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Items: 1 to 50 of 316

1.

Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.

Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ.

PLoS One. 2019 Apr 22;14(4):e0215504. doi: 10.1371/journal.pone.0215504. eCollection 2019.

2.

Cadmium down-regulates apolipoprotein E (ApoE) expression during malignant transformation of rat liver cells: direct evidence for DNA hypermethylation in the promoter region of ApoE.

Hirao-Suzuki M, Takeda S, Kobayashi T, Kino K, Miyazawa H, Waalkes MP, Takiguchi M.

J Toxicol Sci. 2018;43(9):537-543. doi: 10.2131/jts.43.537.

3.

NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation: Research Report 3 [Internet].

Morgan DL, Dixon D, King DH, Travlos GS, Herbert RA, French JE, Tokar EJ, Waalkes MP, Jokinen MP.

Durham (NC): National Toxicology Program; 2017 Aug.

4.

Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness.

Suzuki M, Takeda S, Teraoka-Nishitani N, Yamagata A, Tanaka T, Sasaki M, Yasuda N, Oda M, Okano T, Yamahira K, Nakamura Y, Kobayashi T, Kino K, Miyazawa H, Waalkes MP, Takiguchi M.

Toxicology. 2017 May 1;382:16-23. doi: 10.1016/j.tox.2017.03.014. Epub 2017 Mar 16.

PMID:
28315714
5.

Silencing KRAS Overexpression in Cadmium-Transformed Prostate Epithelial Cells Mitigates Malignant Phenotype.

Ngalame NN, Waalkes MP, Tokar EJ.

Chem Res Toxicol. 2016 Sep 19;29(9):1458-67. doi: 10.1021/acs.chemrestox.6b00137. Epub 2016 Aug 19.

6.

Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration.

Ngalame NN, Makia NL, Waalkes MP, Tokar EJ.

Toxicol Appl Pharmacol. 2016 Dec 1;312:11-18. doi: 10.1016/j.taap.2015.12.013. Epub 2015 Dec 22.

7.

Arsenic and Environmental Health: State of the Science and Future Research Opportunities.

Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA.

Environ Health Perspect. 2016 Jul;124(7):890-9. doi: 10.1289/ehp.1510209. Epub 2015 Nov 20. Review.

8.

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.

Sharma NK, Kumar A, Kumari A, Tokar EJ, Waalkes MP, Bortner CD, Williams J, Ehrenshaft M, Mason RP, Sinha BK.

PLoS One. 2015 Nov 5;10(11):e0141897. doi: 10.1371/journal.pone.0141897. eCollection 2015.

9.

Chronic cadmium exposure in rats produces pancreatic impairment and insulin resistance in multiple peripheral tissues.

Treviño S, Waalkes MP, Flores Hernández JA, León-Chavez BA, Aguilar-Alonso P, Brambila E.

Arch Biochem Biophys. 2015 Oct 1;583:27-35. doi: 10.1016/j.abb.2015.07.010. Epub 2015 Aug 5.

PMID:
26253262
10.

Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium.

Pelch KE, Tokar EJ, Merrick BA, Waalkes MP.

Toxicol Appl Pharmacol. 2015 Aug 1;286(3):159-67. doi: 10.1016/j.taap.2015.04.011. Epub 2015 Apr 25.

11.

Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells.

Person RJ, Ngalame NN, Makia NL, Bell MW, Waalkes MP, Tokar EJ.

Toxicol Appl Pharmacol. 2015 Jul 1;286(1):36-43. doi: 10.1016/j.taap.2015.03.014. Epub 2015 Mar 21.

12.

Macrophage solubilization and cytotoxicity of indium-containing particles as in vitro correlates to pulmonary toxicity in vivo.

Gwinn WM, Qu W, Bousquet RW, Price H, Shines CJ, Taylor GJ, Waalkes MP, Morgan DL.

Toxicol Sci. 2015 Mar;144(1):17-26. doi: 10.1093/toxsci/kfu273. Epub 2014 Dec 19.

13.

Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure.

Qu W, Waalkes MP.

Toxicol Appl Pharmacol. 2015 Feb 1;282(3):267-74. doi: 10.1016/j.taap.2014.11.014. Epub 2014 Dec 5.

14.

Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways.

Gao X, Yu L, Moore AB, Kissling GE, Waalkes MP, Dixon D.

Environ Health Perspect. 2015 Apr;123(4):331-6. doi: 10.1289/ehp.1408234. Epub 2014 Oct 24.

15.

Silencing KRAS overexpression in arsenic-transformed prostate epithelial and stem cells partially mitigates malignant phenotype.

Ngalame NN, Tokar EJ, Person RJ, Waalkes MP.

Toxicol Sci. 2014 Dec;142(2):489-96. doi: 10.1093/toxsci/kfu201. Epub 2014 Sep 30.

16.

Response to letter to the editor by Cohen et al. (2014) "Re: Waalkes et al.: Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014".

Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D.

Arch Toxicol. 2014 Nov;88(11):2063-5. doi: 10.1007/s00204-014-1369-5. Epub 2014 Sep 25. No abstract available.

17.

Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses.

Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D.

Arch Toxicol. 2014 Aug;88(8):1619-29. doi: 10.1007/s00204-014-1305-8. Epub 2014 Jul 9.

18.

Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.

Ngalame NN, Tokar EJ, Person RJ, Xu Y, Waalkes MP.

Toxicol Sci. 2014 Apr;138(2):268-77. doi: 10.1093/toxsci/kfu002. Epub 2014 Jan 15.

19.

Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic.

Tokar EJ, Kojima C, Waalkes MP.

Arch Toxicol. 2014 Feb;88(2):249-61. doi: 10.1007/s00204-013-1141-2. Epub 2013 Oct 5.

20.

Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation.

Xu Y, Tokar EJ, Waalkes MP.

Arch Toxicol. 2014 Feb;88(2):263-74. doi: 10.1007/s00204-013-1131-4. Epub 2013 Sep 26.

21.

Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation.

Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW.

Epigenetics. 2013 Oct;8(10):1080-8. doi: 10.4161/epi.25926. Epub 2013 Aug 6.

22.

Macrophage solubilization and cytotoxicity of indium-containing particles in vitro.

Gwinn WM, Qu W, Shines CJ, Bousquet RW, Taylor GJ, Waalkes MP, Morgan DL.

Toxicol Sci. 2013 Oct;135(2):414-24. doi: 10.1093/toxsci/kft154. Epub 2013 Jul 19.

23.

Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells.

Person RJ, Tokar EJ, Xu Y, Orihuela R, Ngalame NN, Waalkes MP.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):281-8. doi: 10.1016/j.taap.2013.06.013. Epub 2013 Jun 26.

24.

Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen.

Xu Y, Tokar EJ, Person RJ, Orihuela RG, Ngalame NN, Waalkes MP.

Environ Health Perspect. 2013 Aug;121(8):944-50. doi: 10.1289/ehp.1306714. Epub 2013 May 17.

25.

Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity.

Das S, Kumar A, Seth RK, Tokar EJ, Kadiiska MB, Waalkes MP, Mason RP, Chatterjee S.

Toxicol Appl Pharmacol. 2013 Jun 15;269(3):297-306. doi: 10.1016/j.taap.2013.02.003. Epub 2013 Feb 22.

26.

Oxidative DNA damage after acute exposure to arsenite and monomethylarsonous acid in biomethylation-deficient human cells.

Orihuela R, Kojima C, Tokar EJ, Person RJ, Xu Y, Qu W, Waalkes MP.

Toxicol Mech Methods. 2013 Jul;23(6):389-95. doi: 10.3109/15376516.2012.762570. Epub 2013 Feb 6.

PMID:
23301828
27.

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.

Chatterjee S, Ganini D, Tokar EJ, Kumar A, Das S, Corbett J, Kadiiska MB, Waalkes MP, Diehl AM, Mason RP.

J Hepatol. 2013 Apr;58(4):778-84. doi: 10.1016/j.jhep.2012.11.035. Epub 2012 Dec 1.

28.

Chronic exposure of renal stem cells to inorganic arsenic induces a cancer phenotype.

Tokar EJ, Person RJ, Sun Y, Perantoni AO, Waalkes MP.

Chem Res Toxicol. 2013 Jan 18;26(1):96-105. doi: 10.1021/tx3004054. Epub 2012 Nov 19.

29.

Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation.

Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW.

Epigenetics. 2012 Nov;7(11):1238-48. doi: 10.4161/epi.22163. Epub 2012 Sep 13.

30.

The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic.

Tsang V, Fry RC, Niculescu MD, Rager JE, Saunders J, Paul DS, Zeisel SH, Waalkes MP, Stýblo M, Drobná Z.

Toxicol Appl Pharmacol. 2012 Nov 1;264(3):439-50. doi: 10.1016/j.taap.2012.08.022. Epub 2012 Aug 31.

31.

Metallothionein blocks oxidative DNA damage in vitro.

Qu W, Pi J, Waalkes MP.

Arch Toxicol. 2013 Feb;87(2):311-21. doi: 10.1007/s00204-012-0927-y. Epub 2012 Aug 23.

32.

Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells.

Zhan L, Zhang H, Zhang Q, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J.

Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.

33.

Predicting later-life outcomes of early-life exposures.

Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM.

Environ Health Perspect. 2012 Oct;120(10):1353-61. doi: 10.1289/ehp.1204934. Epub 2012 Jun 6. Review.

34.

Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells.

Qu W, Tokar EJ, Kim AJ, Bell MW, Waalkes MP.

Environ Health Perspect. 2012 Sep;120(9):1265-71. doi: 10.1289/ehp.1205082. Epub 2012 May 24.

35.

Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype.

Xu Y, Tokar EJ, Sun Y, Waalkes MP.

Environ Health Perspect. 2012 Jun;120(6):865-71. doi: 10.1289/ehp.1204987. Epub 2012 Apr 4.

36.

Sexual dimorphism of cadmium-induced toxicity in rats: involvement of sex hormones.

Shimada H, Hashiguchi T, Yasutake A, Waalkes MP, Imamura Y.

Arch Toxicol. 2012 Sep;86(9):1475-80. doi: 10.1007/s00204-012-0844-0. Epub 2012 Mar 31.

PMID:
22466070
37.

Cadmium induces p53-dependent apoptosis in human prostate epithelial cells.

Aimola P, Carmignani M, Volpe AR, Di Benedetto A, Claudio L, Waalkes MP, van Bokhoven A, Tokar EJ, Claudio PP.

PLoS One. 2012;7(3):e33647. doi: 10.1371/journal.pone.0033647. Epub 2012 Mar 20.

38.

Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice.

Tokar EJ, Diwan BA, Thomas DJ, Waalkes MP.

Arch Toxicol. 2012 Jun;86(6):975-82. doi: 10.1007/s00204-012-0820-8. Epub 2012 Mar 8.

39.

Renal, hepatic, pulmonary and adrenal tumors induced by prenatal inorganic arsenic followed by dimethylarsinic acid in adulthood in CD1 mice.

Tokar EJ, Diwan BA, Waalkes MP.

Toxicol Lett. 2012 Mar 7;209(2):179-85. doi: 10.1016/j.toxlet.2011.12.016. Epub 2011 Dec 31.

40.

Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

Sun Y, Tokar EJ, Waalkes MP.

Toxicol Sci. 2012 Jan;125(1):20-9. doi: 10.1093/toxsci/kfr282. Epub 2011 Oct 19.

41.

Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response.

Sun Y, Kojima C, Chignell C, Mason R, Waalkes MP.

Toxicol Appl Pharmacol. 2011 Sep 15;255(3):242-50. doi: 10.1016/j.taap.2011.07.006. Epub 2011 Jul 21.

42.

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.

Shpyleva SI, Muskhelishvili L, Tryndyak VP, Koturbash I, Tokar EJ, Waalkes MP, Beland FA, Pogribny IP.

Toxicol Sci. 2011 Oct;123(2):433-40. doi: 10.1093/toxsci/kfr193. Epub 2011 Jul 23.

43.

Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1.

Qu W, Cheng L, Dill AL, Saavedra JE, Hong SY, Keefer LK, Waalkes MP.

Chem Biol Interact. 2011 Aug 15;193(1):88-96. doi: 10.1016/j.cbi.2011.05.005. Epub 2011 May 20.

44.

Metal ions in human cancer development.

Tokar EJ, Benbrahim-Tallaa L, Waalkes MP.

Met Ions Life Sci. 2011;8:375-401.

PMID:
21473387
45.

Arsenic, stem cells, and the developmental basis of adult cancer.

Tokar EJ, Qu W, Waalkes MP.

Toxicol Sci. 2011 Mar;120 Suppl 1:S192-203. doi: 10.1093/toxsci/kfq342. Epub 2010 Nov 11.

46.

Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice.

Tokar EJ, Diwan BA, Ward JM, Delker DA, Waalkes MP.

Toxicol Sci. 2011 Jan;119(1):73-83. doi: 10.1093/toxsci/kfq315. Epub 2010 Oct 11.

47.

Cancer in experimental animals exposed to arsenic and arsenic compounds.

Tokar EJ, Benbrahim-Tallaa L, Ward JM, Lunn R, Sams RL 2nd, Waalkes MP.

Crit Rev Toxicol. 2010 Nov;40(10):912-27. doi: 10.3109/10408444.2010.506641. Review.

48.

Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.

Zhao R, Hou Y, Xue P, Woods CG, Fu J, Feng B, Guan D, Sun G, Chan JY, Waalkes MP, Andersen ME, Pi J.

Environ Health Perspect. 2011 Jan;119(1):56-62. doi: 10.1289/ehp.1002304. Epub 2010 Aug 30.

49.
50.

Arsenic exposure in utero and nonepidermal proliferative response in adulthood in Tg.AC mice.

Tokar EJ, Diwan BA, Waalkes MP.

Int J Toxicol. 2010 May-Jun;29(3):291-6. doi: 10.1177/1091581810362804.

PMID:
20448261

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