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Items: 46


Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment.

Eftychi C, Schwarzer R, Vlantis K, Wachsmuth L, Basic M, Wagle P, Neurath MF, Becker C, Bleich A, Pasparakis M.

Immunity. 2019 Aug 20;51(2):367-380.e4. doi: 10.1016/j.immuni.2019.06.008. Epub 2019 Jul 23.


Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.

Hohoff C, Zhang M, Ambrée O, Kravchenko M, Buschert J, Kerkenberg N, Gorinski N, Abdel Galil D, Schettler C, Vom Werth KL, Wewer MF, Schneider I, Grotegerd D, Wachsmuth L, Faber C, Skryabin BV, Brosius J, Ponimaskin E, Zhang W.

Brain Struct Funct. 2019 Jul;224(6):2213-2230. doi: 10.1007/s00429-019-01898-6. Epub 2019 Jun 10.


Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal.

van Alst TM, Wachsmuth L, Datunashvili M, Albers F, Just N, Budde T, Faber C.

Neuroimage. 2019 Jul 15;195:89-103. doi: 10.1016/j.neuroimage.2019.03.057. Epub 2019 Mar 28.


Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.

Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG.

J Clin Invest. 2019 Mar 26;129(6):2357-2373. doi: 10.1172/JCI124218.


Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.

Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J.

Nat Commun. 2019 Feb 8;10(1):688. doi: 10.1038/s41467-019-08405-9.


Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI.

Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblätter M, Wildgruber M, Faber C.

Sci Rep. 2018 Jun 22;8(1):9563. doi: 10.1038/s41598-018-27879-z.


Defining mechanisms of neural plasticity after brainstem ischemia in rats.

Minnerup J, Strecker JK, Wachsmuth L, Hoppen M, Schmidt A, Hermann DM, Wiendl H, Meuth S, Faber C, Diederich K, Schäbitz WR.

Ann Neurol. 2018 May;83(5):1003-1015. doi: 10.1002/ana.25238. Epub 2018 May 11.


Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes.

Androulidaki A, Wachsmuth L, Polykratis A, Pasparakis M.

PLoS One. 2018 Mar 9;13(3):e0194048. doi: 10.1371/journal.pone.0194048. eCollection 2018.


Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith DM, Fricke IB, Just N, Doblas S, Sinkus R, Döring C, Schäfers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH.

J Nucl Med. 2018 Jul;59(7):1063-1069. doi: 10.2967/jnumed.117.206250. Epub 2018 Feb 23.


Vasopressors for acute myocardial infarction complicated by cardiogenic shock.

Prondzinsky R, Hirsch K, Wachsmuth L, Buerke M, Unverzagt S.

Med Klin Intensivmed Notfmed. 2019 Feb;114(1):21-29. doi: 10.1007/s00063-017-0378-6. Epub 2017 Dec 4. Review.


Multimodal Functional Neuroimaging by Simultaneous BOLD fMRI and Fiber-Optic Calcium Recordings and Optogenetic Control.

Albers F, Wachsmuth L, van Alst TM, Faber C.

Mol Imaging Biol. 2018 Apr;20(2):171-182. doi: 10.1007/s11307-017-1130-6. Review.


Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves.

Schwalm M, Schmid F, Wachsmuth L, Backhaus H, Kronfeld A, Aedo Jury F, Prouvot PH, Fois C, Albers F, van Alst T, Faber C, Stroh A.

Elife. 2017 Sep 15;6. pii: e27602. doi: 10.7554/eLife.27602.


Do Biology Students Really Hate Math? Empirical Insights into Undergraduate Life Science Majors' Emotions about Mathematics.

Wachsmuth LP, Runyon CR, Drake JM, Dolan EL.

CBE Life Sci Educ. 2017 Fall;16(3). pii: ar49. doi: 10.1187/cbe.16-08-0248.


Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.

Wachsmuth LM, Johnson MG, Gavenonis J.

PLoS Negl Trop Dis. 2017 Jun 29;11(6):e0005720. doi: 10.1371/journal.pntd.0005720. eCollection 2017 Jun.


A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann M, Zinnhardt B, Reinhardt D, Eligehausen S, Wachsmuth L, Hermann S, Dederen PJ, Hellwich M, Kuhlmann MT, Broersen LM, Heerschap A, Jacobs AH, Kiliaan AJ.

Theranostics. 2017 Jan 6;7(2):493-512. doi: 10.7150/thno.17559. eCollection 2017.


Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.

Zinnhardt B, Pigeon H, Thézé B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schäfers M, Winkeler A, Jacobs AH.

Cancer Res. 2017 Apr 15;77(8):1831-1841. doi: 10.1158/0008-5472.CAN-16-2628. Epub 2017 Jan 30.


Line scanning fMRI reveals earlier onset of optogenetically evoked BOLD response in rat somatosensory cortex as compared to sensory stimulation.

Albers F, Schmid F, Wachsmuth L, Faber C.

Neuroimage. 2018 Jan 1;164:144-154. doi: 10.1016/j.neuroimage.2016.12.059. Epub 2016 Dec 21.


RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.

Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M.

Nature. 2016 Dec 1;540(7631):124-128. doi: 10.1038/nature20558. Epub 2016 Nov 7.


Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings.

Schmid F, Wachsmuth L, Schwalm M, Prouvot PH, Jubal ER, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A.

J Cereb Blood Flow Metab. 2016 Nov;36(11):1885-1900. Epub 2015 Nov 30.


Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K.

Sci Transl Med. 2016 Oct 26;8(362):362ra146.


Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith DM, Griffiths JR, Faber C, Jacobs AH.

Cancer Res. 2016 Dec 15;76(24):7096-7105. Epub 2016 Oct 26.


Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S.

Nature. 2016 Aug 11;536(7615):215-8. Epub 2016 Aug 3.


Performance of MRS in metabolic profiling of the lumbar spinal cord in rat and mice.

Amirmohseni S, Wachsmuth L, Just N, Faber C.

Magn Reson Imaging. 2016 Oct;34(8):1155-60. doi: 10.1016/j.mri.2016.06.001. Epub 2016 Jun 7.


Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers.

O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schäfers M, O'Brien D, Prehn JH, Jacobs AH, Byrne AT.

Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1673-83. doi: 10.1007/s00259-016-3343-3. Epub 2016 Mar 15.


6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.

Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dollé F, Kuhlmann MT, Schäfers K, Hermann S, Schwamborn JC, Jacobs AH.

Eur J Neurosci. 2016 May;43(10):1352-65. doi: 10.1111/ejn.13232. Epub 2016 Apr 5.


True and apparent optogenetic BOLD fMRI signals.

Schmid F, Wachsmuth L, Albers F, Schwalm M, Stroh A, Faber C.

Magn Reson Med. 2017 Jan;77(1):126-136. doi: 10.1002/mrm.26095. Epub 2016 Jan 17.


Characterization of incisional and inflammatory pain in rats using functional tools of MRI.

Amirmohseni S, Segelcke D, Reichl S, Wachsmuth L, Görlich D, Faber C, Pogatzki-Zahn E.

Neuroimage. 2016 Feb 15;127:110-122. doi: 10.1016/j.neuroimage.2015.11.052. Epub 2015 Nov 27.


The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.

Tucker JM, Larango ME, Wachsmuth LP, Kannan N, Garfinkel DJ.

PLoS Genet. 2015 Oct 9;11(10):e1005571. doi: 10.1371/journal.pgen.1005571. eCollection 2015 Oct.


Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.

Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dollé F, Pappata S, Planas AM, Tavitian B, Schäfers M, Sorokin LM, Kuhlmann MT, Jacobs AH.

J Cereb Blood Flow Metab. 2015 Nov;35(11):1711-21. doi: 10.1038/jcbfm.2015.149. Epub 2015 Jul 1.


Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

Doblas S, Almeida GS, Blé FX, Garteiser P, Hoff BA, McIntyre DJ, Wachsmuth L, Chenevert TL, Faber C, Griffiths JR, Jacobs AH, Morris DM, O'Connor JP, Robinson SP, Van Beers BE, Waterton JC.

J Magn Reson Imaging. 2015 Dec;42(6):1759-64. doi: 10.1002/jmri.24955. Epub 2015 May 26.


RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M.

Nature. 2014 Sep 4;513(7516):90-4. doi: 10.1038/nature13608. Epub 2014 Aug 17.


Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith DM, Hermann S, Wagner S, Kuhlmann MT, Müller-Tidow C, Kopka K, Schober O, Schäfers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH.

J Nucl Med. 2014 Jun;55(6):983-8. doi: 10.2967/jnumed.113.133348. Epub 2014 Apr 28.


Inotropic agents and vasodilator strategies for acute myocardial infarction complicated by cardiogenic shock or low cardiac output syndrome.

Unverzagt S, Wachsmuth L, Hirsch K, Thiele H, Buerke M, Haerting J, Werdan K, Prondzinsky R.

Cochrane Database Syst Rev. 2014 Jan 2;(1):CD009669. doi: 10.1002/14651858.CD009669.pub2. Review. Update in: Cochrane Database Syst Rev. 2018 Jan 29;1:CD009669.


Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

Singh KK, Wachsmuth L, Kulozik AE, Gehring NH.

RNA Biol. 2013 Aug;10(8):1291-8. doi: 10.4161/rna.25827. Epub 2013 Jul 23.


Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.

Viel T, Schelhaas S, Wagner S, Wachsmuth L, Schwegmann K, Kuhlmann M, Faber C, Kopka K, Schäfers M, Jacobs AH.

PLoS One. 2013 Jul 4;8(7):e67911. doi: 10.1371/journal.pone.0067911. Print 2013.


4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

Göbel K, Wedell JH, Herrmann AM, Wachsmuth L, Pankratz S, Bittner S, Budde T, Kleinschnitz C, Faber C, Wiendl H, Meuth SG.

Exp Neurol. 2013 Oct;248:62-71. doi: 10.1016/j.expneurol.2013.05.016. Epub 2013 Jun 5.


Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis.

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V.

Arthritis Rheum. 2013 Sep;65(9):2290-300. doi: 10.1002/art.38026.


Early detection of lung inflammation: exploiting T1-effects of iron oxide particles using UTE MRI.

Strobel K, Hoerr V, Schmid F, Wachsmuth L, Löffler B, Faber C.

Magn Reson Med. 2012 Dec;68(6):1924-31. doi: 10.1002/mrm.24180. Epub 2012 Feb 24.


(23)Na magnetic resonance imaging of tissue sodium.

Kopp C, Linz P, Wachsmuth L, Dahlmann A, Horbach T, Schöfl C, Renz W, Santoro D, Niendorf T, Müller DN, Neininger M, Cavallaro A, Eckardt KU, Schmieder RE, Luft FC, Uder M, Titze J.

Hypertension. 2012 Jan;59(1):167-72. doi: 10.1161/HYPERTENSIONAHA.111.183517. Epub 2011 Dec 5.


Micro-morphometrical assessment of the effect of Harpagophytum procumbens extract on articular cartilage in rabbits with experimental osteoarthritis using magnetic resonance imaging.

Wachsmuth L, Lindhorst E, Wrubel S, Hadzhiyski H, Hudelmaier M, Eckstein F, Chrubasik S.

Phytother Res. 2011 Aug;25(8):1133-40. doi: 10.1002/ptr.3410. Epub 2011 Feb 1.


Immunolocalization of matrix proteins in different human cartilage subtypes.

Wachsmuth L, Söder S, Fan Z, Finger F, Aigner T.

Histol Histopathol. 2006 May;21(5):477-85. doi: 10.14670/HH-21.477.


Increase in degraded collagen type II in synovial fluid early in the rabbit meniscectomy model of osteoarthritis.

Lindhorst E, Wachsmuth L, Kimmig N, Raiss R, Aigner T, Atley L, Eyre D.

Osteoarthritis Cartilage. 2005 Feb;13(2):139-45.


High-resolution imaging of osteoarthritis using microcomputed tomography.

Wachsmuth L, Engelke K.

Methods Mol Med. 2004;101:231-48.


ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta.

Wachsmuth L, Bau B, Fan Z, Pecht A, Gerwin N, Aigner T.

J Rheumatol. 2004 Feb;31(2):315-20.


In vivo contrast-enhanced micro MR-imaging of experimental osteoarthritis in the rabbit knee joint at 7.1T1.

Wachsmuth L, Keiffer R, Juretschke HP, Raiss RX, Kimmig N, Lindhorst E.

Osteoarthritis Cartilage. 2003 Dec;11(12):891-902.


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