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Items: 26


Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

Bell JA, Carslake D, Wade KH, Richmond RC, Langdon RJ, Vincent EE, Holmes MV, Timpson NJ, Davey Smith G.

PLoS Med. 2018 Aug 28;15(8):e1002641. doi: 10.1371/journal.pmed.1002641. eCollection 2018 Aug.


Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics.

Khouja JN, Simpkin AJ, O'Keeffe LM, Wade KH, Houtepen LC, Relton CL, Suderman M, Howe LD.

Clin Epigenetics. 2018 Jun 27;10:86. doi: 10.1186/s13148-018-0520-1. eCollection 2018.


Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?

Yarmolinsky J, Wade KH, Richmond RC, Langdon RJ, Bull CJ, Tilling KM, Relton CL, Lewis SJ, Davey Smith G, Martin RM.

Cancer Epidemiol Biomarkers Prev. 2018 Sep;27(9):995-1010. doi: 10.1158/1055-9965.EPI-17-1177. Epub 2018 Jun 25. Review.


The MR-Base platform supports systematic causal inference across the human phenome.

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC.

Elife. 2018 May 30;7. pii: e34408. doi: 10.7554/eLife.34408.


Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.

O'Keeffe LM, Howe LD, Fraser A, Hughes AD, Wade KH, Anderson EL, Lawlor DA, Erzurumluoglu AM, Davey-Smith G, Rodriguez S, Stergiakouli E.

Atherosclerosis. 2018 Jul;274:94-103. doi: 10.1016/j.atherosclerosis.2018.04.027. Epub 2018 Apr 25.


Physical activity and longevity: how to move closer to causal inference.

Wade KH, Richmond RC, Davey Smith G.

Br J Sports Med. 2018 Jul;52(14):890-891. doi: 10.1136/bjsports-2017-098995. Epub 2018 Mar 15. No abstract available.


Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

Corbin LJ, Tan VY, Hughes DA, Wade KH, Paul DS, Tansey KE, Butcher F, Dudbridge F, Howson JM, Jallow MW, John C, Kingston N, Lindgren CM, O'Donavan M, O'Rahilly S, Owen MJ, Palmer CNA, Pearson ER, Scott RA, van Heel DA, Whittaker J, Frayling T, Tobin MD, Wain LV, Smith GD, Evans DM, Karpe F, McCarthy MI, Danesh J, Franks PW, Timpson NJ.

Nat Commun. 2018 Feb 19;9(1):711. doi: 10.1038/s41467-018-03109-y. Review.


Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans.

Cho Y, Kwak S, Lewis SJ, Wade KH, Relton CL, Smith GD, Shin MJ.

Sci Rep. 2018 Jan 11;8(1):458. doi: 10.1038/s41598-017-18856-z.


The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study.

Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Brennan P.

J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx012.


Assessing the causal role of adiposity on disordered eating in childhood, adolescence, and adulthood: a Mendelian randomization analysis.

Reed ZE, Micali N, Bulik CM, Davey Smith G, Wade KH.

Am J Clin Nutr. 2017 Sep;106(3):764-772. doi: 10.3945/ajcn.117.154104. Epub 2017 Jul 26.


Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study.

Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Albanes D, Aldrich MC, Andrew A, Arnold SM, Bickeböller H, Bojesen SE, Brunnström H, Manjer J, Brüske I, Caporaso NE, Chen C, Christiani DC, Christian WJ, Doherty JA, Duell EJ, Field JK, Davies MPA, Marcus MW, Goodman GE, Grankvist K, Haugen A, Hong YC, Kiemeney LA, van der Heijden EHFM, Kraft P, Johansson MB, Lam S, Landi MT, Lazarus P, Le Marchand L, Liu G, Melander O, Park SL, Rennert G, Risch A, Haura EB, Scelo G, Zaridze D, Mukeriya A, Savić M, Lissowska J, Swiatkowska B, Janout V, Holcatova I, Mates D, Schabath MB, Shen H, Tardon A, Teare MD, Woll P, Tsao MS, Wu X, Yuan JM, Hung RJ, Amos CI, McKay J, Brennan P.

PLoS One. 2017 Jun 8;12(6):e0177875. doi: 10.1371/journal.pone.0177875. eCollection 2017.


Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G.

JAMA Oncol. 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945.


Prospective associations between problematic eating attitudes in midchildhood and the future onset of adolescent obesity and high blood pressure.

Wade KH, Kramer MS, Oken E, Timpson NJ, Skugarevsky O, Patel R, Bogdanovich N, Vilchuck K, Davey Smith G, Thompson J, Martin RM.

Am J Clin Nutr. 2017 Feb;105(2):306-312. doi: 10.3945/ajcn.116.141697. Epub 2016 Dec 14.


Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer.

Bull CJ, Yarmolinsky J, Wade KH.

Int J Epidemiol. 2016 Oct;45(5):1631-1633. No abstract available.


BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization.

Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, Timpson NJ.

Diabetes. 2016 Oct;65(10):3002-7. doi: 10.2337/db16-0418. Epub 2016 Jul 8.


Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies.

Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey Smith G.

Am J Clin Nutr. 2016 Apr;103(4):965-78.


Blood pressure and mortality: using offspring blood pressure as an instrument for own blood pressure in the HUNT study.

Wade KH, Carslake D, Nilsen TI, Timpson NJ, Davey Smith G, Romundstad P.

Sci Rep. 2015 Jul 22;5:12399. doi: 10.1038/srep12399.


Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid.

Wade KH, Forouhi NG, Cook DG, Johnson P, McConnachie A, Morris RW, Rodriguez S, Ye Z, Ebrahim S, Padmanabhan S, Watt G, Bruckdorfer KR, Wareham NJ, Whincup PH, Chanock S, Sattar N, Lawlor DA, Davey Smith G, Timpson NJ.

Am J Clin Nutr. 2015 Jan;101(1):202-9. doi: 10.3945/ajcn.114.092981. Epub 2014 Nov 19.


The association of early childhood cognitive development and behavioural difficulties with pre-adolescent problematic eating attitudes.

Richmond RC, Skugarevsky O, Yang S, Kramer MS, Wade KH, Patel R, Bogdanovich N, Vilchuck K, Sergeichick N, Smith GD, Oken E, Martin RM.

PLoS One. 2014 Aug 7;9(8):e104132. doi: 10.1371/journal.pone.0104132. eCollection 2014.


Effects of promoting longer-term and exclusive breastfeeding on childhood eating attitudes: a cluster-randomized trial.

Skugarevsky O, Wade KH, Richmond RC, Martin RM, Tilling K, Patel R, Vilchuck K, Bogdanovich N, Sergeichick N, Davey Smith G, Gillman MW, Oken E, Kramer MS.

Int J Epidemiol. 2014 Aug;43(4):1263-71. doi: 10.1093/ije/dyu072. Epub 2014 Apr 4.


Prospective associations of parental smoking, alcohol use, marital status, maternal satisfaction, and parental and childhood body mass index at 6.5 years with later problematic eating attitudes.

Wade KH, Skugarevsky O, Kramer MS, Patel R, Bogdanovich N, Vilchuck K, Sergeichick N, Richmond R, Palmer T, Davey Smith G, Gillman M, Oken E, Martin RM.

Nutr Diabetes. 2014 Jan 6;4:e100. doi: 10.1038/nutd.2013.40.


Mendelian randomization: application to cardiovascular disease.

Timpson NJ, Wade KH, Smith GD.

Curr Hypertens Rep. 2012 Feb;14(1):29-37. doi: 10.1007/s11906-011-0242-7. Review.


[Prevention of the acute tolerence with fentanyl by ketamine].

Ndoye Diop M, Khalil Y, Diatta B, Seck M, Ndiaye M, Niang B, Wade KH, Wade A.

Dakar Med. 2008;53(2):122-6. French.


A mutation in GerE that affects cotC promoter activation in Bacillus subtilis.

Crater DL, Wade KH, Resnekov O, Ichikawa HT, Kroos L, Brannigan JA, Moran CP Jr.

Biochim Biophys Acta. 2002 Jun 7;1576(1-2):30-8.


A region of sigmaK involved in promoter activation by GerE in Bacillus subtilis.

Wade KH, Schyns G, Opdyke JA, Moran CP Jr.

J Bacteriol. 1999 Jul;181(14):4365-73.


A single amino acid substitution in sigma E affects its ability to bind core RNA polymerase.

Shuler MF, Tatti KM, Wade KH, Moran CP Jr.

J Bacteriol. 1995 Jul;177(13):3687-94.

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