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Items: 28


Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.

Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC, Wright GD.

Nat Biotechnol. 2019 Sep 9. doi: 10.1038/s41587-019-0241-9. [Epub ahead of print]


Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance.

Waglechner N, McArthur AG, Wright GD.

Nat Microbiol. 2019 Aug 12. doi: 10.1038/s41564-019-0531-5. [Epub ahead of print]


The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD.

ISME J. 2018 Mar;12(3):885-897. doi: 10.1038/s41396-017-0017-5. Epub 2017 Dec 19.


Antibiotic resistance: it's bad, but why isn't it worse?

Waglechner N, Wright GD.

BMC Biol. 2017 Sep 15;15(1):84. doi: 10.1186/s12915-017-0423-1. Review.


CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database.

Jia B, Raphenya AR, Alcock B, Waglechner N, Guo P, Tsang KK, Lago BA, Dave BM, Pereira S, Sharma AN, Doshi S, Courtot M, Lo R, Williams LE, Frye JG, Elsayegh T, Sardar D, Westman EL, Pawlowski AC, Johnson TA, Brinkman FS, Wright GD, McArthur AG.

Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.


Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.

Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.

Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015. Epub 2016 Oct 13.


The Prehistory of Antibiotic Resistance.

Perry J, Waglechner N, Wright G.

Cold Spring Harb Perspect Med. 2016 Jun 1;6(6). pii: a025197. doi: 10.1101/cshperspect.a025197. Review.


Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD.

Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.


Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus.

Bos KI, Herbig A, Sahl J, Waglechner N, Fourment M, Forrest SA, Klunk J, Schuenemann VJ, Poinar D, Kuch M, Golding GB, Dutour O, Keim P, Wagner DM, Holmes EC, Krause J, Poinar HN.

Elife. 2016 Jan 21;5:e12994. doi: 10.7554/eLife.12994.


Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.

Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel É, Grimwood K, Hancock RE, Harrison JJ, Heeb S, Jelsbak L, Jia B, Kenna DT, Kidd TJ, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, Manos J, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Pirnay JP, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Thrane SW, Wright GD, Brinkman FS, Tucker NP, Tümmler B, Winstanley C, Levesque RC.

Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036. eCollection 2015.


IslandViewer 3: more flexible, interactive genomic island discovery, visualization and analysis.

Dhillon BK, Laird MR, Shay JA, Winsor GL, Lo R, Nizam F, Pereira SK, Waglechner N, McArthur AG, Langille MG, Brinkman FS.

Nucleic Acids Res. 2015 Jul 1;43(W1):W104-8. doi: 10.1093/nar/gkv401. Epub 2015 Apr 27.


Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy.

Thaker MN, Kalan L, Waglechner N, Eshaghi A, Patel SN, Poutanen S, Willey B, Coburn B, McGeer A, Low DE, Wright GD.

Antimicrob Agents Chemother. 2015 Mar;59(3):1405-10. doi: 10.1128/AAC.04490-14. Epub 2014 Dec 15.


Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster.

Yim G, Kalan L, Koteva K, Thaker MN, Waglechner N, Tang I, Wright GD.

Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179. Epub 2014 Sep 26.


Antibiotic resistance-mediated isolation of scaffold-specific natural product producers.

Thaker MN, Waglechner N, Wright GD.

Nat Protoc. 2014;9(6):1469-79. doi: 10.1038/nprot.2014.093. Epub 2014 May 29.


A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.

Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111. Epub 2014 Apr 28.


Draft Genome Sequence of the Sulfonamide Antibiotic-Degrading Microbacterium sp. Strain C448.

Martin-Laurent F, Marti R, Waglechner N, Wright GD, Topp E.

Genome Announc. 2014 Feb 13;2(1). pii: e01113-13. doi: 10.1128/genomeA.01113-13.


Yersinia pestis and the plague of Justinian 541-543 AD: a genomic analysis.

Wagner DM, Klunk J, Harbeck M, Devault A, Waglechner N, Sahl JW, Enk J, Birdsell DN, Kuch M, Lumibao C, Poinar D, Pearson T, Fourment M, Golding B, Riehm JM, Earn DJ, Dewitte S, Rouillard JM, Grupe G, Wiechmann I, Bliska JB, Keim PS, Scholz HC, Holmes EC, Poinar H.

Lancet Infect Dis. 2014 Apr;14(4):319-26. doi: 10.1016/S1473-3099(13)70323-2. Epub 2014 Jan 28.


Second-pandemic strain of Vibrio cholerae from the Philadelphia cholera outbreak of 1849.

Devault AM, Golding GB, Waglechner N, Enk JM, Kuch M, Tien JH, Shi M, Fisman DN, Dhody AN, Forrest S, Bos KI, Earn DJ, Holmes EC, Poinar HN.

N Engl J Med. 2014 Jan 23;370(4):334-40. doi: 10.1056/NEJMoa1308663. Epub 2014 Jan 8.


A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene.

Kalan L, Gessner A, Thaker MN, Waglechner N, Zhu X, Szawiola A, Bechthold A, Wright GD, Zechel DL.

Chem Biol. 2013 Oct 24;20(10):1214-24. doi: 10.1016/j.chembiol.2013.09.006. Epub 2013 Oct 10.


Identifying producers of antibacterial compounds by screening for antibiotic resistance.

Thaker MN, Wang W, Spanogiannopoulos P, Waglechner N, King AM, Medina R, Wright GD.

Nat Biotechnol. 2013 Oct;31(10):922-7. doi: 10.1038/nbt.2685. Epub 2013 Sep 22.


Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ.

Westman EL, Yan M, Waglechner N, Koteva K, Wright GD.

Chem Biol. 2013 Aug 22;20(8):983-90. doi: 10.1016/j.chembiol.2013.06.010. Epub 2013 Jul 25.


The comprehensive antibiotic resistance database.

McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O'Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD.

Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.


Bacterial inactivation of the anticancer drug doxorubicin.

Westman EL, Canova MJ, Radhi IJ, Koteva K, Kireeva I, Waglechner N, Wright GD.

Chem Biol. 2012 Oct 26;19(10):1255-64. doi: 10.1016/j.chembiol.2012.08.011.


Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes.

Spanogiannopoulos P, Thaker M, Koteva K, Waglechner N, Wright GD.

Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. Epub 2012 Jul 16.


Antibiotic resistance is prevalent in an isolated cave microbiome.

Bhullar K, Waglechner N, Pawlowski A, Koteva K, Banks ED, Johnston MD, Barton HA, Wright GD.

PLoS One. 2012;7(4):e34953. doi: 10.1371/journal.pone.0034953. Epub 2012 Apr 11.


A small molecule discrimination map of the antibiotic resistance kinome.

Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD.

Chem Biol. 2011 Dec 23;18(12):1591-601. doi: 10.1016/j.chembiol.2011.10.018.


Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.

D'Costa VM, Mukhtar TA, Patel T, Koteva K, Waglechner N, Hughes DW, Wright GD, De Pascale G.

Antimicrob Agents Chemother. 2012 Feb;56(2):757-64. doi: 10.1128/AAC.05441-11. Epub 2011 Nov 14.


A draft genome of Yersinia pestis from victims of the Black Death.

Bos KI, Schuenemann VJ, Golding GB, Burbano HA, Waglechner N, Coombes BK, McPhee JB, DeWitte SN, Meyer M, Schmedes S, Wood J, Earn DJ, Herring DA, Bauer P, Poinar HN, Krause J.

Nature. 2011 Oct 12;478(7370):506-10. doi: 10.1038/nature10549. Erratum in: Nature. 2011 Dec 8;480(7376):278.

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