Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 60

1.

Molecular Structure of the PKD Protein Complex Finally Solved.

Woodward OM, Watnick T.

Am J Kidney Dis. 2019 May;73(5):620-623. doi: 10.1053/j.ajkd.2018.12.022. Epub 2019 Jan 28. No abstract available.

PMID:
30704879
2.

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.

Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE.

J Am Soc Nephrol. 2018 Oct;29(10):2458-2470. doi: 10.1681/ASN.2018060590. Epub 2018 Sep 18.

PMID:
30228150
3.

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.

Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T, Köttgen M.

PLoS Biol. 2018 Aug 6;16(8):e2005651. doi: 10.1371/journal.pbio.2005651. eCollection 2018 Aug.

4.

A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.

Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, Pan D.

Genes Dev. 2018 Jun 1;32(11-12):781-793. doi: 10.1101/gad.315127.118. Epub 2018 Jun 11.

5.

A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.

Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT.

Am J Nephrol. 2018;47(5):352-360. doi: 10.1159/000488807. Epub 2018 May 18.

6.

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease.

Liu Y, Pejchinovski M, Wang X, Fu X, Castelletti D, Watnick TJ, Arcaro A, Siwy J, Mullen W, Mischak H, Serra AL.

Sci Rep. 2018 Apr 3;8(1):5584. doi: 10.1038/s41598-018-22938-x.

7.

Genomic Analysis to Avoid Misdiagnosis of Adults With Bilateral Renal Cysts.

Gulati A, Bae KT, Somlo S, Watnick T.

Ann Intern Med. 2018 Jul 17;169(2):130-131. doi: 10.7326/L17-0644. Epub 2018 Mar 27. No abstract available.

PMID:
29582070
8.

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.

Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG.

Sci Rep. 2018 Feb 9;8(1):2743. doi: 10.1038/s41598-018-20856-6.

9.

Isolated polycystic liver disease genes define effectors of polycystin-1 function.

Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S.

J Clin Invest. 2017 Sep 1;127(9):3558. doi: 10.1172/JCI96729. Epub 2017 Sep 1.

10.

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.

Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.

Sci Rep. 2017 Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4.

11.

A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism.

Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu X, Xu H, Huang Q, Yao Q, Qian F, Germino GG, Watnick T.

Kidney Int. 2017 Nov;92(5):1130-1144. doi: 10.1016/j.kint.2017.04.027. Epub 2017 Jul 18.

12.

Isolated polycystic liver disease genes define effectors of polycystin-1 function.

Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S.

J Clin Invest. 2017 May 1;127(5):1772-1785. doi: 10.1172/JCI90129. Epub 2017 Apr 4. Erratum in: J Clin Invest. 2017 Sep 1;127(9):3558.

13.

Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats.

Ta MH, Schwensen KG, Liuwantara D, Huso DL, Watnick T, Rangan GK.

World J Nephrol. 2016 Jul 6;5(4):339-57. doi: 10.5527/wjn.v5.i4.339.

14.

Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease.

Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD, Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, Tasic V, Watnick TJ, Chapman AB, Vigneau C, Lavainne F, Audrézet MP, Ferec C, Le Meur Y, Torres VE; Genkyst Study Group, HALT Progression of Polycystic Kidney Disease Group; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease, Harris PC.

Am J Hum Genet. 2016 Jun 2;98(6):1193-1207. doi: 10.1016/j.ajhg.2016.05.004.

15.

The polycystin complex mediates Wnt/Ca(2+) signalling.

Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L.

Nat Cell Biol. 2016 Jul;18(7):752-764. doi: 10.1038/ncb3363. Epub 2016 May 23.

16.

Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.

Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP.

PLoS One. 2016 May 19;11(5):e0155577. doi: 10.1371/journal.pone.0155577. eCollection 2016.

17.

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease.

Cebotaru L, Liu Q, Yanda MK, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V.

Kidney Int. 2016 Jul;90(1):90-9. doi: 10.1016/j.kint.2016.01.026. Epub 2016 Mar 25.

18.

Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition.

Hofherr A, Wagner CJ, Watnick T, Köttgen M.

Kidney Int. 2016 Apr;89(4):949-55. doi: 10.1016/j.kint.2015.11.015. Epub 2016 Jan 6.

19.

Vascular complications in autosomal dominant polycystic kidney disease.

Perrone RD, Malek AM, Watnick T.

Nat Rev Nephrol. 2015 Oct;11(10):589-98. doi: 10.1038/nrneph.2015.128. Epub 2015 Aug 11. Review.

20.

Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; Conference Participants.

Kidney Int. 2015 Jul;88(1):17-27. doi: 10.1038/ki.2015.59. Epub 2015 Mar 18.

21.

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, Cebotaru V, Chiaravalli M, Boletta A, Piontek K, Germino GG, Weinman EJ, Watnick T, Qian F.

Nat Commun. 2014 Nov 18;5:5482. doi: 10.1038/ncomms6482.

22.

Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.

Tan M, Wettersten HI, Chu K, Huso DL, Watnick T, Friedlander S, Landesman Y, Weiss RH.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1179-86. doi: 10.1152/ajprenal.00406.2014. Epub 2014 Sep 18.

23.

Polycystin signaling is required for directed endothelial cell migration and lymphatic development.

Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T.

Cell Rep. 2014 May 8;7(3):634-44. doi: 10.1016/j.celrep.2014.03.064. Epub 2014 Apr 24.

24.

Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.

Fonseca JM, Bastos AP, Amaral AG, Sousa MF, Souza LE, Malheiros DM, Piontek K, Irigoyen MC, Watnick TJ, Onuchic LF.

Kidney Int. 2014 May;85(5):1137-50. doi: 10.1038/ki.2013.501. Epub 2014 Jan 15.

25.

A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.

Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T.

J Am Soc Nephrol. 2014 Jan;25(1):81-91. doi: 10.1681/ASN.2012050486. Epub 2013 Sep 26.

26.

Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated.

Watnick TJ, Germino GG.

Nat Rev Nephrol. 2013 May;9(5):249-50. doi: 10.1038/nrneph.2013.73. Epub 2013 Apr 9. No abstract available.

PMID:
23567275
27.

A missense mutation in PKD1 attenuates the severity of renal disease.

Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T.

Kidney Int. 2012 Feb;81(4):412-7. doi: 10.1038/ki.2011.370. Epub 2011 Oct 26.

28.

Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience.

Higashihara E, Torres VE, Chapman AB, Grantham JJ, Bae K, Watnick TJ, Horie S, Nutahara K, Ouyang J, Krasa HB, Czerwiec FS; TEMPOFormula and 156-05-002 Study Investigators.

Clin J Am Soc Nephrol. 2011 Oct;6(10):2499-507. doi: 10.2215/CJN.03530411. Epub 2011 Sep 8.

29.

Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels.

Köttgen M, Hofherr A, Li W, Chu K, Cook S, Montell C, Watnick T.

PLoS One. 2011;6(5):e20031. doi: 10.1371/journal.pone.0020031. Epub 2011 May 20.

30.

Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.

31.

Pkd1 and Pkd2 are required for normal placental development.

Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T.

PLoS One. 2010 Sep 16;5(9). pii: e12821. doi: 10.1371/journal.pone.0012821.

32.

Not all renal cysts are created equal.

Shah S, Watnick T, Atta MG.

Lancet. 2010 Sep 18;376(9745):1024. doi: 10.1016/S0140-6736(10)60956-7. No abstract available.

PMID:
20851261
33.

mTOR inhibitors in polycystic kidney disease.

Watnick T, Germino GG.

N Engl J Med. 2010 Aug 26;363(9):879-81. doi: 10.1056/NEJMe1006925. Epub 2010 Jun 26. No abstract available.

PMID:
20581393
34.

Aortic abnormalities in males with Alport syndrome.

Kashtan CE, Segal Y, Flinter F, Makanjuola D, Gan JS, Watnick T.

Nephrol Dial Transplant. 2010 Nov;25(11):3554-60. doi: 10.1093/ndt/gfq271. Epub 2010 May 21.

35.

Diagnosis and screening of autosomal dominant polycystic kidney disease.

Pei Y, Watnick T.

Adv Chronic Kidney Dis. 2010 Mar;17(2):140-52. doi: 10.1053/j.ackd.2009.12.001. Review.

36.

Autosomal dominant polycystic kidney disease.

Pei Y, Watnick T.

Adv Chronic Kidney Dis. 2010 Mar;17(2):115-7. doi: 10.1053/j.ackd.2009.12.002. No abstract available.

37.

DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease.

Huang E, Samaniego-Picota M, McCune T, Melancon JK, Montgomery RA, Ugarte R, Kraus E, Womer K, Rabb H, Watnick T.

Transplantation. 2009 Jan 15;87(1):133-7. doi: 10.1097/TP.0b013e318191e729.

38.

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP.

Hum Mol Genet. 2009 Jan 1;18(1):151-63. doi: 10.1093/hmg/ddn325. Epub 2008 Oct 9.

39.

TRPP2 and TRPV4 form a polymodal sensory channel complex.

Köttgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G.

J Cell Biol. 2008 Aug 11;182(3):437-47. doi: 10.1083/jcb.200805124.

40.

Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.

Tan PL, Barr T, Inglis PN, Mitsuma N, Huang SM, Garcia-Gonzalez MA, Bradley BA, Coforio S, Albrecht PJ, Watnick T, Germino GG, Beales PL, Caterina MJ, Leroux MR, Rice FL, Katsanis N.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17524-9. Epub 2007 Oct 24.

41.

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.

Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.

Hum Mol Genet. 2007 Aug 15;16(16):1940-50. Epub 2007 Jun 16.

42.

Evaluating the clinical utility of a molecular genetic test for polycystic kidney disease.

Garcia-Gonzalez MA, Jones JG, Allen SK, Palatucci CM, Batish SD, Seltzer WK, Lan Z, Allen E, Qian F, Lens XM, Pei Y, Germino GG, Watnick TJ.

Mol Genet Metab. 2007 Sep-Oct;92(1-2):160-7. Epub 2007 Jun 18.

43.

A flagellar polycystin-2 homolog required for male fertility in Drosophila.

Watnick TJ, Jin Y, Matunis E, Kernan MJ, Montell C.

Curr Biol. 2003 Dec 16;13(24):2179-84.

44.

From cilia to cyst.

Watnick T, Germino G.

Nat Genet. 2003 Aug;34(4):355-6. No abstract available.

PMID:
12923538
45.

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16981-6. Epub 2002 Dec 13.

46.

Mutation analysis of the entire replicated portion of PKD1 using genomic DNA samples.

Phakdeekitcharoen B, Watnick TJ, Germino GG.

J Am Soc Nephrol. 2001 May;12(5):955-63.

47.

Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease.

Pei Y, Paterson AD, Wang KR, He N, Hefferton D, Watnick T, Germino GG, Parfrey P, Somlo S, St George-Hyslop P.

Am J Hum Genet. 2001 Feb;68(2):355-63. Epub 2001 Jan 10.

48.

Thirteen novel mutations of the replicated region of PKD1 in an Asian population.

Phakdeekitcharoen B, Watnick TJ, Ahn C, Whang DY, Burkhart B, Germino GG.

Kidney Int. 2000 Oct;58(4):1400-12.

49.

Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations.

Watnick T, He N, Wang K, Liang Y, Parfrey P, Hefferton D, St George-Hyslop P, Germino G, Pei Y.

Nat Genet. 2000 Jun;25(2):143-4.

PMID:
10835625
50.

Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease.

Watnick T, Phakdeekitcharoen B, Johnson A, Gandolph M, Wang M, Briefel G, Klinger KW, Kimberling W, Gabow P, Germino GG.

Am J Hum Genet. 1999 Dec;65(6):1561-71.

Supplemental Content

Loading ...
Support Center