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Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Kim J, Cocciolone AJ, Staiculescu MC, Mecham RP, Wagenseil JE.

Biomech Model Mechanobiol. 2019 Jul 3. doi: 10.1007/s10237-019-01198-2. [Epub ahead of print]


Elastic fiber fragmentation increases transmural hydraulic conductance and solute transport in mouse arteries.

Cocciolone AJ, Johnson E, Shao JY, Wagenseil JE.

J Biomech Eng. 2018 Dec 5. doi: 10.1115/1.4042173. [Epub ahead of print]


Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans.

Yamashiro Y, Thang BQ, Shin SJ, Lino CA, Nakamura T, Kim J, Sugiyama K, Tokunaga C, Sakamoto H, Osaka M, Davis EC, Wagenseil JE, Hiramatsu Y, Yanagisawa H.

Circ Res. 2018 Aug 31;123(6):660-672. doi: 10.1161/CIRCRESAHA.118.313105.


Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aorta.

Staiculescu MC, Cocciolone AJ, Procknow JD, Kim J, Wagenseil JE.

Physiol Genomics. 2018 Nov 1;50(11):988-1001. doi: 10.1152/physiolgenomics.00080.2018. Epub 2018 Oct 12.


Bio-chemo-mechanics of thoracic aortic aneurysms.

Wagenseil JE.

Curr Opin Biomed Eng. 2018 Mar;5:50-57. doi: 10.1016/j.cobme.2018.01.002. Epub 2018 Feb 7.


Reduced embryonic blood flow impacts extracellular matrix deposition in the maturing aorta.

Espinosa MG, Taber LA, Wagenseil JE.

Dev Dyn. 2018 Jul;247(7):914-923. doi: 10.1002/dvdy.24635. Epub 2018 May 26.


Elastin, arterial mechanics, and cardiovascular disease.

Cocciolone AJ, Hawes JZ, Staiculescu MC, Johnson EO, Murshed M, Wagenseil JE.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H189-H205. doi: 10.1152/ajpheart.00087.2018. Epub 2018 Apr 6. Review.


Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness.

Knutsen RH, Beeman SC, Broekelmann TJ, Liu D, Tsang KM, Kovacs A, Ye L, Danback JR, Watson A, Wardlaw A, Wagenseil JE, Garbow JR, Shoykhet M, Kozel BA.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H18-H32. doi: 10.1152/ajpheart.00683.2017. Epub 2018 Mar 2.


Effects of Increased Arterial Stiffness on Atherosclerotic Plaque Amounts.

Stoka KV, Maedeker JA, Bennett L, Bhayani SA, Gardner WS, Procknow JD, Cocciolone AJ, Walji TA, Craft CS, Wagenseil JE.

J Biomech Eng. 2018 May 1;140(5). doi: 10.1115/1.4039175.


Elastic Fibers and Large Artery Mechanics in Animal Models of Development and Disease.

Gabriela Espinosa M, Catalin Staiculescu M, Kim J, Marin E, Wagenseil JE.

J Biomech Eng. 2018 Feb 1;140(2). doi: 10.1115/1.4038704. Review.


A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.


Does elastin deficiency cause chronic kidney disease?

Wagenseil JE.

Kidney Int. 2017 Nov;92(5):1036-1038. doi: 10.1016/j.kint.2017.05.027.


Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration.

Eekhoff JD, Fang F, Kahan LG, Espinosa G, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP.

J Biomech Eng. 2017 Nov 1;139(11). doi: 10.1115/1.4037932.


Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.

Kim J, Staiculescu MC, Cocciolone AJ, Yanagisawa H, Mecham RP, Wagenseil JE.

J Biomech. 2017 Aug 16;61:199-207. doi: 10.1016/j.jbiomech.2017.07.011. Epub 2017 Jul 25.


Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.

Staiculescu MC, Kim J, Mecham RP, Wagenseil JE.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H446-H456. doi: 10.1152/ajpheart.00712.2016. Epub 2017 May 26.


Special Issue: Spotlight of the Future of Cardiovascular Engineering Frontiers and Challenges in Cardiovascular Biomechanics.

Holmes JW, Wagenseil JE.

J Biomech Eng. 2016 Nov 1;138(11). doi: 10.1115/1.4034873. No abstract available.


Hypertension and decreased aortic compliance due to reduced elastin amounts do not increase atherosclerotic plaque accumulation in Ldlr-/- mice.

Maedeker JA, Stoka KV, Bhayani SA, Gardner WS, Bennett L, Procknow JD, Staiculescu MC, Walji TA, Craft CS, Wagenseil JE.

Atherosclerosis. 2016 Jun;249:22-9. doi: 10.1016/j.atherosclerosis.2016.03.022. Epub 2016 Mar 21.


Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.

Yamashiro Y, Papke CL, Kim J, Ringuette LJ, Zhang QJ, Liu ZP, Mirzaei H, Wagenseil JE, Davis EC, Yanagisawa H.

Sci Signal. 2015 Oct 20;8(399):ra105. doi: 10.1126/scisignal.aab3141.


Elastin Insufficiency Predisposes Mice to Impaired Glucose Metabolism.

DeMarsilis AJ, Walji TA, Maedeker JA, Stoka KV, Kozel BA, Mecham RP, Wagenseil JE, Craft CS.

J Mol Genet Med. 2014 Oct;8(3). pii: 129.


Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice.

Kim J, Procknow JD, Yanagisawa H, Wagenseil JE.

Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H103-13. doi: 10.1152/ajpheart.00178.2015. Epub 2015 May 1.


Critical buckling pressure in mouse carotid arteries with altered elastic fibers.

Luetkemeyer CM, James RH, Devarakonda ST, Le VP, Liu Q, Han HC, Wagenseil JE.

J Mech Behav Biomed Mater. 2015 Jun;46:69-82. doi: 10.1016/j.jmbbm.2015.02.013. Epub 2015 Feb 28.


Mechanical factors direct mouse aortic remodelling during early maturation.

Le VP, Cheng JK, Kim J, Staiculescu MC, Ficker SW, Sheth SC, Bhayani SA, Mecham RP, Yanagisawa H, Wagenseil JE.

J R Soc Interface. 2015 Mar 6;12(104):20141350. doi: 10.1098/rsif.2014.1350.


Bio-Chemo-Mechanical Models of Vascular Mechanics.

Kim J, Wagenseil JE.

Ann Biomed Eng. 2015 Jul;43(7):1477-87. doi: 10.1007/s10439-014-1201-7. Epub 2014 Dec 3. Review.


Fibulin-5 null mice with decreased arterial compliance maintain normal systolic left ventricular function, but not diastolic function during maturation.

Le VP, Stoka KV, Yanagisawa H, Wagenseil JE.

Physiol Rep. 2014 Mar 20;2(3):e00257. doi: 10.1002/phy2.257. Print 2014.


Measuring, reversing, and modeling the mechanical changes due to the absence of Fibulin-4 in mouse arteries.

Le VP, Yamashiro Y, Yanagisawa H, Wagenseil JE.

Biomech Model Mechanobiol. 2014 Oct;13(5):1081-95. doi: 10.1007/s10237-014-0556-x. Epub 2014 Feb 14.


The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells.

Gabriela Espinosa M, Gardner WS, Bennett L, Sather BA, Yanagisawa H, Wagenseil JE.

J Biomech Eng. 2014 Feb;136(2):021030. doi: 10.1115/1.4026203.


Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.

Huang J, Yamashiro Y, Papke CL, Ikeda Y, Lin Y, Patel M, Inagami T, Le VP, Wagenseil JE, Yanagisawa H.

Sci Transl Med. 2013 May 1;5(183):183ra58, 1-11. doi: 10.1126/scitranslmed.3005025.


Murray's Law in elastin haploinsufficient (Eln+/-) and wild-type (WT) mice.

Sather BA, Hageman D, Wagenseil JE.

J Biomech Eng. 2012 Dec;134(12):124504. doi: 10.1115/1.4023093.


A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta.

Cheng JK, Stoilov I, Mecham RP, Wagenseil JE.

Biomech Model Mechanobiol. 2013 Jun;12(3):497-510. doi: 10.1007/s10237-012-0420-9. Epub 2012 Jul 12.


Extracellular matrix and the mechanics of large artery development.

Cheng JK, Wagenseil JE.

Biomech Model Mechanobiol. 2012 Nov;11(8):1169-86. doi: 10.1007/s10237-012-0405-8. Epub 2012 May 15.


Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.

Sugitani H, Hirano E, Knutsen RH, Shifren A, Wagenseil JE, Ciliberto C, Kozel BA, Urban Z, Davis EC, Broekelmann TJ, Mecham RP.

J Biol Chem. 2012 Jun 22;287(26):22055-67. doi: 10.1074/jbc.M111.327940. Epub 2012 May 9.


Measuring left ventricular pressure in late embryonic and neonatal mice.

Le VP, Kovacs A, Wagenseil JE.

J Vis Exp. 2012 Feb 23;(60). pii: 3756. doi: 10.3791/3756.


Mechanical testing of mouse carotid arteries: from newborn to adult.

Amin M, Le VP, Wagenseil JE.

J Vis Exp. 2012 Feb 23;(60). pii: 3733. doi: 10.3791/3733.


Elastin in large artery stiffness and hypertension.

Wagenseil JE, Mecham RP.

J Cardiovasc Transl Res. 2012 Jun;5(3):264-73. doi: 10.1007/s12265-012-9349-8. Review.


Effect of storage duration on the mechanical behavior of mouse carotid artery.

Amin M, Kunkel AG, Le VP, Wagenseil JE.

J Biomech Eng. 2011 Jul;133(7):071007. doi: 10.1115/1.4004415.


Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice.

Le VP, Knutsen RH, Mecham RP, Wagenseil JE.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H221-9. doi: 10.1152/ajpheart.00119.2011. Epub 2011 May 2.


A constrained mixture model for developing mouse aorta.

Wagenseil JE.

Biomech Model Mechanobiol. 2011 Oct;10(5):671-87. doi: 10.1007/s10237-010-0265-z. Epub 2010 Nov 3.


The importance of elastin to aortic development in mice.

Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H257-64. doi: 10.1152/ajpheart.00194.2010. Epub 2010 May 21.


Discrete contributions of elastic fiber components to arterial development and mechanical compliance.

Carta L, Wagenseil JE, Knutsen RH, Mariko B, Faury G, Davis EC, Starcher B, Mecham RP, Ramirez F.

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2083-9. doi: 10.1161/ATVBAHA.109.193227. Epub 2009 Oct 22.


Vascular extracellular matrix and arterial mechanics.

Wagenseil JE, Mecham RP.

Physiol Rev. 2009 Jul;89(3):957-89. doi: 10.1152/physrev.00041.2008. Review.


Reduced vessel elasticity alters cardiovascular structure and function in newborn mice.

Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP.

Circ Res. 2009 May 22;104(10):1217-24. doi: 10.1161/CIRCRESAHA.108.192054. Epub 2009 Apr 16.


New insights into elastic fiber assembly.

Wagenseil JE, Mecham RP.

Birth Defects Res C Embryo Today. 2007 Dec;81(4):229-40. doi: 10.1002/bdrc.20111. Review.


Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture.

Wagenseil JE, Knutsen RH, Li DY, Mecham RP.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H574-82. Epub 2007 Mar 30.


Modeling cell and matrix anisotropy in fibroblast populated collagen vessels.

Wagenseil JE, Okamoto RJ.

Biomech Model Mechanobiol. 2007 Apr;6(3):151-62. Epub 2006 Mar 7.


Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters.

Kozel BA, Rongish BJ, Czirok A, Zach J, Little CD, Davis EC, Knutsen RH, Wagenseil JE, Levy MA, Mecham RP.

J Cell Physiol. 2006 Apr;207(1):87-96.


Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries.

Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1209-17. Epub 2005 Apr 29.


Cell orientation influences the biaxial mechanical properties of fibroblast populated collagen vessels.

Wagenseil JE, Elson EL, Okamoto RJ.

Ann Biomed Eng. 2004 May;32(5):720-31.


One-dimensional viscoelastic behavior of fibroblast populated collagen matrices.

Wagenseil JE, Wakatsuki T, Okamoto RJ, Zahalak GI, Elson EL.

J Biomech Eng. 2003 Oct;125(5):719-25.


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