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Items: 1 to 50 of 185

1.

NMDA Receptor Opening and Closing-Transitions of a Molecular Machine Revealed by Molecular Dynamics.

Černý J, Božíková P, Balík A, Marques SM, Vyklický L.

Biomolecules. 2019 Sep 28;9(10). pii: E546. doi: 10.3390/biom9100546.

2.

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.

Adla SK, Slavikova B, Chodounska H, Vyklicky V, Ladislav M, Hubalkova P, Krausova B, Smejkalova T, Nekardova M, Smidkova M, Monincova L, Soucek R, Vyklicky L, Kudova E.

Front Pharmacol. 2018 Nov 12;9:1299. doi: 10.3389/fphar.2018.01299. eCollection 2018.

3.

Positive Modulators of the N-Methyl-d-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters.

Krausova B, Slavikova B, Nekardova M, Hubalkova P, Vyklicky V, Chodounska H, Vyklicky L, Kudova E.

J Med Chem. 2018 May 24;61(10):4505-4516. doi: 10.1021/acs.jmedchem.8b00255. Epub 2018 May 4.

PMID:
29708744
4.

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate.

Ladislav M, Cerny J, Krusek J, Horak M, Balik A, Vyklicky L.

Front Mol Neurosci. 2018 Apr 6;11:113. doi: 10.3389/fnmol.2018.00113. eCollection 2018.

5.

Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit.

Vyklicky V, Krausova B, Cerny J, Ladislav M, Smejkalova T, Kysilov B, Korinek M, Danacikova S, Horak M, Chodounska H, Kudova E, Vyklicky L.

Front Mol Neurosci. 2018 Apr 6;11:110. doi: 10.3389/fnmol.2018.00110. eCollection 2018.

6.

Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor.

Kapras V, Vyklicky V, Budesinsky M, Cisarova I, Vyklicky L, Chodounska H, Jahn U.

Org Lett. 2018 Feb 16;20(4):946-949. doi: 10.1021/acs.orglett.7b03838. Epub 2018 Jan 24.

PMID:
29364682
7.

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus.

Bousova K, Herman P, Vecer J, Bednarova L, Monincova L, Majer P, Vyklicky L, Vondrasek J, Teisinger J.

FEBS J. 2018 Feb;285(3):599-613. doi: 10.1111/febs.14362. Epub 2017 Dec 29.

8.

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation.

Petrovic MM, Viana da Silva S, Clement JP, Vyklicky L, Mulle C, González-González IM, Henley JM.

Nat Neurosci. 2017 Apr;20(4):529-539. doi: 10.1038/nn.4505. Epub 2017 Feb 13.

PMID:
28192396
9.

The pharmacology of tacrine at N-methyl-d-aspartate receptors.

Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A, Ricny J, Vales K, Soukup O.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:54-62. doi: 10.1016/j.pnpbp.2017.01.003. Epub 2017 Jan 13. Review.

PMID:
28089695
10.

Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors.

Adla SK, Slavikova B, Smidkova M, Tloustova E, Svoboda M, Vyklicky V, Krausova B, Hubalkova P, Nekardova M, Holubova K, Vales K, Budesinsky M, Vyklicky L, Chodounska H, Kudova E.

Steroids. 2017 Jan;117:52-61. doi: 10.1016/j.steroids.2016.08.010. Epub 2016 Aug 17.

PMID:
27544449
11.

The characterization of a novel S100A1 binding site in the N-terminus of TRPM1.

Jirku M, Lansky Z, Bednarova L, Sulc M, Monincova L, Majer P, Vyklicky L, Vondrasek J, Teisinger J, Bousova K.

Int J Biochem Cell Biol. 2016 Sep;78:186-193. doi: 10.1016/j.biocel.2016.07.014. Epub 2016 Jul 17.

PMID:
27435061
12.

Biochemical and electrophysiological characterization of N-glycans on NMDA receptor subunits.

Kaniakova M, Lichnerova K, Skrenkova K, Vyklicky L, Horak M.

J Neurochem. 2016 Aug;138(4):546-56. doi: 10.1111/jnc.13679. Epub 2016 Jun 15.

13.

Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene.

Slavikova B, Chodounska H, Nekardova M, Vyklicky V, Ladislav M, Hubalkova P, Krausova B, Vyklicky L, Kudova E.

J Med Chem. 2016 May 26;59(10):4724-39. doi: 10.1021/acs.jmedchem.6b00079. Epub 2016 Apr 26.

PMID:
27064517
14.

Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives.

Vyklicky V, Smejkalova T, Krausova B, Balik A, Korinek M, Borovska J, Horak M, Chvojkova M, Kleteckova L, Vales K, Cerny J, Nekardova M, Chodounska H, Kudova E, Vyklicky L.

J Neurosci. 2016 Feb 17;36(7):2161-75. doi: 10.1523/JNEUROSCI.3181-15.2016.

15.

Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel.

Jirku M, Bumba L, Bednarova L, Kubala M, Sulc M, Franek M, Vyklicky L, Vondrasek J, Teisinger J, Bousova K.

Biophys Chem. 2015 Dec;207:135-42. doi: 10.1016/j.bpc.2015.10.005. Epub 2015 Oct 27.

PMID:
26544986
16.

A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications.

Kudova E, Chodounska H, Slavikova B, Budesinsky M, Nekardova M, Vyklicky V, Krausova B, Svehla P, Vyklicky L.

J Med Chem. 2015 Aug 13;58(15):5950-66. doi: 10.1021/acs.jmedchem.5b00570. Epub 2015 Jul 29.

PMID:
26171651
17.

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.

Vyklicky V, Krausova B, Cerny J, Balik A, Zapotocky M, Novotny M, Lichnerova K, Smejkalova T, Kaniakova M, Korinek M, Petrovic M, Kacer P, Horak M, Chodounska H, Vyklicky L.

Sci Rep. 2015 Jun 18;5:10935. doi: 10.1038/srep10935.

18.

PIP2 and PIP3 interact with N-terminus region of TRPM4 channel.

Bousova K, Jirku M, Bumba L, Bednarova L, Sulc M, Franek M, Vyklicky L, Vondrasek J, Teisinger J.

Biophys Chem. 2015 Oct;205:24-32. doi: 10.1016/j.bpc.2015.06.004. Epub 2015 Jun 9.

PMID:
26071843
19.

Cholesterol modulates open probability and desensitization of NMDA receptors.

Korinek M, Vyklicky V, Borovska J, Lichnerova K, Kaniakova M, Krausova B, Krusek J, Balik A, Smejkalova T, Horak M, Vyklicky L.

J Physiol. 2015 May 15;593(10):2279-93. doi: 10.1113/jphysiol.2014.288209. Epub 2015 Mar 24.

20.

Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors.

Lichnerova K, Kaniakova M, Skrenkova K, Vyklicky L, Horak M.

Front Cell Neurosci. 2014 Nov 10;8:375. doi: 10.3389/fncel.2014.00375. eCollection 2014.

21.

Structure, function, and pharmacology of NMDA receptor channels.

Vyklicky V, Korinek M, Smejkalova T, Balik A, Krausova B, Kaniakova M, Lichnerova K, Cerny J, Krusek J, Dittert I, Horak M, Vyklicky L.

Physiol Res. 2014;63 Suppl 1:S191-203. Review.

22.

Pregnenolone sulfate activates NMDA receptor channels.

Adamusová E, Cais O, Vyklický V, Kudová E, Chodounská H, Horák M, Vyklický L Jr.

Physiol Res. 2013;62(6):731-6.

23.

Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors.

Kaniakova M, Lichnerova K, Vyklicky L, Horak M.

J Neurochem. 2012 Nov;123(3):385-95. doi: 10.1111/jnc.12002. Epub 2012 Sep 28.

24.

Neuroactive steroids with perfluorobenzoyl group.

Cerný I, Buděšínský M, Pouzar V, Vyklický V, Krausová B, Vyklický L Jr.

Steroids. 2012 Oct;77(12):1233-41. doi: 10.1016/j.steroids.2012.07.004. Epub 2012 Jul 25.

PMID:
22842234
25.

3α5β-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia.

Vales K, Rambousek L, Holubova K, Svoboda J, Bubenikova-Valesova V, Chodounska H, Vyklicky L, Stuchlik A.

Behav Brain Res. 2012 Nov 1;235(1):82-8. doi: 10.1016/j.bbr.2012.07.020. Epub 2012 Jul 20.

PMID:
22820236
26.

Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors.

Kaniakova M, Krausova B, Vyklicky V, Korinek M, Lichnerova K, Vyklicky L, Horak M.

J Biol Chem. 2012 Jul 27;287(31):26423-34. doi: 10.1074/jbc.M112.339085. Epub 2012 Jun 18.

27.

New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.

Palma-Cerda F, Auger C, Crawford DJ, Hodgson AC, Reynolds SJ, Cowell JK, Swift KA, Cais O, Vyklicky L, Corrie JE, Ogden D.

Neuropharmacology. 2012 Sep;63(4):624-34. doi: 10.1016/j.neuropharm.2012.05.010. Epub 2012 May 17. Erratum in: Neuropharmacology. 2013 Feb;65:245.

PMID:
22609535
28.

Synthesis of deuterium labeled NMDA receptor inhibitor - 20-Oxo-5β-[9,12,12-(2)H(3)]pregnan-3α-yl-L-glutamyl 1-ester.

Kapras V, Slavickova A, Stastna E, Vyklicky L Jr, Vales K, Chodounska H.

Steroids. 2012 Feb;77(3):282-7. doi: 10.1016/j.steroids.2011.12.019. Epub 2011 Dec 19.

PMID:
22209708
29.

Access of inhibitory neurosteroids to the NMDA receptor.

Borovska J, Vyklicky V, Stastna E, Kapras V, Slavikova B, Horak M, Chodounska H, Vyklicky L Jr.

Br J Pharmacol. 2012 Jun;166(3):1069-83. doi: 10.1111/j.1476-5381.2011.01816.x.

30.

Neurosteroid modulation of N-methyl-D-aspartate receptors: molecular mechanism and behavioral effects.

Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr.

Steroids. 2011 Dec 11;76(13):1409-18. doi: 10.1016/j.steroids.2011.09.002. Epub 2011 Sep 7. Review.

PMID:
21925193
31.

Azido analogs of neuroactive steroids.

Vidrna L, Černý I, Pouzar V, Borovská J, Vyklický V, Vyklický L Jr, Chodounská H.

Steroids. 2011 Sep-Oct;76(10-11):1043-50. doi: 10.1016/j.steroids.2011.04.008. Epub 2011 Apr 25.

PMID:
21545806
32.

Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.

Rambousek L, Bubenikova-Valesova V, Kacer P, Syslova K, Kenney J, Holubova K, Najmanova V, Zach P, Svoboda J, Stuchlik A, Chodounska H, Kapras V, Adamusova E, Borovska J, Vyklicky L, Vales K.

Neuropharmacology. 2011 Jul-Aug;61(1-2):61-8. doi: 10.1016/j.neuropharm.2011.02.018. Epub 2011 Feb 24.

PMID:
21354187
33.

Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents.

Korinek M, Sedlacek M, Cais O, Dittert I, Vyklicky L Jr.

Neuroscience. 2010 Feb 3;165(3):736-48. doi: 10.1016/j.neuroscience.2009.10.058. Epub 2009 Oct 31.

PMID:
19883737
34.

Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent.

Petrovic M, Sedlacek M, Cais O, Horak M, Chodounska H, Vyklicky L Jr.

Neuroscience. 2009 May 19;160(3):616-28. doi: 10.1016/j.neuroscience.2009.02.052. Epub 2009 Mar 6.

PMID:
19272423
35.

Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons.

Stastna E, Chodounska H, Pouzar V, Kapras V, Borovska J, Cais O, Vyklicky L Jr.

Steroids. 2009 Feb;74(2):256-63. doi: 10.1016/j.steroids.2008.11.011. Epub 2008 Nov 24.

PMID:
19071149
36.

Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.

Sedlácek M, Korínek M, Petrovic M, Cais O, Adamusová E, Chodounská H, Vyklický L Jr.

Physiol Res. 2008;57 Suppl 3:S49-57. Epub 2008 May 13. Review.

37.

Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.

Vyklický L, Nováková-Tousová K, Benedikt J, Samad A, Touska F, Vlachová V.

Physiol Res. 2008;57 Suppl 3:S59-68. Epub 2008 May 13.

38.

Temperature dependence of NR1/NR2B NMDA receptor channels.

Cais O, Sedlacek M, Horak M, Dittert I, Vyklicky L Jr.

Neuroscience. 2008 Jan 24;151(2):428-38. Epub 2007 Nov 7.

PMID:
18068304
39.

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

Novakova-Tousova K, Vyklicky L, Susankova K, Benedikt J, Samad A, Teisinger J, Vlachova V.

Neuroscience. 2007 Oct 12;149(1):144-54. Epub 2007 Aug 8.

PMID:
17869438
40.

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).

Susankova K, Ettrich R, Vyklicky L, Teisinger J, Vlachova V.

J Neurosci. 2007 Jul 11;27(28):7578-85.

41.

Morphology and physiology of lamina I neurons of the caudal part of the trigeminal nucleus.

Sedlacek M, Horak M, Vyklický L Jr.

Neuroscience. 2007 Jun 29;147(2):325-33. Epub 2007 Jun 1.

PMID:
17543462
42.

Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.

Benedikt J, Teisinger J, Vyklicky L, Vlachova V.

J Neurochem. 2007 Jan;100(1):211-24. Epub 2006 Oct 27.

43.

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.

Susankova K, Tousova K, Vyklicky L, Teisinger J, Vlachova V.

Mol Pharmacol. 2006 Jul;70(1):383-94. Epub 2006 Apr 13.

PMID:
16614139
44.

Self-assembly and oligomerization of alkyne-terminated molecules on metal and oxide surfaces.

Vyklický L, Afzali-Ardakani A, Kagan CR.

Langmuir. 2005 Dec 6;21(25):11574-7.

PMID:
16316082
45.

Physiology and pathology of NMDA receptors.

Petrović M, Horák M, Sedlácek M, Vyklický L Jr.

Prague Med Rep. 2005;106(2):113-36. Review.

PMID:
16315761
46.

Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate.

Horak M, Vlcek K, Chodounska H, Vyklicky L Jr.

Neuroscience. 2006;137(1):93-102. Epub 2005 Oct 28.

PMID:
16257494
47.

20-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor.

Petrovic M, Sedlacek M, Horak M, Chodounska H, Vyklický L Jr.

J Neurosci. 2005 Sep 14;25(37):8439-50.

48.

Improved superfusion technique for rapid cooling or heating of cultured cells under patch-clamp conditions.

Dittert I, Benedikt J, Vyklický L, Zimmermann K, Reeh PW, Vlachová V.

J Neurosci Methods. 2006 Mar 15;151(2):178-85. Epub 2005 Aug 29.

PMID:
16129494
49.

Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites.

Tousova K, Vyklicky L, Susankova K, Benedikt J, Vlachova V.

Mol Cell Neurosci. 2005 Oct;30(2):207-17.

PMID:
16099171
50.

Molecular mechanism of pregnenolone sulfate action at NR1/NR2B receptors.

Horak M, Vlcek K, Petrovic M, Chodounska H, Vyklicky L Jr.

J Neurosci. 2004 Nov 17;24(46):10318-25.

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