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Items: 1 to 50 of 55

1.

CpALS4770 and CpALS4780 contribution to the virulence of Candida parapsilosis.

Zoppo M, Di Luca M, Franco M, Rizzato C, Lupetti A, Stringaro A, De Bernardis F, Schaudinn C, Barrasa MI, Bottai D, Vyas VK, Tavanti A.

Microbiol Res. 2019 Oct 18;231:126351. doi: 10.1016/j.micres.2019.126351. [Epub ahead of print]

PMID:
31707298
2.

A CRISPR/Cas9-based strategy to simultaneously inactivate the entire ALS gene family in Candida orthopsilosis.

Zoppo M, Di Luca M, Villarreal SN, Poma N, Barrasa MI, Bottai D, Vyas VK, Tavanti A.

Future Microbiol. 2019 Oct 29. doi: 10.2217/fmb-2019-0168. [Epub ahead of print]

PMID:
31659913
3.

Correction: Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts.

Mertens S, Gallone B, Steensels J, Herrera-Malaver B, Cortebeek J, Nolmans R, Saels V, Vyas VK, Verstrepen KJ.

PLoS One. 2019 Oct 24;14(10):e0224525. doi: 10.1371/journal.pone.0224525. eCollection 2019.

4.

Highly Enantioselective One-Pot Synthesis of Chiral β-Heterosubstituted Alcohols via Ruthenium-Prolinamide-Catalyzed Asymmetric Transfer Hydrogenation.

Vyas VK, Srivastava P, Bhatt P, Shende V, Ghosh P, Bhanage BM.

ACS Omega. 2018 Oct 5;3(10):12737-12745. doi: 10.1021/acsomega.8b01316. eCollection 2018 Oct 31.

5.

3D QSAR-based design and liquid phase combinatorial synthesis of 1,2-disubstituted benzimidazole-5-carboxylic acid and 3-substituted-5H-benzimidazo[1,2-d][1,4]benzodiazepin-6(7H)-one derivatives as anti-mycobacterial agents.

Sitwala ND, Vyas VK, Gedia P, Patel K, Bouzeyen R, Kidwai S, Singh R, Ghate MD.

Medchemcomm. 2019 Mar 22;10(5):817-827. doi: 10.1039/c9md00006b. eCollection 2019 May 1.

PMID:
31293724
6.

CoMFA, CoMSIA, Topomer CoMFA, HQSAR, molecular docking and molecular dynamics simulations study of triazine morpholino derivatives as mTOR inhibitors for the treatment of breast cancer.

Chhatbar DM, Chaube UJ, Vyas VK, Bhatt HG.

Comput Biol Chem. 2019 Jun;80:351-363. doi: 10.1016/j.compbiolchem.2019.04.017. Epub 2019 May 3.

PMID:
31085426
7.

Synthesis of 2-,4,-6-, and/or 7-substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents: 3D QSAR-assisted design.

Vyas VK, Qureshi G, Oza D, Patel H, Parmar K, Patel P, Ghate MD.

Bioorg Med Chem Lett. 2019 Apr 1;29(7):917-922. doi: 10.1016/j.bmcl.2019.01.038. Epub 2019 Jan 31.

PMID:
30738663
8.

Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts.

Mertens S, Gallone B, Steensels J, Herrera-Malaver B, Cortebeek J, Nolmans R, Saels V, Vyas VK, Verstrepen KJ.

PLoS One. 2019 Jan 9;14(1):e0209124. doi: 10.1371/journal.pone.0209124. eCollection 2019. Erratum in: PLoS One. 2019 Oct 24;14(10):e0224525.

9.

CRISPR-mediated Genome Editing of the Human Fungal Pathogen Candida albicans.

Evans BA, Pickerill ES, Vyas VK, Bernstein DA.

J Vis Exp. 2018 Nov 14;(141). doi: 10.3791/58764.

PMID:
30507925
10.

Studies on effect of CuO addition on mechanical properties and in vitro cytocompatibility in 1393 bioactive glass scaffold.

Ali A, Ershad M, Vyas VK, Hira SK, Manna PP, Singh BN, Yadav S, Srivastava P, Singh SP, Pyare R.

Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:341-355. doi: 10.1016/j.msec.2018.08.003. Epub 2018 Aug 3.

PMID:
30274066
11.

Medicinal Chemistry of Potassium Channel Modulators: An Update of Recent Progress (2011-2017).

Vyas VK, Parikh P, Ramani J, Ghate M.

Curr Med Chem. 2019;26(12):2062-2084. doi: 10.2174/0929867325666180430152023. Review.

PMID:
29714134
12.

New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi.

Vyas VK, Bushkin GG, Bernstein DA, Getz MA, Sewastianik M, Barrasa MI, Bartel DP, Fink GR.

mSphere. 2018 Apr 25;3(2). pii: e00154-18. doi: 10.1128/mSphere.00154-18. Print 2018 Apr 25.

13.

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.

Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE.

PLoS Genet. 2018 Mar 28;14(3):e1007270. doi: 10.1371/journal.pgen.1007270. eCollection 2018 Mar.

14.

Combining Electronic and Steric Effects To Generate Hindered Propargylic Alcohols in High Enantiomeric Excess.

Vyas VK, Knighton RC, Bhanage BM, Wills M.

Org Lett. 2018 Feb 16;20(4):975-978. doi: 10.1021/acs.orglett.7b03884. Epub 2018 Jan 31.

PMID:
29384378
15.

Kinetic resolution of 1,2-diols using immobilized Burkholderia cepacia lipase: A combined experimental and molecular dynamics investigation.

Mathpati AC, Vyas VK, Bhanage BM.

J Biotechnol. 2017 Nov 20;262:1-10. doi: 10.1016/j.jbiotec.2017.09.017. Epub 2017 Sep 25.

PMID:
28958793
16.

Liquid phase combinatorial synthesis of 1,2,5-trisubstituted benzimidazole derivatives as human DHODH inhibitors.

Sitwala ND, Vyas VK, Variya BC, Patel SS, Mehta CC, Rana DN, Ghate MD.

Bioorg Chem. 2017 Dec;75:118-126. doi: 10.1016/j.bioorg.2017.08.016. Epub 2017 Aug 30.

PMID:
28941392
17.

Combined in silico approaches for the identification of novel inhibitors of human islet amyloid polypeptide (hIAPP) fibrillation.

Patel P, Parmar K, Vyas VK, Patel D, Das M.

J Mol Graph Model. 2017 Oct;77:295-310. doi: 10.1016/j.jmgm.2017.09.004. Epub 2017 Sep 6.

PMID:
28917147
18.
20.

Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity.

Bhadada SV, Vyas VK, Goyal RK.

Biomed Pharmacother. 2016 Oct;83:221-228. doi: 10.1016/j.biopha.2016.05.018. Epub 2016 Jun 30.

PMID:
27372406
21.

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.

Srivastava P, Vyas VK, Variya B, Patel P, Qureshi G, Ghate M.

Bioorg Chem. 2016 Aug;67:130-8. doi: 10.1016/j.bioorg.2016.06.004. Epub 2016 Jun 17.

PMID:
27376460
22.

Molecular modeling study for the design of novel acetyl-CoA carboxylase inhibitors using 3D QSAR, molecular docking and dynamic simulations.

Vyas VK, Dabasia M, Qureshi G, Patel P, Ghate M.

J Biomol Struct Dyn. 2017 Jul;35(9):2003-2015. doi: 10.1080/07391102.2016.1204945. Epub 2016 Jul 12.

PMID:
27335214
23.

Identification of novel PfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking and in vivo antimalarial activity.

Vyas VK, Qureshi G, Ghate M, Patel H, Dalai S.

SAR QSAR Environ Res. 2016 Jun;27(6):427-40. doi: 10.1080/1062936X.2016.1189959. Epub 2016 Jun 16.

PMID:
27310104
24.

Homology modeling, binding site identification and docking study of human angiotensin II type I (Ang II-AT1) receptor.

Vyas VK, Ghate M, Patel K, Qureshi G, Shah S.

Biomed Pharmacother. 2015 Aug;74:42-8. doi: 10.1016/j.biopha.2015.07.008. Epub 2015 Jul 31.

PMID:
26349961
25.
26.

Influence of barium substitution on bioactivity, thermal and physico-mechanical properties of bioactive glass.

Arepalli SK, Tripathi H, Vyas VK, Jain S, Suman SK, Pyare R, Singh SP.

Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:549-559. doi: 10.1016/j.msec.2015.01.049. Epub 2015 Jan 12.

PMID:
25686983
27.

Ligand and structure-based approaches for the identification of SIRT1 activators.

Vyas VK, Goel A, Ghate M, Patel P.

Chem Biol Interact. 2015 Feb 25;228:9-17. doi: 10.1016/j.cbi.2015.01.001. Epub 2015 Jan 13.

PMID:
25595223
28.

Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents.

Vyas VK, Variya B, Ghate MD.

Eur J Med Chem. 2014 Jul 23;82:385-93. doi: 10.1016/j.ejmech.2014.05.064. Epub 2014 May 27.

PMID:
24929289
29.
30.

3D QSAR studies on substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist.

Vyas VK, Ghate M, Chintha C, Patel P.

Curr Comput Aided Drug Des. 2013 Sep;9(3):433-45.

PMID:
24010938
31.

Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.

Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL.

PLoS Pathog. 2013;9(6):e1003446. doi: 10.1371/journal.ppat.1003446. Epub 2013 Jun 27.

32.

Development of docking-based 3D QSAR models for the design of substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors.

Vyas VK, Ghate M.

SAR QSAR Environ Res. 2013 Aug;24(8):625-45. doi: 10.1080/1062936X.2013.792871. Epub 2013 May 28.

PMID:
23714018
33.

Therapeutic potential of snake venom in cancer therapy: current perspectives.

Vyas VK, Brahmbhatt K, Bhatt H, Parmar U.

Asian Pac J Trop Biomed. 2013 Feb;3(2):156-62. doi: 10.1016/S2221-1691(13)60042-8. Review.

34.

Pharmacophore modeling, virtual screening, docking and in silico ADMET analysis of protein kinase B (PKB β) inhibitors.

Vyas VK, Ghate M, Goel A.

J Mol Graph Model. 2013 May;42:17-25. doi: 10.1016/j.jmgm.2013.01.010. Epub 2013 Feb 24.

PMID:
23507201
35.

CoMFA and CoMSIA studies on C-aryl glucoside SGLT2 inhibitors as potential anti-diabetic agents.

Vyas VK, Bhatt HG, Patel PK, Jalu J, Chintha C, Gupta N, Ghate M.

SAR QSAR Environ Res. 2013;24(7):519-51. doi: 10.1080/1062936X.2012.751553. Epub 2013 Jan 11.

PMID:
23305412
36.

Homology modeling a fast tool for drug discovery: current perspectives.

Vyas VK, Ukawala RD, Ghate M, Chintha C.

Indian J Pharm Sci. 2012 Jan;74(1):1-17. doi: 10.4103/0250-474X.102537.

37.

Genes come and go: the evolutionarily plastic path of budding yeast RNase III enzymes.

Bernstein DA, Vyas VK, Fink GR.

RNA Biol. 2012 Sep;9(9):1123-8. doi: 10.4161/rna.21360. Epub 2012 Sep 1. Review.

40.

Biology and medicinal chemistry approaches towards various apoptosis inducers.

Vyas VK, Chintha C, Pandya MR.

Anticancer Agents Med Chem. 2013 Mar;13(3):433-55. Review.

PMID:
22721391
41.

2D and 3D-QSAR study on 4-anilinoquinozaline derivatives as potent apoptosis inducer and efficacious anticancer agent.

Vyas VK, Ghate M, Katariya H.

Org Med Chem Lett. 2011 Oct 4;1(1):13. doi: 10.1186/2191-2858-1-13.

42.
43.

The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells.

Kuhn DM, Vyas VK.

FEMS Yeast Res. 2012 Jun;12(4):398-414. doi: 10.1111/j.1567-1364.2011.00785.x. Epub 2012 Jan 23.

44.

Candida albicans Dicer (CaDcr1) is required for efficient ribosomal and spliceosomal RNA maturation.

Bernstein DA, Vyas VK, Weinberg DE, Drinnenberg IA, Bartel DP, Fink GR.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):523-8. doi: 10.1073/pnas.1118859109. Epub 2011 Dec 15.

45.
46.

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages.

Esteban A, Popp MW, Vyas VK, Strijbis K, Ploegh HL, Fink GR.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14270-5. doi: 10.1073/pnas.1111415108. Epub 2011 Aug 8.

47.

Substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist: a review.

Vyas VK, Ghate M.

Mini Rev Med Chem. 2010 Dec;10(14):1366-84. Review.

PMID:
20937029
48.

Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae.

Vyas VK, Berkey CD, Miyao T, Carlson M.

Eukaryot Cell. 2005 Nov;4(11):1882-91.

49.
50.

Std1p (Msn3p) positively regulates the Snf1 kinase in Saccharomyces cerevisiae.

Kuchin S, Vyas VK, Kanter E, Hong SP, Carlson M.

Genetics. 2003 Feb;163(2):507-14.

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