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Items: 1 to 50 of 111

1.

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R.

Hum Mol Genet. 2019 Feb 11. doi: 10.1093/hmg/ddz038. [Epub ahead of print]

PMID:
30753527
2.

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R.

Cell Stem Cell. 2019 Jan 3;24(1):93-106.e6. doi: 10.1016/j.stem.2018.10.023. Epub 2018 Nov 29.

3.

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells.

Smith AM, Depp C, Ryan BJ, Johnston GI, Alegre-Abarrategui J, Evetts S, Rolinski M, Baig F, Ruffmann C, Simon AK, Hu MTM, Wade-Martins R.

Mov Disord. 2018 Oct;33(10):1580-1590. doi: 10.1002/mds.104. Epub 2018 Oct 7.

4.

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Gordon D, Dafinca R, Scaber J, Alegre-Abarrategui J, Farrimond L, Scott C, Biggs D, Kent L, Oliver PL, Davies B, Ansorge O, Wade-Martins R, Talbot K.

Neurobiol Dis. 2019 Jan;121:148-162. doi: 10.1016/j.nbd.2018.09.024. Epub 2018 Oct 2.

PMID:
30290270
5.

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.

Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT.

Neurology. 2018 Oct 16;91(16):e1528-e1538. doi: 10.1212/WNL.0000000000006366. Epub 2018 Sep 19.

6.

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.

Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ.

Metabolites. 2018 Sep 7;8(3). pii: E50. doi: 10.3390/metabo8030050.

7.

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.

Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL.

Mol Neurobiol. 2019 Mar;56(3):1558-1577. doi: 10.1007/s12035-018-1174-x. Epub 2018 Jun 15.

8.

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.

Lai MC, Bechy AL, Denk F, Collins E, Gavriliouk M, Zaugg JB, Ryan BJ, Wade-Martins R, Caffrey TM.

Mol Neurodegener. 2017 Oct 30;12(1):79. doi: 10.1186/s13024-017-0224-6.

9.

Are rodent models of Parkinson's disease behaving as they should?

Vingill S, Connor-Robson N, Wade-Martins R.

Behav Brain Res. 2018 Oct 15;352:133-141. doi: 10.1016/j.bbr.2017.10.021. Epub 2017 Oct 24. Review.

PMID:
29074404
10.

Convergent pathways in Parkinson's disease.

Cherubini M, Wade-Martins R.

Cell Tissue Res. 2018 Jul;373(1):79-90. doi: 10.1007/s00441-017-2700-2. Epub 2017 Oct 23. Review.

11.

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA.

Mol Ther. 2017 Oct 4;25(10):2404-2414. doi: 10.1016/j.ymthe.2017.08.017. Epub 2017 Aug 31.

12.

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA.

Sci Rep. 2017 Aug 21;7(1):9003. doi: 10.1038/s41598-017-09362-3.

13.

Alpha-synuclein oligomers: a new hope.

Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J.

Acta Neuropathol. 2017 Dec;134(6):819-838. doi: 10.1007/s00401-017-1755-1. Epub 2017 Aug 12. Review.

14.

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.

Doucet M, El-Turabi A, Zabel F, Hunn BHM, Bengoa-Vergniory N, Cioroch M, Ramm M, Smith AM, Gomes AC, Cabral de Miranda G, Wade-Martins R, Bachmann MF.

PLoS One. 2017 Aug 10;12(8):e0181844. doi: 10.1371/journal.pone.0181844. eCollection 2017.

15.

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM.

Stem Cell Reports. 2017 Aug 8;9(2):587-599. doi: 10.1016/j.stemcr.2017.06.005. Epub 2017 Jul 6.

16.

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA.

Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.

17.

The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.

Booth HDE, Hirst WD, Wade-Martins R.

Trends Neurosci. 2017 Jun;40(6):358-370. doi: 10.1016/j.tins.2017.04.001. Epub 2017 May 17. Review.

18.

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice.

Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O, Wade-Martins R.

Front Neurosci. 2017 Apr 24;11:201. doi: 10.3389/fnins.2017.00201. eCollection 2017.

19.

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

Kerr AG, Tam LCS, Hale AB, Cioroch M, Douglas G, Agkatsev S, Hibbitt O, Mason J, Holt-Martyn J, Bataille CJR, Wynne GM, Channon KM, Russell AJ, Wade-Martins R.

J Pharmacol Exp Ther. 2017 Jun;361(3):417-428. doi: 10.1124/jpet.116.239574. Epub 2017 Mar 30.

20.

Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D, Wade-Martins R.

Sci Rep. 2017 Feb 24;7:43198. doi: 10.1038/srep43198.

21.

Whole-exome sequencing of 228 patients with sporadic Parkinson's disease.

Sandor C, Honti F, Haerty W, Szewczyk-Krolikowski K, Tomlinson P, Evetts S, Millin S, Keane T, McCarthy SA, Durbin R, Talbot K, Hu M, Webber C, Ponting CP, Wade-Martins R.

Sci Rep. 2017 Jan 24;7:41188. doi: 10.1038/srep41188.

22.

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Bailey J, Shaw A, Fischer R, Ryan BJ, Kessler BM, McCullagh J, Wade-Martins R, Channon KM, Crabtree MJ.

Free Radic Biol Med. 2017 Mar;104:214-225. doi: 10.1016/j.freeradbiomed.2017.01.012. Epub 2017 Jan 17.

23.

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C.

Hum Mol Genet. 2017 Feb 1;26(3):552-566. doi: 10.1093/hmg/ddw412.

24.

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.

Fernandes HJ, Ryan BJ, Wade-Martins R.

Front Neurosci. 2016 Dec 23;10:578. doi: 10.3389/fnins.2016.00578. eCollection 2016. No abstract available.

25.

Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

Kerr AG, Tam LC, Hale AB, Cioroch M, Douglas G, Channon KM, Wade-Martins R.

Mol Ther Nucleic Acids. 2016 Nov 8;5(11):e383. doi: 10.1038/mtna.2016.86.

26.

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, Joachim C, Esiri M, Evetts SG, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Hu MT, Parkkinen L, Green AJ.

Ann Clin Transl Neurol. 2016 Aug 28;3(10):812-818. eCollection 2016 Oct.

27.

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.

Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D.

Nucleic Acids Res. 2016 Dec 15;44(22):10960-10973. Epub 2016 Aug 17.

28.

The infectious BAC genomic DNA expression library: a high capacity vector system for functional genomics.

Lufino MM, Edser PA, Quail MA, Rice S, Adams DJ, Wade-Martins R.

Sci Rep. 2016 Jun 29;6:28644. doi: 10.1038/srep28644.

29.

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Dafinca R, Scaber J, Ababneh N, Lalic T, Weir G, Christian H, Vowles J, Douglas AG, Fletcher-Jones A, Browne C, Nakanishi M, Turner MR, Wade-Martins R, Cowley SA, Talbot K.

Stem Cells. 2016 Aug;34(8):2063-78. doi: 10.1002/stem.2388. Epub 2016 May 4.

30.

Improving the physiological realism of experimental models.

Vinnakota KC, Cha CY, Rorsman P, Balaban RS, La Gerche A, Wade-Martins R, Beard DA, Jeneson JA.

Interface Focus. 2016 Apr 6;6(2):20150076. doi: 10.1098/rsfs.2015.0076. Review.

31.

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

Dodson PD, Dreyer JK, Jennings KA, Syed EC, Wade-Martins R, Cragg SJ, Bolam JP, Magill PJ.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2180-8. doi: 10.1073/pnas.1515941113. Epub 2016 Mar 21.

32.

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R.

Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.

33.

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R.

Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6.

34.

Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease.

Keane H, Ryan BJ, Jackson B, Whitmore A, Wade-Martins R.

Sci Rep. 2015 Nov 26;5:17004. doi: 10.1038/srep17004.

35.

Can pathological oligomeric proteins make good biomarkers? (Commentary on Williams et al.).

Roberts RF, Wade-Martins R.

Eur J Neurosci. 2016 Jan;43(1):1-2. doi: 10.1111/ejn.13115. Epub 2015 Dec 10. No abstract available.

PMID:
26503665
36.

Restoration of Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in Genetically Deficient Induced Pluripotent Stem Cells.

Ramakrishnan VM, Yang JY, Tien KT, McKinley TR, Bocard BR, Maijub JG, Burchell PO, Williams SK, Morris ME, Hoying JB, Wade-Martins R, West FD, Boyd NL.

Sci Rep. 2015 Aug 26;5:13231. doi: 10.1038/srep13231.

37.

Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels.

Sacilotto N, Castillo J, Riffo-Campos ÁL, Flores JM, Hibbitt O, Wade-Martins R, López C, Rodrigo MI, Franco L, López-Rodas G.

PLoS One. 2015 Jul 10;10(7):e0132477. doi: 10.1371/journal.pone.0132477. eCollection 2015.

38.

Delivery of the 135 kb human frataxin genomic DNA locus gives rise to different frataxin isoforms.

Pérez-Luz S, Gimenez-Cassina A, Fernández-Frías I, Wade-Martins R, Díaz-Nido J.

Genomics. 2015 Aug;106(2):76-82. doi: 10.1016/j.ygeno.2015.05.006. Epub 2015 May 28.

39.

Identification of distinct circulating exosomes in Parkinson's disease.

Tomlinson PR, Zheng Y, Fischer R, Heidasch R, Gardiner C, Evetts S, Hu M, Wade-Martins R, Turner MR, Morris J, Talbot K, Kessler BM, Tofaris GK.

Ann Clin Transl Neurol. 2015 Apr;2(4):353-61. doi: 10.1002/acn3.175. Epub 2015 Feb 6.

40.

Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.

Silva AM, Brown JM, Buckle VJ, Wade-Martins R, Lufino MM.

Hum Mol Genet. 2015 Jun 15;24(12):3457-71. doi: 10.1093/hmg/ddv096. Epub 2015 Mar 26.

41.

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.

Ryan BJ, Hoek S, Fon EA, Wade-Martins R.

Trends Biochem Sci. 2015 Apr;40(4):200-10. doi: 10.1016/j.tibs.2015.02.003. Epub 2015 Mar 8. Review.

PMID:
25757399
42.

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.

Roberts RF, Wade-Martins R, Alegre-Abarrategui J.

Brain. 2015 Jun;138(Pt 6):1642-57. doi: 10.1093/brain/awv040. Epub 2015 Mar 1.

43.

Impaired intracellular trafficking defines early Parkinson's disease.

Hunn BH, Cragg SJ, Bolam JP, Spillantini MG, Wade-Martins R.

Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29. Review.

44.

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.

Mutihac R, Alegre-Abarrategui J, Gordon D, Farrimond L, Yamasaki-Mann M, Talbot K, Wade-Martins R.

Neurobiol Dis. 2015 Mar;75:64-77. doi: 10.1016/j.nbd.2014.12.010. Epub 2014 Dec 17.

PMID:
25526708
45.

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.

Ryan BJ, Crabtree MJ, Channon KM, Wade-Martins R.

Brain. 2015 May;138(Pt 5):e348. doi: 10.1093/brain/awu308. Epub 2014 Nov 14. No abstract available.

46.

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

Groh M, Lufino MM, Wade-Martins R, Gromak N.

PLoS Genet. 2014 May 1;10(5):e1004318. doi: 10.1371/journal.pgen.1004318. eCollection 2014 May.

47.

Physiological characterisation of human iPS-derived dopaminergic neurons.

Hartfield EM, Yamasaki-Mann M, Ribeiro Fernandes HJ, Vowles J, James WS, Cowley SA, Wade-Martins R.

PLoS One. 2014 Feb 21;9(2):e87388. doi: 10.1371/journal.pone.0087388. eCollection 2014.

48.

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease.

Beevers JE, Caffrey TM, Wade-Martins R.

Biochem Soc Trans. 2013 Dec;41(6):1503-8. doi: 10.1042/BST20130194. Review.

PMID:
24256244
49.

The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.

Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Wade-Martins R, Talbot K, Ben-Shlomo Y, Hu MT.

Parkinsonism Relat Disord. 2014 Jan;20(1):99-105. doi: 10.1016/j.parkreldis.2013.09.025. Epub 2013 Oct 12.

PMID:
24183678
50.

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.

Ryan BJ, Lourenço-Venda LL, Crabtree MJ, Hale AB, Channon KM, Wade-Martins R.

Free Radic Biol Med. 2014 Feb;67:58-68. doi: 10.1016/j.freeradbiomed.2013.10.008. Epub 2013 Oct 19.

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