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Items: 1 to 50 of 75

1.

AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts.

Remes A, Franz M, Mohr F, Weber A, Rapti K, Jungmann A, Karck M, Hecker M, Kallenbach K, Müller OJ, Arif R, Wagner AH.

Mol Ther Methods Clin Dev. 2019 Oct 2;15:246-256. doi: 10.1016/j.omtm.2019.09.009. eCollection 2019 Dec 13.

PMID:
31720303
2.

Endothelial cell modulation of cardiomyocyte gene expression.

Jiang F, Mohr F, Ullrich ND, Hecker M, Wagner AH.

Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

PMID:
31442451
3.

Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease.

Sultan CS, Weitnauer M, Turinsky M, Kessler T, Brune M, Gleissner CA, Leuschner F, Wagner AH, Hecker M.

Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]

PMID:
31373353
4.

15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells With a Genetically Determined NO Deficit.

Urban I, Turinsky M, Gehrmann S, Morgenstern J, Brune M, Milewski MR, Wagner AH, Rumig C, Fleming T, Leuschner F, Gleissner CA, Hecker M.

Circ Res. 2019 Jul 19;125(3):282-294. doi: 10.1161/CIRCRESAHA.118.313820. Epub 2019 Jun 19.

PMID:
31213138
5.

Marfan syndrome: A therapeutic challenge for long-term care.

Wagner AH, Zaradzki M, Arif R, Remes A, Müller OJ, Kallenbach K.

Biochem Pharmacol. 2019 Jun;164:53-63. doi: 10.1016/j.bcp.2019.03.034. Epub 2019 Mar 27. Review.

PMID:
30926475
6.

Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels.

Sachdeva R, Fleming T, Schumacher D, Homberg S, Stilz K, Mohr F, Wagner AH, Tsvilovskyy V, Mathar I, Freichel M.

Cell Calcium. 2019 Mar;78:66-75. doi: 10.1016/j.ceca.2019.01.002. Epub 2019 Jan 9.

PMID:
30658323
7.

A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data.

Ainscough BJ, Barnell EK, Ronning P, Campbell KM, Wagner AH, Fehniger TA, Dunn GP, Uppaluri R, Govindan R, Rohan TE, Griffith M, Mardis ER, Swamidass SJ, Griffith OL.

Nat Genet. 2018 Dec;50(12):1735-1743. doi: 10.1038/s41588-018-0257-y. Epub 2018 Nov 5.

8.

Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model.

Arif R, Franz M, Remes A, Zaradzki M, Hecker M, Karck M, Müller OJ, Kallenbach K, Wagner AH.

Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

PMID:
30352477
9.

Adapting crowdsourced clinical cancer curation in CIViC to the ClinGen minimum variant level data community-driven standards.

Danos AM, Ritter DI, Wagner AH, Krysiak K, Sonkin D, Micheel C, McCoy M, Rao S, Raca G, Boca SM, Roy A, Barnell EK, McMichael JF, Kiwala S, Coffman AC, Kujan L, Kulkarni S, Griffith M, Madhavan S, Griffith OL; Clinical Genome Resource Somatic Working Group and Clinical Interpretation of Variants in Cancer team members.

Hum Mutat. 2018 Nov;39(11):1721-1732. doi: 10.1002/humu.23651.

10.

Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples.

Barnell EK, Ronning P, Campbell KM, Krysiak K, Ainscough BJ, Sheta LM, Pema SP, Schmidt AD, Richters M, Cotto KC, Danos AM, Ramirez C, Skidmore ZL, Spies NC, Hundal J, Sediqzad MS, Kunisaki J, Gomez F, Trani L, Matlock M, Wagner AH, Swamidass SJ, Griffith M, Griffith OL.

Genet Med. 2019 Apr;21(4):972-981. doi: 10.1038/s41436-018-0278-z. Epub 2018 Oct 5.

11.

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.

Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R.

Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9.

12.

Strategy for marker-based differentiation of pro- and anti-inflammatory macrophages using matrix-assisted laser desorption/ionization mass spectrometry imaging.

Khamehgir-Silz P, Schnitter F, Wagner AH, Gerbig S, Schulz S, Hecker M, Spengler B.

Analyst. 2018 Sep 10;143(18):4273-4282. doi: 10.1039/c8an00659h.

PMID:
30027181
13.

Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction.

Popa M, Tahir S, Elrod J, Kim SH, Leuschner F, Kessler T, Bugert P, Pohl U, Wagner AH, Hecker M.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5556-E5565. doi: 10.1073/pnas.1801366115. Epub 2018 May 23.

14.

Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice.

Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T.

Front Physiol. 2018 Apr 4;9:320. doi: 10.3389/fphys.2018.00320. eCollection 2018.

15.

Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal.

Weigand T, Singler B, Fleming T, Nawroth P, Klika KD, Thiel C, Baelde H, Garbade SF, Wagner AH, Hecker M, Yard BA, Amberger A, Zschocke J, Schmitt CP, Peters V.

Cell Physiol Biochem. 2018;46(2):713-726. doi: 10.1159/000488727. Epub 2018 Mar 29.

16.

Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.

Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH.

Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1.

17.

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome.

Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K.

Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.

18.

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M.

J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.

PMID:
29223856
19.

DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.

Cotto KC, Wagner AH, Feng YY, Kiwala S, Coffman AC, Spies G, Wollam A, Spies NC, Griffith OL, Griffith M.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1068-D1073. doi: 10.1093/nar/gkx1143.

20.

Role of protein carbonylation in diabetes.

Hecker M, Wagner AH.

J Inherit Metab Dis. 2018 Jan;41(1):29-38. doi: 10.1007/s10545-017-0104-9. Epub 2017 Nov 6. Review.

PMID:
29110177
21.

Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.

Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.

22.

Transcription factor decoy technology: A therapeutic update.

Hecker M, Wagner AH.

Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

PMID:
28642036
23.

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.

Griffith M, Spies NC, Krysiak K, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL.

Nat Genet. 2017 Jan 31;49(2):170-174. doi: 10.1038/ng.3774. No abstract available.

24.

DoCM: a database of curated mutations in cancer.

Ainscough BJ, Griffith M, Coffman AC, Wagner AH, Kunisaki J, Choudhary MN, McMichael JF, Fulton RS, Wilson RK, Griffith OL, Mardis ER.

Nat Methods. 2016 Sep 29;13(10):806-7. doi: 10.1038/nmeth.4000. No abstract available.

25.

GenVisR: Genomic Visualizations in R.

Skidmore ZL, Wagner AH, Lesurf R, Campbell KM, Kunisaki J, Griffith OL, Griffith M.

Bioinformatics. 2016 Oct 1;32(19):3012-4. doi: 10.1093/bioinformatics/btw325. Epub 2016 Jun 10.

26.

Whole-gene sequencing investigation of SAT1 in attempted suicide.

Monson ET, de Klerk K, Gaynor SC, Wagner AH, Breen ME, Parsons M, Casavant TL, Zandi PP, Potash JB, Willour VL.

Am J Med Genet B Neuropsychiatr Genet. 2016 Sep;171(6):888-95. doi: 10.1002/ajmg.b.32462. Epub 2016 May 27.

27.

Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.

Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ.

Exp Hematol. 2016 Jul;44(7):603-13. doi: 10.1016/j.exphem.2016.04.011. Epub 2016 May 13.

28.

Varicose Remodeling of Veins Is Suppressed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors.

Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T.

J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002405. doi: 10.1161/JAHA.115.002405.

29.

Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy.

Seppelt PC, Schwill S, Weymann A, Arif R, Weber A, Zaradzki M, Richter K, Ensminger S, Robinson PN, Wagner AH, Karck M, Kallenbach K.

PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.

30.

DGIdb 2.0: mining clinically relevant drug-gene interactions.

Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, Walker JR, Wilson RK, Mardis ER, Griffith M, Griffith OL.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1036-44. doi: 10.1093/nar/gkv1165. Epub 2015 Nov 3.

31.

Carnosine metabolism in diabetes is altered by reactive metabolites.

Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP.

Amino Acids. 2015 Nov;47(11):2367-76. doi: 10.1007/s00726-015-2024-z. Epub 2015 Jun 17.

PMID:
26081982
32.

Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells.

Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M.

J Am Heart Assoc. 2015 Jun 12;4(6):e001712. doi: 10.1161/JAHA.114.001712.

33.

von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.

Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-Valdes N, Umansky V, Schneider SW.

Blood. 2015 May 14;125(20):3153-63. doi: 10.1182/blood-2014-08-595686. Epub 2015 Feb 24.

34.

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter.

Wagner AH, Conzelmann M, Fitzer F, Giese T, Gülow K, Falk CS, Krämer OH, Dietrich S, Hecker M, Luft T.

Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.

PMID:
25931145
35.

Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.

Möller K, Adolph O, Grünow J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C, Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH, Hecker M.

Thromb Haemost. 2015 May;113(5):1095-108. doi: 10.1160/TH14-04-0336. Epub 2015 Jan 22.

PMID:
25608503
36.

TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells.

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T.

Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014.

37.

Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq.

Whitmore SS, Wagner AH, DeLuca AP, Drack AV, Stone EM, Tucker BA, Zeng S, Braun TA, Mullins RF, Scheetz TE.

Exp Eye Res. 2014 Dec;129:93-106. doi: 10.1016/j.exer.2014.11.001. Epub 2014 Nov 5.

38.

Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.

Sharma TP, McDowell CM, Liu Y, Wagner AH, Thole D, Faga BP, Wordinger RJ, Braun TA, Clark AF.

Mol Neurodegener. 2014 Apr 27;9:14. doi: 10.1186/1750-1326-9-14.

39.

Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells.

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T.

J Am Heart Assoc. 2014 Mar 10;3(2):e000626. doi: 10.1161/JAHA.113.000626.

40.

The Global Alliance against Respiratory Diseases (GARD) Country Report.

Yorgancioglu A, Cruz AA, Bousquet J, Khaltaev N, Mendis S, Chuchalin A, Bateman ED, Camargos P, Chavannes NH, Bai C, Deleanu D, Kolek V, Kuna P, Laurendi G, Masjedi MR, Mele S, Mihaltan F, Pinto JR, Samolinski B, Scalera G, Sooronbaev T, Tageldin MA, Tuyetlan le T, Yusuf O, Akdis C, Baigenzhin A, Cagnani CB, Fletcher M, Gemicioglu B, Muhammed Y, Sagra H, To T, Wagner AH.

Prim Care Respir J. 2014 Mar;23(1):98-101. doi: 10.4104/pcrj.2014.00014. No abstract available.

41.

High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statin therapy.

Dietrich S, Okun JG, Schmidt K, Falk CS, Wagner AH, Karamustafa S, Radujkovic A, Hegenbart U, Ho AD, Dreger P, Luft T.

Haematologica. 2014 Mar;99(3):541-7. doi: 10.3324/haematol.2013.090209. Epub 2013 Oct 18.

42.

Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease.

Braun TA, Mullins RF, Wagner AH, Andorf JL, Johnston RM, Bakall BB, Deluca AP, Fishman GA, Lam BL, Weleber RG, Cideciyan AV, Jacobson SG, Sheffield VC, Tucker BA, Stone EM.

Hum Mol Genet. 2013 Dec 20;22(25):5136-45. doi: 10.1093/hmg/ddt367. Epub 2013 Aug 4.

43.

Prioritization of retinal disease genes: an integrative approach.

Wagner AH, Taylor KR, DeLuca AP, Casavant TL, Mullins RF, Stone EM, Scheetz TE, Braun TA.

Hum Mutat. 2013 Jun;34(6):853-9. doi: 10.1002/humu.22317. Epub 2013 Apr 12.

44.

Exon-level expression profiling of ocular tissues.

Wagner AH, Anand VN, Wang WH, Chatterton JE, Sun D, Shepard AR, Jacobson N, Pang IH, Deluca AP, Casavant TL, Scheetz TE, Mullins RF, Braun TA, Clark AF.

Exp Eye Res. 2013 Jun;111:105-11. doi: 10.1016/j.exer.2013.03.004. Epub 2013 Mar 14.

45.

Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells.

Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M.

Blood. 2011 Sep 29;118(13):3734-42. doi: 10.1182/blood-2010-11-320259. Epub 2011 Aug 10.

PMID:
21832282
46.

Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells.

Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H.

Basic Res Cardiol. 2011 Jun;106(4):551-61. doi: 10.1007/s00395-011-0170-3. Epub 2011 Mar 12.

PMID:
21399967
47.

IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production.

Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T.

Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. doi: 10.1016/j.bcp.2010.07.040. Epub 2010 Aug 13.

PMID:
20709027
48.

Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model.

Lührmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner AH.

Exp Lung Res. 2010 Mar;36(2):85-93. doi: 10.3109/01902140903144138.

PMID:
20205594
49.

Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells.

Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Güldenzoph B, Bermejo JL, Korff T, Hecker M.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1894-901. doi: 10.1161/ATVBAHA.109.194738. Epub 2009 Sep 3.

PMID:
19729606
50.

STAT-1 decoy oligodeoxynucleotide inhibition of acute rejection in mouse heart transplants.

Stojanovic T, Wagner AH, Wang S, Kiss E, Rockstroh N, Bedke J, Gröne HJ, Hecker M.

Basic Res Cardiol. 2009 Nov;104(6):719-29. doi: 10.1007/s00395-009-0028-0. Epub 2009 Apr 8.

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