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Items: 24


Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.

Jeay S, Ferretti S, Holzer P, Fuchs J, Chapeau EA, Wartmann M, Sterker D, Romanet V, Murakami M, Kerr G, Durand EY, Gaulis S, Cortes-Cros M, Ruetz S, Stachyra TM, Kallen J, Furet P, Würthner J, Guerreiro N, Halilovic E, Jullion A, Kauffmann A, Kuriakose E, Wiesmann M, Jensen MR, Hofmann F, Sellers WR.

Cancer Res. 2018 Nov 1;78(21):6257-6267. doi: 10.1158/0008-5472.CAN-18-0338. Epub 2018 Aug 22.


Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.

Jeay S, Gaulis S, Ferretti S, Bitter H, Ito M, Valat T, Murakami M, Ruetz S, Guthy DA, Rynn C, Jensen MR, Wiesmann M, Kallen J, Furet P, Gessier F, Holzer P, Masuya K, Würthner J, Halilovic E, Hofmann F, Sellers WR, Graus Porta D.

Elife. 2016 Nov 17;5. pii: e19317. doi: 10.7554/eLife.19317. No abstract available.


A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.

Jeay S, Gaulis S, Ferretti S, Bitter H, Ito M, Valat T, Murakami M, Ruetz S, Guthy DA, Rynn C, Jensen MR, Wiesmann M, Kallen J, Furet P, Gessier F, Holzer P, Masuya K, Würthner J, Halilovic E, Hofmann F, Sellers WR, Graus Porta D.

Elife. 2015 May 12;4. pii: e06498. doi: 10.7554/eLife.06498. Erratum in: Elife. 2016 Nov 17;5:null.


Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study.

Al-Sarraj S, King A, Cleveland M, Pradat PF, Corse A, Rothstein JD, Leigh PN, Abila B, Bates S, Wurthner J, Meininger V.

Acta Neuropathol Commun. 2014 Dec 14;2:165. doi: 10.1186/s40478-014-0165-z.


Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.

Meininger V, Pradat PF, Corse A, Al-Sarraj S, Rix Brooks B, Caress JB, Cudkowicz M, Kolb SJ, Lange D, Leigh PN, Meyer T, Milleri S, Morrison KE, Orrell RW, Peters G, Rothstein JD, Shefner J, Lavrov A, Williams N, Overend P, Price J, Bates S, Bullman J, Krull D, Berges A, Abila B, Meno-Tetang G, Wurthner J.

PLoS One. 2014 May 19;9(5):e97803. doi: 10.1371/journal.pone.0097803. eCollection 2014.


Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-α receptor 1.

Holland MC, Wurthner JU, Morley PJ, Birchler MA, Lambert J, Albayaty M, Serone AP, Wilson R, Chen Y, Forrest RM, Cordy JC, Lipson DA, Bayliffe AI.

J Clin Immunol. 2013 Oct;33(7):1192-203. doi: 10.1007/s10875-013-9915-0. Epub 2013 Jul 6.


[(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load.

Pullambhatla M, Tessier J, Beck G, Jedynak B, Wurthner JU, Pomper MG.

Am J Nucl Med Mol Imaging. 2012;2(3):260-70. Epub 2012 Jul 10.


A pilot study assessing the prognostic value of CK18 and nDNA biomarkers in severe sepsis patients.

Moore DJ, Greystoke A, Butt F, Wurthner J, Growcott J, Hughes A, Dive C.

Clin Drug Investig. 2012 Mar 1;32(3):179-87. doi: 10.2165/11598610-000000000-00000.


The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.

Messler S, Kropp S, Episkopou V, Felici A, Würthner J, Lemke R, Jerabek-Willemsen M, Willecke R, Scheu S, Pfeffer K, Wurthner JU.

Immunobiology. 2011 Mar;216(3):343-50. doi: 10.1016/j.imbio.2010.07.006. Epub 2010 Aug 19.


A set of novel multiplex Taqman real-time PCRs for the detection of diarrhoeagenic Escherichia coli and its use in determining the prevalence of EPEC and EAEC in a university hospital.

Hardegen C, Messler S, Henrich B, Pfeffer K, Würthner J, MacKenzie CR.

Ann Clin Microbiol Antimicrob. 2010 Jan 22;9:5. doi: 10.1186/1476-0711-9-5.


Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Würthner J, Kurig S, Beer S, Pfeffer K.

J Immunol. 2007 Dec 1;179(11):7729-40.


In silico and in vitro characterization of mGBP4 splice variants.

Konermann C, Kresse A, Beuter-Gunia C, Würthner J, Degrandi D, Pfeffer K, Beer S.

DNA Cell Biol. 2007 Dec;26(12):847-51.


Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus.

Hoff NP, Degrandi D, Hengge U, Pfeffer K, Wurthner JU.

J Clin Immunol. 2007 Nov;27(6):568-79. Epub 2007 Jul 20.


S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4.

Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T.

J Invest Dermatol. 2007 Nov;127(11):2596-604. Epub 2007 Jul 12.


Fever, episcleritis, epistaxis, and rash after safari holiday in Swaziland.

Büchau AS, Wurthner JU, Reifenberger J, Ruzicka T.

Arch Dermatol. 2006 Oct;142(10):1365-6. No abstract available.


[Rickettsiosis subsequent to vacation in Swaziland].

Büchau AS, Würthner JU, Bylaite M, Kukova G, Ruzicka T, Reifenberger J.

Hautarzt. 2006 Apr;57(4):328-30. German. No abstract available.


TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

Felici A, Wurthner JU, Parks WT, Giam LR, Reiss M, Karpova TS, McNally JG, Roberts AB.

EMBO J. 2003 Sep 1;22(17):4465-77.


Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells.

Cao Z, Flanders KC, Bertolette D, Lyakh LA, Wurthner JU, Parks WT, Letterio JJ, Ruscetti FW, Roberts AB.

Blood. 2003 Jan 15;101(2):498-507. Epub 2002 Sep 12.


X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling.

Birkey Reffey S, Wurthner JU, Parks WT, Roberts AB, Duckett CS.

J Biol Chem. 2001 Jul 13;276(28):26542-9. Epub 2001 May 16.


Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.

Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB.

J Biol Chem. 2001 Jun 1;276(22):19495-502. Epub 2001 Feb 20.


A cellular automaton model of cellular signal transduction.

Wurthner JU, Mukhopadhyay AK, Peimann CJ.

Comput Biol Med. 2000 Jan;30(1):1-21.


Management of acute myeloid leukaemia following myelodysplastic syndrome in a kidney graft recipient.

Würthner J, Rump LC, Grotz W, Engelhardt R, Lübbert M.

Nephrol Dial Transplant. 1999 Feb;14(2):501-6. No abstract available.


LH/hCG-receptor is coupled to both adenylate cyclase and protein kinase C signaling pathways in isolated mouse Leydig cells.

Würthner JU, Kistler M, Kratzmeier M, Mukhopadhyay AK.

Endocrine. 1995 Aug;3(8):579-84. doi: 10.1007/BF02953022.


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