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Items: 1 to 50 of 134

1.

What's in a (Sub)strain?

Goldstein JM, Wagers AJ.

Stem Cell Reports. 2018 Aug 14;11(2):303-305. doi: 10.1016/j.stemcr.2018.07.011.

2.

Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.

Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K.

Stem Cell Reports. 2018 May 8;10(5):1505-1521. doi: 10.1016/j.stemcr.2018.04.009.

3.

Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group.

Teot LA, Schneider M, Thorner AR, Tian J, Chi YY, Ducar M, Lin L, Wlodarski M, Grier HE, Fletcher CDM, van Hummelen P, Skapek SX, Hawkins DS, Wagers AJ, Rodriguez-Galindo C, Hettmer S.

Cancer. 2018 May 1;124(9):1973-1981. doi: 10.1002/cncr.31286. Epub 2018 Feb 20.

PMID:
29461635
4.

Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues.

Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N.

Cell. 2017 Oct 5;171(2):398-413.e21. doi: 10.1016/j.cell.2017.08.024. Epub 2017 Sep 21.

PMID:
28942919
5.

Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity.

Sinha I, Sakthivel D, Olenchock BA, Kruse CR, Williams J, Varon DE, Smith JD, Madenci AL, Nuutila K, Wagers AJ.

Front Endocrinol (Lausanne). 2017 Jul 5;8:153. doi: 10.3389/fendo.2017.00153. eCollection 2017.

6.

Structural basis for potency differences between GDF8 and GDF11.

Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB.

BMC Biol. 2017 Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1.

7.

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB.

Sci Transl Med. 2016 Nov 23;8(366):366ra163.

PMID:
27881824
8.

Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function.

Oh J, Sinha I, Tan KY, Rosner B, Dreyfuss JM, Gjata O, Tran P, Shoelson SE, Wagers AJ.

Aging (Albany NY). 2016 Nov 14;8(11):2871-2896. doi: 10.18632/aging.101098.

9.

Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting.

Maesner CC, Almada AE, Wagers AJ.

Skelet Muscle. 2016 Nov 8;6:35. doi: 10.1186/s13395-016-0106-6. eCollection 2016.

10.

A multifunctional AAV-CRISPR-Cas9 and its host response.

Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM.

Nat Methods. 2016 Oct;13(10):868-74. doi: 10.1038/nmeth.3993. Epub 2016 Sep 5.

11.

The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury.

Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB.

Endocrinology. 2016 Oct;157(10):4066-4075. Epub 2016 Aug 15.

12.

Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.

Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ.

J Exp Med. 2016 Jul 25;213(8):1497-512. doi: 10.1084/jem.20151912. Epub 2016 Jul 11.

13.

Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

Gage FH, Guarente LP, Wagers AJ.

Trends Mol Med. 2016 Aug;22(8):633-634. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5. No abstract available.

PMID:
27396512
14.

Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization.

Wang LD, Ficarro SB, Hutchinson JN, Csepanyi-Komi R, Nguyen PT, Wisniewski E, Sullivan J, Hofmann O, Ligeti E, Marto JA, Wagers AJ.

Blood. 2016 Sep 15;128(11):1465-74. doi: 10.1182/blood-2016-05-711424. Epub 2016 Jun 30.

15.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Apr 7;165(2):497. doi: 10.1016/j.cell.2016.03.037. No abstract available.

16.

Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.

Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT.

Circ Res. 2016 Apr 1;118(7):1125-41; discussion 1142. doi: 10.1161/CIRCRESAHA.116.308391. Review.

17.

Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease.

Almada AE, Wagers AJ.

Nat Rev Mol Cell Biol. 2016 May;17(5):267-79. doi: 10.1038/nrm.2016.7. Epub 2016 Mar 9. Review.

18.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Erratum in: Cell. 2016 Apr 7;165(2):497.

19.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D.

Immunity. 2016 Feb 16;44(2):355-67. doi: 10.1016/j.immuni.2016.01.009. Epub 2016 Feb 9.

20.

In vivo gene editing in dystrophic mouse muscle and muscle stem cells.

Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ.

Science. 2016 Jan 22;351(6271):407-411. doi: 10.1126/science.aad5177. Epub 2015 Dec 31.

21.

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.

Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson RT, Richards NG, Hahn WC, Wagers AJ.

Elife. 2015 Oct 24;4. pii: e09436. doi: 10.7554/eLife.09436.

22.

Circulating Growth Differentiation Factor 11/8 Levels Decline With Age.

Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT.

Circ Res. 2016 Jan 8;118(1):29-37. doi: 10.1161/CIRCRESAHA.115.307521. Epub 2015 Oct 21. Erratum in: Circ Res. 2018 Jan 5;122(1):e3-e4.

23.

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.

Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ.

Exp Cell Res. 2016 Jan 1;340(1):43-52. doi: 10.1016/j.yexcr.2015.10.008. Epub 2015 Oct 13.

24.

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.

Kowalczyk MS, Tirosh I, Heckl D, Rao TN, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A.

Genome Res. 2015 Dec;25(12):1860-72. doi: 10.1101/gr.192237.115. Epub 2015 Oct 1.

25.

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts.

Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN.

Stem Cells Transl Med. 2015 Oct;4(10):1101-8. doi: 10.5966/sctm.2014-0217. Epub 2015 Aug 7.

26.

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.

Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN.

Cell Metab. 2015 Aug 4;22(2):239-52. doi: 10.1016/j.cmet.2015.07.015.

27.

FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration.

Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P.

PLoS One. 2015 Jun 3;10(6):e0128094. doi: 10.1371/journal.pone.0128094. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0133101.

28.

Young, proliferative thymic epithelial cells engraft and function in aging thymuses.

Kim MJ, Miller CM, Shadrach JL, Wagers AJ, Serwold T.

J Immunol. 2015 May 15;194(10):4784-95. doi: 10.4049/jimmunol.1403158. Epub 2015 Apr 13.

29.

Engineering Escherichia coli into a protein delivery system for mammalian cells.

Reeves AZ, Spears WE, Du J, Tan KY, Wagers AJ, Lesser CF.

ACS Synth Biol. 2015 May 15;4(5):644-54. doi: 10.1021/acssynbio.5b00002. Epub 2015 Apr 24.

30.

High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.

Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ.

Stem Cell Res. 2015 May;14(3):307-22. doi: 10.1016/j.scr.2015.02.001. Epub 2015 Feb 18.

31.

Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Hettmer S, Bronson RT, Wagers AJ.

Front Oncol. 2015 Feb 24;5:50. doi: 10.3389/fonc.2015.00050. eCollection 2015.

32.

The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.

Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ.

Leukemia. 2015 Jun;29(6):1320-30. doi: 10.1038/leu.2015.19. Epub 2015 Feb 6.

33.

Rhabdomyosarcoma: current challenges and their implications for developing therapies.

Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C.

Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. Review.

34.

How stem cells get "turned on".

Wagers AJ.

EMBO J. 2014 Dec 1;33(23):2743-4. doi: 10.15252/embj.201490272. Epub 2014 Oct 24. No abstract available.

35.

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.

Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT.

Blood. 2014 Nov 6;124(19):2937-47. doi: 10.1182/blood-2014-08-593426. Epub 2014 Sep 8.

36.

Stem cell aging: mechanisms, regulators and therapeutic opportunities.

Oh J, Lee YD, Wagers AJ.

Nat Med. 2014 Aug;20(8):870-80. doi: 10.1038/nm.3651. Review.

37.

The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD.

Cancer Cell. 2014 Aug 11;26(2):273-87. doi: 10.1016/j.ccr.2014.05.029. Epub 2014 Jul 31.

38.

Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration.

Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ.

Neuron. 2014 Jul 16;83(2):331-343. doi: 10.1016/j.neuron.2014.06.016.

39.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.

Genes Dev. 2014 Jul 15;28(14):1578-91. doi: 10.1101/gad.238733.114.

40.

Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.

Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA.

Cell Rep. 2014 Jul 10;8(1):256-71. doi: 10.1016/j.celrep.2014.06.007. Epub 2014 Jul 4.

41.

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model.

Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I.

Cell Tissue Res. 2014 Sep;357(3):815-21. doi: 10.1007/s00441-014-1900-2. Epub 2014 May 24.

42.

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.

Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.

43.

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ.

Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5.

44.

Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle.

Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ.

Stem Cell Reports. 2014 Jan 14;2(1):92-106. doi: 10.1016/j.stemcr.2013.12.006. eCollection 2014 Jan 14. Erratum in: Stem Cell Reports. 2014;2(4):560.

45.

Myogenic tumors in nevoid Basal cell carcinoma syndrome.

Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ.

J Pediatr Hematol Oncol. 2015 Mar;37(2):147-9. doi: 10.1097/MPH.0000000000000115.

46.

Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.

Cell. 2014 Jan 30;156(3):440-55. doi: 10.1016/j.cell.2013.12.039.

47.

Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.

Kikuchi K, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C.

PLoS Genet. 2014 Jan;10(1):e1004107. doi: 10.1371/journal.pgen.1004107. Epub 2014 Jan 16.

48.

Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle.

Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ.

Stem Cell Reports. 2014 Jan 14;2(1):92-106. doi: 10.1016/j.stemcr.2013.12.006. Epub 2014 Jan 14.

49.

Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.

Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D.

Cancer. 2014 Apr 1;120(7):1068-75. doi: 10.1002/cncr.28507. Epub 2013 Dec 30. Erratum in: Cancer. 2014 Jun 15;120(12):1910.

50.

Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells.

Gazit R, Garrison BS, Rao TN, Shay T, Costello J, Ericson J, Kim F, Collins JJ, Regev A, Wagers AJ, Rossi DJ; Immunological Genome Project Consortium.

Stem Cell Reports. 2013 Aug 15;1(3):266-80. doi: 10.1016/j.stemcr.2013.07.004. eCollection 2013.

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