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Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O.

Nature. 2019 Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2.


The Integrator complex cleaves nascent mRNAs to attenuate transcription.

Tatomer DC, Elrod ND, Liang D, Xiao MS, Jiang JZ, Jonathan M, Huang KL, Wagner EJ, Cherry S, Wilusz JE.

Genes Dev. 2019 Nov 1;33(21-22):1525-1538. doi: 10.1101/gad.330167.119. Epub 2019 Sep 17.


Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.

Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen NY, Molina JG, Collum S, Mertens TC, Luo F, Philip K, Davies J, Huang J, Wilson C, Thandavarayan RA, Bruckner BA, Jyothula SS, Volcik KA, Li L, Han L, Li W, Assassi S, Karmouty-Quintana H, Wagner EJ, Blackburn MR.

J Clin Invest. 2019 Feb 28;129(5):1984-1999. doi: 10.1172/JCI122106. Print 2019 May 1.


Biochemical and Next Generation Sequencing Approaches to Study RNA Regulation.

Wagner EJ, Goldstrohm AC.

Methods. 2019 Feb 15;155:1-2. doi: 10.1016/j.ymeth.2019.02.012. No abstract available.


Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner.

Hernandez J, Fabelo C, Perez L, Moore C, Chang R, Wagner EJ.

Biol Sex Differ. 2019 Feb 12;10(1):9. doi: 10.1186/s13293-019-0220-3.


Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.

Chu Y, Elrod N, Wang C, Li L, Chen T, Routh A, Xia Z, Li W, Wagner EJ, Ji P.

Oncogene. 2019 May;38(21):4154-4168. doi: 10.1038/s41388-019-0714-9. Epub 2019 Jan 31.


Development of Poly(A)-ClickSeq as a tool enabling simultaneous genome-wide poly(A)-site identification and differential expression analysis.

Elrod ND, Jaworski EA, Ji P, Wagner EJ, Routh A.

Methods. 2019 Feb 15;155:20-29. doi: 10.1016/j.ymeth.2019.01.002. Epub 2019 Jan 6.


Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster.

Matera AG, Raimer AC, Schmidt CA, Kelly JA, Droby GN, Baillat D, Ten Have S, Lamond AI, Wagner EJ, Gray KM.

G3 (Bethesda). 2019 Feb 7;9(2):491-503. doi: 10.1534/g3.118.200874.


TC3A: The Cancer 3' UTR Atlas.

Feng X, Li L, Wagner EJ, Li W.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1027-D1030. doi: 10.1093/nar/gkx892.


Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive.

Fabelo C, Hernandez J, Chang R, Seng S, Alicea N, Tian S, Conde K, Wagner EJ.

Front Mol Neurosci. 2018 Jun 19;11:214. doi: 10.3389/fnmol.2018.00214. eCollection 2018.


3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.

Park HJ, Ji P, Kim S, Xia Z, Rodriguez B, Li L, Su J, Chen K, Masamha CP, Baillat D, Fontes-Garfias CR, Shyu AB, Neilson JR, Wagner EJ, Li W.

Nat Genet. 2018 Jun;50(6):783-789. doi: 10.1038/s41588-018-0118-8. Epub 2018 May 21.


Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.

Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ.

Nucleic Acids Res. 2018 May 4;46(8):4241-4255. doi: 10.1093/nar/gky100.


Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron.

Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG.

Mol Biol Cell. 2018 Jan 15;29(2):96-110. doi: 10.1091/mbc.E17-11-0627. Epub 2017 Nov 22.


Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance.

Qiu J, Bosch MA, Meza C, Navarro UV, Nestor CC, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Endocrinology. 2018 Feb 1;159(2):647-664. doi: 10.1210/en.2017-00793.


The contribution of alternative polyadenylation to the cancer phenotype.

Masamha CP, Wagner EJ.

Carcinogenesis. 2018 Jan 12;39(1):2-10. doi: 10.1093/carcin/bgx096. Review.


Genome-Wide RNAi Screens for RNA Processing Events in Drosophila melanogaster S2 Cells.

Peart N, Wagner EJ.

Methods Mol Biol. 2017;1648:235-245. doi: 10.1007/978-1-4939-7204-3_17.


Correction: Human mutations in integrator complex subunits link transcriptome integrity to brain development.

Oegema R, Baillat D, Schot R, van Unen LM, Brooks A, Kia SK, Hoogeboom AJM, Xia Z, Li W, Cesaroni M, Lequin MH, van Slegtenhorst M, Dobyns WB, de Coo IFM, van den Berg D, Verheijen FW, Kremer A, van der Spek PJ, Heijsman D, Wagner EJ, Fornerod M, Mancini GMS.

PLoS Genet. 2017 Aug 1;13(8):e1006923. doi: 10.1371/journal.pgen.1006923. eCollection 2017 Aug.


Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels.

Qiu J, Wagner EJ, Rønnekleiv OK, Kelly MJ.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12501. Review.


Human mutations in integrator complex subunits link transcriptome integrity to brain development.

Oegema R, Baillat D, Schot R, van Unen LM, Brooks A, Kia SK, Hoogeboom AJM, Xia Z, Li W, Cesaroni M, Lequin MH, van Slegtenhorst M, Dobyns WB, de Coo IFM, Verheijen FW, Kremer A, van der Spek PJ, Heijsman D, Wagner EJ, Fornerod M, Mancini GMS.

PLoS Genet. 2017 May 25;13(5):e1006809. doi: 10.1371/journal.pgen.1006809. eCollection 2017 May. Erratum in: PLoS Genet. 2017 Aug 1;13(8):e1006923.


A distal auxiliary element facilitates cleavage and polyadenylation of Dux4 mRNA in the pathogenic haplotype of FSHD.

Peart N, Wagner EJ.

Hum Genet. 2017 Sep;136(9):1291-1301. doi: 10.1007/s00439-017-1813-8. Epub 2017 May 24.


Poly(A)-ClickSeq: click-chemistry for next-generation 3΄-end sequencing without RNA enrichment or fragmentation.

Routh A, Ji P, Jaworski E, Xia Z, Li W, Wagner EJ.

Nucleic Acids Res. 2017 Jul 7;45(12):e112. doi: 10.1093/nar/gkx286.


Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.

Wu Y, Albrecht TR, Baillat D, Wagner EJ, Tong L.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4394-4399. doi: 10.1073/pnas.1616605114. Epub 2017 Apr 10.


Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α.

Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ.

Neuroendocrinology. 2017;105(4):341-356. doi: 10.1159/000453370. Epub 2016 Nov 21.


CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells.

Baillat D, Russell WK, Wagner EJ.

Protein Expr Purif. 2016 Dec;128:101-8. doi: 10.1016/j.pep.2016.08.011. Epub 2016 Aug 19.


CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.

Masamha CP, Xia Z, Peart N, Collum S, Li W, Wagner EJ, Shyu AB.

RNA. 2016 Jun;22(6):830-8. doi: 10.1261/rna.055939.116. Epub 2016 Apr 19.


Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.

Masamha CP, Albrecht TR, Wagner EJ.

J Hematol Oncol. 2016 Mar 29;9:30. doi: 10.1186/s13045-016-0260-7.


Gain-of-function reporters for analysis of mRNA 3'-end formation: Design and optimization.

Peart N, Wagner EJ.

Biotechniques. 2016 Mar 1;60(3):137-40. doi: 10.2144/000114390. eCollection 2016.


Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis.

Wagner EJ.

Front Neuroendocrinol. 2016 Jan;40:101-9. doi: 10.1016/j.yfrne.2016.01.003. Epub 2016 Jan 19. Review.


Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.

Conde K, Meza C, Kelly MJ, Sinchak K, Wagner EJ.

Neuroendocrinology. 2016;103(6):787-805. doi: 10.1159/000443765. Epub 2016 Jan 16.


Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis.

Mela V, Vargas A, Meza C, Kachani M, Wagner EJ.

J Steroid Biochem Mol Biol. 2016 Jun;160:15-26. doi: 10.1016/j.jsbmb.2015.07.014. Epub 2015 Jul 29. Review.


Integrator: surprisingly diverse functions in gene expression.

Baillat D, Wagner EJ.

Trends Biochem Sci. 2015 May;40(5):257-64. doi: 10.1016/j.tibs.2015.03.005. Epub 2015 Apr 13. Review.


Use of penicillin and streptomycin to reduce spread of bacterial coldwater disease I: antibiotics in sperm extenders.

Oplinger RW, Wagner EJ.

J Aquat Anim Health. 2015 Mar;27(1):25-31. doi: 10.1080/08997659.2014.966211.


Use of Penicillin and Streptomycin to Reduce Spread of Bacterial Coldwater Disease II: Efficacy of Using Antibiotics in Diluents and During Water Hardening.

Oplinger RW, Wagner EJ, Cavender W.

J Aquat Anim Health. 2015 Mar;27(1):32-7. doi: 10.1080/08997659.2014.945049.


The role of AMP-activated protein kinase in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis.

Borgquist A, Meza C, Wagner EJ.

Am J Physiol Endocrinol Metab. 2015 Mar 15;308(6):E482-95. doi: 10.1152/ajpendo.00421.2014. Epub 2014 Dec 30.


Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W.

Nat Commun. 2014 Nov 20;5:5274. doi: 10.1038/ncomms6274.


Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis.

Borgquist A, Meza C, Wagner EJ.

J Neurophysiol. 2015 Feb 1;113(3):904-14. doi: 10.1152/jn.00615.2014. Epub 2014 Nov 12.


Comparison of the susceptibility of four rainbow trout strains to cold-water disease.

Wagner EJ, Oplinger RW.

J Aquat Anim Health. 2014 Sep;26(3):160-7. doi: 10.1080/08997659.2014.922514.


Integrator regulates transcriptional initiation and pause release following activation.

Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R.

Mol Cell. 2014 Oct 2;56(1):128-139. doi: 10.1016/j.molcel.2014.08.004. Epub 2014 Sep 4.


CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.

Masamha CP, Xia Z, Yang J, Albrecht TR, Li M, Shyu AB, Li W, Wagner EJ.

Nature. 2014 Jun 19;510(7505):412-6. doi: 10.1038/nature13261. Epub 2014 May 11.


Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.

Qiu J, Zhang C, Borgquist A, Nestor CC, Smith AW, Bosch MA, Ku S, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Cell Metab. 2014 Apr 1;19(4):682-93. doi: 10.1016/j.cmet.2014.03.004.


MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab.

Zhang KL, Zhou X, Han L, Chen LY, Chen LC, Shi ZD, Yang M, Ren Y, Yang JX, Frank TS, Zhang CB, Zhang JX, Pu PY, Zhang JN, Jiang T, Wagner EJ, Li M, Kang CS.

Mol Cancer. 2014 Mar 20;13:63. doi: 10.1186/1476-4598-13-63.


Gonadal steroids differentially modulate the actions of orphanin FQ/nociceptin at a physiologically relevant circuit controlling female sexual receptivity.

Borgquist A, Rivas VM, Kachani M, Sinchak K, Wagner EJ.

J Neuroendocrinol. 2014 May;26(5):329-40. doi: 10.1111/jne.12148.


The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms.

Jodoin JN, Shboul M, Albrecht TR, Lee E, Wagner EJ, Reversade B, Lee LA.

Biol Open. 2013 Dec 15;2(12):1390-6. doi: 10.1242/bio.20136981.


Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.

Jodoin JN, Sitaram P, Albrecht TR, May SB, Shboul M, Lee E, Reversade B, Wagner EJ, Lee LA.

Mol Biol Cell. 2013 Sep;24(18):2954-65. doi: 10.1091/mbc.E13-05-0254. Epub 2013 Jul 31.


Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.

Wang S, Wagner EJ, Mattox W.

RNA Biol. 2013 Aug;10(8):1396-406. doi: 10.4161/rna.25645. Epub 2013 Jul 9.


The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.

Smith AW, Bosch MA, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E632-40. doi: 10.1152/ajpendo.00281.2013. Epub 2013 Jul 2.


Non-mRNA 3' end formation: how the other half lives.

Peart N, Sataluri A, Baillat D, Wagner EJ.

Wiley Interdiscip Rev RNA. 2013 Sep-Oct;4(5):491-506. doi: 10.1002/wrna.1174. Epub 2013 Jun 10. Review.


Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses.

Borgquist A, Kachani M, Tavitian N, Sinchak K, Wagner EJ.

Neuroendocrinology. 2013;98(1):60-72. doi: 10.1159/000351868. Epub 2013 Jul 2.


Toxicity of copper sulfate to Flavobacterium psychrophilum and Rainbow Trout eggs.

Wagner EJ, Oplinger RW.

J Aquat Anim Health. 2013 Jun;25(2):125-30. doi: 10.1080/08997659.2013.788580.


Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex.

Chen J, Waltenspiel B, Warren WD, Wagner EJ.

J Biol Chem. 2013 Feb 15;288(7):4867-77. doi: 10.1074/jbc.M112.425892. Epub 2013 Jan 3.

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