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Items: 49

1.

Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes.

Wärri A, Cook KL, Hu R, Jin L, Zwart A, Soto-Pantoja DR, Liu J, Finkel T, Clarke R.

Cell Death Discov. 2018 Oct 15;4:40. doi: 10.1038/s41420-018-0105-y. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.

2.

Epithelial vimentin plays a functional role in mammary gland development.

Peuhu E, Virtakoivu R, Mai A, Wärri A, Ivaska J.

Development. 2017 Nov 15;144(22):4103-4113. doi: 10.1242/dev.154229. Epub 2017 Sep 25.

3.

Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats.

Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L.

Clin Cancer Res. 2017 Feb 1;23(3):814-824. doi: 10.1158/1078-0432.CCR-16-1735.

4.

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.

Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier MA, Eliceiri KW, Ivaska J.

EMBO J. 2017 Jan 17;36(2):165-182. doi: 10.15252/embj.201694387. Epub 2016 Dec 14.

5.

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer.

Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R.

Cancer Res. 2016 Oct 1;76(19):5657-5670.

6.

Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model.

Hilakivi-Clarke L, Wärri A, Bouker KB, Zhang X, Cook KL, Jin L, Zwart A, Nguyen N, Hu R, Cruz MI, de Assis S, Wang X, Xuan J, Wang Y, Wehrenberg B, Clarke R.

J Natl Cancer Inst. 2016 Sep 8;109(1). doi: 10.1093/jnci/djw188. Print 2017 Jan.

7.

Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.

Schwartz-Roberts JL, Cook KL, Chen C, Shajahan-Haq AN, Axelrod M, Wärri A, Riggins RB, Jin L, Haddad BR, Kallakury BV, Baumann WT, Clarke R.

Cancer Res. 2015 Mar 15;75(6):1046-55. doi: 10.1158/0008-5472.CAN-14-1851. Epub 2015 Jan 9.

8.

NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.

Hu R, Warri A, Jin L, Zwart A, Riggins RB, Fang HB, Clarke R.

Mol Cell Biol. 2015 Jan;35(2):379-90. doi: 10.1128/MCB.00847-14. Epub 2014 Nov 3.

9.

MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer.

Shajahan-Haq AN, Cook KL, Schwartz-Roberts JL, Eltayeb AE, Demas DM, Warri AM, Facey CO, Hilakivi-Clarke LA, Clarke R.

Mol Cancer. 2014 Oct 23;13:239. doi: 10.1186/1476-4598-13-239.

10.

Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer.

Cook KL, Wärri A, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Clarke R.

Clin Cancer Res. 2014 Jun 15;20(12):3222-32. doi: 10.1158/1078-0432.CCR-13-3227. Erratum in: Clin Cancer Res. 2016 Jun 1;22(11):2825.

11.

Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death.

Cook KL, Clarke PA, Parmar J, Hu R, Schwartz-Roberts JL, Abu-Asab M, Wärri A, Baumann WT, Clarke R.

FASEB J. 2014 Sep;28(9):3891-905. doi: 10.1096/fj.13-247353. Epub 2014 May 23.

12.

Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.

Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Wärri A, Grunau S, Antonenkov VD, Hiltunen JK.

Dev Biol. 2014 Jul 1;391(1):66-80. doi: 10.1016/j.ydbio.2014.03.022. Epub 2014 Apr 12.

13.

GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.

Schwartz-Roberts JL, Shajahan AN, Cook KL, Wärri A, Abu-Asab M, Clarke R.

Mol Cancer Ther. 2013 Apr;12(4):448-59. doi: 10.1158/1535-7163.MCT-12-0617. Epub 2013 Feb 8.

14.

Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk.

Hilakivi-Clarke L, de Assis S, Warri A.

J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):25-42. doi: 10.1007/s10911-013-9274-8. Epub 2013 Feb 8. Review.

15.

High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring.

de Assis S, Warri A, Cruz MI, Laja O, Tian Y, Zhang B, Wang Y, Huang TH, Hilakivi-Clarke L.

Nat Commun. 2012;3:1053. doi: 10.1038/ncomms2058.

16.

Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.

Cook KL, Shajahan AN, Wärri A, Jin L, Hilakivi-Clarke LA, Clarke R.

Cancer Res. 2012 Jul 1;72(13):3337-49. doi: 10.1158/0008-5472.CAN-12-0269.

17.

Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis.

Pollari S, Käkönen RS, Mohammad KS, Rissanen JP, Halleen JM, Wärri A, Nissinen L, Pihlavisto M, Marjamäki A, Perälä M, Guise TA, Kallioniemi O, Käkönen SM.

Mol Cancer Res. 2012 May;10(5):597-604. doi: 10.1158/1541-7786.MCR-11-0482. Epub 2012 Apr 20.

18.

Pregnancy hormonal environment and mother's breast cancer risk.

Hilakivi-Clarke L, de Assis S, Warri A, Luoto R.

Horm Mol Biol Clin Investig. 2012 Apr 1;9(1):11-23. doi: 10.1515/hmbci-2012-0019.

PMID:
25961351
19.

Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate.

Clarke R, Cook KL, Hu R, Facey CO, Tavassoly I, Schwartz JL, Baumann WT, Tyson JJ, Xuan J, Wang Y, Wärri A, Shajahan AN.

Cancer Res. 2012 Mar 15;72(6):1321-31. doi: 10.1158/0008-5472.CAN-11-3213. Review.

20.

Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention.

Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R.

J Agric Food Chem. 2012 Jun 13;60(23):5693-708. doi: 10.1021/jf204084f. Epub 2012 Feb 22. Review.

21.

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.

de Assis S, Warri A, Benitez C, Helferich W, Hilakivi-Clarke L.

Cancer Prev Res (Phila). 2011 Sep;4(9):1436-48. doi: 10.1158/1940-6207.CAPR-10-0346. Epub 2011 Jun 16.

22.

Effects of maternal exposure to cow's milk high or low in isoflavones on carcinogen-induced mammary tumorigenesis among rat offspring.

Nielsen TS, Purup S, Wärri A, Godschalk RW, Hilakivi-Clarke L.

Cancer Prev Res (Phila). 2011 May;4(5):694-701. doi: 10.1158/1940-6207.CAPR-10-0220. Epub 2011 Apr 5.

23.

Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer.

Clarke R, Shajahan AN, Wang Y, Tyson JJ, Riggins RB, Weiner LM, Bauman WT, Xuan J, Zhang B, Facey C, Aiyer H, Cook K, Hickman FE, Tavassoly I, Verdugo A, Chen C, Zwart A, Wärri A, Hilakivi-Clarke LA.

Horm Mol Biol Clin Investig. 2011 Mar;5(1):35-44.

24.

Changes in mammary gland morphology and breast cancer risk in rats.

de Assis S, Warri A, Cruz MI, Hilakivi-Clarke L.

J Vis Exp. 2010 Oct 16;(44). pii: 2260. doi: 10.3791/2260.

25.

Dietary vitamin D exposure prevents obesity-induced increase in endometrial cancer in Pten+/- mice.

Yu W, Cline M, Maxwell LG, Berrigan D, Rodriguez G, Warri A, Hilakivi-Clarke L.

Cancer Prev Res (Phila). 2010 Oct;3(10):1246-58. doi: 10.1158/1940-6207.CAPR-10-0088. Epub 2010 Sep 21.

26.

Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance.

Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K, Kallioniemi O, Bono P, Heikkilä P, Joensuu H, Wärri A, Ivaska J.

Clin Cancer Res. 2009 Nov 1;15(21):6570-81. doi: 10.1158/1078-0432.CCR-09-0773. Epub 2009 Oct 13.

27.

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453).

Saarinen NM, Bingham C, Lorenzetti S, Mortensen A, Mäkelä S, Penttinen P, Sørensen IK, Valsta LM, Virgili F, Vollmer G, Wärri A, Zierau O.

Genes Nutr. 2006 Sep;1(3-4):143-58. doi: 10.1007/BF02829964.

28.

Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.

Saarinen NM, Wärri A, Dings RP, Airio M, Smeds AI, Mäkelä S.

Int J Cancer. 2008 Sep 1;123(5):1196-204. doi: 10.1002/ijc.23614.

29.

The role of early life genistein exposures in modifying breast cancer risk.

Warri A, Saarinen NM, Makela S, Hilakivi-Clarke L.

Br J Cancer. 2008 May 6;98(9):1485-93. doi: 10.1038/sj.bjc.6604321. Epub 2008 Apr 8. Review.

30.

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

Borgenström M, Wärri A, Hiilesvuo K, Käkönen R, Käkönen S, Nissinen L, Pihlavisto M, Marjamäki A, Vlodavsky I, Naggi A, Torri G, Casu B, Veromaa T, Salmivirta M, Elenius K.

Semin Thromb Hemost. 2007 Jul;33(5):547-56.

PMID:
17629853
31.

Ectopic expression of syndecan-1 in basal epidermis affects keratinocyte proliferation and wound re-epithelialization.

Ojeh N, Hiilesvuo K, Wärri A, Salmivirta M, Henttinen T, Määttä A.

J Invest Dermatol. 2008 Jan;128(1):26-34. Epub 2007 Jul 12.

32.

Role of dietary lignans in the reduction of breast cancer risk.

Saarinen NM, Wärri A, Airio M, Smeds A, Mäkelä S.

Mol Nutr Food Res. 2007 Jul;51(7):857-66. Review.

PMID:
17576639
33.

Progesterone enhances branching morphogenesis in the mouse mammary gland by increased expression of Msx2.

Satoh K, Hovey RC, Malewski T, Warri A, Goldhar AS, Ginsburg E, Saito K, Lydon JP, Vonderhaar BK.

Oncogene. 2007 Nov 29;26(54):7526-34. Epub 2007 Jun 4.

PMID:
17546050
34.

Can modulation of mammary gland development by dietary factors support breast cancer prevention?

Wärri AM, Saarinen NM, Mäkelä SI.

Horm Res. 2007;68(5):248-60. Epub 2007 May 14. Review.

35.

Effects of neonatal exposure to diethylstilbestrol, tamoxifen, and toremifene on the BALB/c mouse mammary gland.

Hovey RC, Asai-Sato M, Warri A, Terry-Koroma B, Colyn N, Ginsburg E, Vonderhaar BK.

Biol Reprod. 2005 Feb;72(2):423-35. Epub 2004 Oct 6.

PMID:
15470002
36.

Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.

Saarinen NM, Huovinen R, Wärri A, Mäkelä SI, Valentín-Blasini L, Sjöholm R, Ammälä J, Lehtilä R, Eckerman C, Collan YU, Santti RS.

Mol Cancer Ther. 2002 Aug;1(10):869-76.

37.

Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium.

Förster C, Mäkela S, Wärri A, Kietz S, Becker D, Hultenby K, Warner M, Gustafsson JA.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15578-83. Epub 2002 Nov 18. Erratum in: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8298.

38.

Mammary gland development in transgenic male mice expressing human P450 aromatase.

Li X, Wärri A, Mäkelä S, Ahonen T, Streng T, Santti R, Poutanen M.

Endocrinology. 2002 Oct;143(10):4074-83.

PMID:
12239119
39.

Uptake and metabolism of hydroxymatairesinol in relation to its anticarcinogenicity in DMBA-induced rat mammary carcinoma model.

Saarinen NM, Huovinen R, Wärri A, Mäkelä SI, Valentín-Blasini L, Needham L, Eckerman C, Collan YU, Santti R.

Nutr Cancer. 2001;41(1-2):82-90.

PMID:
12094633
40.

Estrogen receptor beta in breast cancer.

Palmieri C, Cheng GJ, Saji S, Zelada-Hedman M, Wärri A, Weihua Z, Van Noorden S, Wahlstrom T, Coombes RC, Warner M, Gustafsson JA.

Endocr Relat Cancer. 2002 Mar;9(1):1-13. Review.

PMID:
11914179
41.

Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase.

Li X, Nokkala E, Yan W, Streng T, Saarinen N, Wärri A, Huhtaniemi I, Santti R, Mäkelä S, Poutanen M.

Endocrinology. 2001 Jun;142(6):2435-42.

PMID:
11356692
42.

Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).

Saarinen NM, Wärri A, Mäkelä SI, Eckerman C, Reunanen M, Ahotupa M, Salmi SM, Franke AA, Kangas L, Santti R.

Nutr Cancer. 2000;36(2):207-16.

PMID:
10890032
43.
44.
45.

Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro.

Wärri AM, Huovinen RL, Laine AM, Martikainen PM, Härkönen PL.

J Natl Cancer Inst. 1993 Sep 1;85(17):1412-8.

PMID:
8350365
46.

Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.

Lehtola L, Partanen J, Sistonen L, Korhonen J, Wärri A, Härkönen P, Clarke R, Alitalo K.

Int J Cancer. 1992 Feb 20;50(4):598-603.

PMID:
1311287
47.

Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice.

Wärri AM, Laine AM, Majasuo KE, Alitalo KK, Härkönen PL.

Int J Cancer. 1991 Oct 21;49(4):616-23.

PMID:
1680817
48.

Effect of toremifene on the activity of NK-cells in NZB/NZW mice.

Wärri A, Kangas L.

J Steroid Biochem. 1990 Jun 22;36(3):207-9.

PMID:
2142234
49.

Expression of the c-Ha-ras and neu oncogenes in DMBA-induced, anti-estrogen-treated rat mammary tumors.

Vuorio T, Wärri A, Sandberg M, Alitalo K, Vuorio E.

Int J Cancer. 1988 Nov 15;42(5):774-9.

PMID:
2972630

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