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Items: 1 to 50 of 131

1.

AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.

Ishizuka Y, Kakiya N, Witters LA, Oshiro N, Shirao T, Nawa H, Takei N.

J Neurochem. 2013 Oct;127(1):66-77. doi: 10.1111/jnc.12362. Epub 2013 Jul 29.

2.

Glucose represses PPARα gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell.

Joly E, Roduit R, Peyot ML, Habinowski SA, Ruderman NB, Witters LA, Prentki M.

J Diabetes. 2009 Dec;1(4):263-72. doi: 10.1111/j.1753-0407.2009.00043.x. Epub 2009 Jul 8.

3.

Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.

Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI.

Mol Cell Biol. 2009 Jul;29(13):3455-64. doi: 10.1128/MCB.00054-09. Epub 2009 Apr 20.

4.

Hypothalamic CaMKK2 contributes to the regulation of energy balance.

Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, Muehlbauer MJ, Witters LA, Kemp BE, Means AR.

Cell Metab. 2008 May;7(5):377-88. doi: 10.1016/j.cmet.2008.02.011.

5.

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.

J Clin Invest. 2008 Feb;118(2):752-62. doi: 10.1172/JCI29723.

6.

AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.

Iseli TJ, Oakhill JS, Bailey MF, Wee S, Walter M, van Denderen BJ, Castelli LA, Katsis F, Witters LA, Stapleton D, Macaulay SL, Michell BJ, Kemp BE.

J Biol Chem. 2008 Feb 22;283(8):4799-807. Epub 2007 Dec 13.

7.

The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.

Folmes KD, Witters LA, Allard MF, Young ME, Dyck JR.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3456-64. Epub 2007 Sep 28.

8.

Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.

Ho RC, Fujii N, Witters LA, Hirshman MF, Goodyear LJ.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):354-9. Epub 2007 Aug 7.

9.

Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.

Röckl KS, Hirshman MF, Brandauer J, Fujii N, Witters LA, Goodyear LJ.

Diabetes. 2007 Aug;56(8):2062-9. Epub 2007 May 18.

10.

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.

Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ.

J Biol Chem. 2007 Apr 6;282(14):10341-51. Epub 2007 Feb 7.

11.

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

Barré L, Richardson C, Hirshman MF, Brozinick J, Fiering S, Kemp BE, Goodyear LJ, Witters LA.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E802-11. Epub 2006 Nov 14.

12.

Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.

Hurley RL, Barré LK, Wood SD, Anderson KA, Kemp BE, Means AR, Witters LA.

J Biol Chem. 2006 Dec 1;281(48):36662-72. Epub 2006 Oct 5.

13.

Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.

Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M.

FEBS J. 2006 Jun;273(12):2730-48.

14.

Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation.

Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM.

J Biol Chem. 2006 Feb 17;281(7):4231-41. Epub 2005 Dec 18.

15.

Chutes and Ladders: the search for protein kinases that act on AMPK.

Witters LA, Kemp BE, Means AR.

Trends Biochem Sci. 2006 Jan;31(1):13-6. Epub 2005 Dec 13. Review.

PMID:
16356723
16.

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA.

J Biol Chem. 2005 Aug 12;280(32):29060-6. Epub 2005 Jun 24.

17.

Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells.

Konrad D, Rudich A, Bilan PJ, Patel N, Richardson C, Witters LA, Klip A.

Diabetologia. 2005 May;48(5):954-66. Epub 2005 Apr 15.

PMID:
15834551
18.

AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270).

Iseli TJ, Walter M, van Denderen BJ, Katsis F, Witters LA, Kemp BE, Michell BJ, Stapleton D.

J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.

19.

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

Baron SJ, Li J, Russell RR 3rd, Neumann D, Miller EJ, Tuerk R, Wallimann T, Hurley RL, Witters LA, Young LH.

Circ Res. 2005 Feb 18;96(3):337-45. Epub 2005 Jan 13.

PMID:
15653571
20.

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr.

Genes Dev. 2004 Dec 1;18(23):2893-904. Epub 2004 Nov 15.

21.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.

22.

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site.

Adams J, Chen ZP, Van Denderen BJ, Morton CJ, Parker MW, Witters LA, Stapleton D, Kemp BE.

Protein Sci. 2004 Jan;13(1):155-65.

23.

C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.

Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV.

J Biol Chem. 2004 Jan 30;279(5):3817-27. Epub 2003 Nov 13.

24.

Effect of exercise intensity on skeletal muscle AMPK signaling in humans.

Chen ZP, Stephens TJ, Murthy S, Canny BJ, Hargreaves M, Witters LA, Kemp BE, McConell GK.

Diabetes. 2003 Sep;52(9):2205-12.

25.

Insulin-like growth factor 1 is essential for normal dendritic growth.

Cheng CM, Mervis RF, Niu SL, Salem N Jr, Witters LA, Tseng V, Reinhardt R, Bondy CA.

J Neurosci Res. 2003 Jul 1;73(1):1-9.

PMID:
12815703
26.

AMPK beta subunit targets metabolic stress sensing to glycogen.

Polekhina G, Gupta A, Michell BJ, van Denderen B, Murthy S, Feil SC, Jennings IG, Campbell DJ, Witters LA, Parker MW, Kemp BE, Stapleton D.

Curr Biol. 2003 May 13;13(10):867-71.

27.

Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination.

Salles J, Sargueil F, Knoll-Gellida A, Witters LA, Cassagne C, Garbay B.

Biochim Biophys Acta. 2003 Apr 8;1631(3):229-38.

PMID:
12668174
28.

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway.

Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K, Kemp BE, Witters LA, Mimura O, Yonezawa K.

Genes Cells. 2003 Jan;8(1):65-79.

29.

AMP-activated protein kinase, super metabolic regulator.

Kemp BE, Stapleton D, Campbell DJ, Chen ZP, Murthy S, Walter M, Gupta A, Adams JJ, Katsis F, van Denderen B, Jennings IG, Iseli T, Michell BJ, Witters LA.

Biochem Soc Trans. 2003 Feb;31(Pt 1):162-8. Review.

PMID:
12546677
30.

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.

Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK.

Am J Physiol Cell Physiol. 2003 May;284(5):C1297-308. Epub 2003 Jan 2.

31.

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells.

Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK.

J Biol Chem. 2003 Jan 10;278(2):998-1004. Epub 2002 Nov 8.

32.

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment.

Kim EK, Miller I, Landree LE, Borisy-Rudin FF, Brown P, Tihan T, Townsend CA, Witters LA, Moran TH, Kuhajda FP, Ronnett GV.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E867-79.

33.

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.

Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, Unger RH.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11848-53. Epub 2002 Aug 23.

34.

AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.

Hamilton SR, O'Donnell JB Jr, Hammet A, Stapleton D, Habinowski SA, Means AR, Kemp BE, Witters LA.

Biochem Biophys Res Commun. 2002 May 10;293(3):892-8.

PMID:
12051742
35.

Fatty acid synthase expression during peripheral nervous system myelination.

Salles J, Sargueil F, Knoll-Gellida A, Witters LA, Shy M, Jiang H, Cassagne C, Garbay B.

Brain Res Mol Brain Res. 2002 May 30;101(1-2):52-8.

PMID:
12007831
36.

Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line.

Habinowski SA, Hirshman M, Sakamoto K, Kemp BE, Gould SJ, Goodyear LJ, Witters LA.

Arch Biochem Biophys. 2001 Dec 1;396(1):71-9.

PMID:
11716464
37.

The blooming of the French lilac.

Witters LA.

J Clin Invest. 2001 Oct;108(8):1105-7. Review. No abstract available.

38.

The effects of AICAR on adipocyte differentiation of 3T3-L1 cells.

Habinowski SA, Witters LA.

Biochem Biophys Res Commun. 2001 Sep 7;286(5):852-6.

PMID:
11527376
39.

An activating mutation in the gamma1 subunit of the AMP-activated protein kinase.

Hamilton SR, Stapleton D, O'Donnell JB Jr, Kung JT, Dalal SR, Kemp BE, Witters LA.

FEBS Lett. 2001 Jul 6;500(3):163-8.

40.

AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle.

Musi N, Hayashi T, Fujii N, Hirshman MF, Witters LA, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E677-84.

41.

Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization.

Warden SM, Richardson C, O'Donnell J Jr, Stapleton D, Kemp BE, Witters LA.

Biochem J. 2001 Mar 1;354(Pt 2):275-83.

42.

AMP-Activated protein kinase is activated by the stimulations of G(q)-coupled receptors.

Kishi K, Yuasa T, Minami A, Yamada M, Hagi A, Hayashi H, Kemp BE, Witters LA, Ebina Y.

Biochem Biophys Res Commun. 2000 Sep 16;276(1):16-22.

PMID:
11006075
44.

Muscle phosphorylase kinase is not a substrate of AMP-activated protein kinase.

Beyer A, Kitzerow A, Crute B, Kemp BE, Witters LA, Heilmeyer LM Jr.

Biol Chem. 2000 May-Jun;381(5-6):457-61.

PMID:
10937878
45.

Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport.

Abbud W, Habinowski S, Zhang JZ, Kendrew J, Elkairi FS, Kemp BE, Witters LA, Ismail-Beigi F.

Arch Biochem Biophys. 2000 Aug 15;380(2):347-52.

PMID:
10933890
46.

Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle.

Derave W, Ai H, Ihlemann J, Witters LA, Kristiansen S, Richter EA, Ploug T.

Diabetes. 2000 Aug;49(8):1281-7.

PMID:
10923626
47.

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.

Fujii N, Hayashi T, Hirshman MF, Smith JT, Habinowski SA, Kaijser L, Mu J, Ljungqvist O, Birnbaum MJ, Witters LA, Thorell A, Goodyear LJ.

Biochem Biophys Res Commun. 2000 Jul 14;273(3):1150-5.

PMID:
10891387
48.

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, Goodyear LJ.

Diabetes. 2000 Apr;49(4):527-31.

PMID:
10871188
49.
50.

Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle.

Chen Z, Heierhorst J, Mann RJ, Mitchelhill KI, Michell BJ, Witters LA, Lynch GS, Kemp BE, Stapleton D.

FEBS Lett. 1999 Oct 29;460(2):343-8.

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