 2017 Jan 10;33(1):253-261. doi: 10.1021/acs.langmuir.6b03874. Epub 2016 Dec 20.

PMID:
27996278
22.

Limited Blood Transfusions Are Safe in Orthopaedic Trauma Patients.

Dolenc AJ, Morris WZ, Como JJ, Wagner KG, Vallier HA.

J Orthop Trauma. 2016 Dec;30(12):e384-e389.

PMID:
27763957
23.

Micro-scale prediction method for API-solubility in polymeric matrices and process model for forming amorphous solid dispersion by hot-melt extrusion.

Bochmann ES, Neumann D, Gryczke A, Wagner KG.

Eur J Pharm Biopharm. 2016 Oct;107:40-8. doi: 10.1016/j.ejpb.2016.06.015. Epub 2016 Jun 25.

PMID:
27349807
24.

Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics.

Locher K, Borghardt JM, Frank KJ, Kloft C, Wagner KG.

Eur J Pharm Biopharm. 2016 Aug;105:166-75. doi: 10.1016/j.ejpb.2016.06.008. Epub 2016 Jun 11.

PMID:
27297570
25.

Hot Melt Extrusion for Sustained Protein Release: Matrix Erosion and In Vitro Release of PLGA-Based Implants.

Cossé A, König C, Lamprecht A, Wagner KG.

AAPS PharmSciTech. 2017 Jan 1;18(1):15-26. doi: 10.1208/s12249-016-0548-5. Epub 2016 May 18.

PMID:
27193002
26.

Complications are reduced with a protocol to standardize timing of fixation based on response to resuscitation.

Vallier HA, Moore TA, Como JJ, Wilczewski PA, Steinmetz MP, Wagner KG, Smith CE, Wang XF, Dolenc AJ.

J Orthop Surg Res. 2015 Oct 1;10:155. doi: 10.1186/s13018-015-0298-1.

27.

Teamwork in Trauma: System Adjustment to a Protocol for the Management of Multiply Injured Patients.

Vallier HA, Moore TA, Como JJ, Dolenc AJ, Steinmetz MP, Wagner KG, Smith CE, Wilczewski PA.

J Orthop Trauma. 2015 Nov;29(11):e446-50. doi: 10.1097/BOT.0000000000000383.

PMID:
26165260
28.

Site specific solubility improvement using solid dispersions of HPMC-AS/HPC SSL--mixtures.

Zecevic DE, Meier R, Daniels R, Wagner KG.

Eur J Pharm Biopharm. 2014 Jul;87(2):264-70. doi: 10.1016/j.ejpb.2014.03.018. Epub 2014 Apr 21.

PMID:
24768770
29.

In vivo predictive mini-scale dissolution for weak bases: Advantages of pH-shift in combination with an absorptive compartment.

Frank KJ, Locher K, Zecevic DE, Fleth J, Wagner KG.

Eur J Pharm Sci. 2014 Sep 30;61:32-9. doi: 10.1016/j.ejps.2013.12.015. Epub 2014 Jan 8.

PMID:
24413061
30.

Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools.

Zecevic DE, Wagner KG.

J Pharm Sci. 2013 Jul;102(7):2297-310. doi: 10.1002/jps.23592. Epub 2013 May 9.

PMID:
23661396
31.

Influence of PEG in PEG-PLGA microspheres on particle properties and protein release.

Buske J, König C, Bassarab S, Lamprecht A, Mühlau S, Wagner KG.

Eur J Pharm Biopharm. 2012 May;81(1):57-63. doi: 10.1016/j.ejpb.2012.01.009. Epub 2012 Jan 28.

PMID:
22306701
32.

Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test.

Heigoldt U, Sommer F, Daniels R, Wagner KG.

Eur J Pharm Biopharm. 2010 Sep;76(1):105-11. doi: 10.1016/j.ejpb.2010.05.006. Epub 2010 May 22.

PMID:
20472059
33.
35.

Hydrophilic solutes in modified carbon dioxide extraction-prediction of the extractability using molecular dynamic simulation.

Günther M, Maus M, Wagner KG, Schmidt PC.

Eur J Pharm Sci. 2005 Jun;25(2-3):321-9. Epub 2005 Apr 14.

PMID:
15911229
36.

Quantification of the leaching of triethyl citrate/polysorbate 80 mixtures from Eudragit RS films by differential scanning calorimetry.

Gruetzmann R, Wagner KG.

Eur J Pharm Biopharm. 2005 May;60(1):159-62. Epub 2005 Jan 12.

PMID:
15848068
37.

Development of disintegrating multiple-unit tablets on a high-speed rotary tablet press.

Wagner KG, Krumme M, Beckert TE, Schmidt PC.

Eur J Pharm Biopharm. 2000 Sep;50(2):285-92.

PMID:
10962240
38.

Development of matrix-based theophylline sustained-release microtablets.

Rey H, Wagner KG, Wehrlé P, Schmidt PC.

Drug Dev Ind Pharm. 2000 Jan;26(1):21-6.

PMID:
10677806
39.

Investigation of the pellet-distribution in single tablets via image analysis.

Wagner KG, Krumme M, Schmidt PC.

Eur J Pharm Biopharm. 1999 Jan;47(1):79-85.

PMID:
10234530
40.

Synergistic effects of ajoene and the microwave power density memories of water on germination inhibition of fungal spores.

Rai S, Singh UP, Mishra GD, Singh SP, Samarketu, Wagner KG.

Med Biol Eng Comput. 1995 May;33(3):313-6.

PMID:
7475368
41.

Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells.

Gebhardt R, Beck H, Wagner KG.

Biochim Biophys Acta. 1994 Jun 23;1213(1):57-62.

PMID:
8011681
42.
43.
44.

The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines.

Scharfenberg K, Wagner R, Wagner KG.

Cancer Lett. 1990 Sep;53(2-3):103-8.

PMID:
2208068
45.

Medium scale production of L-myo-inositol 1-phosphate.

Feth F, Wagner R, Baydoun H, Wray V, Wagner KG.

Biotechnol Appl Biochem. 1990 Aug;12(4):364-9.

PMID:
2205246
46.

Diacylglycerol kinase from suspension cultured plant cells : purification and properties.

Wissing J, Heim S, Wagner KG.

Plant Physiol. 1989 Aug;90(4):1546-51.

47.
48.

Regulation in tobacco callus of enzyme activities of the nicotine pathway : II. The pyridine-nucleotide cycle.

Wagner R, Feth F, Wagner KG.

Planta. 1986 Sep;168(3):408-13. doi: 10.1007/BF00392369.

PMID:
24232153
49.

Regulation in tobacco callus of enzyme activities of the nicotine pathway : I. The route ornithine to methylpyrroline.

Feth F, Wagner R, Wagner KG.

Planta. 1986 Sep;168(3):402-7. doi: 10.1007/BF00392368.

PMID:
24232152
50.

Purification and characterization of the Ro and La antigens. Modulation of their binding affinities to poly(U) by phosphorylation and the presence of ATP.

Bachmann M, Schröder HC, Wagner KG, Mayet WJ, Pfeifer K, Müller WE.

Biol Chem Hoppe Seyler. 1986 Aug;367(8):671-80.

PMID:
3768138

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