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Items: 9


Estimating kinetic constants in the Michaelis-Menten model from one enzymatic assay using Approximate Bayesian Computation.

Tomczak JM, Węglarz-Tomczak E.

FEBS Lett. 2019 Oct;593(19):2742-2750. doi: 10.1002/1873-3468.13531. Epub 2019 Jul 21.


Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics.

Drewniak M, Węglarz-Tomczak E, Ożga K, Rudzińska-Szostak E, Macegoniuk K, Tomczak JM, Bejger M, Rypniewski W, Berlicki Ł.

Bioorg Chem. 2018 Dec;81:356-361. doi: 10.1016/j.bioorg.2018.07.012. Epub 2018 Jul 17.


Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.

Węglarz-Tomczak E, Talma M, Giurg M, Westerhoff HV, Janowski R, Mucha A.

Oncotarget. 2018 Jun 29;9(50):29365-29378. doi: 10.18632/oncotarget.25532. eCollection 2018 Jun 29.


Controlling the Helix Handedness of ααβ-Peptide Foldamers through Sequence Shifting.

Szefczyk M, Węglarz-Tomczak E, Fortuna P, Krzysztoń A, Rudzińska-Szostak E, Berlicki Ł.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2087-2091. doi: 10.1002/anie.201610154. Epub 2017 Jan 12.


Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.

Węglarz-Tomczak E, Burda-Grabowska M, Giurg M, Mucha A.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5254-5259. doi: 10.1016/j.bmcl.2016.09.050. Epub 2016 Sep 20.


Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.

Węglarz-Tomczak E, Vassiliou S, Mucha A.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):4122-6. doi: 10.1016/j.bmcl.2016.06.062. Epub 2016 Jun 25.


A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.

Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Joachimiak A, Mucha A.

Eur J Med Chem. 2016 Jul 19;117:187-96. doi: 10.1016/j.ejmech.2016.04.018. Epub 2016 Apr 9.


Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.

Vassiliou S, Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Mulligan R, Joachimiak A, Mucha A.

J Med Chem. 2014 Oct 9;57(19):8140-51. doi: 10.1021/jm501071f. Epub 2014 Sep 22.


An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.

Węglarz-Tomczak E, Poręba M, Byzia A, Berlicki Ł, Nocek B, Mulligan R, Joachimiak A, Drąg M, Mucha A.

Biochimie. 2013 Feb;95(2):419-28. doi: 10.1016/j.biochi.2012.10.018. Epub 2012 Nov 3.

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