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Items: 1 to 50 of 96

1.

Metabolite Changes in Maternal and Fetal Plasma Following Spontaneous Labour at Term in Humans Using Untargeted Metabolomics Analysis: A Pilot Study.

Birchenall KA, Welsh GI, López Bernal A.

Int J Environ Res Public Health. 2019 Apr 30;16(9). pii: E1527. doi: 10.3390/ijerph16091527.

2.

Renal Consequences of Therapeutic Interventions in Premature Neonates.

Fryer HJ, Welsh GI.

Nephron. 2019;142(2):117-124. doi: 10.1159/000497162. Epub 2019 Feb 6. Review.

3.

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM.

Nat Commun. 2019 Jan 24;10(1):403. doi: 10.1038/s41467-018-08235-1.

4.

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways.

Dorval G, Kuzmuk V, Gribouval O, Welsh GI, Bierzynska A, Schmitt A, Miserey-Lenkei S, Koziell A, Haq S, Benmerah A, Mollet G, Boyer O, Saleem MA, Antignac C.

Am J Hum Genet. 2019 Feb 7;104(2):348-355. doi: 10.1016/j.ajhg.2018.12.016. Epub 2019 Jan 17.

PMID:
30661770
5.

VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy.

Onions KL, Gamez M, Buckner NR, Baker SL, Betteridge KB, Desideri S, Dallyn BP, Ramnath RD, Neal CR, Farmer LK, Mathieson PW, Gnudi L, Alitalo K, Bates DO, Salmon AHJ, Welsh GI, Satchell SC, Foster RR.

Diabetes. 2019 Jan;68(1):172-187. doi: 10.2337/db18-0045. Epub 2018 Nov 2.

6.

Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx.

Butler MJ, Ramnath R, Kadoya H, Desposito D, Riquier-Brison A, Ferguson JK, Onions KL, Ogier AS, ElHegni H, Coward RJ, Welsh GI, Foster RR, Peti-Peterdi J, Satchell SC.

Kidney Int. 2019 Jan;95(1):94-107. doi: 10.1016/j.kint.2018.08.024. Epub 2018 Oct 31.

PMID:
30389198
7.

Engineered basement membranes: from in vivo considerations to cell-based assays.

Perry G, Xiao W, Welsh GI, Perriman AW, Lennon R.

Integr Biol (Camb). 2018 Nov 12;10(11):680-695. doi: 10.1039/c8ib00138c. Review.

PMID:
30295300
8.

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes.

Li Z, Tuffin J, Lei IM, Ruggeri FS, Lewis NS, Gill EL, Savin T, Huleihel L, Badylak SF, Knowles T, Satchell SC, Welsh GI, Saleem MA, Huang YYS.

Acta Biomater. 2018 Sep 15;78:111-122. doi: 10.1016/j.actbio.2018.08.010. Epub 2018 Aug 10.

PMID:
30099199
9.

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.

Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR.

Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9.

10.

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

Barratt SL, Blythe T, Ourradi K, Jarrett C, Welsh GI, Bates DO, Millar AB.

Respir Res. 2018 Jan 15;19(1):9. doi: 10.1186/s12931-017-0711-x.

11.

The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.

Sadreev II, Chen MZQ, Umezawa Y, Biktashev VN, Kemper C, Salakhieva DV, Welsh GI, Kotov NV.

Immunology. 2018 Apr;153(4):488-501. doi: 10.1111/imm.12851. Epub 2017 Nov 22.

12.

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Østergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM.

Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29.

13.

Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations.

Sen ES, Dean P, Yarram-Smith L, Bierzynska A, Woodward G, Buxton C, Dennis G, Welsh GI, Williams M, Saleem MA.

J Med Genet. 2017 Dec;54(12):795-804. doi: 10.1136/jmedgenet-2017-104811. Epub 2017 Aug 5.

14.

Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis.

Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, Hames TJ, Scotton CJ, Welsh GI, Bates DO, Millar AB.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):479-493. doi: 10.1164/rccm.201603-0568OC.

15.

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells.

Ourradi K, Blythe T, Jarrett C, Barratt SL, Welsh GI, Millar AB.

Respir Res. 2017 Jun 2;18(1):116. doi: 10.1186/s12931-017-0602-1.

16.

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

Bierzynska A, McCarthy HJ, Soderquest K, Sen ES, Colby E, Ding WY, Nabhan MM, Kerecuk L, Hegde S, Hughes D, Marks S, Feather S, Jones C, Webb NJ, Ognjanovic M, Christian M, Gilbert RD, Sinha MD, Lord GM, Simpson M, Koziell AB, Welsh GI, Saleem MA.

Kidney Int. 2017 Apr;91(4):937-947. doi: 10.1016/j.kint.2016.10.013. Epub 2017 Jan 20.

PMID:
28117080
17.

MAGI2 Mutations Cause Congenital Nephrotic Syndrome.

Bierzynska A, Soderquest K, Dean P, Colby E, Rollason R, Jones C, Inward CD, McCarthy HJ, Simpson MA, Lord GM, Williams M, Welsh GI, Koziell AB, Saleem MA; NephroS; UK study of Nephrotic Syndrome.

J Am Soc Nephrol. 2017 May;28(5):1614-1621. doi: 10.1681/ASN.2016040387. Epub 2016 Dec 8.

18.

VEGF regulates local inhibitory complement proteins in the eye and kidney.

Keir LS, Firth R, Aponik L, Feitelberg D, Sakimoto S, Aguilar E, Welsh GI, Richards A, Usui Y, Satchell SC, Kuzmuk V, Coward RJ, Goult J, Bull KR, Sharma R, Bharti K, Westenskow PD, Michael IP, Saleem MA, Friedlander M.

J Clin Invest. 2017 Jan 3;127(1):199-214. doi: 10.1172/JCI86418. Epub 2016 Dec 5.

19.

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways.

Jiang L, Hindmarch CC, Rogers M, Campbell C, Waterfall C, Coghill J, Mathieson PW, Welsh GI.

Sci Rep. 2016 Oct 24;6:35671. doi: 10.1038/srep35671.

20.

Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement.

Rigothier C, Saleem MA, Bourget C, Mathieson PW, Combe C, Welsh GI.

Cell Signal. 2016 Oct;28(10):1470-8. doi: 10.1016/j.cellsig.2016.06.017. Epub 2016 Jul 1.

PMID:
27377965
21.

Kinetic regulation of multi-ligand binding proteins.

Salakhieva DV, Sadreev II, Chen MZ, Umezawa Y, Evstifeev AI, Welsh GI, Kotov NV.

BMC Syst Biol. 2016 Apr 18;10:32. doi: 10.1186/s12918-016-0277-0.

22.

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.

Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI.

Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252.

23.

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus.

Kumar PA, Welsh GI, Raghu G, Menon RK, Saleem MA, Reddy GB.

Arch Biochem Biophys. 2016 Jan 15;590:10-19. doi: 10.1016/j.abb.2015.11.003. Epub 2015 Nov 10.

PMID:
26550927
24.

Editorial: Podocyte Pathology and Nephropathy.

Lewko B, Welsh GI, Jankowski M.

Front Endocrinol (Lausanne). 2015 Sep 17;6:145. doi: 10.3389/fendo.2015.00145. eCollection 2015. No abstract available.

25.

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.

Santamaria B, Marquez E, Lay A, Carew RM, González-Rodríguez Á, Welsh GI, Ni L, Hale LJ, Ortiz A, Saleem MA, Brazil DP, Coward RJ, Valverde ÁM.

Biochim Biophys Acta. 2015 Dec;1853(12):3224-34. doi: 10.1016/j.bbamcr.2015.09.020. Epub 2015 Sep 16. Erratum in: Biochim Biophys Acta. 2016 Apr;1863(4):786.

26.

Clinical and genetic analysis of patients with cystinuria in the United Kingdom.

Rhodes HL, Yarram-Smith L, Rice SJ, Tabaksert A, Edwards N, Hartley A, Woodward MN, Smithson SL, Tomson C, Welsh GI, Williams M, Thwaites DT, Sayer JA, Coward RJ.

Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1235-45. doi: 10.2215/CJN.10981114. Epub 2015 May 11.

27.

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.

Lennon R, Stuart HM, Bierzynska A, Randles MJ, Kerr B, Hillman KA, Batra G, Campbell J, Storey H, Flinter FA, Koziell A, Welsh GI, Saleem MA, Webb NJ, Woolf AS.

Pediatr Nephrol. 2015 Sep;30(9):1459-65. doi: 10.1007/s00467-015-3067-9. Epub 2015 Mar 5.

28.

Generating conditionally immortalised podocyte cell lines from wild-type mice.

Keir LS, Firth R, May C, Ni L, Welsh GI, Saleem MA.

Nephron. 2015;129(2):128-36.

PMID:
25720381
29.

Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte.

Jiang L, Dasgupta I, Hurcombe JA, Colyer HF, Mathieson PW, Welsh GI.

Clin Sci (Lond). 2015 Jun;128(12):883-93. doi: 10.1042/CS20140749.

PMID:
25626449
30.

A systems model of phosphorylation for inflammatory signaling events.

Sadreev II, Chen MZ, Welsh GI, Umezawa Y, Kotov NV, Valeyev NV.

PLoS One. 2014 Oct 21;9(10):e110913. doi: 10.1371/journal.pone.0110913. eCollection 2014.

31.

Podocyte dedifferentiation: a specialized process for a specialized cell.

May CJ, Saleem M, Welsh GI.

Front Endocrinol (Lausanne). 2014 Oct 1;5:148. doi: 10.3389/fendo.2014.00148. eCollection 2014. Review.

32.

Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus.

Anil Kumar P, Welsh GI, Saleem MA, Menon RK.

Front Endocrinol (Lausanne). 2014 Sep 25;5:151. doi: 10.3389/fendo.2014.00151. eCollection 2014. Review.

33.

Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction.

Ramnath R, Foster RR, Qiu Y, Cope G, Butler MJ, Salmon AH, Mathieson PW, Coward RJ, Welsh GI, Satchell SC.

FASEB J. 2014 Nov;28(11):4686-99. doi: 10.1096/fj.14-252221. Epub 2014 Aug 13.

PMID:
25122554
34.

High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine.

Sleeman P, Patel NN, Lin H, Walkden GJ, Ray P, Welsh GI, Satchell SC, Murphy GJ.

Crit Care. 2013 Oct 31;17(5):R262. doi: 10.1186/cc13092.

35.

Glycosaminoglycan regulation by VEGFA and VEGFC of the glomerular microvascular endothelial cell glycocalyx in vitro.

Foster RR, Armstrong L, Baker S, Wong DW, Wylie EC, Ramnath R, Jenkins R, Singh A, Steadman R, Welsh GI, Mathieson PW, Satchell SC.

Am J Pathol. 2013 Aug;183(2):604-16. doi: 10.1016/j.ajpath.2013.04.019. Epub 2013 Jun 12.

36.

Insulin directly stimulates VEGF-A production in the glomerular podocyte.

Hale LJ, Hurcombe J, Lay A, Santamaría B, Valverde AM, Saleem MA, Mathieson PW, Welsh GI, Coward RJ.

Am J Physiol Renal Physiol. 2013 Jul 15;305(2):F182-8. doi: 10.1152/ajprenal.00548.2012. Epub 2013 May 22.

37.

Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx.

Singh A, Ramnath RD, Foster RR, Wylie EC, Fridén V, Dasgupta I, Haraldsson B, Welsh GI, Mathieson PW, Satchell SC.

PLoS One. 2013;8(2):e55852. doi: 10.1371/journal.pone.0055852. Epub 2013 Feb 14.

38.

Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1.

Harris JJ, McCarthy HJ, Ni L, Wherlock M, Kang H, Wetzels JF, Welsh GI, Saleem MA.

J Pathol. 2013 Apr;229(5):660-71. doi: 10.1002/path.4149. Epub 2013 Feb 22.

PMID:
23436459
39.

Simultaneous sequencing of 24 genes associated with steroid-resistant nephrotic syndrome.

McCarthy HJ, Bierzynska A, Wherlock M, Ognjanovic M, Kerecuk L, Hegde S, Feather S, Gilbert RD, Krischock L, Jones C, Sinha MD, Webb NJ, Christian M, Williams MM, Marks S, Koziell A, Welsh GI, Saleem MA; RADAR the UK SRNS Study Group.

Clin J Am Soc Nephrol. 2013 Apr;8(4):637-48. doi: 10.2215/CJN.07200712. Epub 2013 Jan 24.

40.

Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.

Hale LJ, Welsh GI, Perks CM, Hurcombe JA, Moore S, Hers I, Saleem MA, Mathieson PW, Murphy AJ, Jeansson M, Holly JM, Hardouin SN, Coward RJ.

J Pathol. 2013 May;230(1):95-106. doi: 10.1002/path.4165. Epub 2013 Mar 21.

PMID:
23299523
41.

Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes.

Slater SC, Ramnath RD, Uttridge K, Saleem MA, Cahill PA, Mathieson PW, Welsh GI, Satchell SC.

Int J Biochem Cell Biol. 2012 Sep;44(9):1482-90. doi: 10.1016/j.biocel.2012.05.020. Epub 2012 Jun 6.

PMID:
22683691
42.

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro.

Rigothier C, Auguste P, Welsh GI, Lepreux S, Deminière C, Mathieson PW, Saleem MA, Ripoche J, Combe C.

PLoS One. 2012;7(5):e37695. doi: 10.1371/journal.pone.0037695. Epub 2012 May 25.

43.

VEGF and sVEGFR-1 in malignant pleural effusions: association with survival and pleurodesis outcomes.

Hooper CE, Elvers KT, Welsh GI, Millar AB, Maskell NA.

Lung Cancer. 2012 Aug;77(2):443-9. doi: 10.1016/j.lungcan.2012.03.006. Epub 2012 Apr 7.

PMID:
22487430
44.

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.

Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR.

Cancer Cell. 2011 Dec 13;20(6):768-80. doi: 10.1016/j.ccr.2011.10.016.

45.

The podocyte cytoskeleton--key to a functioning glomerulus in health and disease.

Welsh GI, Saleem MA.

Nat Rev Nephrol. 2011 Oct 25;8(1):14-21. doi: 10.1038/nrneph.2011.151. Review.

PMID:
22025085
46.

Phosphodiesterase-5 inhibition prevents postcardiopulmonary bypass acute kidney injury in swine.

Patel NN, Lin H, Toth T, Jones C, Ray P, Welsh GI, Satchell SC, Sleeman P, Angelini GD, Murphy GJ.

Ann Thorac Surg. 2011 Dec;92(6):2168-76. doi: 10.1016/j.athoracsur.2011.07.002. Epub 2011 Oct 8.

PMID:
21983073
47.

Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase.

Bevan HS, Slater SC, Clarke H, Cahill PA, Mathieson PW, Welsh GI, Satchell SC.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F733-42. doi: 10.1152/ajprenal.00458.2010. Epub 2011 Jul 20.

48.

An in vitro model of the glomerular capillary wall using electrospun collagen nanofibres in a bioartificial composite basement membrane.

Slater SC, Beachley V, Hayes T, Zhang D, Welsh GI, Saleem MA, Mathieson PW, Wen X, Su B, Satchell SC.

PLoS One. 2011;6(6):e20802. doi: 10.1371/journal.pone.0020802. Epub 2011 Jun 24.

49.

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

Sarrab RM, Lennon R, Ni L, Wherlock MD, Welsh GI, Saleem MA.

Am J Physiol Renal Physiol. 2011 Nov;301(5):F1131-8. doi: 10.1152/ajprenal.00589.2010. Epub 2011 Jun 8.

50.

Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine.

Patel NN, Lin H, Toth T, Welsh GI, Jones C, Ray P, Satchell SC, Sleeman P, Angelini GD, Murphy GJ.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F605-14. doi: 10.1152/ajprenal.00145.2011. Epub 2011 Jun 8.

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