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The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions.

Noor S, Sanchez JJ, Sun MS, Pervin Z, Sanchez JE, Havard MA, Epler LT, Nysus MV, Norenberg JP, Wagner CR, Davies S, Jennifer L W, Savage DD, Jantzie LL, Mellios N, Milligan ED.

Brain Behav Immun. 2020 Jan 6. pii: S0889-1591(19)30559-8. doi: 10.1016/j.bbi.2020.01.002. [Epub ahead of print]


LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes.

Noor S, Sun MS, Vanderwall AG, Havard MA, Sanchez JE, Harris NW, Nysus MV, Norenberg JP, West HT, Wagner CR, Jantzie LL, Mellios N, Milligan ED.

Neuroimmunol Neuroinflamm. 2019;6. pii: 10. doi: 10.20517/2347-8659.2019.18. Epub 2019 Jul 22.


Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.

Shah RM, Peterson C, Strom A, Dillenburg M, Finzel B, Kitto KF, Fairbanks C, Wilcox G, Wagner CR.

ACS Chem Neurosci. 2019 Oct 16;10(10):4385-4393. doi: 10.1021/acschemneuro.9b00432. Epub 2019 Sep 25.


A Great Ride.

Wagner CR.

Mol Pharm. 2018 Dec 3;15(12):5445. doi: 10.1021/acs.molpharmaceut.8b01121. No abstract available.


Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure.

Sanchez JJ, Sanchez JE, Noor S, Ruffaner-Hanson CD, Davies S, Wagner CR, Jantzie LL, Mellios N, Savage DD, Milligan ED.

Acta Neuropathol Commun. 2019 Apr 8;7(1):54. doi: 10.1186/s40478-019-0701-y.


111In-DANBIRT In Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis.

Mota R, Campen MJ, Cuellar ME, Garver WS, Hesterman J, Qutaish M, Daniels T, Nysus M, Wagner CR, Norenberg JP.

Contrast Media Mol Imaging. 2018 Nov 13;2018:6508724. doi: 10.1155/2018/6508724. eCollection 2018.


Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density.

Csizmar CM, Petersburg JR, Perry TJ, Rozumalski L, Hackel BJ, Wagner CR.

J Am Chem Soc. 2019 Jan 9;141(1):251-261. doi: 10.1021/jacs.8b09198. Epub 2018 Dec 17.


Programming Cell-Cell Interactions through Non-genetic Membrane Engineering.

Csizmar CM, Petersburg JR, Wagner CR.

Cell Chem Biol. 2018 Aug 16;25(8):931-940. doi: 10.1016/j.chembiol.2018.05.009. Epub 2018 Jun 14. Review.


Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells.

Petersburg JR, Shen J, Csizmar CM, Murphy KA, Spanier J, Gabrielse K, Griffith TS, Fife B, Wagner CR.

ACS Nano. 2018 Jul 24;12(7):6563-6576. doi: 10.1021/acsnano.8b01308. Epub 2018 Jun 4.


Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.

Shah RM, Maize KM, West HT, Strom AM, Finzel BC, Wagner CR.

J Mol Biol. 2018 Aug 17;430(17):2709-2721. doi: 10.1016/j.jmb.2018.05.028. Epub 2018 May 19.


Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation.

West HT, Csizmar CM, Wagner CR.

Biomacromolecules. 2018 Jul 9;19(7):2650-2656. doi: 10.1021/acs.biomac.8b00254. Epub 2018 May 1.


Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors.

Csizmar CM, Petersburg JR, Hendricks A, Stern LA, Hackel BJ, Wagner CR.

Bioconjug Chem. 2018 Apr 18;29(4):1291-1301. doi: 10.1021/acs.bioconjchem.8b00058. Epub 2018 Mar 23.


Induction of the p53 Tumor Suppressor in Cancer Cells through Inhibition of Cap-Dependent Translation.

Harris BRE, Wang D, Zhang Y, Ferrari M, Okon A, Cleary MP, Wagner CR, Yang DQ.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00367-17. doi: 10.1128/MCB.00367-17. Print 2018 May 15.


Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.

Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI.

Cancer Immunol Immunother. 2018 Feb;67(2):327. doi: 10.1007/s00262-017-2102-z.


Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.

Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI.

Cancer Immunol Immunother. 2018 Feb;67(2):311-325. doi: 10.1007/s00262-017-2073-0. Epub 2017 Oct 20. Erratum in: Cancer Immunol Immunother. 2017 Dec 20;:.


A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.

Maize KM, Shah R, Strom A, Kumarapperuma S, Zhou A, Wagner CR, Finzel BC.

Mol Pharm. 2017 Nov 6;14(11):3987-3997. doi: 10.1021/acs.molpharmaceut.7b00664. Epub 2017 Oct 26.


Anchimerically Activatable Antiviral ProTides.

Okon A, Matos de Souza MR, Shah R, Amorim R, da Costa LJ, Wagner CR.

ACS Med Chem Lett. 2017 Aug 14;8(9):958-962. doi: 10.1021/acsmedchemlett.7b00277. eCollection 2017 Sep 14.


Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.

Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR.

J Med Chem. 2017 Oct 12;60(19):8131-8144. doi: 10.1021/acs.jmedchem.7b00916. Epub 2017 Sep 20.


Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.

Shah R, Chou TF, Maize KM, Strom A, Finzel BC, Wagner CR.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):760-766. doi: 10.1016/j.bbrc.2017.07.111. Epub 2017 Jul 21.


Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).

Shah R, Maize KM, Zhou X, Finzel BC, Wagner CR.

Biochemistry. 2017 Jul 18;56(28):3559-3570. doi: 10.1021/acs.biochem.7b00148. Epub 2017 Jul 10.


Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands.

Stern LA, Csizmar CM, Woldring DR, Wagner CR, Hackel BJ.

ACS Comb Sci. 2017 May 8;19(5):315-323. doi: 10.1021/acscombsci.6b00191. Epub 2017 Mar 31.


Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.

Shah R, Strom A, Zhou A, Maize KM, Finzel BC, Wagner CR.

ACS Med Chem Lett. 2016 Jun 15;7(8):780-4. doi: 10.1021/acsmedchemlett.6b00169. eCollection 2016 Aug 11.


In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures.

Shah R, Petersburg J, Gangar AC, Fegan A, Wagner CR, Kumarapperuma SC.

Mol Pharm. 2016 Jul 5;13(7):2193-203. doi: 10.1021/acs.molpharmaceut.6b00110. Epub 2016 Mar 29.


Skin Conductance Level Reactivity Moderates the Association Between Parental Psychological Control and Relational Aggression in Emerging Adulthood.

Wagner CR, Abaied JL.

J Youth Adolesc. 2016 Apr;45(4):687-700. doi: 10.1007/s10964-016-0422-5. Epub 2016 Jan 13.


Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.

Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB.

Sci Rep. 2015 Dec 18;5:18233. doi: 10.1038/srep18233.


Prosthetic Antigen Receptors.

Shen J, Vallera DA, Wagner CR.

J Am Chem Soc. 2015 Aug 19;137(32):10108-11. doi: 10.1021/jacs.5b06166. Epub 2015 Aug 6.


Relational victimization and proactive versus reactive relational aggression: The moderating effects of respiratory sinus arrhythmia and skin conductance.

Wagner CR, Abaied JL.

Aggress Behav. 2015 Nov-Dec;41(6):566-79. doi: 10.1002/ab.21596. Epub 2015 Jul 14.


HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia.

Garzón J, Herrero-Labrador R, Rodríguez-Muñoz M, Shah R, Vicente-Sánchez A, Wagner CR, Sánchez-Blázquez P.

Neuropharmacology. 2015 Feb;89:412-23.


Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.

Chen EZ, Jacobson BA, Patel MR, Okon AM, Li S, Xiong K, Vaidya AJ, Bitterman PB, Wagner CR, Kratzke RA.

Invest New Drugs. 2014 Aug;32(4):598-603. doi: 10.1007/s10637-014-0076-7. Epub 2014 Apr 9.


Reversible re-programing of cell-cell interactions.

Gabrielse K, Gangar A, Kumar N, Lee JC, Fegan A, Shen JJ, Li Q, Vallera D, Wagner CR.

Angew Chem Int Ed Engl. 2014 May 12;53(20):5112-6. doi: 10.1002/anie.201310645. Epub 2014 Apr 2.


Intrinsic embedded sensors for polymeric mechatronics: flexure and force sensing.

Jentoft LP, Dollar AM, Wagner CR, Howe RD.

Sensors (Basel). 2014 Feb 25;14(3):3861-70. doi: 10.3390/s140303861.


Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α.

Cao J, He L, Lin G, Hu C, Dong R, Zhang J, Zhu H, Hu Y, Wagner CR, He Q, Yang B.

Biochem Pharmacol. 2014 May 1;89(1):20-30. doi: 10.1016/j.bcp.2013.12.002. Epub 2013 Dec 15.


Simultaneous dual protein labeling using a triorthogonal reagent.

Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD.

J Am Chem Soc. 2013 Nov 6;135(44):16388-96. doi: 10.1021/ja403813b. Epub 2013 Oct 17.


Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures.

Gangar A, Fegan A, Kumarapperuma SC, Huynh P, Benyumov A, Wagner CR.

Mol Pharm. 2013 Sep 3;10(9):3514-8. doi: 10.1021/mp400164f. Epub 2013 Jul 30.


Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.

Maize KM, Wagner CR, Finzel BC.

FEBS J. 2013 Jul;280(14):3389-98. doi: 10.1111/febs.12330. Epub 2013 Jun 10.


Distinct translational control in CD4+ T cell subsets.

Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR, Sonenberg N, Piccirillo CA.

PLoS Genet. 2013 May;9(5):e1003494. doi: 10.1371/journal.pgen.1003494. Epub 2013 May 2.


Kinetic mechanism of human histidine triad nucleotide binding protein 1.

Zhou X, Chou TF, Aubol BE, Park CJ, Wolfenden R, Adams J, Wagner CR.

Biochemistry. 2013 May 21;52(20):3588-600. doi: 10.1021/bi301616c. Epub 2013 May 7.


A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation.

Rashidian M, Mahmoodi MM, Shah R, Dozier JK, Wagner CR, Distefano MD.

Bioconjug Chem. 2013 Mar 20;24(3):333-42. doi: 10.1021/bc3004167. Epub 2013 Mar 6.


Chemically self-assembled antibody nanostructures as potential drug carriers.

Fegan A, Kumarapperuma SC, Wagner CR.

Mol Pharm. 2012 Nov 5;9(11):3218-27. doi: 10.1021/mp300303k. Epub 2012 Oct 16.


Left atrium reverse remodeling in patients with mitral valve stenosis after percutaneous valvuloplasty: a 2- and 3-dimensional echocardiographic study.

Vieira ML, Silva MC, Wagner CR, Dallan LA, Kajita LJ, Oliveira WA, Samesina N, Hotta VT, Mathias W Jr, Spina G, Cardoso L, Pastore CA, Tarasoutchi F, Grinberg M.

Rev Esp Cardiol (Engl Ed). 2013 Jan;66(1):17-23. doi: 10.1016/j.recesp.2012.05.007. Epub 2012 Aug 9. English, Spanish.


Protein interface remodeling in a chemically induced protein dimer.

White BR, Carlson JC, Kerns JL, Wagner CR.

J Mol Recognit. 2012 Jul;25(7):393-403. doi: 10.1002/jmr.2196.


Single photon emission computerized tomography and conventional computerized tomography (SPECT/CT) for evaluation of patients after anterior cruciate ligament reconstruction: a novel standardized algorithm combining mechanical and metabolic information.

Hirschmann MT, Mathis D, Afifi FK, Rasch H, Henckel J, Amsler F, Wagner CR, Friederich NF, Arnold MP.

Knee Surg Sports Traumatol Arthrosc. 2013 Apr;21(4):965-74. doi: 10.1007/s00167-012-2083-6. Epub 2012 Jun 13.


Blood-nanoparticle interactions and in vivo biodistribution: impact of surface PEG and ligand properties.

Shah NB, Vercellotti GM, White JG, Fegan A, Wagner CR, Bischof JC.

Mol Pharm. 2012 Aug 6;9(8):2146-55. doi: 10.1021/mp200626j. Epub 2012 Jul 23.


Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.

Jia Y, Polunovsky V, Bitterman PB, Wagner CR.

Med Res Rev. 2012 Jul;32(4):786-814. doi: 10.1002/med.21260. Epub 2012 Apr 11. Review.


Standardized volumetric 3D-analysis of SPECT/CT imaging in orthopaedics: overcoming the limitations of qualitative 2D analysis.

Hirschmann MT, Wagner CR, Rasch H, Henckel J.

BMC Med Imaging. 2012 Mar 29;12:5. doi: 10.1186/1471-2342-12-5.


Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

Gangar A, Fegan A, Kumarapperuma SC, Wagner CR.

J Am Chem Soc. 2012 Feb 15;134(6):2895-7. doi: 10.1021/ja210894g. Epub 2012 Feb 1.


Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins.

Bardaweel SK, Ghosh B, Wagner CR.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):558-60. doi: 10.1016/j.bmcl.2011.10.082. Epub 2011 Oct 31.


E. coli histidine triad nucleotide binding protein 1 (ecHinT) is a catalytic regulator of D-alanine dehydrogenase (DadA) activity in vivo.

Bardaweel S, Ghosh B, Chou TF, Sadowsky MJ, Wagner CR.

PLoS One. 2011;6(7):e20897. doi: 10.1371/journal.pone.0020897. Epub 2011 Jul 6.

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