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Items: 1 to 50 of 222

1.

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.

Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G.

MBio. 2019 Feb 5;10(1). pii: e02624-18. doi: 10.1128/mBio.02624-18.

2.

Candida albicans Factor H Binding Molecule Hgt1p - A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils.

Kenno S, Speth C, Rambach G, Binder U, Chatterjee S, Caramalho R, Haas H, Lass-Flörl C, Shaughnessy J, Ram S, Gow NAR, Orth-Höller D, Würzner R.

Front Microbiol. 2019 Jan 15;9:3319. doi: 10.3389/fmicb.2018.03319. eCollection 2018.

3.

The structure of the Shiga toxin 2a A-subunit dictates the interactions of the toxin with blood components.

Brigotti M, Orth-Höller D, Carnicelli D, Porcellini E, Galassi E, Tazzari PL, Ricci F, Manoli F, Manet I, Talasz H, Lindner HH, Speth C, Erbeznik T, Fuchs S, Posch W, Chatterjee S, Würzner R.

Cell Microbiol. 2018 Dec 22:e13000. doi: 10.1111/cmi.13000. [Epub ahead of print]

PMID:
30578712
4.

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Gaya da Costa M, Poppelaars F, van Kooten C, Mollnes TE, Tedesco F, Würzner R, Trouw LA, Truedsson L, Daha MR, Roos A, Seelen MA.

Front Immunol. 2018 Nov 20;9:2664. doi: 10.3389/fimmu.2018.02664. eCollection 2018.

5.

The utility of complement assays in clinical immunology: A comprehensive review.

Lung T, Risch L, Risch M, Sakem B, Würzner R, Nydegger U.

J Autoimmun. 2018 Dec;95:191-200. doi: 10.1016/j.jaut.2018.10.013. Epub 2018 Oct 31. Review.

PMID:
30391025
6.

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex.

Schiela B, Bernklau S, Malekshahi Z, Deutschmann D, Koske I, Banki Z, Thielens NM, Würzner R, Speth C, Weiss G, Stiasny K, Steinmann E, Stoiber H.

Front Immunol. 2018 Oct 17;9:2177. doi: 10.3389/fimmu.2018.02177. eCollection 2018.

7.

Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets.

Knabl L, Berktold M, Hamad OA, Fromell K, Chatterjee S, Speth C, Talasz H, Lindner K, Hermann M, Nilsson-Ekdahl K, Nilsson B, Streif W, Martini J, Würzner R, Orth-Höller D.

Int J Med Microbiol. 2018 Oct;308(7):969-976. doi: 10.1016/j.ijmm.2018.07.008. Epub 2018 Jul 23.

PMID:
30064820
8.

Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells.

Loeschenberger B, Niess L, Würzner R, Schwelberger H, Eder IE, Puhr M, Guenther J, Troppmair J, Rudnicki M, Neuwirt H.

Eur J Immunol. 2018 Feb;48(2):330-343. doi: 10.1002/eji.201747135. Epub 2017 Dec 11.

9.

Diagnosing filamentous fungal infections in immunocompromised patients applying computed tomography-guided percutaneous lung biopsies: a 12-year experience.

Lass-Flörl C, Aigner M, Nachbaur D, Eschertzhuber S, Bucher B, Geltner C, Bellmann R, Lackner M, Orth-Höller D, Würzner R, Weiss G, Glodny B.

Infection. 2017 Dec;45(6):867-875. doi: 10.1007/s15010-017-1072-6. Epub 2017 Sep 27.

10.

Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab.

Riedl M, Hofer J, Giner T, Rosales A, Häffner K, Simonetti GD, Walden U, Maier T, Heininger D, Jeller V, Weiss G, van den Heuvel L, Zimmerhackl LB, Würzner R, Jungraithmayr TC.

J Immunol Methods. 2016 Aug;435:60-7. doi: 10.1016/j.jim.2016.05.009. Epub 2016 May 26. No abstract available.

11.

Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.

Zlamy M, Almanzar G, Parson W, Schmidt C, Leierer J, Weinberger B, Jeller V, Unsinn K, Eyrich M, Würzner R, Prelog M.

Immun Ageing. 2016 Feb 2;13:3. doi: 10.1186/s12979-016-0058-z. eCollection 2016.

12.

European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB.

Mol Immunol. 2015 Nov;68(1):63-6. doi: 10.1016/j.molimm.2015.05.003. Epub 2015 May 23. Review.

PMID:
26006049
13.

Complement and platelets: Mutual interference in the immune network.

Speth C, Rambach G, Würzner R, Lass-Flörl C, Kozarcanin H, Hamad OA, Nilsson B, Ekdahl KN.

Mol Immunol. 2015 Sep;67(1):108-18. doi: 10.1016/j.molimm.2015.03.244. Epub 2015 Apr 14. Review.

PMID:
25886718
14.

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.

Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A.

Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19.

15.

An update on the thrombotic microangiopathies hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP).

Riedl M, Orth-Höller D, Würzner R.

Semin Thromb Hemost. 2014 Jun;40(4):413-5. doi: 10.1055/s-0034-1376521. Epub 2014 Jun 9. No abstract available.

PMID:
24911557
16.

Treatment of enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome (eHUS).

Würzner R, Riedl M, Rosales A, Orth-Höller D.

Semin Thromb Hemost. 2014 Jun;40(4):508-16. doi: 10.1055/s-0034-1375298. Epub 2014 May 6. Review.

PMID:
24802085
17.

Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome.

Orth-Höller D, Würzner R.

Semin Thromb Hemost. 2014 Jun;40(4):503-7. doi: 10.1055/s-0034-1375295. Epub 2014 May 5. Review.

PMID:
24799304
18.

Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.

Dettmar AK, Binder E, Greiner FR, Liebau MC, Kurschat CE, Jungraithmayr TC, Saleem MA, Schmitt CP, Feifel E, Orth-Höller D, Kemper MJ, Pepys M, Würzner R, Oh J.

Infect Immun. 2014 May;82(5):1872-9. doi: 10.1128/IAI.01591-14. Epub 2014 Feb 24.

19.

Compound heterozygous mutations in the C6 gene of a child with recurrent infections.

Westra D, Kurvers RA, van den Heuvel LP, Würzner R, Hoppenreijs EP, van der Flier M, van de Kar NC, Warris A.

Mol Immunol. 2014 Apr;58(2):201-5. doi: 10.1016/j.molimm.2013.11.023. Epub 2013 Dec 30.

PMID:
24378253
20.

Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R.

Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5.

PMID:
24317278
21.

Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto's thyroiditis.

Prelog M, Schönlaub J, Würzner R, Koppelstaetter C, Almanzar G, Brunner A, Gasser M, Prommegger R, Häusler G, Kapelari K, Högler W.

BMC Endocr Disord. 2013 Sep 5;13:34. doi: 10.1186/1472-6823-13-34.

22.

Virulence and thrombocyte affectation of two Aspergillus terreus isolates differing in amphotericin B susceptibility.

Speth C, Blum G, Hagleitner M, Hörtnagl C, Pfaller K, Posch B, Ott HW, Würzner R, Lass-Flörl C, Rambach G.

Med Microbiol Immunol. 2013 Oct;202(5):379-89. doi: 10.1007/s00430-013-0300-7. Epub 2013 May 31.

PMID:
23722593
23.

Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells.

Ehrlenbach S, Rosales A, Posch W, Wilflingseder D, Hermann M, Brockmeyer J, Karch H, Satchell SC, Würzner R, Orth-Höller D.

Infect Immun. 2013 Aug;81(8):2678-85. doi: 10.1128/IAI.01079-12. Epub 2013 May 20.

24.

Reduced varicella-zoster-virus (VZV)-specific lymphocytes and IgG antibody avidity in solid organ transplant recipients.

Prelog M, Schönlaub J, Jeller V, Almanzar G, Höfner K, Gruber S, Eiwegger T, Würzner R.

Vaccine. 2013 May 7;31(20):2420-6. doi: 10.1016/j.vaccine.2013.03.058. Epub 2013 Apr 10.

PMID:
23583889
25.

The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections.

Zlamy M, Kofler S, Orth D, Würzner R, Heinz-Erian P, Streng A, Prelog M.

BMC Infect Dis. 2013 Mar 1;13:112. doi: 10.1186/1471-2334-13-112.

26.

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Clark SJ, Ridge LA, Herbert AP, Hakobyan S, Mulloy B, Lennon R, Würzner R, Morgan BP, Uhrín D, Bishop PN, Day AJ.

J Immunol. 2013 Mar 1;190(5):2049-57. doi: 10.4049/jimmunol.1201751. Epub 2013 Jan 30.

27.

Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.

Hofer J, Janecke AR, Zimmerhackl LB, Riedl M, Rosales A, Giner T, Cortina G, Haindl CJ, Petzelberger B, Pawlik M, Jeller V, Vester U, Gadner B, van Husen M, Moritz ML, Würzner R, Jungraithmayr T; German-Austrian HUS Study Group.

Clin J Am Soc Nephrol. 2013 Mar;8(3):407-15. doi: 10.2215/CJN.01260212. Epub 2012 Dec 14.

28.

[ESBL-producing E. coli and EHEC in dogs and cats in the Tyrol as possible source of human infection].

Franiek N, Orth D, Grif K, Ewers C, Wieler LH, Thalhammer JG, Würzner R.

Berl Munch Tierarztl Wochenschr. 2012 Nov-Dec;125(11-12):469-75. German.

PMID:
23227764
29.

Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds.

Speth C, Hagleitner M, Ott HW, Würzner R, Lass-Flörl C, Rambach G.

J Infect Dis. 2013 Mar 1;207(5):823-33. doi: 10.1093/infdis/jis743. Epub 2012 Dec 7.

PMID:
23225903
30.

Genetic characterization of Panton-Valentine leukocidin-producing methicillin-resistant Staphylococcus aureus in Western Austria.

Berktold M, Grif K, Mäser M, Witte W, Würzner R, Orth-Höller D.

Wien Klin Wochenschr. 2012 Oct;124(19-20):709-15. doi: 10.1007/s00508-012-0244-8. Epub 2012 Sep 28.

PMID:
23053569
31.

Complement component C5 and C6 mutation screening indicated in meningococcal disease in South Africa.

Owen EP, Leisegang F, Whitelaw A, Simpson J, Baker S, Würzner R, Potter P, Orren A.

S Afr Med J. 2012 May 23;102(6):525-7.

PMID:
22668955
32.

Rapid detection of bloodstream pathogens by real-time PCR in patients with sepsis.

Grif K, Fille M, Würzner R, Weiss G, Lorenz I, Gruber G, Eschertzhuber S, Nachbaur D, Lass-Flörl C, Orth D.

Wien Klin Wochenschr. 2012 Apr;124(7-8):266-70. doi: 10.1007/s00508-012-0159-4. Epub 2012 Apr 14.

PMID:
22527822
33.

Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae.

Rosales A, Hofer J, Zimmerhackl LB, Jungraithmayr TC, Riedl M, Giner T, Strasak A, Orth-Höller D, Würzner R, Karch H; German-Austrian HUS Study Group.

Clin Infect Dis. 2012 May;54(10):1413-21. doi: 10.1093/cid/cis196. Epub 2012 Mar 12.

PMID:
22412065
34.

Detection of Candida albicans by mass spectrometric fingerprinting.

Zehm S, Schweinitz S, Würzner R, Colvin HP, Rieder J.

Curr Microbiol. 2012 Mar;64(3):271-5. doi: 10.1007/s00284-011-0064-5. Epub 2011 Dec 16.

PMID:
22173653
35.

Inhibition of terminal complement activation in severe Shiga toxin-associated HUS - perfect example for a fast track from bench to bedside.

Orth-Höller D, Riedl M, Würzner R.

EMBO Mol Med. 2011 Nov;3(11):617-9. doi: 10.1002/emmm.201100169. Epub 2011 Sep 23. No abstract available.

36.

Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule.

Lesiak-Markowicz I, Vogl G, Schwarzmüller T, Speth C, Lass-Flörl C, Dierich MP, Kuchler K, Würzner R.

J Infect Dis. 2011 Sep 1;204(5):802-9. doi: 10.1093/infdis/jir455.

37.

Gliotoxin as putative virulence factor and immunotherapeutic target in a cell culture model of cerebral aspergillosis.

Speth C, Kupfahl C, Pfaller K, Hagleitner M, Deutinger M, Würzner R, Mohsenipour I, Lass-Flörl C, Rambach G.

Mol Immunol. 2011 Sep;48(15-16):2122-9. doi: 10.1016/j.molimm.2011.07.005. Epub 2011 Jul 30.

PMID:
21803423
38.

Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?

Poolpol K, Gadner B, Neururer S, Mellmann A, Karch H, Orth D, Würzner R.

Int J Immunogenet. 2011 Oct;38(5):383-7. doi: 10.1111/j.1744-313X.2011.01017.x. Epub 2011 Jun 7.

PMID:
21649859
39.

Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis.

Brunner J, Prelog M, Riedl M, Giner T, Hofer J, Würzner R, Zimmerhackl LB.

Rheumatol Int. 2012 Jun;32(6):1815-8. doi: 10.1007/s00296-011-1973-0. Epub 2011 Jun 7.

PMID:
21647665
40.

Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy.

Zlamy M, Würzner R, Holzmann H, Brandstätter A, Jeller V, Zimmerhackl LB, Prelog M.

Vaccine. 2010 Nov 29;28(51):8053-60. doi: 10.1016/j.vaccine.2010.10.002. Epub 2010 Oct 16.

PMID:
20955827
41.

Complement in typical hemolytic uremic syndrome.

Orth D, Würzner R.

Semin Thromb Hemost. 2010 Sep;36(6):620-4. doi: 10.1055/s-0030-1262883. Epub 2010 Sep 23. Review.

PMID:
20865638
42.

Modern determination of complement activation.

Oppermann M, Würzner R.

Semin Thromb Hemost. 2010 Sep;36(6):611-9. doi: 10.1055/s-0030-1262882. Epub 2010 Sep 23. Review.

PMID:
20865637
43.

Hemolytic uremic syndrome. Foreword.

Würzner R, Zimmerhackl LB.

Semin Thromb Hemost. 2010 Sep;36(6):571-2. doi: 10.1055/s-0030-1262877. Epub 2010 Sep 23. No abstract available.

PMID:
20865632
44.

EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5.

Orth D, Ehrlenbach S, Brockmeyer J, Khan AB, Huber G, Karch H, Sarg B, Lindner H, Würzner R.

Infect Immun. 2010 Oct;78(10):4294-301. doi: 10.1128/IAI.00488-10. Epub 2010 Jul 19.

45.

Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome.

Zimmerhackl LB, Hofer J, Cortina G, Mark W, Würzner R, Jungraithmayr TC, Khursigara G, Kliche KO, Radauer W.

N Engl J Med. 2010 May 6;362(18):1746-8. doi: 10.1056/NEJMc1001060. No abstract available.

PMID:
20445192
46.

Secretion of a fungal protease represents a complement evasion mechanism in cerebral aspergillosis.

Rambach G, Dum D, Mohsenipour I, Hagleitner M, Würzner R, Lass-Flörl C, Speth C.

Mol Immunol. 2010 Apr;47(7-8):1438-49. doi: 10.1016/j.molimm.2010.02.010. Epub 2010 Mar 19.

PMID:
20303595
47.

A large family with a gain-of-function mutation of complement C3 predisposing to atypical hemolytic uremic syndrome, microhematuria, hypertension and chronic renal failure.

Lhotta K, Janecke AR, Scheiring J, Petzlberger B, Giner T, Fally V, Würzner R, Zimmerhackl LB, Mayer G, Fremeaux-Bacchi V.

Clin J Am Soc Nephrol. 2009 Aug;4(8):1356-62. doi: 10.2215/CJN.06281208. Epub 2009 Jul 9.

48.

Complement in human diseases: Lessons from complement deficiencies.

Botto M, Kirschfink M, Macor P, Pickering MC, Würzner R, Tedesco F.

Mol Immunol. 2009 Sep;46(14):2774-83. doi: 10.1016/j.molimm.2009.04.029. Epub 2009 May 28. Review.

PMID:
19481265
49.

Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndrome.

Orth D, Khan AB, Naim A, Grif K, Brockmeyer J, Karch H, Joannidis M, Clark SJ, Day AJ, Fidanzi S, Stoiber H, Dierich MP, Zimmerhackl LB, Würzner R.

J Immunol. 2009 May 15;182(10):6394-400. doi: 10.4049/jimmunol.0900151.

50.

Epidemiology of listeriosis in Austria.

Kasper S, Huhulescu S, Auer B, Heller I, Karner F, Würzner R, Wagner M, Allerberger F.

Wien Klin Wochenschr. 2009;121(3-4):113-9. doi: 10.1007/s00508-008-1130-2.

PMID:
19280136

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