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Items: 1 to 50 of 64

1.

Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy.

Eleftheriadou O, Boguslavskyi A, Longman MR, Cowan J, Francois A, Heads RJ, Wadzinski BE, Ryan A, Shattock MJ, Snabaitis AK.

Basic Res Cardiol. 2017 Jul;112(4):37. doi: 10.1007/s00395-017-0625-2. Epub 2017 May 19.

2.

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.

LeNoue-Newton ML, Wadzinski BE, Spiller BW.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8.

3.

Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells.

Mo ST, Chiang SJ, Lai TY, Cheng YL, Chung CE, Kuo SC, Reece KM, Chen YC, Chang NS, Wadzinski BE, Chiang CW.

PLoS One. 2014 Dec 23;9(12):e116074. doi: 10.1371/journal.pone.0116074. eCollection 2014.

4.

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.

Williams BC, Filter JJ, Blake-Hodek KA, Wadzinski BE, Fuda NJ, Shalloway D, Goldberg ML.

Elife. 2014 Mar 11;3:e01695. doi: 10.7554/eLife.01695.

5.

Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.

Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE.

J Biol Chem. 2014 Feb 14;289(7):4219-32. doi: 10.1074/jbc.M113.518514. Epub 2013 Dec 26.

6.

High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit.

Arora DK, Machhadieh B, Matti A, Wadzinski BE, Ramanadham S, Kowluru A.

Endocrinology. 2014 Feb;155(2):380-91. doi: 10.1210/en.2013-1773. Epub 2013 Nov 21.

7.

Protein phosphatase 2A family members (PP2A and PP6) associate with U1 snRNP and the spliceosome during pre-mRNA splicing.

Kamoun M, Filali M, Murray MV, Awasthi S, Wadzinski BE.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):306-11. doi: 10.1016/j.bbrc.2013.09.068. Epub 2013 Sep 21.

8.

Structural basis of protein phosphatase 2A stable latency.

Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, Xing Y.

Nat Commun. 2013;4:1699. doi: 10.1038/ncomms2663.

9.

Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster.

Wang N, Leung HT, Mazalouskas MD, Watkins GR, Gomez RJ, Wadzinski BE.

PLoS One. 2012;7(6):e38569. doi: 10.1371/journal.pone.0038569. Epub 2012 Jun 6.

10.

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

Watkins GR, Wang N, Mazalouskas MD, Gomez RJ, Guthrie CR, Kraemer BC, Schweiger S, Spiller BW, Wadzinski BE.

J Biol Chem. 2012 Jul 13;287(29):24207-15. doi: 10.1074/jbc.M112.368613. Epub 2012 May 21.

11.

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW.

J Biol Chem. 2011 May 20;286(20):17665-71. doi: 10.1074/jbc.M111.222414. Epub 2011 Mar 29.

12.

Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle.

Panosian TD, Nannemann DP, Watkins GR, Phelan VV, McDonald WH, Wadzinski BE, Bachmann BO, Iverson TM.

J Biol Chem. 2011 Mar 11;286(10):8043-54. doi: 10.1074/jbc.M110.201350. Epub 2010 Dec 30.

13.

Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.

Widau RC, Jin Y, Dixon SA, Wadzinski BE, Gallagher PJ.

J Biol Chem. 2010 Apr 30;285(18):13827-38. doi: 10.1074/jbc.M109.085076. Epub 2010 Mar 10.

14.

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

McConnell JL, Watkins GR, Soss SE, Franz HS, McCorvey LR, Spiller BW, Chazin WJ, Wadzinski BE.

Biochemistry. 2010 Mar 2;49(8):1713-8. doi: 10.1021/bi901837h.

15.

The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.

Reece KM, Mazalouskas MD, Wadzinski BE.

Biochem Biophys Res Commun. 2009 Sep 4;386(4):582-7. doi: 10.1016/j.bbrc.2009.06.062. Epub 2009 Jun 16.

16.

Targeting protein serine/threonine phosphatases for drug development.

McConnell JL, Wadzinski BE.

Mol Pharmacol. 2009 Jun;75(6):1249-61. doi: 10.1124/mol.108.053140. Epub 2009 Mar 19. Review.

17.

The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.

Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R.

J Biol Chem. 2009 Jan 9;284(2):759-65. doi: 10.1074/jbc.M806314200. Epub 2008 Nov 12.

18.

Role of protein phosphatase 2A in regulating the visual signaling in Drosophila.

Wang N, Leung HT, Pak WL, Carl YT, Wadzinski BE, Shieh BH.

J Neurosci. 2008 Feb 6;28(6):1444-51. doi: 10.1523/JNEUROSCI.5134-07.2008.

19.

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.

McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE.

Oncogene. 2007 Sep 6;26(41):6021-30. Epub 2007 Mar 26.

PMID:
17384681
20.

Isolation and characterization of PP2A holoenzymes containing FLAG-tagged B subunits.

Adams DG, Wadzinski BE.

Methods Mol Biol. 2007;365:101-11.

PMID:
17200557
21.

An automated fluorescence-based method for continuous assay of PP2A activity.

Wegner AM, McConnell JL, Blakely RD, Wadzinski BE.

Methods Mol Biol. 2007;365:61-9.

PMID:
17200554
22.

Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.

Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME.

Circulation. 2006 Sep 26;114(13):1352-9. Epub 2006 Sep 18.

PMID:
16982937
23.

Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage.

Codreanu SG, Adams DG, Dawson ES, Wadzinski BE, Liebler DC.

Biochemistry. 2006 Aug 22;45(33):10020-9.

PMID:
16906760
24.
25.

Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.

Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR.

J Biol Chem. 2006 Mar 10;281(10):6236-45. Epub 2006 Jan 9.

26.

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

Adams DG, Coffee RL Jr, Zhang H, Pelech S, Strack S, Wadzinski BE.

J Biol Chem. 2005 Dec 30;280(52):42644-54. Epub 2005 Oct 20.

27.

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.

Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S.

J Biol Chem. 2005 Oct 28;280(43):36029-36. Epub 2005 Aug 28.

28.

Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.

Kray AE, Carter RS, Pennington KN, Gomez RJ, Sanders LE, Llanes JM, Khan WN, Ballard DW, Wadzinski BE.

J Biol Chem. 2005 Oct 28;280(43):35974-82. Epub 2005 Aug 26.

29.

Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.

Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E.

Genes Dev. 2005 Apr 1;19(7):827-39.

30.

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.

Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X.

Cell Cycle. 2004 Oct;3(10):1320-30. Epub 2004 Oct 15. Erratum in: Cell Cycle. 2005 Mar;4(3):e45.

PMID:
15467457
31.

O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits.

Wells L, Kreppel LK, Comer FI, Wadzinski BE, Hart GW.

J Biol Chem. 2004 Sep 10;279(37):38466-70. Epub 2004 Jul 7.

32.

Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.

Anderson KA, Noeldner PK, Reece K, Wadzinski BE, Means AR.

J Biol Chem. 2004 Jul 23;279(30):31708-16. Epub 2004 May 13.

33.

Analysis of specific interactions of native protein phosphatase 1 isoforms with targeting subunits.

Colbran RJ, Carmody LC, Bauman PA, Wadzinski BE, Bass MA.

Methods Enzymol. 2003;366:156-75.

PMID:
14674248
34.

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.

PMID:
12963337
35.
36.

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5107-12. Epub 2003 Apr 8.

37.

A novel in vitro assay for deubiquitination of I kappa B alpha.

Strayhorn WD, Wadzinski BE.

Arch Biochem Biophys. 2002 Apr 1;400(1):76-84.

PMID:
11913973
38.

Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells.

Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K.

J Am Soc Nephrol. 2001 Dec;12(12):2601-8.

39.

Protein phosphatase 2A interacts with and directly dephosphorylates RelA.

Yang J, Fan GH, Wadzinski BE, Sakurai H, Richmond A.

J Biol Chem. 2001 Dec 21;276(51):47828-33. Epub 2001 Oct 8.

40.

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.

Chiang CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S, Wadzinski BE, Yang E.

Blood. 2001 Mar 1;97(5):1289-97.

41.

Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.

Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD.

J Neurosci. 2000 Oct 15;20(20):7571-8.

42.

Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors.

Liu M, Parker LL, Wadzinski BE, Shieh BH.

J Biol Chem. 2000 Apr 21;275(16):12194-9.

43.

Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin, and selected catalytic subunit isoforms.

MacMillan LB, Bass MA, Cheng N, Howard EF, Tamura M, Strack S, Wadzinski BE, Colbran RJ.

J Biol Chem. 1999 Dec 10;274(50):35845-54.

44.

Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A.

Strack S, Chang D, Zaucha JA, Colbran RJ, Wadzinski BE.

FEBS Lett. 1999 Nov 5;460(3):462-6.

45.

Differential cellular and subcellular localization of protein phosphatase 1 isoforms in brain.

Strack S, Kini S, Ebner FF, Wadzinski BE, Colbran RJ.

J Comp Neurol. 1999 Oct 25;413(3):373-84.

PMID:
10502246
46.
47.
48.

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

Westphal RS, Coffee RL Jr, Marotta A, Pelech SL, Wadzinski BE.

J Biol Chem. 1999 Jan 8;274(2):687-92.

49.

protein phosphatase 2A regulatory subunits. cDNA cloning and analysis of mRNA expression.

Zaucha JA, Westphal RS, Wadzinski BE.

Methods Mol Biol. 1998;93:279-91. No abstract available.

PMID:
9664545
50.

A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

Westphal RS, Anderson KA, Means AR, Wadzinski BE.

Science. 1998 May 22;280(5367):1258-61.

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