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Items: 13


Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease.

Quetglas EG, Mujagic Z, Wigge S, Keszthelyi D, Wachten S, Masclee A, Reinisch W.

World J Gastroenterol. 2015 Nov 28;21(44):12519-43. doi: 10.3748/wjg.v21.i44.12519. Review.


TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases.

Willoughby D, Ong HL, De Souza LB, Wachten S, Ambudkar IS, Cooper DM.

Biochem J. 2014 Nov 15;464(1):73-84. doi: 10.1042/BJ20140766.


Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.

Shen JX, Wachten S, Halls ML, Everett KL, Cooper DM.

Biochem J. 2012 Nov 1;447(3):393-405. doi: 10.1042/BJ20120279.


Functional characterization of transmembrane adenylyl cyclases from the honeybee brain.

Balfanz S, Ehling P, Wachten S, Jordan N, Erber J, Mujagic S, Baumann A.

Insect Biochem Mol Biol. 2012 Jun;42(6):435-45. doi: 10.1016/j.ibmb.2012.02.005. Epub 2012 Mar 9.


Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells.

Friedlander RS, Moss CE, Mace J, Parker HE, Tolhurst G, Habib AM, Wachten S, Cooper DM, Gribble FM, Reimann F.

Br J Pharmacol. 2011 May;163(2):261-71. doi: 10.1111/j.1476-5381.2010.01107.x.


Biochemical properties of heterologously expressed and native adenylyl cyclases from the honeybee brain (Apis mellifera L.).

Fuss N, Mujagic S, Erber J, Wachten S, Baumann A.

Insect Biochem Mol Biol. 2010 Aug;40(8):573-80. doi: 10.1016/j.ibmb.2010.05.004. Epub 2010 Jun 2.


AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, Ciruela A, Cooper DM.

J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.


Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase.

Willoughby D, Wachten S, Masada N, Cooper DM.

J Cell Sci. 2010 Jan 1;123(Pt 1):107-17. doi: 10.1242/jcs.062067.


Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.

Wachten S, Masada N, Ayling LJ, Ciruela A, Nikolaev VO, Lohse MJ, Cooper DM.

J Cell Sci. 2010 Jan 1;123(Pt 1):95-106. doi: 10.1242/jcs.058594.


Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.

Macdougall DA, Wachten S, Ciruela A, Sinz A, Cooper DM.

J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.


Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.

Martin AC, Willoughby D, Ciruela A, Ayling LJ, Pagano M, Wachten S, Tengholm A, Cooper DM.

Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26. Erratum in: Mol Pharmacol. 2009 May;75(5):1248.


Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.

Pagano M, Clynes MA, Masada N, Ciruela A, Ayling LJ, Wachten S, Cooper DM.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C607-19. doi: 10.1152/ajpcell.00488.2008. Epub 2009 Jan 21.


Molecular identification and functional characterization of an adenylyl cyclase from the honeybee.

Wachten S, Schlenstedt J, Gauss R, Baumann A.

J Neurochem. 2006 Mar;96(6):1580-90. Epub 2006 Feb 8.

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