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Items: 34


Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.

O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM, Waddell SJ, Ward SE, Richardson GP, Kros CJ, Derudas M.

J Med Chem. 2019 Jun 13;62(11):5312-5329. doi: 10.1021/acs.jmedchem.8b01325. Epub 2019 May 24.


Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells.

Waddell SJ, de Andrés MC, Tsimbouri PM, Alakpa EV, Cusack M, Dalby MJ, Oreffo RO.

J Tissue Eng. 2018 Sep 4;9:2041731418794007. doi: 10.1177/2041731418794007. eCollection 2018 Jan-Dec.


Transcriptional Profiling Mycobacterium tuberculosis from Patient Sputa.

Wildner LM, Gould KA, Waddell SJ.

Methods Mol Biol. 2018;1736:117-128. doi: 10.1007/978-1-4939-7638-6_11.


Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death.

Kenyon EJ, Kirkwood NK, Kitcher SR, O'Reilly M, Derudas M, Cantillon DM, Goodyear RJ, Secker A, Baxendale S, Bull JC, Waddell SJ, Whitfield TT, Ward SE, Kros CJ, Richardson GP.

JCI Insight. 2017 Dec 21;2(24). pii: 96773. doi: 10.1172/jci.insight.96773.


Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin M.

PLoS One. 2017 Nov 15;12(11):e0185973. doi: 10.1371/journal.pone.0185973. eCollection 2017.


A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria.

Perrone F, De Siena B, Muscariello L, Kendall SL, Waddell SJ, Sacco M.

Front Microbiol. 2017 Oct 23;8:2039. doi: 10.3389/fmicb.2017.02039. eCollection 2017.


A non-canonical mismatch repair pathway in prokaryotes.

Castañeda-García A, Prieto AI, Rodríguez-Beltrán J, Alonso N, Cantillon D, Costas C, Pérez-Lago L, Zegeye ED, Herranz M, Plociński P, Tonjum T, García de Viedma D, Paget M, Waddell SJ, Rojas AM, Doherty AJ, Blázquez J.

Nat Commun. 2017 Jan 27;8:14246. doi: 10.1038/ncomms14246.


Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy.

Honeyborne I, McHugh TD, Kuittinen I, Cichonska A, Evangelopoulos D, Ronacher K, van Helden PD, Gillespie SH, Fernandez-Reyes D, Walzl G, Rousu J, Butcher PD, Waddell SJ.

BMC Med. 2016 Apr 7;14:68. doi: 10.1186/s12916-016-0609-3.


Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them.

Evangelopoulos D, da Fonseca JD, Waddell SJ.

Int J Infect Dis. 2015 Mar;32:76-80. doi: 10.1016/j.ijid.2014.11.028. Review.


Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states.

Salina EG, Waddell SJ, Hoffmann N, Rosenkrands I, Butcher PD, Kaprelyants AS.

Open Biol. 2014 Oct;4(10). pii: 140106. doi: 10.1098/rsob.140106.


Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 Jul 10.


Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. Epub 2014 Mar 3.


Distance-based differential analysis of gene curves.

Minas C, Waddell SJ, Montana G.

Bioinformatics. 2011 Nov 15;27(22):3135-41. doi: 10.1093/bioinformatics/btr528. Epub 2011 Oct 7.


Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages.

Botella H, Peyron P, Levillain F, Poincloux R, Poquet Y, Brandli I, Wang C, Tailleux L, Tilleul S, Charrière GM, Waddell SJ, Foti M, Lugo-Villarino G, Gao Q, Maridonneau-Parini I, Butcher PD, Castagnoli PR, Gicquel B, de Chastellier C, Neyrolles O.

Cell Host Microbe. 2011 Sep 15;10(3):248-59. doi: 10.1016/j.chom.2011.08.006.


Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.

Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M.

Crit Care Med. 2011 Jul;39(7):1692-711. doi: 10.1097/CCM.0b013e3182186d27.


Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling.

Tudó G, Laing K, Mitchison DA, Butcher PD, Waddell SJ.

Future Med Chem. 2010 Aug;2(8):1371-83. doi: 10.4155/fmc.10.219.


Effects of low incubation temperatures on the bactericidal activity of anti-tuberculosis drugs.

Coleman D, Waddell SJ, Mitchison DA.

J Antimicrob Chemother. 2011 Jan;66(1):146-50. doi: 10.1093/jac/dkq414. Epub 2010 Nov 11.


Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages.

Li AH, Waddell SJ, Hinds J, Malloff CA, Bains M, Hancock RE, Lam WL, Butcher PD, Stokes RW.

PLoS One. 2010 Jun 10;5(6):e11066. doi: 10.1371/journal.pone.0011066.


Use of DNA arrays to study transcriptional responses to antimycobacterial compounds.

Waddell SJ, Butcher PD.

Methods Mol Biol. 2010;642:75-91. doi: 10.1007/978-1-60327-279-7_6.


Dissecting interferon-induced transcriptional programs in human peripheral blood cells.

Waddell SJ, Popper SJ, Rubins KH, Griffiths MJ, Brown PO, Levin M, Relman DA.

PLoS One. 2010 Mar 22;5(3):e9753. doi: 10.1371/journal.pone.0009753.


Adjusting to a new home: Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle.

Stokes RW, Waddell SJ.

Future Microbiol. 2009 Dec;4(10):1317-35. doi: 10.2217/fmb.09.94. Review.


Whole genome analysis using microarrays.

Waddell SJ, Hinds J, Butcher PD.

Methods Mol Biol. 2009;465:83-93. doi: 10.1007/978-1-59745-207-6_6.


Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.

Garton NJ, Waddell SJ, Sherratt AL, Lee SM, Smith RJ, Senner C, Hinds J, Rajakumar K, Adegbola RA, Besra GS, Butcher PD, Barer MR.

PLoS Med. 2008 Apr 1;5(4):e75. doi: 10.1371/journal.pmed.0050075.


Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies.

Waddell SJ, Laing K, Senner C, Butcher PD.

BMC Genomics. 2008 Feb 25;9:94. doi: 10.1186/1471-2164-9-94.


Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages.

Tailleux L, Waddell SJ, Pelizzola M, Mortellaro A, Withers M, Tanne A, Castagnoli PR, Gicquel B, Stoker NG, Butcher PD, Foti M, Neyrolles O.

PLoS One. 2008 Jan 2;3(1):e1403. doi: 10.1371/journal.pone.0001403.


Quantification of global transcription patterns in prokaryotes using spotted microarrays.

Sidders B, Withers M, Kendall SL, Bacon J, Waddell SJ, Hinds J, Golby P, Movahedzadeh F, Cox RA, Frita R, Ten Bokum AM, Wernisch L, Stoker NG.

Genome Biol. 2007;8(12):R265.


RNA profiling in host-pathogen interactions.

Waddell SJ, Butcher PD, Stoker NG.

Curr Opin Microbiol. 2007 Jun;10(3):297-302. Epub 2007 Jun 15. Review.


Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis.

Waddell SJ, Butcher PD.

Curr Mol Med. 2007 May;7(3):287-96. Review.


Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.

Waddell SJ, Chung GA, Gibson KJ, Everett MJ, Minnikin DE, Besra GS, Butcher PD.

Lett Appl Microbiol. 2005;40(3):201-6.


The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.

Waddell SJ, Stabler RA, Laing K, Kremer L, Reynolds RC, Besra GS.

Tuberculosis (Edinb). 2004;84(3-4):263-74.


Increased transcription of a potential sigma factor regulatory gene Rv1364c in Mycobacterium bovis BCG while residing in macrophages indicates use of alternative promoters.

Li MS, Waddell SJ, Monahan IM, Mangan JA, Martin SL, Everett MJ, Butcher PD.

FEMS Microbiol Lett. 2004 Apr 15;233(2):333-9.


cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG.

Li MS, Monahan IM, Waddell SJ, Mangan JA, Martin SL, Everett MJ, Butcher PD.

Microbiology. 2001 Aug;147(Pt 8):2293-305.


The Parkinson's Disease Information and Research Center.

Waddell SJ.

Public Health Rep. 1968 May;83(5):391-5. No abstract available.

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